Search results for: Depletion instability
282 Molecular Dynamics Simulation of Lubricant Adsorption and Thermal Depletion Instability
Authors: Bei Li, Qiu B. Chen, Chee H. Wong
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In this work, we incorporated a quartic bond potential into a coarse-grained bead-spring model to study lubricant adsorption on a solid surface as well as depletion instability. The surface tension density and the number density profiles were examined to verify the solid-liquid and liquid-vapor interfaces during heat treatment. It was found that both the liquid-vapor interfacial thickness and the solid-vapor separation increase with the temperatureT* when T*is below the phase transition temperature Tc *. At high temperatures (T*>Tc *), the solid-vapor separation decreases gradually as the temperature increases. In addition, we evaluated the lubricant weight and bond loss profiles at different temperatures. It was observed that the lubricant desorption is favored over decomposition and is the main cause of the lubricant failure at the head disk interface in our simulations.Keywords: Depletion instability, Lubricant film, Thermal adsorption, Molecular dynamics (MD).
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1770281 Depletion Layer Parameters of Al-MoO3-P-CdTe-Al MOS Structures
Authors: A. C. Sarmah
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The Al-MoO3-P-CdTe-Al MOS sandwich structures were fabricated by vacuum deposition method on cleaned glass substrates. Capacitance versus voltage measurements were performed at different frequencies and sweep rates of applied voltages for oxide and semiconductor films of different thicknesses. In the negative voltage region of the C-V curve a high differential capacitance of the semiconductor was observed and at high frequencies (<10 kHz) the transition from accumulation to depletion and further to deep depletion was observed as the voltage was swept from negative to positive. A study have been undertaken to determine the value of acceptor density and some depletion layer parameters such as depletion layer capacitance, depletion width, impurity concentration, flat band voltage, Debye length, flat band capacitance, diffusion or built-in-potential, space charge per unit area etc. These were determined from C-V measurements for different oxide and semiconductor thicknesses.
Keywords: Debye length, Depletion width, flat band capacitance, impurity concentration.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1569280 Instability of a Nonlinear Differential Equation of Fifth Order with Variable Delay
Authors: Cemil Tunc
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In this paper, we study the instability of the zero solution to a nonlinear differential equation with variable delay. By using the Lyapunov functional approach, some sufficient conditions for instability of the zero solution are obtained.
Keywords: Instability, Lyapunov-Krasovskii functional, delay differential equation, fifth order.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1454279 Density Wave Instability of Supercritical Kerosene in Active Cooling Channels of Scramjets
Authors: N. Wang, Y. Pan, J. Zhou, J. Lei, X. Z. Yang
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Experimental investigations were made on the instability of supercritical kerosene flowing in active cooling channels. Two approaches were used to control the pressure in the channel. One is the back-pressure valve while the other is the venturi. In both conditions, a kind of low-frequency oscillation of pressure and temperature is observed. And the oscillation periods are calculated. By comparison with the flow time, it is concluded that the instability occurred in active cooling channels is probably one kind of density wave instability. And its period has no relationship with the cooling channel geometry, nor the pressure, but only depends on the flow time of kerosene in active cooling channels. When the mass flow rate, density and pressure drop couple with each other, the density wave instability will appear.
