Search results for: Weir structure
1635 Forces Association-Based Active Contour
Authors: Aicha Baya Goumeidane, Nafaa. Nacereddine
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A welded structure must be inspected to guarantee that the weld quality meets the design requirements to assure safety and reliability. However, X-ray image analyses and defect recognition with the computer vision techniques are very complex. Most difficulties lie in finding the small, irregular defects in poor contrast images which requires pre processing to image, extract, and classify features from strong background noise. This paper addresses the issue of designing methodology to extract defect from noisy background radiograph with image processing. Based on the use of actives contours this methodology seems to give good results
Keywords: Welding, Radiography, Computer vision, Active contour.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18881634 Vertex Configurations and Their Relationship on Orthogonal Pseudo-Polyhedra
Authors: Jefri Marzal, Hong Xie, Chun Che Fung
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Vertex configuration for a vertex in an orthogonal pseudo-polyhedron is an identity of a vertex that is determined by the number of edges, dihedral angles, and non-manifold properties meeting at the vertex. There are up to sixteen vertex configurations for any orthogonal pseudo-polyhedron (OPP). Understanding the relationship between these vertex configurations will give us insight into the structure of an OPP and help us design better algorithms for many 3-dimensional geometric problems. In this paper, 16 vertex configurations for OPP are described first. This is followed by a number of formulas giving insight into the relationship between different vertex configurations in an OPP. These formulas will be useful as an extension of orthogonal polyhedra usefulness on pattern analysis in 3D-digital images.Keywords: Orthogonal Pseudo Polyhedra, Vertex configuration
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 13691633 A High-Crosstalk Silicon Photonic Arrayed Waveguide Grating
Authors: Qing Fang, Lianxi Jia, Junfeng Song, Chao Li, Xianshu Luo, Mingbin Yu, Guoqiang Lo
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In this paper, we demonstrated a 1 × 4 silicon photonic cascaded arrayed waveguide grating, which is fabricated on a SOI wafer with a 220 nm top Si layer and a 2µm buried oxide layer. The measured on-chip transmission loss of this cascaded arrayed waveguide grating is ~ 5.6 dB, including the fiber-to-waveguide coupling loss. The adjacent crosstalk is 33.2 dB. Compared to the normal single silicon photonic arrayed waveguide grating with a crosstalk of ~ 12.5 dB, the crosstalk of this device has been dramatically increased.
Keywords: Silicon photonic, arrayed waveguide grating, high-crosstalk, cascaded structure.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18081632 Analysis of a Novel Strained Silicon RF LDMOS
Authors: V.Fathipour, M. A. Malakootian, S. Fathipour, M. Fathipour
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In this paper we propose a novel RF LDMOS structure which employs a thin strained silicon layer at the top of the channel and the N-Drift region. The strain is induced by a relaxed Si0.8 Ge0.2 layer which is on top of a compositionally graded SiGe buffer. We explain the underlying physics of the device and compare the proposed device with a conventional LDMOS in terms of energy band diagram and carrier concentration. Numerical simulations of the proposed strained silicon laterally diffused MOS using a 2 dimensional device simulator indicate improvements in saturation and linear transconductance, current drivability, cut off frequency and on resistance. These improvements are however accompanied with a suppression in the break down voltage.
