Search results for: Mina Najafi
54 New Exact Solutions for the (3+1)-Dimensional Breaking Soliton Equation
Authors: Mohammad Taghi Darvishi, Maliheh Najafi, Mohammad Najafi
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In this work, we obtain some analytic solutions for the (3+1)-dimensional breaking soliton after obtaining its Hirota-s bilinear form. Our calculations show that, three-wave method is very easy and straightforward to solve nonlinear partial differential equations.
Keywords: (3+1)-dimensional breaking soliton equation, Hirota'sbilinear form.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 167053 New Application of EHTA for the Generalized(2+1)-Dimensional Nonlinear Evolution Equations
Authors: Mohammad Taghi Darvishi, Maliheh Najafi, Mohammad Najafi
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In this paper, the generalized (2+1)-dimensional Calogero-Bogoyavlenskii-Schiff (shortly CBS) equations are investigated. We employ the Hirota-s bilinear method to obtain the bilinear form of CBS equations. Then by the idea of extended homoclinic test approach (shortly EHTA), some exact soliton solutions including breather type solutions are presented.
Keywords: EHTA, (2+1)-dimensional CBS equations, (2+1)-dimensional breaking solution equation, Hirota's bilinear form.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 148752 Exact Three-wave Solutions for High Nonlinear Form of Benjamin-Bona-Mahony-Burgers Equations
Authors: Mohammad Taghi Darvishi, Maliheh Najafi, Mohammad Najafi
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By means of the idea of three-wave method, we obtain some analytic solutions for high nonlinear form of Benjamin-Bona- Mahony-Burgers (shortly BBMB) equations in its bilinear form.
Keywords: Benjamin-Bona-Mahony-Burgers equations, Hirota's bilinear form, three-wave method.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 157651 The Concept of Place and Sense of Place In Architectural Studies
Authors: Mina Najafi, Mustafa Kamal Bin Mohd Shariff
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Place is a where dimension formed by people-s relationship with physical settings, individual and group activities, and meanings. 'Place Attachment', 'Place Identity'and 'Sense of Place' are some concepts that could describe the quality of people-s relationships with a place. The concept of Sense of place is used in studying human-place bonding, attachment and place meaning. Sense of Place usually is defined as an overarching impression encompassing the general ways in which people feel about places, senses it, and assign concepts and values to it. Sense of place is highlighted in this article as one of the prevailing concepts among place-based researches. Considering dimensions of sense of place has always been beneficial for investigating public place attachment and pro-environmental attitudes towards these places. The creation or preservation of Sense of place is important in maintaining the quality of the environment as well as the integrity of human life within it. While many scholars argued that sense of place is a vague concept, this paper will summarize and analyze the existing seminal literature. Therefore, in this paper first the concept of Sense of place and its characteristics will be examined afterward the scales of Sense of place will be reviewed and the factors that contribute to form Sense of place will be evaluated and finally Place Attachment as an objective dimension for measuring the sense of place will be described.Keywords: Place, Place Attachment, Sense of place
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1899850 Traveling Wave Solutions for the (3+1)-Dimensional Breaking Soliton Equation by (G'/G)- Expansion Method and Modified F-Expansion Method
Authors: Mohammad Taghi Darvishi, Maliheh Najafi, Mohammad Najafi
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In this paper, using (G/G )-expansion method and modified F-expansion method, we give some explicit formulas of exact traveling wave solutions for the (3+1)-dimensional breaking soliton equation. A modified F-expansion method is proposed by taking full advantages of F-expansion method and Riccati equation in seeking exact solutions of the equation.
Keywords: Exact solution, The (3+1)-dimensional breaking soliton equation, ( G G )-expansion method, Riccati equation, Modified Fexpansion method.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 272449 Thermal Performance and Environmental Assessment of Evaporative Cooling Systems: Case of Mina Valley, Saudi Arabia
Authors: A. Alharbi, R. Boukhanouf, T. Habeebullah, H. Ibrahim
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This paper presents a detailed description of evaporative cooling systems used for space cooling in Mina Valley, Saudi Arabia. The thermal performance and environmental impact of the evaporative coolers were evaluated. It was found that the evaporative cooling systems used for space cooling in pilgrims’ accommodations and in the train stations could reduce energy consumption by as much as 75% and cut carbon dioxide emission by 78% compared to traditional vapour compression systems.