Keywords: scramjets, active cooling, instability, density wave
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1541278 Effect of Shallow Groundwater Table on the Moisture Depletion Pattern in Crop Root Zone
Authors: Vijay Shankar
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Different techniques for estimating seasonal water use from soil profile water depletion frequently do not account for flux below the root zone. Shallow water table contribution to supply crop water use may be important in arid and semi-arid regions. Development of predictive root uptake models, under influence of shallow water table makes it possible for planners to incorporate interaction between water table and root zone into design of irrigation projects. A model for obtaining soil moisture depletion from root zone and water movement below it is discussed with the objective to determine impact of shallow water table on seasonal moisture depletion patterns under water table depth variation, up to the bottom of root zone. The role of different boundary conditions has also been considered. Three crops: Wheat (Triticum aestivum), Corn (Zea mays) and Potato (Solanum tuberosum), common in arid & semi-arid regions, are chosen for the study. Using experimentally obtained soil moisture depletion values for potential soil moisture conditions, moisture depletion patterns using a non linear root uptake model have been obtained for different water table depths. Comparative analysis of the moisture depletion patterns under these conditions show a wide difference in percent depletion from different layers of root zone particularly top and bottom layers with middle layers showing insignificant variation in moisture depletion values. Moisture depletion in top layer, when the water table rises to root zone increases by 19.7%, 22.9% & 28.2%, whereas decrease in bottom layer is 68.8%, 61.6% & 64.9% in case of wheat, corn & potato respectively. The paper also discusses the causes and consequences of increase in moisture depletion from top layers and exceptionally high reduction in bottom layer, and the possible remedies for the same. The numerical model developed for the study can be used to help formulating irrigation strategies for areas where shallow groundwater of questionable quality is an option for crop production.Keywords: Moisture Depletion, crop root zone, ground water table, irrigation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2027277 Weak Instability in Direct Integration Methods for Structural Dynamics
Authors: Shuenn-Yih Chang, Chiu-Li Huang
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Three structure-dependent integration methods have been developed for solving equations of motion, which are second-order ordinary differential equations, for structural dynamics and earthquake engineering applications. Although they generally have the same numerical properties, such as explicit formulation, unconditional stability and second-order accuracy, a different performance is found in solving the free vibration response to either linear elastic or nonlinear systems with high frequency modes. The root cause of this different performance in the free vibration responses is analytically explored herein. As a result, it is verified that a weak instability is responsible for the different performance of the integration methods. In general, a weak instability will result in an inaccurate solution or even numerical instability in the free vibration responses of high frequency modes. As a result, a weak instability must be prohibited for time integration methods.Keywords: Dynamic analysis, high frequency, integration method, overshoot, weak instability.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 677276 Instability of Ties in Compression
Authors: T. Cornelius
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Masonry cavity walls are loaded by wind pressure and vertical load from upper floors. These loads results in bending moments and compression forces in the ties connecting the outer and the inner wall in a cavity wall. Large cavity walls are furthermore loaded by differential movements from the temperature gradient between the outer and the inner wall, which results in critical increase of the bending moments in the ties. Since the ties are loaded by combined compression and moment forces, the loadbearing capacity is derived from instability equilibrium equations. Most of them are iterative, since exact instability solutions are complex to derive, not to mention the extra complexity introducing dimensional instability from the temperature gradients. Using an inverse variable substitution and comparing an exact theory with an analytical instability solution a method to design tie-connectors in cavity walls was developed. The method takes into account constraint conditions limiting the free length of the wall tie, and the instability in case of pure compression which gives an optimal load bearing capacity. The model is illustrated with examples from praxis.
Keywords: Masonry, tie connectors, cavity wall, instability, differential movements, combined bending and compression.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1697275 Spectral Analysis of Radiation-Induced Natural Convection in Littoral Waters
Authors: Yadan Mao, Chengwang Lei, John C. Patterson
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The mixing of pollutions and sediments in near shore regions of natural water bodies depends heavily on the characteristics such as the strength and frequency of flow instability. In the present paper, the instability of natural convection induced by absorption of solar radiation in littoral regions is considered. Spectral analysis is conducted on the quasi-steady state flow to reveal the power and frequency modes of the instability at various positions. Results indicate that the power of instability, the number of frequency modes, the prominence of higher frequency modes, and the highest frequency mode increase with the offshore distance and/or Rayleigh number. Harmonic modes are present at relatively low Rayleigh numbers. For a given offshore distance, the position with the strongest power of instability is located adjacent to the sloping bottom while the frequency modes are the same over the local depth. As the Rayleigh number increases, the unstable region extends toward the shore.
