Search results for: rectangular surfaces

Authors: Yang-Keun Ahn, Kwang-Soon Choi, Young-Choong Park, Kwang-Mo Jung

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This paper proposes a method to recognize the tip of a finger and space touch hand gesture using an infrared camera in a smart device environment. The proposed method estimates the tip of a finger with a curvature-based ellipse fitting algorithm, and verifies that the estimated object is indeed a finger with an ellipse fitting rectangular area. The feature extracted from the verified finger tip is used to implement the movement of a mouse and clicking gesture. The proposed algorithm was implemented with an actual smart device to test the proposed method. Empirical parameters were obtained from the keypad software and an image analysis tool for the performance optimization, and a comparative analysis with conventional research showed improved performance with the proposed method.

Keywords: Infrared camera, Hand gesture, Smart device, Space touch.

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Authors: K. Sivasubramanian, K. B. Jayanthi

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Floorplanning plays a vital role in the physical design process of Very Large Scale Integrated (VLSI) chips. It is an essential design step to estimate the chip area prior to the optimized placement of digital blocks and their interconnections. Since VLSI floorplanning is an NP-hard problem, many optimization techniques were adopted in the literature. In this work, a music-inspired Harmony Search (HS) algorithm is used for the fixed die outline constrained floorplanning, with the aim of reducing the total chip area. HS draws inspiration from the musical improvisation process of searching for a perfect state of harmony. Initially, B*-tree is used to generate the primary floorplan for the given rectangular hard modules and then HS algorithm is applied to obtain an optimal solution for the efficient floorplan. The experimental results of the HS algorithm are obtained for the MCNC benchmark circuits.

Keywords: Floor planning, harmony search, non-slicing floorplan, very large scale integrated circuits.

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Authors: W. Sun, W. Wen, J. Lu, A. A. Becker

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In this work, methods for determining creep properties which can be used to represent the full life until failure from miniature specimen creep tests based on analytical solutions are presented. Examples used to demonstrate the application of the methods include a miniature rectangular thin beam specimen creep test under three-point bending and a miniature two-material tensile specimen creep test subjected to a steady load. Mathematical expressions for deflection and creep strain rate of the two specimens were presented for the Kachanov-Rabotnov creep damage model. On this basis, an inverse procedure was developed which has potential applications for deriving the full life creep damage constitutive properties from a very small volume of material, in particular, for various microstructure constitutive  regions, e.g. within heat-affected zones of power plant pipe weldments. Further work on validation and improvement of the method is addressed.

Keywords: Creep damage property, analytical solutions, inverse approach, miniature specimen test.

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Authors: A. Manallah, C. Meier

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Confocal spectral interferometry (CSI) is an innovative optical method for determining microtopography of surfaces and thickness of transparent layers, based on the combination of two optical principles: confocal imaging, and spectral interferometry. Confocal optical system images at each instant a single point of the sample. The whole surface is reconstructed by plan scanning. The interference signal generated by mixing two white-light beams is analyzed using a spectrometer. In this work, five ‘rugotests’ of known standard roughnesses are investigated. The topography is then measured and illustrated, and the equivalent roughness is determined and compared with the standard values.

Keywords: Confocal spectral interferometry, Nondestructive testing, Optical metrology, Surface topography, Roughness.

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Authors: Abdelkader Benzian

Abstract:

Spectroscopy is the study of the spectrum produced by the radiation-matter interaction which requires the study of electromagnetic radiation (or electrons) emitted, absorbed, or scattered by matter. Thus, the spectral analysis is using spectrometers which enables us to obtain curves that express the distribution of the energy emitted (spectrum). Analysis of emission spectra can therefore constitute several methods depending on the range of radiation energy. The most common methods used are Auger electron spectroscopy (AES) and Electron Energy Losses Spectroscopy (EELS), which allow the determination of the atomic structure on the surface. This paper focalized essentially on the Electron Energy Loss Spectroscopy.

