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315 Enzymatic Esterification of Carboxylic Acids and Higher Alcohols in Organic Medium
Authors: D.T. Mirzarakhmetova
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The studying of enzymatic esterification of carboxylic acids and higher alcohols was performed by esterase Saccharomyces cerevisiae in water-organic medium. Investigation of the enzyme specificity to acetic substrates showed the best result with acetic acid in esterification reactions with ethanol whereas within other carboxylic acids the esterification decreased with acids: hexanoic > pentanoic > butyric > decanoic. In relation to higher alcohols C3-C5, esterification increased with alcohols propanol < butanol < amylol. Also it was determined that esterase was more specific to alcohols with branched chain such as isobutyl alcohol and isoamyl alcohol. Data obtained may have important practical implications, for example, for application of yeast esterase in producing various volatile esters as well as in enzymatic transformation of volatile acids and toxic fusel alcohols into volatile esters by providing the production of the high quality alcoholic beverages with redused content of higher alcohols as well as with improved degustational and hygienic properties.Keywords: enzymes in non-conventional media, esterification, higher alcohols, volatile esters, yeast esterase
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3498314 Modeling and Design of an Active Leg Orthosis for Tumble Protection
Authors: Eileen Chih-Ying Yang, Liang-Han Wu, Chieh-Min Chang
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The design of an active leg orthosis for tumble protection is proposed in this paper. The orthosis would be applied to assist elders or invalids in rebalancing while they fall unexpectedly. We observe the regain balance motion of healthy and youthful people, and find the difference to elders or invalids. First, the physical model of leg would be established, and we consider the leg motions are achieve through four joints (phalanx stem, ankle, knee, and hip joint) and five links (phalanges, talus, tibia, femur, and hip bone). To formulate the dynamic equations, the coordinates which can clearly describe the position in 3D space are first defined accordance with the human movement of leg, and the kinematics and dynamics of the leg movement can be formulated based on the robotics. For the purpose, assisting elders and invalids in avoiding tumble, the posture variation of unbalance and regaining balance motion are recorded by the motion-capture image system, and the trajectory is taken as the desire one. Then we calculate the force and moment of each joint based on the leg motion model through programming MATLAB code. The results would be primary information of the active leg orthosis design for tumble protection.Keywords: Active leg orthosis, Tumble protection
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1642313 A New Fuzzy Mathematical Model in Recycling Collection Networks: A Possibilistic Approach
Authors: B. Vahdani, R. Tavakkoli-Moghaddam, A. Baboli, S. M. Mousavi
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Focusing on the environmental issues, including the reduction of scrap and consumer residuals, along with the benefiting from the economic value during the life cycle of goods/products leads the companies to have an important competitive approach. The aim of this paper is to present a new mixed nonlinear facility locationallocation model in recycling collection networks by considering multi-echelon, multi-suppliers, multi-collection centers and multifacilities in the recycling network. To make an appropriate decision in reality, demands, returns, capacities, costs and distances, are regarded uncertain in our model. For this purpose, a fuzzy mathematical programming-based possibilistic approach is introduced as a solution methodology from the recent literature to solve the proposed mixed-nonlinear programming model (MNLP). The computational experiments are provided to illustrate the applicability of the designed model in a supply chain environment and to help the decision makers to facilitate their analysis.
Keywords: Location-allocation model, recycling collection networks, fuzzy mathematical programming.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2097312 BEM Formulations Based on Kirchhoffs Hypoyhesis to Perform Linear Bending Analysis of Plates Reinforced by Beams
Authors: Gabriela R. Fernandes, Renato F. Denadai, Guido J. Denipotti
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In this work, are discussed two formulations of the boundary element method - BEM to perform linear bending analysis of plates reinforced by beams. Both formulations are based on the Kirchhoff's hypothesis and they are obtained from the reciprocity theorem applied to zoned plates, where each sub-region defines a beam or a slab. In the first model the problem values are defined along the interfaces and the external boundary. Then, in order to reduce the number of degrees of freedom kinematics hypothesis are assumed along the beam cross section, leading to a second formulation where the collocation points are defined along the beam skeleton, instead of being placed on interfaces. On these formulations no approximation of the generalized forces along the interface is required. Moreover, compatibility and equilibrium conditions along the interface are automatically imposed by the integral equation. Thus, these formulations require less approximation and the total number of the degree s of freedom is reduced. In the numerical examples are discussed the differences between these two BEM formulations, comparing as well the results to a well-known finite element code.