Keywords: Instability, Littoral waters, natural convection, Spectral analysis
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1358274 The Use of Voltage Stability Indices and Proposed Instability Prediction to Coordinate with Protection Systems
Authors: R. Leelaruji, V. Knazkins
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This paper proposes a methodology for mitigating the occurrence of cascading failure in stressed power systems. The methodology is essentially based on predicting voltage instability in the power system using a voltage stability index and then devising a corrective action in order to increase the voltage stability margin. The paper starts with a brief description of the cascading failure mechanism which is probable root cause of severe blackouts. Then, the voltage instability indices are introduced in order to evaluate stability limit. The aim of the analysis is to assure that the coordination of protection, by adopting load shedding scheme, capable of enhancing performance of the system after the major location of instability is determined. Finally, the proposed method to generate instability prediction is introduced.
Keywords: Blackouts, cascading failure, voltage stability indices, singular value decomposition, load shedding.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1551273 Assessment of Collapse Potential of Degrading SDOF Systems
Authors: Muzaffer Borekci, Murat S. Kirçil
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Predicting the collapse potential of a structure during earthquakes is an important issue in earthquake engineering. Many researchers proposed different methods to assess the collapse potential of structures under the effect of strong ground motions. However most of them did not consider degradation and softening effect in hysteretic behavior. In this study, collapse potential of SDOF systems caused by dynamic instability with stiffness and strength degradation has been investigated. An equation was proposed for the estimation of collapse period of SDOF system which is a limit value of period for dynamic instability. If period of the considered SDOF system is shorter than the collapse period then the relevant system exhibits dynamic instability and collapse occurs.
Keywords: Collapse, degradation, dynamic instability, seismic response.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2099272 Evaluation of Groundwater Trend of Arsanjan Plain
Authors: Mohammad Hosein Hojati , Fardin Boustani
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Groundwater resources in Arsanjan plain provide water for agriculture, industry, and human consumption. Continued agricultural development in this area needs to additional groundwater resources for, particularly during of drought periods, and effects on the quantity and quality of ground water available. The purpose of this study is to evaluate water level changes in the aquifer of Arsanjan plain in the Fars province in order to determine the areas of greatest depletion and the causes of depletion. In this plain, farmers and other users are pumping groundwater faster than its natural replenishment rate, causing a continuous drop in groundwater tables and depletion of this resource. In this research variation of groundwater level, their effects and ways to help control groundwater levels in aquifer of the Arsanjan plains were evaluated .Excessive exploitation of groundwater in this aquifer caused the groundwater levels fall too fast or to unacceptable levels. The average drawdown of the groundwater level in this plain were 19.66 meters during 1996 to 2003.Keywords: Aquifer , ground water depletion, water table
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1444271 Research of Amplitude-Frequency Characteristics of Nonlinear Oscillations of the Interface of Two-Layered Liquid
Authors: Win Ko Ko, A. N. Temnov
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The problem of nonlinear oscillations of a two-layer liquid completely filling a limited volume is considered. Using two basic asymmetric harmonics excited in two mutually perpendicular planes, ordinary differential equations of nonlinear oscillations of the interface of a two-layer liquid are investigated. In this paper, hydrodynamic coefficients of linear and nonlinear problems in integral relations were determined. As a result, the instability regions of forced oscillations of a two-layered liquid in a cylindrical tank occurring in the plane of action of the disturbing force are constructed, as well as the dynamic instability regions of the parametric resonance for different ratios of densities of the upper and lower liquids depending on the amplitudes of liquids from the excitations frequencies. Steady-state regimes of fluid motion were found in the regions of dynamic instability of the initial oscillation form. The Bubnov-Galerkin method is used to construct instability regions for approximate solution of nonlinear differential equations.