Keywords: Dielectric, plasmon, mean free path, spectroscopy of electron energy losses.

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Authors: A. Ghaznavi Jahromi, F. Mohajeri

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In this paper the design, fabrication, and testing of a miniaturized rectangular microstrip patch antenna loaded with DNG metamaterials is reported. The metamaterial is composed of two nested spiral strips and a single straight strip which are etched on two sides of a 5.7 mm×5.7 mm Rogers RT/duroid 5880 with 0.5 mm thickness and dielectric constant of 2.2. Two units of this structure as a double negative (DNG) medium in combination with air as a double positive (DPS) medium are used as substrate of the microstrip patch antenna. By placing these metamaterial structures under the patch, a sub-wavelength resonance occurs which leads to a smaller size patch antenna compared to the conventional antenna at that frequency. The total size of the proposed antenna is reduced 54.6%. The dimensions of the proposed patch antenna are significantly smaller than the wavelength of the operation frequency with respect to the conventional patch antenna. Simulation result and test result for the proposed patch antenna are given and compared.

Keywords: Antennas, Metamaterials, Microstrip Antennas, Miniaturization.

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Authors: Farhana Mohamad Yusop, Syafrudin Masri, Dahaman Ishak, Mohamad Kamarol

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Electromagnetic forces on three-phase five-wire (3P5W) busbar system is investigated under three-phase short-circuits current. The conductor busbar placed in compact galvanized steel enclosure is in the rectangular shape. Transient analysis from Opera-2D is carried out to develop the model of three-phase short-circuits current in the system. The result of the simulation is compared with the calculation result, which is obtained by applying the theories of Biot Savart’s law and Laplace equation. Under this analytical approach, the moment of peak short-circuit current is taken into account. The effect upon geometrical arrangement of the conductor and the present of the steel enclosure are considered by the theory of image. The result depict that the electromagnetic force due to the transient short-circuit from simulation is agreed with the calculation.

Keywords: Busbar, electromagnetic force, short-circuit current, transient analysis.

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Authors: A. Karimipour, M. Afrand, M. Akbari, M.R. Safaei

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Mixed convection in two-dimensional shallow rectangular enclosure is considered. The top hot wall moves with constant velocity while the cold bottom wall has no motion. Simulations are performed for Richardson number ranging from Ri = 0.001 to 100 and for Reynolds number keeping fixed at Re = 408.21. Under these conditions cavity encompasses three regimes: dominating forced, mixed and free convection flow. The Prandtl number is set to 6 and the effects of cavity inclination on the flow and heat transfer are studied for different Richardson number. With increasing the inclination angle, interesting behavior of the flow and thermal fields are observed. The streamlines and isotherm plots and the variation of the Nusselt numbers on the hot wall are presented. The average Nusselt number is found to increase with cavity inclination for Ri ³ 1 . Also it is shown that the average Nusselt number changes mildly with the cavity inclination in the dominant forced convection regime but it increases considerably in the regime with dominant natural convection.

Keywords: Mixed convection, inclined driven cavity, Richardson number.

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Authors: Mohammadreza Nezamirad, Sepideh Amirahmadian, Nasim Sabetpour, Azadeh Yazdi, Amirmasoud Hamedi

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Cavitation inside a diesel injector nozzle is investigated numerically in this study. The Reynolds Stress Navier Stokes set of equations (RANS) are utilized to investigate flow behavior inside the nozzle numerically. Moreover, K-ε turbulent model is found to be a better approach comparing to K-ω turbulent model. The Winklhofer rectangular shape nozzle is also simulated in order to verify the current numerical scheme, and with the mass flow rate approach, the current solution is verified. Afterward, a six-hole real size nozzle was simulated and it was found that among the different fuels used in this study with the same condition, diesel fuel provides the largest length of cavitation. Also, it was found that at the same boundary condition, rapeseed methyl ester (RME) fuel leads to the highest value of discharge coefficient and mass flow rate.

