Richtmyer-Meshkov Instability and Gas-Particle Interaction of Contoured Shock-Tube Flows: A Numerical Study
Authors: Yi Liu
In this paper, computational fluid dynamics (CFD) is utilized to characterize a prototype biolistic delivery system, the biomedical device based on the contoured-shock-tube design (CST), with the aim at investigating shocks induced flow instabilities within the contoured shock tube. The shock/interface interactions, the growth of perturbation at an interface between two fluids of different density are interrogated. The key features of the gas dynamics and gas-particle interaction are discussed
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1327907Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1425
 B.J. Bellhouse, D.F. Sarphie and J.C. Greenford (1994) Needless syringe using supersonic gas flow for micro-particle delivery, Int. Patent WO94/24263
 B.J. Bellhouse, N.J. Quinlan and R.W. Ainsworth (1997) Needle-less delivery of drugs, in dry powder form, using shock waves and supersonic gas flow, Proc. 21st Int. Symp. on Shock Waves, Queensland, Australia
 Y. Liu, and M.A.F. Kendall (2004) Numerical Simulation of Heat Transfer from a Transonic Jet Impinging on Skin for Needle-free Powdered Drug and Vaccine Delivery, Journal of Mechanical Engineering Science, Proceedings of the Institution of Mechanical Engineers Part C, 218(11): 1373-1383
 Y. Liu (2007) Impact studies of high speed micro-particles following biolistic delivery. IEEE Transactions on Biomedical Engineering 54(8): 1507-1513.
 D.L. Youngs (1994) Numerical simulation of mixing by Rayleigh-Taylor and Richtmyer-Meshkov instability, Laser Particle Beams 12(4): 725-750
 R.L. Holmes, G. Dimonte, B. Fryxell, M.L. Gittings, J.W. Grove, M. Schneider, D.H. Sharp, A.L. Velikovich, R.P. Weaver and Q. Zhang (1999) Richtmyer-Meshkov instability growth: experiment, simulation and theory, Journal of Fluid Mechanics 389: 55-79
 S. Kumar, P. Vorobieff, G. Orlicz, A. Palekar, C. Tomkins, C. Goodenough, M. Marr-Lyon, K.P. Prestridge and R.F. Benjamin (2007) Complex flow morphologies in shock-accelerated gaseous flows, Physica D: Nonlinear Phenomena, 235(1-2): 21- 28
 N.K. Truong, Y. Liu, M.A.F. Kendall (2006) Gas and particle dynamics of a contoured shock tube for pre-clinical microparticle drug delivery, Shock Waves, 15(3-4): 149-164
 C.B. Henderson (1976) Drag coefficient of spheres in continuum and rarefied flows, AIAA J. 14(6): 707-708.
 O. Igra, K. Takayama (1993) Shock tube study of the drag coefficient of a sphere in a non-stationary flow, Proc R. Soc. Lond. A, 442: 231-247.
 J. Kurian, H.K. Das (1997) Studies of shock Wave Propagation in gas-particle mixtures, in: Proc. 21st Int. Symp. on Shock Waves, Great Keppel Island, Australia.