Keywords: High Frequency MOSFET, Design of RF LDMOS, Strained-Silicon, LDMOS.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17951631 Numerical Investigation on Damage Evolution of Piles inside Liquefied Soil Foundation - Dynamic-Loading Experiments -
Authors: Ahmed Mohammed Youssef Mohammed, Mohammad Reza Okhovat, Koichi Maekawa
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The large and small-scale shaking table tests, which was conducted for investigating damage evolution of piles inside liquefied soil, are numerically simulated and experimental verified by the3D nonlinear finite element analysis. Damage evolution of elasto-plastic circular steel piles and reinforced concrete (RC) one with cracking and yield of reinforcement are focused on, and the failure patterns and residual damages are captured by the proposed constitutive models. The superstructure excitation behind quay wall is reproduced as well.Keywords: Soil-Structure Interaction, Piles, Soil Liquefaction.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 19981630 Introduction to Electron Spectroscopy for Surfaces Characterization
Authors: Abdelkader Benzian
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Spectroscopy is the study of the spectrum produced by the radiation-matter interaction which requires the study of electromagnetic radiation (or electrons) emitted, absorbed, or scattered by matter. Thus, the spectral analysis is using spectrometers which enables us to obtain curves that express the distribution of the energy emitted (spectrum). Analysis of emission spectra can therefore constitute several methods depending on the range of radiation energy. The most common methods used are Auger electron spectroscopy (AES) and Electron Energy Losses Spectroscopy (EELS), which allow the determination of the atomic structure on the surface. This paper focalized essentially on the Electron Energy Loss Spectroscopy.
Keywords: Dielectric, plasmon, mean free path, spectroscopy of electron energy losses.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 7721629 Numerical Solution of Linear Ordinary Differential Equations in Quantum Chemistry by Clenshaw Method
Authors: M. Saravi, F. Ashrafi, S.R. Mirrajei
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As we know, most differential equations concerning physical phenomenon could not be solved by analytical method. Even if we use Series Method, some times we need an appropriate change of variable, and even when we can, their closed form solution may be so complicated that using it to obtain an image or to examine the structure of the system is impossible. For example, if we consider Schrodinger equation, i.e., We come to a three-term recursion relations, which work with it takes, at least, a little bit time to get a series solution[6]. For this reason we use a change of variable such as or when we consider the orbital angular momentum[1], it will be necessary to solve. As we can observe, working with this equation is tedious. In this paper, after introducing Clenshaw method, which is a kind of Spectral method, we try to solve some of such equations.Keywords: Chebyshev polynomials, Clenshaw method, ODEs, Spectral methods
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14201628 Investigation of Utilization Possibility of Fluid Gas Desulfurization Waste for Industrial Waste Water Treatment
Authors: S. Kızıltas Demir, A. S. Kipcak, E. Moroydor Derun, N. Tugrul, S. Piskin
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Flue gas desulfurization gypsum (FGD) is a waste material arouse from coal power plants. Hydroxyapatite (HAP) is a biomaterial with porous structure. In this study, FGD gypsum which retrieved from coal power plant in Turkey was characterized and HAP particles which can be used as an adsorbent in wastewater treatment application were synthesized from the FGD gypsum. The raw materials are characterized by using X Ray Diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) techniques and produced HAP are characterized by using XRD. As a result, HAP particles were synthesized at the molar ratio of 5:10, 5:15, 5:20, 5:24, at room temperature, in alkaline medium (pH=11) and in 1 hour-reaction time. Among these conditions, 5:20 had the best result.Keywords: FGD wastes, HAP, gypsum, wastewater.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16061627 Bowden Cable Based Powered Ball and Socket Wrist Actuator
Authors: Samee Ahmad, Adnan Masood, Umar S. Khan
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A 2-Degrees of freedom powered prosthetic wrist actuator has been proposed that can provide the Abduction/Adduction & Flexion/Extension movements of the human wrist. The basic structure of the actuator is a Ball and Socket joint and the force is transmitted from the DC geared servo motors to the joint through the Bowden cables. The proposed design is capable of providing the required DOF in both axes i.e. 85° & 90° in flexion extension axis. The size and weight of the actuator lies within the ranges of an average human being-s wrist.Keywords: Actuator, Ball & Socket, Bowden Cable, Prosthetic, Wrist
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 35041626 Vibration Base Identification of Impact Force Using Genetic Algorithm
Authors: R. Hashemi, M.H.Kargarnovin