Keywords: Boundary elements, Building floor structures, Platebending.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1663311 Assamese Numeral Speech Recognition using Multiple Features and Cooperative LVQ -Architectures
Authors: Manash Pratim Sarma, Kandarpa Kumar Sarma
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A set of Artificial Neural Network (ANN) based methods for the design of an effective system of speech recognition of numerals of Assamese language captured under varied recording conditions and moods is presented here. The work is related to the formulation of several ANN models configured to use Linear Predictive Code (LPC), Principal Component Analysis (PCA) and other features to tackle mood and gender variations uttering numbers as part of an Automatic Speech Recognition (ASR) system in Assamese. The ANN models are designed using a combination of Self Organizing Map (SOM) and Multi Layer Perceptron (MLP) constituting a Learning Vector Quantization (LVQ) block trained in a cooperative environment to handle male and female speech samples of numerals of Assamese- a language spoken by a sizable population in the North-Eastern part of India. The work provides a comparative evaluation of several such combinations while subjected to handle speech samples with gender based differences captured by a microphone in four different conditions viz. noiseless, noise mixed, stressed and stress-free.Keywords: Assamese, Recognition, LPC, Spectral, ANN.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1990310 Strategies of Entrepreneurs to Collaborate with Alliances for Commercializing Technology and New Product Innovation: A Practical Learning in Thailand
Authors: Kusumaphorn Sompong, Helen Lawton Smith, Barbara Igel
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This paper provides a key driver-based conceptual framework that can be used to improve a firm-s success in commercializing technology and in new product innovation resulting from collaboration with other organizations through strategic alliances. Based on a qualitative study using an interview approach, strategic alliances of entrepreneurs in the food processing industry in Thailand are explored. This paper describes factors affecting decisions to collaborate through alliances. It identifies four issues: maintaining the efficiency of the value chain for production capability, adapting to present and future competition, careful assessment of value of outcomes, and management of innovation. We consider five driving factors: resource orientation, assessment of risk, business opportunity, sharing of benefits and confidence in alliance partners. These factors will be of interest to entrepreneurs and policy makers with regard to further understanding of the direction of business strategies.
Keywords: Managing collaboration, strategic alliance, technology commercialization, innovation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1559309 Performance Study of Scraped Surface Heat Exchanger with Helical Ribbons
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In this work, numerical simulations were carried out using a specific CFD code in order to study the performance of an innovative Scraped Surface Heat Exchanger (SSHE) with helical ribbons for Bingham fluids (threshold fluids). The resolution of three-dimensional form of the conservation equations (continuity, momentum and energy equations) was carried out basing on the finite volume method (FVM). After studying the effect of dimensionless numbers (axial Reynolds, rotational Reynolds and Oldroyd numbers) on the hydrodynamic and thermal behaviors within SSHE, a parametric study was developed, by varying the width of the helical ribbon, the clearance between the stator wall and the tip of the ribbon and the number of turns of the helical ribbon, in order to improve the heat transfer inside the exchanger. The effect of these geometrical numbers on the hydrodynamic and thermal behaviors was discussed.Keywords: Heat transfer, helical ribbons, hydrodynamic behavior, parametric study, scraped surface heat exchanger, thermal behavior.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1248308 Aircraft Supplier Selection Process with Fuzzy Proximity Measure Method using Multiple Criteria Group Decision Making Analysis
Authors: C. Ardil
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Being effective in every organizational activity has become necessary due to the escalating level of competition in all areas of corporate life. In the context of supply chain management, aircraft supplier selection is currently one of the most crucial activities. It is possible to choose the best aircraft supplier and deliver efficiency in terms of cost, quality, delivery time, economic status, and institutionalization if a systematic supplier selection approach is used. In this study, an effective multiple criteria decision-making methodology, proximity measure method (PMM), is used within a fuzzy environment based on the vague structure of the real working environment. The best appropriate aircraft suppliers are identified and ranked after the proposed multiple criteria decision making technique is used in a real-life scenario.