Keywords: cavitation, diesel fuel, CFD, real size nozzle, discharge coefficient

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Authors: Munawwar Mohabuth, Andrei Kotousov, Ching-Tai Ng

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On the basis of the theory of nonlinear elasticity, the effect of homogeneous stress on the propagation of Lamb waves in an initially isotropic hyperelastic plate is analysed. The equations governing the propagation of small amplitude waves in the prestressed plate are derived using the theory of small deformations superimposed on large deformations. By enforcing traction free boundary conditions at the upper and lower surfaces of the plate, acoustoelastic dispersion equations for Lamb wave propagation are obtained, which are solved numerically. Results are given for an aluminum plate subjected to a range of applied stresses.

Keywords: Acoustoelasticity, dispersion, finite deformation, lamb waves.

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Authors: Sasitharan Ambicapathy, J. Vignesh, P. Sivaraj, Godfrey Derek Sams, K. Sabarinath, V. R. Sanal Kumar

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The external flow simulation of a flying car at take off phase is a daunting task owing to the fact that the prediction of the transient unsteady flow features during its deployment phase is very complex. In this paper 3D numerical simulations of external flow of Ferrari F430 proposed flying car with different NACA 9618 rectangular wings have been carried. Additionally, the aerodynamics characteristics have been generated for optimizing its geometry for achieving the minimum take off velocity with better overall performance in both road and air. The three-dimensional standard k-omega turbulence model has been used for capturing the intrinsic flow physics during the take off phase. In the numerical study, a fully implicit finite volume scheme of the compressible, Reynolds-Averaged, Navier-Stokes equations is employed. Through the detailed parametric analytical studies we have conjectured that Ferrari F430 flying car facilitated with high wings having three different deployment histories during the take off phase is the best choice for accomplishing its better performance for the commercial applications.

Keywords: Aerodynamics of flying car, air taxi, negative lift. roadable airplane.

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Authors: S. I. Abu Alasal, M. M. Esbeih, E. R. Fayyad, R. S. Gharaibeh, M. Z. Ali, A. A. Freewan, M. M. Jamhawi

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This research proposes a novel reconstruction protocol for restoring missing surfaces and low-quality edges and shapes in photos of artifacts at historical sites. The protocol starts with the extraction of a cloud of points. This extraction process is based on four subordinate algorithms, which differ in the robustness and amount of resultant. Moreover, they use different -but complementary- accuracy to some related features and to the way they build a quality mesh. The performance of our proposed protocol is compared with other state-of-the-art algorithms and toolkits. The statistical analysis shows that our algorithm significantly outperforms its rivals in the resultant quality of its object files used to reconstruct the desired model.

Keywords: Meshes, Point Clouds, Surface Reconstruction Protocols, 3D Reconstruction.

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Authors: M. Meenasaranya, S. Saravanan

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Conditions corresponding to the unconditional stability of convection in a mechanically anisotropic fluid saturated porous medium of infinite horizontal extent are determined. The medium is heated from below and its bounding surfaces are subjected to temperature modulation which consists of a steady part and a time periodic oscillating part. The Brinkman model is employed in the momentum equation with the Bousinessq approximation. The stability region is found for arbitrary values of modulational frequency and amplitude using the energy method. Higher order numerical computations are carried out to find critical boundaries and subcritical instability regions more accurately.

Keywords: Convection, porous medium, anisotropy, temperature modulation, nonlinear stability.

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Authors: Man Young Kim

Abstract:

The objective of this work is to investigate the turbulent reacting flow in a three dimensional combustor with emphasis on the effect of inlet swirl flow through a numerical simulation. Flow field is analyzed using the SIMPLE method which is known as stable as well as accurate in the combustion modeling, and the finite volume method is adopted in solving the radiative transfer equation. In this work, the thermal and flow characteristics in a three dimensional combustor by changing parameters such as equivalence ratio and inlet swirl angle have investigated. As the equivalence ratio increases, which means that more fuel is supplied due to a larger inlet fuel velocity, the flame temperature increases and the location of maximum temperature has moved towards downstream. In the mean while, the existence of inlet swirl velocity makes the fuel and combustion air more completely mixed and burnt in short distance. Therefore, the locations of the maximum reaction rate and temperature were shifted to forward direction compared with the case of no swirl.