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This paper presents the identification of the impact force acting on a simply supported beam. The force identification is an inverse problem in which the measured response of the structure is used to determine the applied force. The identification problem is formulated as an optimization problem and the genetic algorithm is utilized to solve the optimization problem. The objective function is calculated on the difference between analytical and measured responses and the decision variables are the location and magnitude of the applied force. The results from simulation show the effectiveness of the approach and its robustness vs. the measurement noise and sensor location.Keywords: Genetic Algorithm, Inverse problem, Optimization, Vibration.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15541625 Simulation of Superconducting Nanowire Single-Photon Detector with Circuit Modeling
Authors: Seyed Ali Sedigh Zyabari, A. Zarifkar
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Single photon detectors have been fabricated NbN nano wire. These detectors are fabricated from high quality, ultra high vacuum sputtered NbN thin films on a sapphire substrate. In this work a typical schematic of the nanowire Single Photon Detector structure and then driving and measurement electronic circuit are shown. The response of superconducting nanowire single photon detectors during a photo detection event, is modeled by a special electrical circuits (two circuit). Finally, current through the wire is calculated by solving equations of models.Keywords: NbN, nanowire meander, superconducting single photon detector, kinetic inductance.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15031624 Development of Energy Management System Based on Internet of Things Technique
Authors: Wen-Jye Shyr, Chia-Ming Lin, Hung-Yun Feng
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The purpose of this study was to develop an energy management system for university campuses based on the Internet of Things (IoT) technique. The proposed IoT technique based on WebAccess is used via network browser Internet Explore and applies TCP/IP protocol. The case study of IoT for lighting energy usage management system was proposed. Structure of proposed IoT technique included perception layer, equipment layer, control layer, application layer and network layer.
Keywords: Energy management, IoT technique, Sensor, WebAccess
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 11381623 Royal Mound “Baygetobe“ from the Burial Ground Shilikty
Authors: Abdesh Toleubayev, Rinat Zhumatayev, Kulzhazira Toleubayeva
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Mounds are one of the most valuable sources of information on various aspects of life, household skills, rituals and beliefs of the ancient peoples of Kazakhstan. Moreover, the objects associated with the cult of the burial of the dead are the most informative, and often the only source of knowledge about past eras. The present study is devoted to some results of the excavations carried out on the mound "Baygetobe" of Shilikti burial ground. The purpose of the work is associated with certain categories of grave goods and reading "Fine Text" of Shilikti graves, whose structure is the same for burials of nobles and ordinary graves. The safety of a royal burial mounds, the integrity and completeness of the source are of particular value for studying.Keywords: Animal style, barrow, Baygetobe, dromos, Shilikty.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 24491622 Defect Modes in Multilayered Piezoelectric Structures
Authors: D. G. Piliposyan
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Propagation of electro-elastic waves in a piezoelectric waveguide with finite stacks and a defect layer is studied using a modified transfer matrix method. The dispersion equation for a periodic structure consisting of unit cells made up from two piezoelectric materials with metallized interfaces is obtained. An analytical expression, for the transmission coefficient for a waveguide with finite stacks and a defect layer, that is found can be used to accurately detect and control the position of the passband within a stopband. The result can be instrumental in constructing a tunable waveguide made of layers of different or identical piezoelectric crystals and separated by metallized interfaces.Keywords: Defect mode, Bloch waves, periodic phononic crystal, piezoelectric composite waveguide.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 11041621 Investigation and Perfection of Centrifugal Compressor Stages by CFD Methods
Authors: Y. Galerkin, L. Marenina
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Stator elements «Vane diffuser + crossover + return channel» of stages with different specific speed were investigated by CFD calculations. The regime parameter was introduced to present efficiency and loss coefficient performance of all elements together. Flow structure demonstrated advantages and disadvantages of design. Flow separation in crossovers was eliminated by its shape modification. Efficiency increased visibly. Calculated CFD performances are in acceptable correlation with predicted ones by engineering design method. The information obtained is useful for design method better calibration.