Keywords: Aircraft supplier selection, multiple criteria decision making, fuzzy sets, proximity measure method, Minkowski distance family function, Hausdorff distance function, PMM, MCDM
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 342307 Wind Interference Effect on Tall Building
Authors: Atul K. Desai, Jigar K. Sevalia, Sandip A. Vasanwala
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When a building is located in an urban area, it is exposed to a wind of different characteristics then wind over an open terrain. This is development of turbulent wake region behind an upstream building. The interaction with upstream building can produce significant changes in the response of the tall building. Here, in this paper, an attempt has been made to study wind induced interference effects on tall building. In order to study wind induced interference effect (IF) on Tall Building, initially a tall building (which is termed as Principal Building now on wards) with square plan shape has been considered with different Height to Width Ratio and total drag force is obtained considering different terrain conditions as well as different incident wind direction. Then total drag force on Principal Building is obtained by considering adjacent building which is termed as Interfering Building now on wards with different terrain conditions and incident wind angle. To execute study, Computational Fluid Dynamics (CFD) Code namely Fluent and Gambit have been used.
Keywords: Computational Fluid Dynamics, Tall Building, Turbulent, Wake Region, Wind.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3798306 First Studies of the Influence of Single Gene Perturbations on the Inference of Genetic Networks
Authors: Frank Emmert-Streib, Matthias Dehmer
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Inferring the network structure from time series data is a hard problem, especially if the time series is short and noisy. DNA microarray is a technology allowing to monitor the mRNA concentration of thousands of genes simultaneously that produces data of these characteristics. In this study we try to investigate the influence of the experimental design on the quality of the result. More precisely, we investigate the influence of two different types of random single gene perturbations on the inference of genetic networks from time series data. To obtain an objective quality measure for this influence we simulate gene expression values with a biologically plausible model of a known network structure. Within this framework we study the influence of single gene knock-outs in opposite to linearly controlled expression for single genes on the quality of the infered network structure.Keywords: Dynamic Bayesian networks, microarray data, structure learning, Markov chain Monte Carlo.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1549305 Fatty Acid and Amino Acid Composition in Mene maculata in The Sea of Maluku
Authors: Semuel Unwakoly, Reinner Puppela, Maresthy Rumalean, Healthy Kainama
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Fish is a kind of food that contains many nutritions, one of those is the long chain of unsaturated fatty acids as omega-3 and omega-6 fatty acids and essential amino acid in enough amount for the necessity of our body. Like pelagic fish that found in the sea of Maluku. This research was done to identify fatty acids and amino acids composition in Moonfish (M. maculata) using transesterification reaction steps and Gas Chromatograph-Mass Spectrophotometer (GC-MS) and High-Performance Liquid Chromatography (HPLC). The result showed that fatty acids composition in Moonfish (M. maculata) contained tridecanoic acid (2.84%); palmitoleic acid (2.65%); palmitic acid (35.24%); oleic acid (6.2%); stearic acid (14.20%); and 5,8,11,14-eicosatetraenoic acid (1.29%) and 12 amino acids composition that consist of 7 essential amino acids, were leucine, isoleucine, valine, phenylalanine, methionine, lysine, and histidine, and also 5 non-essential amino acid, were tyrosine, glycine, alanine, glutamic acid, and arginine.Thus, these fishes can be used by the people to complete the necessity of essential fatty acid and amino acid.
