@article{(Open Science Index):https://publications.waset.org/pdf/15087,
	  title     = {Influence of Apo E Polymorphism on Coronary Artery Disease},
	  author    = {S. Fallah and  M. Seifi and  M. Firoozrai and  T. Godarzi and  M. Jafarzadeh and  L. H. Ghohari},
	  country	= {},
	  institution	= {},
	  abstract     = {The ε4 allele of the ε2, ε3 and ε4 protein isoform polymorphism in the gene encoding apolipoprotein E (Apo E) has previously been associated with increased cardiac artery disease (CAD); therefore to investigate the significance of this polymorphism in pathogenesis of CAD in Iranian patients with stenosis and control subjects. To investigate the association between 
Apo E polymorphism and coronary artery disease we performed a comparative case control study of the frequency of Apo E 
polymorphism in One hundred CAD patients with stenosis who underwent coronary angiography (>50% stenosis) and 100 control subjects (<10% stenosis). The Apo E alleles and genotypes were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). We observed an association between the Apo E polymorphism and CAD in this study. These data suggest that the Apo ε4 and ε2 alleles increase the risk for CAD in Iranian population (χ2 =4.26, p= 0.05, OR=2 and χ2 =0.38, p=0.53, OR=1.2). These results suggest that ε4 and ε2 alleles are risk factors for stenosis.
},
	    journal   = {International Journal of Medical and Health Sciences},
	  volume    = {3},
	  number    = {9},
	  year      = {2009},
	  pages     = {246 - 250},
	  ee        = {https://publications.waset.org/pdf/15087},
	  url   	= {https://publications.waset.org/vol/33},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 33, 2009},
	}