Keywords: Gaseous Fuel, Inlet Swirl, Thermal Radiation, Turbulent Combustion

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Authors: R. Kumaravelan, V. C. Sathish Gandhi, S. Ramesh, M. Venkatesan

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In the product design and development process, the prototyping or model making is one of the important step to finalize a product which helps in conceptualization of a design. Rapid Prototyping (RP) is layer-by-layer material deposition started during early 1980s with the enormous growth in Computer Aided Design and Manufacturing (CAD/CAM) technologies. The edges and surfaces of a complex solid model and their information are used for defining a product which is further manufactured as a finished product by CNC machining. This paper provides a better platform for researchers, new learners and product manufacturers for various applications of RP models. Subsequently it creates awareness among the peoples of recently developing RP method of manufacturing in product design, developments and its applications.

Keywords: Prototyping, layer-by-layer, CAD/CAM, product design.

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Authors: Behzad Mohammadzadeh, Huyk Chun Noh

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Plate is one of the popular structural elements used in a wide range of industries and structures. They may be subjected to blast loads during explosion events, missile attacks or aircraft attacks. This study is to investigate dynamic responses of the rectangular plate subjected to explosive loads. The effects of material properties and plate thickness on responses of the plate are to be investigated. The compressive pressure is applied to the surface of the plate. Different amounts of thickness in the range from 1mm to 30mm are considered for the plate to evaluate the changes in responses of the plate with respect to plate thickness. Two different properties are considered for the steel. First, the analysis is performed by considering only the elastic-plastic properties for the steel plate. Later on damping is considered to investigate its effects on the responses of the plate. To do analysis, numerical method using a finite element based package ABAQUS is applied. Finally, dynamic responses and graphs showing the relation between maximum displacement of the plate and aim parameters are provided.

Keywords: Impulsive loaded plates, dynamic analysis, abaqus, material nonlinearity.

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Authors: S.Ponmalar, S.Sundaravadivelu

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Traditional optical networks are gradually evolving towards intelligent optical networks due to the need for faster bandwidth provisioning, protection and restoration of the network that can be accomplished with devices like optical switch, add drop multiplexer and cross connects. Since dense wavelength multiplexing forms the physical layer for intelligent optical networking, the roll of high speed all optical switch is important. This paper analyzes such an ultra-high speed polymer electro-optic switch. The performances of the 2x2 optical waveguide switch with rectangular, triangular and trapezoidal grating profiles on various device parameters are analyzed. The simulation result shows that trapezoidal grating is the optimized structure which has the coupling length of 81μm and switching voltage of 11V for the operating wavelength of 1550nm. The switching time for this proposed switch is 0.47 picosecond. This makes the proposed switch to be an important element in the intelligent optical network.

Keywords: Intelligent optical network, optical switch, electrooptic effect, coupled mode theory, waveguide grating structures

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Authors: S. Reaz Ahmed, M. S. Kaiser

Abstract:

The tribological behavior of commercially used Perspex was evaluated under dry and wet sliding condition using a pin-on-disc wear tester with different applied loads ranging from 2.5 to 20 N. Experiments were conducted with varying sliding distance from 0.2 km to 4.6 km, wherein the sliding velocity was kept constant, 0.64 ms^-1. The results reveal that the weight loss increases with applied load and the sliding distance. The nature of the wear rate was very similar in both the sliding environments in which initially the wear rate increased very rapidly with increasing sliding distance and then progressed to a slower rate. Moreover, the wear rate in wet sliding environment was significantly lower than that under dry sliding condition. The worn surfaces were characterized by optical microscope and SEM. It is found that surface modification has significant effect on sliding wear performance of Perspex.