Keywords: Moonfish (M. maculata), fatty acid, amino acid, GC-MS, HPLC.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 907304 Finite Element Modelling of Log Wall Corner Joints
Authors: R. Kalantari, G. Hafeez
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The paper presents outcomes of the numerical research performed on standard and dovetail corner joints under lateral loads. An overview of the past research on log shear walls is also presented. To the authors’ best knowledge, currently, there are no specific design guidelines available in the code for the design of log shear walls, implying the need to investigate the performance of log shear walls. This research explores the performance of the log shear wall corner joint system of standard joint and dovetail types using numerical methods based on research available in the literature. A parametric study is performed to study the effect of gap size provided between two orthogonal logs and the presence of wood and steel dowels provided as joinery between log courses on the performance of such a structural system. The research outcomes are the force-displacement curves. Variability of 8% is seen in the reaction forces with the change of gap size for the case of the standard joint, while a variation of 10% is observed in the reaction forces for the dovetail joint system.
Keywords: dovetail joint, finite element modelling, log shear walls, standard joint
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 496303 Detached-Eddy Simulation of Vortex Generator Jet Using Chimera Grids
Authors: Saqib Mahmood, Rolf Radespiel
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This paper aims at numerically analysing the effect of an active flow control (AFC) by a vortex generator jet (VGJ) submerged in a boundary layer via Chimera Grids and Detached- Eddy Simulation (DES). The performance of DES results are judged against Reynolds-Averaged Navier-Stokes (RANS) and compared with the experiments that showed an unsteady vortex motion downstream of VGJ. Experimental results showed that the mechanism of embedding logitudinal vortex structure in the main stream flow is quite effective in increasing the near wall momentum of separated aircraft wing. In order to simulate such a flow configuration together with the VGJ, an efficient numerical approach is required. This requirement is fulfilled by performing the DES simulation over the flat plate using the DLR TAU Code. The DES predictions identify the vortex region via smooth hybrid length scale and predict the unsteady vortex motion observed in the experiments. The DES results also showed that the sufficient grid refinement in the vortex region resolves the turbulent scales downstream of the VGJ, the spatial vortex core postion and nondimensional momentum coefficient RVx .Keywords: VGJ, Chimera Grid, DES, RANS.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2480302 Deterministic Random Number Generator Algorithm for Cryptosystem Keys
Authors: Adi A. Maaita, Hamza A. A. Al_Sewadi
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One of the crucial parameters of digital cryptographic systems is the selection of the keys used and their distribution. The randomness of the keys has a strong impact on the system’s security strength being difficult to be predicted, guessed, reproduced, or discovered by a cryptanalyst. Therefore, adequate key randomness generation is still sought for the benefit of stronger cryptosystems. This paper suggests an algorithm designed to generate and test pseudo random number sequences intended for cryptographic applications. This algorithm is based on mathematically manipulating a publically agreed upon information between sender and receiver over a public channel. This information is used as a seed for performing some mathematical functions in order to generate a sequence of pseudorandom numbers that will be used for encryption/decryption purposes. This manipulation involves permutations and substitutions that fulfill Shannon’s principle of “confusion and diffusion”. ASCII code characters were utilized in the generation process instead of using bit strings initially, which adds more flexibility in testing different seed values. Finally, the obtained results would indicate sound difficulty of guessing keys by attackers.Keywords: Cryptosystems, Information Security agreement, Key distribution, Random numbers.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3429301 ROSA/LSTF Separate Effect Test on Natural Circulation under High Core Power Condition of Pressurized Water Reactor
Authors: Takeshi Takeda
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A separate effect test (SET) simulated natural circulation (NC) under high core power condition of a pressurized water reactor (PWR) utilizing the ROSA/LSTF (rig of safety assessment/large-scale test facility). The LSTF test results clarified the relationship between the primary loop mass inventory and the primary loop mass flow rate being dependent on the NC mode at a constant core power of 8% of the volumetric-scaled PWR nominal power. When the core power was 9% or more during reflux condensation, large-amplitude level oscillation in a form of slow fill and dump occurred in steam generator (SG) U-tubes. At 11% core power during reflux condensation, intermittent rise took place in the cladding surface temperature of simulated fuel rods. The RELAP5/MOD3.3 code indicated the insufficient prediction of the SG U-tube liquid level behavior during reflux condensation.Keywords: LSTF, natural circulation, core power, RELAP5.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 850300 Holomorphic Prioritization of Sets within Decagram of Strategic Decision Making of POSM Using Operational Research (OR): Analytic Hierarchy Process (AHP) Analysis
Authors: Elias O. Tembe, Hussain A. Al-Salamin
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There is decagram of strategic decisions of operations and production/service management (POSM) within operational research (OR) which must collate, namely: design, inventory, quality, location, process and capacity, layout, scheduling, maintain ace, and supply chain. This paper presents an architectural configuration conceptual framework of a decagram of sets decisions in a form of mathematical complete graph and abelian graph. Mathematically, a complete graph is undirected (UDG), and directed (DG) a relationship where every pair of vertices is connected, collated, confluent, and holomorphic. There has not been any study conducted which, however, prioritizes the holomorphic sets which of POMS within OR field of study. The study utilizes OR structured technique known as The Analytic Hierarchy Process (AHP) analysis for organizing, sorting and prioritizing(ranking) the sets within the decagram of POMS according to their attribution (propensity), and provides an analysis how the prioritization has real-world application within the 21st century.