Keywords: Vane diffuser, return channel, crossover, efficiency, loss coefficient, inlet flow angle.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 21901620 Adolescents’ Role in Family Buying Decision Making
Authors: Harleen Kaur, Deepika Jindal Singla
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Buying decision making is a complicated process, in which consumer’s decision is under the impact of others. The buying decision making is directed in a way that they have to act as customers in the society. Media and family are key socialising agents for adolescents’. Moreover, changes in the socio-cultural environment in India necessitate that adolescents’ influence in family’s buying decision-making should be investigated. In comparison to Western society, Indian is quite different, when compared in terms of family composition and structure, behaviour, values and norms which effect adolescents’ buying decision-making.
Keywords: Adolescents’, buying behaviour, Indian urban families, consumer socialization.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 9311619 Ferrites of the MeFe2O4 System (Me – Zn, Cu, Cd) and Their Two Faces
Authors: B. S. Boyanov, A. B. Peltekov, K. I. Ivanov
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The ferrites ZnFe2O4, CdFe2O4 and CuFe2O4 are synthesized in laboratory conditions using ceramic technology. Their homogeneity and structure are proven by X-Ray diffraction analysis and Mössbauer spectroscopy. The synthesized ferrites are subjected to strong acid and high temperature leaching with solutions of H2SO4, HCl and HNO3. The results indicate that the highest degree of leaching of Zn, Cd and Cu from the ferrites is achieved by use of HCl. The charging of five zinc sulfide concentrates was optimized using the criterion of minimal amount of zinc ferrite produced when roasting the concentrates in a fluidized bed. The results obtained are interpreted in terms of the hydrometallurgical zinc production and maximum recovery of zinc, copper and cadmium from initial zinc concentrates after their roasting.
Keywords: Hydrometallurgy, inorganic acids, solubility, zinc ferrite.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17751618 Cooperative Multi Agent Soccer Robot Team
Authors: Vahid Rostami, Saeed Ebrahimijam, P.khajehpoor, P.Mirzaei, Mahdi Yousefiazar
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This paper introduces our first efforts of developing a new team for RoboCup Middle Size Competition. In our robots we have applied omni directional based mobile system with omnidirectional vision system and fuzzy control algorithm to navigate robots. The control architecture of MRL middle-size robots is a three layered architecture, Planning, Sequencing, and Executing. It also uses Blackboard system to achieve coordination among agents. Moreover, the architecture should have minimum dependency on low level structure and have a uniform protocol to interact with real robot.Keywords: Robocup, Soccer robots, Fuzzy controller, Multi agent.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15581617 Microstrip Patch Antenna Enhancement Techniques
Authors: Ahmad H. Abdelgwad
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Microstrip patch antennas are widely used in many wireless communication applications because of their various advantages such as light weight, compact size, inexpensive, ease of fabrication and high reliability. However, narrow bandwidth and low gain are the major drawbacks of microstrip antennas. The radiation properties of microstrip antenna is affected by many designing factors like feeding techniques, manufacturing substrate, patch and ground structure. This manuscript presents a review of the most popular gain and bandwidth enhancement methods of microstrip antenna and reports a brief description of its feeding techniques.Keywords: Gain and bandwidth enhancement, slotted patch, parasitic patch, electromagnetic band gap, defected ground, feeding techniques.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18191616 Auto Regressive Tree Modeling for Parametric Optimization in Fuzzy Logic Control System
Authors: Arshia Azam, J. Amarnath, Ch. D. V. Paradesi Rao