Keywords: Perspex, wear, friction, SEM.

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Authors: T. Magrakvelidze, N. Bantsadze, N. Lekveishvili, Kh. Lomidze

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The results of an experimental study of the process of convective and boiling heat transfer in the vessel with stirrer for smooth and rough ring-shaped pipes are presented. It is established that creation of two-dimensional artificial roughness on the heated surface causes the essential (~100%) intensification of convective heat transfer. In case of boiling the influence of roughness appears on the initial stage of boiling and in case of fully developed nucleate boiling there was no intensification of heat transfer. The similitude equation for calculating convective heat transfer coefficient, which generalizes well experimental data both for the smooth and the rough surfaces is proposed.

Keywords: boiling, heat transfer, roughness.

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Authors: Jun Peng, Johnny Ching Ming Ho

Abstract:

In order to calculate the flexural strength of normal-strength concrete (NSC) beams, the nonlinear actual concrete stress distribution within the compression zone is normally replaced by an equivalent rectangular stress block, with two coefficients of α and β to regulate the intensity and depth of the equivalent stress respectively. For NSC beams design, α and β are usually assumed constant as 0.85 and 0.80 in reinforced concrete (RC) codes. From an earlier investigation of the authors, α is not a constant but significantly affected by flexural strain gradient, and increases with the increasing of strain gradient till a maximum value. It indicates that larger concrete stress can be developed in flexure than that stipulated by design codes. As an extension and application of the authors- previous study, the modified equivalent concrete stress block is used here to produce a series of design charts showing the maximum design limits of flexural strength and ductility of singly- and doubly- NSC beams, through which both strength and ductility design limits are improved by taking into account strain gradient effect.

Keywords: Concrete beam, Ductility, Equivalent concrete stress, Normal strength, Strain gradient, Strength

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Authors: Victor I. Ilgisonis, Ludmila V. Konovaltseva, Vladimir P. Lakhin, Ekaterina A. Sorokina

Abstract:

The analytical solutions for geodesic acoustic eigenmodes in tokamak plasmas with circular concentric magnetic surfaces are found. In the frame of ideal magnetohydrodynamics the dispersion relation taking into account the toroidal coupling between electrostatic perturbations and electromagnetic perturbations with poloidal mode number |m| = 2 is derived. In the absence of such a coupling the dispersion relation gives the standard continuous spectrum of geodesic acoustic modes. The analysis of the existence of global eigenmodes for plasma equilibria with both off-axis and on-axis maximum of the local geodesic acoustic frequency is performed.

Keywords: Tokamak, MHD, geodesic acoustic mode, eigenmode.

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Authors: S. H. Anilkumar, Ghulam Jilani

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The objective of the present work is to conduct investigations leading to a more complete explanation of single phase natural convective heat transfer in an enclosure with fin utilizing nano fluids. The nano fluid used, which is composed of Aluminum oxide nano particles in suspension of Ethylene glycol, is provided at various volume fractions. The study is carried out numerically for a range of Rayleigh numbers, fin heights and aspect ratio. The flow and temperature distributions are taken to be two-dimensional. Regions with the same velocity and temperature distributions are identified as symmetry of sections. One half of such a rectangular region is chosen as the computational domain taking into account the symmetry about the fin. Transport equations are modeled by a stream functionvorticity formulation and are solved numerically by finite-difference schemes. Comparisons with previously published works on the basis of special cases are done. Results are presented in the form of streamline, vector and isotherm plots as well as the variation of local Nusselt number along the fin under different conditions.

Keywords: Fin height, Nano fluid, natural convection, Rayleigh number.