Keywords: AHP analysis, Decagram, Decagon, Holomorphic.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1999299 Influence of Apo E Polymorphism on Coronary Artery Disease
Authors: S. Fallah, M. Seifi, M. Firoozrai, T. Godarzi, M. Jafarzadeh, L. H. Ghohari
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The ε4 allele of the ε2, ε3 and ε4 protein isoform polymorphism in the gene encoding apolipoprotein E (Apo E) has previously been associated with increased cardiac artery disease (CAD); therefore to investigate the significance of this polymorphism in pathogenesis of CAD in Iranian patients with stenosis and control subjects. To investigate the association between Apo E polymorphism and coronary artery disease we performed a comparative case control study of the frequency of Apo E polymorphism in One hundred CAD patients with stenosis who underwent coronary angiography (>50% stenosis) and 100 control subjects (<10% stenosis). The Apo E alleles and genotypes were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). We observed an association between the Apo E polymorphism and CAD in this study. These data suggest that the Apo ε4 and ε2 alleles increase the risk for CAD in Iranian population (χ2 =4.26, p= 0.05, OR=2 and χ2 =0.38, p=0.53, OR=1.2). These results suggest that ε4 and ε2 alleles are risk factors for stenosis.
Keywords: Arterial blood vessels, atherosclerosis, cholesterol.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1726298 Processing, Morphological, Thermal and Absorption Behavior of PLA/Thermoplastic Starch/Montmorillonite Nanocomposites
Authors: Esmat Jalalvandi, Rohah Abd. Majid, Taravat Ghanbari
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Thermoplastic starch, polylactic acid glycerol and maleic anhydride (MA) were compounded with natural montmorillonite (MMT) through a twin screw extruder to investigate the effects of different loading of MMT on structure, thermal and absorption behavior of the nanocomposites. X-ray diffraction analysis (XRD) showed that sample with MMT loading 4phr exhibited exfoliated structure while sample that contained MMT 8 phr exhibited intercalated structure. FESEM images showed big lump when MMT loading was at 8 phr. The thermal properties were characterized by using differential scanning calorimeter (DSC). The results showed that MMT increased melting temperature and crystallization temperature of matrix but reduction in glass transition temperature was observed Meanwhile the addition of MMT has improved the water barrier property. The nanosize MMT particle is also able to block a tortuous pathway for water to enter the starch chain, thus reducing the water uptake and improved the physical barrier of nanocomposite.Keywords: Montmorillonite, Nanocomposite, Polylactic acid, Starch.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2518297 A Novel Model for Simultaneously Minimising Costs and Risks in Just-in-Time Systems Using Multi-Backup Suppliers: Part 1- Modelling
Authors: Faraj El Dabee, Romeo Marian, Yousef Amer
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Just-In-Time (JIT) is a lean manufacturing tool, which provides the benefits of efficiency, and of minimizing unnecessary costs for many organisations. However, the risks arising from these benefits have been disregarded. These risks impact on system processes disrupting the whole supply chain. This paper proposes an inventory model that can simultaneously reduce costs and risks in JIT systems. This model is developed to ascertain an optimal ordering strategy for procuring raw materials by using regular multi-external and local backup suppliers to reduce the total cost of the products, and at the same time to reduce the risks arising from this cost reduction within production systems. Some results that will be illustrated in the second part of this paper are presented.