Keywords: Hydrodynamic coefficients, instability region, nonlinear oscillations, resonance frequency, two-layered liquid.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 565270 Groundwater Unit Hydrograph Evaluation of Niriz Plain
Authors: Fardin Boustani, Mohammad Hosein Hojati
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Groundwater is one of the most important water resources in Fars province. Based on this study, 95 percent of the total annual water consumption in Fars is used for agriculture, whereas the percentages for domestic and industrial uses are 4 and 1 percent, respectively. Population growth, urban and industrial growth, and agricultural development in Fars have created a condition of water stress. In this province, farmers and other users are pumping groundwater faster than its natural replenishment rate, causing a continuous drop in groundwater tables and depletion of this resource. In this research variation of groundwater level, their effects and ways to help control groundwater levels in aquifer of the Niriz plains in Fars plain were evaluated .Excessive exploitation of groundwater in this aquifer caused the groundwater levels fall too fast or to unacceptable levels. The average drawdown of the groundwater level in this plain were 9.1 meters during 1997 to 2004. The purpose of this study is to evaluate water level changes in the Niriz Aquifer in the Fars province in order to determine the areas of greatest depletion, the cause of depletion, and predict the remaining life of the aquifer.Keywords: Aquifer, ground water depletion, water table
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1497269 Evaluation of Groundwater Unit Hydrograph of Kavar-Maharloo Aquifer
Authors: Mohammad Hosein Hojati, Fardin Boustani
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Groundwater is one of the most important water resources in Fars province. Based on this study, 95 percent of the total annual water consumption in Fars is used for agriculture, whereas the percentages for domestic and industrial uses are 4 and 1 percent, respectively. Population growth, urban and industrial growth, and agricultural development in Fars have created a condition of water stress. In this province, farmers and other users are pumping groundwater faster than its natural replenishment rate, causing a continuous drop in groundwater tables and depletion of this resource. In this research variation of groundwater level, their effects and ways to help control groundwater levels in aquifer of the Kavar- Maharloo plains in Fars plain were evaluated .Excessive exploitation of groundwater in this aquifer caused the groundwater levels fall too fast or to unacceptable levels. The average drawdown of the groundwater level in this plain were 17 meters during 1995 to 2006. The purpose of this study is to evaluate water level changes in the Kavar-Maharloo Aquifer in the Fars province in order to determine the areas of greatest depletion, the cause of depletion, and predict the remaining life of the aquifer.Keywords: Aquifer , ground water depletion, water table
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1682268 Modulational Instability of Electron Plasma Waves in Finite Temperature Quantum Plasma
Authors: Swarniv Chandra, Basudev Ghosh
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Using the quantum hydrodynamic (QHD) model for quantum plasma at finite temperature the modulational instability of electron plasma waves is investigated by deriving a nonlinear Schrodinger equation. It was found that the electron degeneracy parameter significantly affects the linear and nonlinear properties of electron plasma waves in quantum plasma.
Keywords: Amplitude Modulation, Electron Plasma Waves, Finite Temperature Model, Modulational Instability, Quantum Plasma.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1693267 An Adversarial Construction of Instability Bounds in LIS Networks
Authors: Dimitrios Koukopoulos
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In this work, we study the impact of dynamically changing link slowdowns on the stability properties of packetswitched networks under the Adversarial Queueing Theory framework. Especially, we consider the Adversarial, Quasi-Static Slowdown Queueing Theory model, where each link slowdown may take on values in the two-valued set of integers {1, D} with D > 1 which remain fixed for a long time, under a (w, ¤ü)-adversary. In this framework, we present an innovative systematic construction for the estimation of adversarial injection rate lower bounds, which, if exceeded, cause instability in networks that use the LIS (Longest-in- System) protocol for contention-resolution. In addition, we show that a network that uses the LIS protocol for contention-resolution may result in dropping its instability bound at injection rates ¤ü > 0 when the network size and the high slowdown D take large values. This is the best ever known instability lower bound for LIS networks.Keywords: Network stability, quality of service, adversarial queueing theory, greedy scheduling protocols.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1229266 Resistive RAM Based on Hfox and its Temperature Instability Study
Authors: Z. Fang, H.Y. Yu, W.J. Liu, N. Singh, G.Q. Lo