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Authors: Berkay Ergene, Çağın Bolat

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In this study, we mainly focused on a simulation study regarding composite footbed in order to contribute to shoe industry. As a footbed, e-glass fiber reinforced polyurethane was determined since polyurethane based materials are already used for footbed in shoe manufacturing frequently. Flat, elliptical and rectangular grooved shoe soles were modeled and analyzed separately as TPU, 10% glass fiber reinforced, 30% glass fiber reinforced and 50% glass fiber reinforced materials according to their properties under three point bending and compression situations to determine the relationship between model, material type and mechanical behaviours of composite model. ANSYS 14.0 APDL mechanical structural module is utilized in all simulations and analyzed stress and strain distributions for different footbed models and materials. Furthermore, materials constants like young modulus, shear modulus, Poisson ratio and density of the composites were calculated theoretically by using composite mixture rule and interpreted for mechanical aspects.

Keywords: Composite, elastic behaviour, footbed, simulation.

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Authors: Aref Maalej, Marwa Fakhfakh, Wael Ben Amira

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We present in this work a numerical investigation of fluid-structure interaction to study the elastic behavior of flexible rotors. The principal aim is to provide the effect of the aero/hydrodynamic parameters on the bending deformation of flexible rotors. This study is accomplished using the strong two-way fluid-structure interaction (FSI) developed by the ANSYS Workbench software. This method is used for coupling the fluid solver to the transient structural solver to study the elastic behavior of flexible rotors in water. In this study, we use a moderately flexible rotor modeled by a single blade with simplified rectangular geometry. In this work, we focus on the effect of the rotational frequency on the flapwise bending deformation. It is demonstrated that the blade deforms in the downstream direction and the amplitude of these deformations increases with the rotational frequencies. Also, from a critical frequency, the blade begins to deform in the upstream direction.

Keywords: Numerical simulation, flexible blade, fluid-structure interaction, ANSYS Workbench, flapwise deformation.

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Authors: Rouhollah Ahmadi, Tatsuya Ueno, Tomio Okawa

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Bubble generation was observed using a high-speed camera in subcooled flow boiling at low void fraction. Constant heat flux was applied on one side of an upward rectangular channel to make heated test channel. Water as a working fluid from high subcooling to near saturation temperature was injected step by step to investigate bubble behavior during void development. Experiments were performed in two different pressures condition close to 2bar and 4bar. It was observed that in high subcooling when boiling was commenced, bubble after nucleation departed its origin and slid beside heated surface. In an observation window mean release frequency of bubble fb,mean, nucleation site Ns and mean bubble volume Vb,mean in each step of experiments were measured to investigate wall vaporization rate. It was found that in proximity of PNVG vaporization rate was increased significantly in compare with condensation rate which remained in low value.

Keywords: Subcooled flow boiling, Bubble dynamics, Void fraction, Sliding bubble.

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Authors: Taher El-Bitar, Maha El-Meligy, Eman El-Shenawy, Almosilhy Almosilhy, Nader Dawood

Abstract:

The steel contains 0.3% C and 0.004% B, beside Mn, Cr, Mo, and Ni. The alloy was processed by using 20-ton capacity electric arc furnace (EAF), and then refined by ladle furnace (LF). Liquid steel was cast as rectangular ingots. Dilatation test showed the critical transformation temperatures Ac₁, Ac₃, M_s and M_f as 716, 835, 356, and 218 °C. The ingots were austenitized and soaked and then rough rolled to thin slabs with 80 mm thickness. The thin slabs were then reheated and soaked for finish rolling to 6.0 mm thickness plates. During the rough rolling, the roll force increases as a result of rolling at temperatures less than recrystallization temperature. However, during finish rolling, the steel reflects initially continuous static recrystallization after which it shows strain hardening due to fall of temperature. It was concluded that, the steel plates were successfully heat treated by quenching-tempering at 250 ºC for 20 min.

Keywords: Armor steel, austenitizing, critical transformation temperatures, dilatation curve, martensite, quenching, rough and finish rolling processes, soaking, tempering, thermo-mechanical processing.