Keywords: Lean manufacturing, Just-in-Time (JIT), production system, cost-risk reduction, inventory model, eternal supplier, local backup supplier.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1653296 The Relationship between Business-model Innovation and Firm Value: A Dynamic Perspective
Authors: Yung C. Ho, Hui C. Fang, Ming J. Hsieh
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When consistently innovative business-models can give companies a competitive advantage, longitudinal empirical research, which can reflect dynamic business-model changes, has yet to prove a definitive connection. This study consequently employs a dynamic perspective in conjunction with innovation theory to examine the relationship between the types of business-model innovation and firm value. This study tries to examine various types of business-model innovation in high-end and low-end technology industries such as HTC and the 7-Eleven chain stores with research periods of 14 years and 32 years, respectively. The empirical results suggest that adopting radical business-model innovation in addition to expanding new target markets can successfully lead to a competitive advantage. Sustained advanced technological competences and service/product innovation are the key successful factors in high-end and low-end technology industry business-models respectively. In sum up, the business-model innovation can yield a higher market value and financial value in high-end technology industries than low-end ones.Keywords: Business-model, Dynamic Perspective, Firm Value, Innovation
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2743295 Crack Width Evaluation for Flexural RC Members with Axial Tension
Authors: Sukrit Ghorai
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Proof of controlling crack width is a basic condition for securing suitable performance in serviceability limit state. The cracking in concrete can occur at any time from the casting of time to the years after the concrete has been set in place. Most codes struggle with offering procedure for crack width calculation. There is lack in availability of design charts for designers to compute crack width with ease. The focus of the study is to utilize design charts and parametric equations in calculating crack width with minimum error. The paper contains a simplified procedure to calculate crack width for reinforced concrete (RC) sections subjected to bending with axial tensile force following the guidelines of Euro code [DS EN-1992-1-1 & DS EN-1992-1-2]. Numerical examples demonstrate the application of the suggested procedure. Comparison with parallel analytical tools supports the validity of result and show the percentage deviation of crack width in both the procedures. The technique is simple, user friendly and ready to evolve for a greater spectrum of section sizes and materials.
Keywords: Concrete structures, crack width calculation, serviceability limit state, structural design, bridge engineering.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 6667294 Mutational Analysis of CTLA4 Gene in Pakistani SLE Patients
Authors: N. Hussain, G. Jaffery, A.N. Sabri, S. Hasnain
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The main aim is to perform mutational analysis of CTLA4 gene Exon 1 in SLE patients. A total of 61 SLE patients fulfilling “American College of Rheumatology (ACR) criteria" and 61 controls were enrolled in this study. The region of CTLA4 gene exon 1 was amplified by using Step-down PCR technique. Extracted DNA of band 354 bp was sequenced to analyze mutations in the exon-1 of CTLA-4 gene. Further, protein sequences were identified from nucleotide sequences of CTLA4 Exon 1 by using Expasy software and through Blast P software it was found that CTLA4 protein sequences of Pakistani SLE patients were similar to that of Chinese SLE population. No variations were found after patients sequences were compared with that of the control sequence. Furthermore it was found that CTLA4 protein sequences of Pakistani SLE patients were similar to that of Chinese SLE population. Thus CTLA4 gene may not be responsible for an autoimmune disease SLE.