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High performance Resistive Random Access Memory (RRAM) based on HfOx has been prepared and its temperature instability has been investigated in this work. With increasing temperature, it is found that: leakage current at high resistance state increases, which can be explained by the higher density of traps inside dielectrics (related to trap-assistant tunneling), leading to a smaller On/Off ratio; set and reset voltages decrease, which may be attributed to the higher oxygen ion mobility, in addition to the reduced potential barrier to create / recover oxygen ions (or oxygen vacancies); temperature impact on the RRAM retention degradation is more serious than electrical bias.Keywords: RRAM, resistive switching, temperature instability.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2411265 A Systematic Construction of Instability Bounds in LIS Networks
Authors: Dimitrios Koukopoulos
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In this work, we study the impact of dynamically changing link slowdowns on the stability properties of packetswitched networks under the Adversarial Queueing Theory framework. Especially, we consider the Adversarial, Quasi-Static Slowdown Queueing Theory model, where each link slowdown may take on values in the two-valued set of integers {1, D} with D > 1 which remain fixed for a long time, under a (w, p)-adversary. In this framework, we present an innovative systematic construction for the estimation of adversarial injection rate lower bounds, which, if exceeded, cause instability in networks that use the LIS (Longest-in- System) protocol for contention-resolution. In addition, we show that a network that uses the LIS protocol for contention-resolution may result in dropping its instability bound at injection rates p > 0 when the network size and the high slowdown D take large values. This is the best ever known instability lower bound for LIS networks.
Keywords: Parallel computing, network stability, adversarial queuing theory, greedy scheduling protocols.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1415264 Experimental Investigations of a Modified Taylor-Couette Flow
Authors: A. Esmael, A. El Shrif
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In this study the instability problem of a modified Taylor-Couette flow between two vertical coaxial cylinders of radius R1, R2 is considered. The modification is based on the wavy shape of the inner cylinder surface, where inner cylinders with different surface amplitude and wavelength are used. The study aims to discover the effect of the inner surface geometry on the instability phenomenon that undergoes Taylor-Couette flow. The study reveals that the transition processes depends strongly on the amplitude and wavelength of the inner cylinder surface and resulting in flow instabilities that are strongly different from that encountered in the case of the classical Taylor-Couette flow.
Keywords: Hydrodynamic Instability, Modified Taylor-Couette Flow, Turbulence, Taylor vortices.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2469263 Static Voltage Stability Margin Enhancement Using SVC and TCSC
Authors: Mohammed Amroune, Hadi Sebaa, Tarek Bouktir
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Reactive power limit of power system is one of the major causes of voltage instability. The only way to save the system from voltage instability is to reduce the reactive power load or add additional reactive power to reaching the point of voltage collapse. In recent times, the application of FACTS devices is a very effective solution to prevent voltage instability due to their fast and very flexible control. In this paper, voltage stability assessment with SVC and TCSC devices is investigated and compared in the modified IEEE 30-bus test system. The fast voltage stability indicator (FVSI) is used to identify weakest bus and to assess the voltage stability of power system.
Keywords: SVC, TCSC, Voltage stability, Fast Voltage Stability Index (FVSI), Reactive power.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 4075262 Pull-In Instability Determination of Microcapacitive Sensor for Measuring Special Range of Pressure
Authors: Yashar Haghighatfar, Shahrzad Mirhosseini
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Pull-in instability is a nonlinear and crucial effect that is important for the design of microelectromechanical system devices. In this paper, the appropriate electrostatic voltage range is determined by measuring fluid flow pressure via micro pressure sensor based microbeam. The microbeam deflection contains two parts, the static and perturbation deflection of static. The second order equation regarding the equivalent stiffness, mass and damping matrices based on Galerkin method is introduced to predict pull-in instability due to the external voltage. Also the reduced order method is used for solving the second order nonlinear equation of motion. Furthermore, in the present study, the micro capacitive pressure sensor is designed for measuring special fluid flow pressure range. The results show that the measurable pressure range can be optimized, regarding damping field and external voltage.