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Authors: N. K. Singh

Abstract:

In this study the augmentation of heat transfer in a rectangular channel with triangular vortex generators is evaluated. The span wise averaged Nusselt number, mean temperature and total heat flux are compared with and without vortex generators in the channel at a blade angle of 30° for Reynolds numbers 800, 1200, 1600, and 2000. The use of vortex generators increases the span wise averaged Nusselt number compared to the case without vortex generators considerably. At a particular blade angle, increasing the Reynolds number results in an enhancement in the overall performance and span wise averaged Nusselt number was found to be greater at particular location for larger Reynolds number. The total heat flux from the bottom wall with vortex generators was found to be greater than that without vortex generators and the difference increases with increase in Reynolds number.

Keywords: Heat transfer, channel with vortex generators, numerical simulation, effect of Reynolds number on heat transfer.

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Authors: A. Shafaghat, H. Khabbaz, S. Moravej, Ah. Shafaghat

Abstract:

The bearing capacity of closely spaced shallow footings alters with their spacing and the shape of footing. In this study, the bearing capacity and settlement of two adjacent footings constructed on a sand layer are investigated. The effect of different footing shapes including square, circular, ring and strip on sandy soil is captured in the calculations. The investigations are carried out numerically using PLAXIS-3D software and analytically employing conventional settlement equations. For this purpose, foundations are modelled in the program with practical dimensions and various spacing ratios ranging from 1 to 5. The spacing ratio is defined as the centre-to-centre distance to the width of foundations (S/B). Overall, 24 models are analyzed; and the results are compared and discussed in detail. It can be concluded that the presence of adjacent foundation leads to the reduction in bearing capacity for round shape footings while it can increase the bearing capacity of rectangular footings in some specific distances.

Keywords: Bearing capacity, finite element analysis, loose sand, settlement equations, shallow foundation.

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Authors: Meisam Omidi, M. Mirijalili, Mohammadmehdi Choolaei, Z. Sharifi, F. Haghiralsadat, F. Yazdian

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In this work, we have used arrays of micromechanical piezoresistive cantilever with different geometries to detect carcinoembryonic antigen (CEA), which is known as an important biomarker associated with various cancers such as colorectal, lung, breast, pancreatic, and bladder cancer. The sensing principle is based on the surface stress changes induced by antigen–antibody interaction on the microcantilevers surfaces. Different concentrations of CEA in a human serum albumin (HSA) solution were detected as a function of deflection of the beams. According to the experiments, it was revealed that microcantilevers have surface stress sensitivities in the order of 8 (mJ/m). This matter allows them to detect CEA concentrations as low as 3 ng/mL or 18 pM. This indicates the fact that the self-sensing microcantilevers approach is beneficial for pathological tests.

Keywords: Micromechanical biosensors, Carcinoembryonic antigen (CEA), surface stress.

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Authors: Bhuvanendran Nair Gourikutty Sajay, Liu Yuxin, Chang Chia-Pin, Poenar Daniel Puiu, Abdur Rub Abdur Rahman

Abstract:

Size based filtration is one of the common methods employed to isolate circulating tumor cells (CTCs) from whole blood. It is well known that this method suffers from isolation efficiency to purity tradeoff. However, this tradeoff is poorly understood. In this paper, we present the design and manufacturing of a special rectangular slit filter. The filter was designed to retain maximal amounts of nucleated cells, while minimizing the pressure on cells, thereby preserving their morphology. The key parameter, namely, input pressure, was optimized to retain the maximal number of tumor cells, whilst maximizing the depletion of normal blood cells (red and white blood cells and platelets). Our results indicate that for a slit geometry of 5 × 40 μm on a 13 mm circular membrane with a fill factor of 21%, a pressure of 6.9 mBar yields the optimum for maximizing isolation of MCF-7 and depletion of normal blood cells.

Keywords: Circulating tumor cells, Parylene slit membrane, Retention, White Blood Cell depletion.

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