Keywords: American College of Rheumatology criteria, autoimmune disease, Cytotoxic T Lymphocyte Antigen-4, Polymerase Chain Reaction, Systemic Lupus Erythematosus
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1530293 Constructal Enhancement of Fins Design Integrated to Phase Change Materials
Authors: Varun Joshi, Manish K. Rathod
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The latent heat thermal energy storage system is a thrust area of research due to exuberant thermal energy storage potential. The thermal performance of PCM is significantly augmented by installation of the high thermal conductivity fins. The objective of the present study is to obtain optimum size and location of the fins to enhance diffusion heat transfer without altering overall melting time. Hence, the constructal theory is employed to eliminate, resize, and re-position the fins. A numerical code based on conjugate heat transfer coupled enthalpy porosity approached is developed to solve Navier-Stoke and energy equation.The numerical results show that the constructal fin design has enhanced the thermal performance along with the increase in the overall volume of PCM when compared to conventional. The overall volume of PCM is found to be increased by half of total of volume of fins. The elimination and repositioning the fins at high temperature gradient from low temperature gradient is found to be vital.Keywords: Constructal theory, enthalpy porosity approach, phase change materials, fins.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 921292 Generating Qualitative Causal Graph using Modeling Constructs of Qualitative Process Theory for Explaining Organic Chemistry Reactions
Authors: Alicia Y. C. Tang, Rukaini Abdullah, Sharifuddin M. Zain, Noorsaadah A. Rahman
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This paper discusses the causal explanation capability of QRIOM, a tool aimed at supporting learning of organic chemistry reactions. The development of the tool is based on the hybrid use of Qualitative Reasoning (QR) technique and Qualitative Process Theory (QPT) ontology. Our simulation combines symbolic, qualitative description of relations with quantity analysis to generate causal graphs. The pedagogy embedded in the simulator is to both simulate and explain organic reactions. Qualitative reasoning through a causal chain will be presented to explain the overall changes made on the substrate; from initial substrate until the production of final outputs. Several uses of the QPT modeling constructs in supporting behavioral and causal explanation during run-time will also be demonstrated. Explaining organic reactions through causal graph trace can help improve the reasoning ability of learners in that their conceptual understanding of the subject is nurtured.Keywords: Qualitative reasoning, causal graph, organicreactions, explanation, QPT, modeling constructs.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1417291 Efficient Numerical Model for Studying Bridge Pier Collapse in Floods
Authors: Thanut Kallaka, Ching-Jong Wang
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High level and high velocity flood flows are potentially harmful to bridge piers as evidenced in many toppled piers, and among them the single-column piers were considered as the most vulnerable. The flood flow characteristic parameters including drag coefficient, scouring and vortex shedding are built into a pier-flood interaction model to investigate structural safety against flood hazards considering the effects of local scouring, hydrodynamic forces, and vortex induced resonance vibrations. By extracting the pier-flood simulation results embedded in a neural networks code, two cases of pier toppling occurred in typhoon days were reexamined: (1) a bridge overcome by flash flood near a mountain side; (2) a bridge washed off in flood across a wide channel near the estuary. The modeling procedures and simulations are capable of identifying the probable causes for the tumbled bridge piers during heavy floods, which include the excessive pier bending moments and resonance in structural vibrations.Keywords: Bridge piers, Neural networks, Scour depth, Structural safety, Vortex shedding
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2260290 A Framework for Identifying the Critical Factors Affecting the Decision to Adopt and Use Inter-Organizational Information Systems
Authors: K. Bouchbout, Z. Alimazighi
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The importance of inter-organizational system (IOS) has been increasingly recognized by organizations. However, IOS adoption has proved to be difficult and, at this stage, why this is so is not fully uncovered. In practice, benefits have often remained concentrated, primarily accruing to the dominant party, resulting in low rates of adoption and usage, and often culminating in the failure of the IOS. The main research question is why organizations initiate or join IOS and what factors influence their adoption and use levels. This paper reviews the literature on IOS adoption and proposes a theoretical framework in order to identify the critical factors to capture a complete picture of IOS adoption. With our proposed critical factors, we are able to investigate their relative contributions to IOS adoption decisions. We obtain findings that suggested that there are five groups of factors that significantly affect the adoption and use decision of IOS in the Supply Chain Management (SCM) context: 1) interorganizational context, 2) organizational context, 3) technological context, 4) perceived costs, and 5) perceived benefits.Keywords: Business-to-Business relationships, buyer-supplier relationships, Critical factors, Interorganizational Information Systems, IOS adoption and use.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2047289 Intermolecular Dynamics between Alcohols and Fatty Acid Ester Solvents
Authors: Jacques J. Scheepers, Edison Muzenda
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This work focused on the interactions which occur between ester solvents and alcohol solutes. The alcohols selected ranged from the simplest alcohol (methanol) to C10-alcohols, and solubility predictions in the form of infinite dilution activity coefficients were made using the Modified UNIFAC Dortmund group contribution model. The model computation was set up on a Microsoft Excel spreadsheet specifically designed for this purpose. It was found that alcohol/ ester interactions yielded an increase in activity coefficients (i.e. became less soluble) with an increase in the size of the ester solvent molecule. Furthermore, activity coefficients decreased with an increase in the size of the alcohol solute. The activity coefficients also decreased with an increase in the degree of unsaturation of the ester hydrocarbon tail. Tertiary alcohols yielded lower activity coefficients than primary alcohols. Finally, cyclic alcohols yielded higher activity coefficients than straight-chain alcohols until a point is reached where the trend is reversed, referred to as the ‘crossover’ point.