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The advantage of solving the complex nonlinear problems by utilizing fuzzy logic methodologies is that the experience or expert-s knowledge described as a fuzzy rule base can be directly embedded into the systems for dealing with the problems. The current limitation of appropriate and automated designing of fuzzy controllers are focused in this paper. The structure discovery and parameter adjustment of the Branched T-S fuzzy model is addressed by a hybrid technique of type constrained sparse tree algorithms. The simulation result for different system model is evaluated and the identification error is observed to be minimum.Keywords: Fuzzy logic, branch T-S fuzzy model, tree modeling, complex nonlinear system.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 13891615 Block Activity in Metric Neural Networks
Authors: Mario Gonzalez, David Dominguez, Francisco B. Rodriguez
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The model of neural networks on the small-world topology, with metric (local and random connectivity) is investigated. The synaptic weights are random, driving the network towards a chaotic state for the neural activity. An ordered macroscopic neuron state is induced by a bias in the network connections. When the connections are mainly local, the network emulates a block-like structure. It is found that the topology and the bias compete to influence the network to evolve into a global or a block activity ordering, according to the initial conditions.Keywords: Block attractor, random interaction, small world, spin glass.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 13371614 Influence of Strength Abilities on Quality of the Handstand
Authors: P. Hedbávný, G. Bago, M. Kalichová
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The contribution deals with influence of strength abilities on quality of performance of static balance movement structure – handstand. To test the strength abilities we selected following tests: number of push-ups per minute and persistence in trunk backward bend in sitting position. We tested the dependent variable by three tests – persistence in handstand position on a stabilometric platform, persistence in handstand position and evaluation of quality of handstand performance. Pearson’s correlation coefficient was used to formulate the relationship between variables. The results showed a statistically significant dependence using which we deduced conclusions for training practice.
Keywords: Strength abilities, handstand, balance.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 27521613 Experimental Investigation on Excess Pore Water Pressure in Soft Soil-Foundations under Minor Shocks
Authors: Zhiying Zhang, Chongdu Cho, Qiang Pan, Xilin Lu
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In this study, shaking table tests are performed to investigate the behavior of excess pore water pressure in different soft soil-foundations of soil-structure interaction (SSI) system. The variation of the behaviors under cycled minor shock is observed. Moreover, The generation and variation mechanism of excess pore water pressure under earthquake excitation in different soft soilfoundations are analyzed and discussed.
Keywords: Excess pore water pressure, shaking table tests, soft soil foundation, SSI system.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 27171612 Testing the Relationship between Economic Freedoms and Growth by Panel Causality Application: Case of Middle East Countries
Authors: Ahmet Ay, Hakan Acet, Ceyhun Can Özcan
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Economic freedoms, most emphasized issue in the recent years, are considered to affect economic growth and performance via institutional structure. In this context, a model that includes Turkey and Middle East Countries, and where the effects of economic freedom on growth are examined, was formed. For the groups of countries determined, in the study carried out by using the dataset belonging the period of 2004 - 2009, between economic freedoms and growth, a negative relationship was observed as group. In the sense of individual effects, it was identified that there was a positive relationship in terms of some Middle East Countries and Turkey.