Keywords: MEMS, pull-in instability, electrostatically actuated microbeam, reduced order method.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 769261 Instability of Soliton Solutions to the Schamel-nonlinear Schrödinger Equation
Authors: Sarun Phibanchon, Michael A. Allen
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A variational method is used to obtain the growth rate of a transverse long-wavelength perturbation applied to the soliton solution of a nonlinear Schr¨odinger equation with a three-half order potential. We demonstrate numerically that this unstable perturbed soliton will eventually transform into a cylindrical soliton.
Keywords: Soliton, instability, variational method, spectral method.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3702260 Perspectives of Renewable Energy in 21st Century in India: Statistics and Estimation
Authors: Manoj Kumar, Rajesh Kumar
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With the favourable geographical conditions at Indian-subcontinent, it is suitable for flourishing renewable energy. Increasing amount of dependence on coal and other conventional sources is driving the world into pollution and depletion of resources. This paper presents the statistics of energy consumption and energy generation in Indian Sub-continent, which notifies us with the increasing energy demands surpassing energy generation. With the aggrandizement in demand for energy, usage of coal has increased, since the major portion of energy production in India is from thermal power plants. The increase in usage of thermal power plants causes pollution and depletion of reserves; hence, a paradigm shift to renewable sources is inevitable. In this work, the capacity and potential of renewable sources in India are analyzed. Based on the analysis of this work, future potential of these sources is estimated.Keywords: Energy consumption and generation, depletion of reserves, pollution, estimation, renewable sources.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 819259 Sensorless Control of Induction Motor: Design and Stability Analysis
Authors: Nadia Bensiali, Erik Etien, Amar Omeiri, Gerard Champenois
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Adaptive observers used in sensorless control of induction motors suffer from instability especally in regenerating mode. In this paper, an optimal feed back gain design is proposed, it can reduce the instability region in the torque speed plane .
Keywords: Induction motor drive, adaptive observer, regenerating mode, stabilizing design.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1548258 Marangoni Instability in a Fluid Layer with Insoluble Surfactant
Authors: Ainon Syazana Ab. Hamid, Seripah Awang Kechil, Ahmad Sukri Abd. Aziz
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The Marangoni convective instability in a horizontal fluid layer with the insoluble surfactant and nondeformable free surface is investigated. The surface tension at the free surface is linearly dependent on the temperature and concentration gradients. At the bottom surface, the temperature conditions of uniform temperature and uniform heat flux are considered. By linear stability theory, the exact analytical solutions for the steady Marangoni convection are derived and the marginal curves are plotted. The effects of surfactant or elasticity number, Lewis number and Biot number on the marginal Marangoni instability are assessed. The surfactant concentration gradients and the heat transfer mechanism at the free surface have stabilizing effects while the Lewis number destabilizes fluid system. The fluid system with uniform temperature condition at the bottom boundary is more stable than the fluid layer that is subjected to uniform heat flux at the bottom boundary.Keywords: Analytical solutions, Marangoni Instability, Nondeformable free surface, Surfactant.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1832257 Optimization of Breast Tumor Cells Isolation Efficiency and Purity by Membrane Filtration
Authors: Bhuvanendran Nair Gourikutty Sajay, Liu Yuxin, Chang Chia-Pin, Poenar Daniel Puiu, Abdur Rub Abdur Rahman
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Size based filtration is one of the common methods employed to isolate circulating tumor cells (CTCs) from whole blood. It is well known that this method suffers from isolation efficiency to purity tradeoff. However, this tradeoff is poorly understood. In this paper, we present the design and manufacturing of a special rectangular slit filter. The filter was designed to retain maximal amounts of nucleated cells, while minimizing the pressure on cells, thereby preserving their morphology. The key parameter, namely, input pressure, was optimized to retain the maximal number of tumor cells, whilst maximizing the depletion of normal blood cells (red and white blood cells and platelets). Our results indicate that for a slit geometry of 5 × 40 μm on a 13 mm circular membrane with a fill factor of 21%, a pressure of 6.9 mBar yields the optimum for maximizing isolation of MCF-7 and depletion of normal blood cells.Keywords: Circulating tumor cells, Parylene slit membrane, Retention, White Blood Cell depletion.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1837256 Mathematical Model of Depletion of Forestry Resource: Effect of Synthetic Based Industries
Authors: Manisha Chaudhary, Joydip Dhar, Govind Prasad Sahu
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A mathematical model is proposed considering the forest biomass density B(t), density of wood based industries W(t) and density of synthetic industries S(t). It is assumed that the forest biomass grows logistically in the absence of wood based industries, but depletion of forestry biomass is due to presence of wood based industries. The growth of wood based industries depends on B(t), while S(t) grows at a constant rate, independent of B(t). Further there is a competition between W(t) and S(t) according to market demand. The proposed model has four ecologically feasible steady states, namely, E1: forest biomass free and wood industries free equilibrium; E2: wood industries free equilibrium and two coexisting equilibria E∗1 , E∗2 . Behavior of the system near all feasible equilibria is analyzed using the stability theory of differential equations. In the proposed model, the natural depletion rate h1 is a crucial parameter and system exhibits Hopf-bifurcation about the non-trivial equilibrium with respect to h1. The analytical results are verified using numerical simulation.