Keywords: Activity coefficients, alcohols, esters, solubility, van der Waals, UNIFAC.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2072288 Forecast Based on an Empirical Probability Function with an Adjusted Error Using Propagation of Error
Authors: Oscar Javier Herrera, Manuel Ángel Camacho
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This paper addresses a cutting edge method of business demand forecasting, based on an empirical probability function when the historical behavior of the data is random. Additionally, it presents error determination based on the numerical method technique ‘propagation of errors.’ The methodology was conducted characterization and process diagnostics demand planning as part of the production management, then new ways to predict its value through techniques of probability and to calculate their mistake investigated, it was tools used numerical methods. All this based on the behavior of the data. This analysis was determined considering the specific business circumstances of a company in the sector of communications, located in the city of Bogota, Colombia. In conclusion, using this application it was possible to obtain the adequate stock of the products required by the company to provide its services, helping the company reduce its service time, increase the client satisfaction rate, reduce stock which has not been in rotation for a long time, code its inventory, and plan reorder points for the replenishment of stock.Keywords: Demand Forecasting, Empirical Distribution, Propagation of Error.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1842287 A Comparative Study on Seismic Provisions Made in UBC-1997 and Saudi Building Code for RC Buildings
Authors: S. Nazar, M. A. Ismaeil
Abstract:
This paper presents a comparative study of static analysis procedure for seismic performance based on UBC-1997 and SBC-301-2007(Saudi Arabia). These building codes define different ductility classes and corresponding response reduction factors based on material, configuration and detailing of reinforcements. Codes differ significantly in specifying the procedures to estimate base shear, drift and effective stiffness of structural members. One of the major improvements made in new SBC (based on IBC-2003) is ground motion parameters used for seismic design. In old SBC (based on UBC) maps have been based on seismic zones. However new SBC provide contour maps giving spectral response quantities. In this approach, a case study of RC frame building located in two different cities and with different ductility classes has been performed. Moreover, equivalent static method based on SBC-301 and UBC-1997 is used to explore the variation in results based on two codes, particularly design base shear, lateral loads and story drifts.
Keywords: Ductility Classes, Equivalent Static method, RC Frames, SBC-301-2007, Story drifts, UBC-1997.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 4195286 Effective Digital Music Retrieval System through Content-based Features
Authors: Bokyung Sung, Kwanghyo Koo, Jungsoo Kim, Myung-Bum Jung, Jinman Kwon, Ilju Ko
Abstract:
In this paper, we propose effective system for digital music retrieval. We divided proposed system into Client and Server. Client part consists of pre-processing and Content-based feature extraction stages. In pre-processing stage, we minimized Time code Gap that is occurred among same music contents. As content-based feature, first-order differentiated MFCC were used. These presented approximately envelop of music feature sequences. Server part included Music Server and Music Matching stage. Extracted features from 1,000 digital music files were stored in Music Server. In Music Matching stage, we found retrieval result through similarity measure by DTW. In experiment, we used 450 queries. These were made by mixing different compression standards and sound qualities from 50 digital music files. Retrieval accurate indicated 97% and retrieval time was average 15ms in every single query. Out experiment proved that proposed system is effective in retrieve digital music and robust at various user environments of web.
Keywords: Music Retrieval, Content-based, Music Feature and Digital Music.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1518