Keywords: Economic Freedoms, Economic Growth, Freedoms.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17831611 Behavior of Cu-WC-Ti Metal Composite Afterusing Planetary Ball Milling
Authors: A.T.Z. Mahamat, A.M. A Rani, Patthi Husain
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Copper based composites reinforced with WC and Ti particles were prepared using planetary ball-mill. The experiment was designed by using Taguchi technique and milling was carried out in an air for several hours. The powder was characterized before and after milling using the SEM, TEM and X-ray for microstructure and for possible new phases. Microstructures show that milled particles size and reduction in particle size depend on many parameters. The distance d between planes of atoms estimated from X-ray powder diffraction data and TEM image. X-ray diffraction patterns of the milled powder did not show clearly any new peak or energy shift, but the TEM images show a significant change in crystalline structure of corporate on titanium in the composites.Keywords: ball milling, microstructures, titanium, tungstencarbides, X-ray
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15961610 Formation of Nanosize Phases under Thermomechanical Strengthening of Low Carbon Steel
Authors: Victor E. Gromov, Yurii F. Ivanov, Vadim B. Kosterev, Sergey V. Konovalov, Veronica I. Myasnikova, Guoyi Tang
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A study of the H-beam's nanosize structure phase states after thermomechanical strengthening was carried out by TEM. The following processes were analyzed. 1. The dispersing of the cementite plates by cutting them by moving dislocations. 2. The dissolution of cementite plates and repeated precipitation of the cementite particles on the dislocations, the boundaries, subgrains and grains. 3. The decay of solid solution of carbon in the α-iron after "self-tempering" of martensite. 4. The final transformation of the retained austenite in beinite with α-iron particles and cementite formation. 5. The implementation of the diffusion mechanism of γ ⇒ α transformation.Keywords: nanosize, phase, steel, strengthening
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16841609 Effect of Field Dielectric Material on Performance of InGaAs Power LDMOSFET
Authors: Yashvir Singh, Swati Chamoli
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In this paper, a power laterally-diffused metal-oxide-semiconductor field-effect transistor (LDMOSFET) on In0.53Ga0.47As is presented. The device utilizes a thicker field-oxide with low dielectric constant under the field-plate in order to achieve possible reduction in device capacitances and reduced-surface-field effect. Using 2D numerical simulations, performance of the proposed device is analyzed and compared with that of the conventional LDMOSFET. The proposed structure provides 50% increase in the breakdown voltage, 21% increase in transit frequency, and 72% improvement in figure-of-merit over the conventional device for same cell pitch.
Keywords: InGaAs, dielectric, lateral, power MOSFET.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 19101608 Meshed Antenna for Ku-band Wireless Communication
Authors: Chokri Baccouch, Chayma Bahhar, Hedi Sakli, Nizar Sakli
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In this article, we present the combination of an antenna patch structure with a photovoltaic cell in one device for telecommunication applications in isolated environments. The radiating patch element of a patch antenna was replaced by a solar cell. DC current generation is the original feature of the solar cell, but now it was additionally able to receive and transmit electromagnetic waves. A mathematical model which serves in the minimization of power losses of the cell and therefore the improvement in conversion performance was studied. Simulation results of this antenna show a resonance at a frequency of 16.55 GHz in Ku-band with a gain of 4.24 dBi.
Keywords: Electric power collected, optical and electrical losses, optimization of the grid of collection, patch antenna, photovoltaic cell.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 7611607 Integrated Method for Detection of Unknown Steganographic Content
Authors: Magdalena Pejas
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This article concerns the presentation of an integrated method for detection of steganographic content embedded by new unknown programs. The method is based on data mining and aggregated hypothesis testing. The article contains the theoretical basics used to deploy the proposed detection system and the description of improvement proposed for the basic system idea. Further main results of experiments and implementation details are collected and described. Finally example results of the tests are presented.Keywords: Steganography, steganalysis, data embedding, data mining, feature extraction, knowledge base, system learning, hypothesis testing, error estimation, black box program, file structure.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15641606 A New Gateway for Rheumatoid Arthritis: COXIBs with an Improved Cardiovascular Profile
Authors: M. Hoxha, V. Capra, C. Buccellati, A. Sala, C. Cena, R. Fruttero, M. Bertinaria, G. E. Rovati
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Today COXIBs are used in the treatment of arthritis and many other painful conditions in selected patients with high gastrointestinal risk and low cardiovascular (CV) risk. Previously, we have identified an unexpected mechanism of action of a traditional non-steroidal anti-inflammatory drug (NSAID) (diclofenac) and a specific inhibitor of cyclooxygenase-2 (COXIB) (lumiracoxib) demonstrating that they possess weak competitive antagonism at the thromboxane receptor (TP). We hypothesize that modifying the structure of a known COXIB so that it becomes also a more potent TP antagonist will preserve the anti-inflammatory and gastrointestinal safety typical of COXIBs and prevent the CV risk associated with long term therapy.
Keywords: Cyclooxygenase, inflammation, lumiracoxib, thromboxane A2.
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