Keywords: A mathematical model, Competition between wood based and synthetic industries, Hopf-bifurcation, Stability analysis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3500255 Richtmyer-Meshkov Instability and Gas-Particle Interaction of Contoured Shock-Tube Flows: A Numerical Study
Authors: Yi Liu
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In this paper, computational fluid dynamics (CFD) is utilized to characterize a prototype biolistic delivery system, the biomedical device based on the contoured-shock-tube design (CST), with the aim at investigating shocks induced flow instabilities within the contoured shock tube. The shock/interface interactions, the growth of perturbation at an interface between two fluids of different density are interrogated. The key features of the gas dynamics and gas-particle interaction are discussed
Keywords: Simulation, Shock wave, Particle, Interface, Supersonic, Richtmyer-Meshkov Instability
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1764254 About the Instability Modes of Current Sheet in Wide Range of Frequencies
Authors: V. V. Lyahov, V. M. Neshchadim
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We offer a new technique for research of stability of current sheaths in space plasma taking into account the effect of polarization. At the beginning, the found perturbation of the distribution function is used for calculation of the dielectric permeability tensor, which simulates inhomogeneous medium of a current sheath. Further, we in the usual manner solve the system of Maxwell's equations closed with the material equation. The amplitudes of Fourier perturbations are considered to be exponentially decaying through the current sheath thickness. The dispersion equation follows from the nontrivial solution requirement for perturbations of the electromagnetic field. The resulting dispersion equation allows one to study the temporal and spatial characteristics of instability modes of the current sheath (within the limits of the proposed model) over a wide frequency range, including low frequencies.
Keywords: Current sheath, distribution function, effect of polarization, instability modes, low frequencies, perturbation of electromagnetic field dispersion equation, space plasma, tensor of dielectric permeability.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1654253 Influence of Measurement System on Negative Bias Temperature Instability Characterization: Fast BTI vs Conventional BTI vs Fast Wafer Level Reliability
Authors: Vincent King Soon Wong, Hong Seng Ng, Florinna Sim
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Negative Bias Temperature Instability (NBTI) is one of the critical degradation mechanisms in semiconductor device reliability that causes shift in the threshold voltage (Vth). However, thorough understanding of this reliability failure mechanism is still unachievable due to a recovery characteristic known as NBTI recovery. This paper will demonstrate the severity of NBTI recovery as well as one of the effective methods used to mitigate, which is the minimization of measurement system delays. Comparison was done in between two measurement systems that have significant differences in measurement delays to show how NBTI recovery causes result deviations and how fast measurement systems can mitigate NBTI recovery. Another method to minimize NBTI recovery without the influence of measurement system known as Fast Wafer Level Reliability (FWLR) NBTI was also done to be used as reference.Keywords: Fast vs slow BTI, Fast wafer level reliability, Negative bias temperature instability, NBTI measurement system, metal-oxide-semiconductor field-effect transistor, MOSFET, NBTI recovery, reliability.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1665