Keywords: Evaporative cooling, vapour compression, electricity consumption and CO2 emission.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 304248 Public Attachment to Religious Places: A Study of Place Attachment to Mosques in Malaysia
Authors: Mina Najafi, Mustafa Kamal Bin Mohd Shariff
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Religious place attachment is an affective bond that develops between people and their religious settings. The published literature shows that although religion has a significant impact on the public ‘place attachment’, the architectural features and attributes of the places could still play an influencing role in strengthening this attachment. However, the role of architectural characteristics and features of the religious places, as the components that give them meaning(s), has not been adequately explored. This paper reports the impacts of factors influencing the physical and ambience quality of different styles of Malaysian mosques from the Muslim public perspective. Thereby, a survey was conducted to investigate Malaysian public attachment to selected five Malaysian state mosques with respect to their architectural characteristics and features. The survey employed the results of series of interviews as its theoretical basis. The finding proved that Malaysian ‘Muslim’ society has equally strong attachment to all selected mosques in spite of their different architectural styles. The findings also confirmed that the emotional attachment to the impressive aspects of architectural features (e.g. dome, minaret etc.) and the unique identity of the studied mosques is irrespective of the architectural styles, e.g. Modern vs. Postmodern. The paper also argued that religious activities and pleasant architectural characteristic of the studied places including the functional facilities are equally important factors in forming place attachment. This is a new approach to the study of physical and ambience quality of mosques, hence providing sufficient theoretical basis for further investigations and improvements.
Keywords: Place Attachment, Place Identity, Physical Features, Malaysian Mosques.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 431347 A New Center of Motion in Cabling Robots
Authors: A. Abbasi Moshaii, F. Najafi
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In this paper a new model for center of motion creating is proposed. This new method uses cables. So, it is very useful in robots because it is light and has easy assembling process. In the robots which need to be in touch with some things this method is so useful. It will be described in the following. The accuracy of the idea is proved by two experiments. This system could be used in the robots which need a fixed point in the contact with some things and make a circular motion.Keywords: Center of Motion, Robotic cables, permanent touching.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 166846 Some Complexiton Type Solutions of the (3+1)-Dimensional Jimbo-Miwa Equation
Authors: Mohammad Taghi Darvishi, Mohammad Najafi
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By means of the extended homoclinic test approach (shortly EHTA) with the aid of a symbolic computation system such as Maple, some complexiton type solutions for the (3+1)-dimensional Jimbo-Miwa equation are presented.
Keywords: Jimbo-Miwa equation, painleve analysis, Hirota's bilinear form, computerized symbolic computation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 189445 Extend Three-wave Method for the (3+1)-Dimensional Soliton Equation
Authors: Somayeh Arbabi Mohammad-Abadi, Maliheh Najafi
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In this paper, we study (3+1)-dimensional Soliton equation. We employ the Hirota-s bilinear method to obtain the bilinear form of (3+1)-dimensional Soliton equation. Then by the idea of extended three-wave method, some exact soliton solutions including breather type solutions are presented.
Keywords: Three-wave method, (3+1)-dimensional Soliton equation, Hirota's bilinear form.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 155944 Scheduling a Project to Minimize Costs of Material Requirements
Authors: Amir Abbas Najafi, Nima Zoraghi, Fatemeh Azimi
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Traditionally, project scheduling and material planning have been treated independently. In this research, a mixed integer programming model is presented to integrate project scheduling and materials ordering problems. The goal is to minimize the total material holding and ordering costs. In addition, an efficient metaheuristic algorithm is proposed to solve the model. The proposed algorithm is computationally tested, the results are analyzed, and conclusions are given.
Keywords: Project scheduling, metaheuristic, material ordering, optimization.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 170243 Some Exact Solutions of the (2+1)-Dimensional Breaking Soliton Equation using the Three-wave Method
Authors: Mohammad Taghi Darvishi, Mohammad Najafi
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This paper considers the (2+1)-dimensional breaking soliton equation in its bilinear form. Some exact solutions to this equation are explicitly derived by the idea of three-wave solution method with the assistance of Maple. We can see that the new idea is very simple and straightforward.
Keywords: Soliton solution, computerized symbolic computation, painleve analysis, (2+1)-dimensional breaking soliton equation, Hirota's bilinear form.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 190942 Estimation of Bayesian Sample Size for Binomial Proportions Using Areas P-tolerance with Lowest Posterior Loss
Authors: H. Bevrani, N. Najafi
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This paper uses p-tolerance with the lowest posterior loss, quadratic loss function, average length criteria, average coverage criteria, and worst outcome criterion for computing of sample size to estimate proportion in Binomial probability function with Beta prior distribution. The proposed methodology is examined, and its effectiveness is shown.Keywords: Bayesian inference, Beta-binomial Distribution, LPLcriteria, quadratic loss function.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 174941 Long-Term Simulation of Digestive Sound Signals by CEPSTRAL Technique
Authors: Einalou Z., Najafi Z., Maghooli K. Zandi Y, Sheibeigi A
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In this study, an investigation over digestive diseases has been done in which the sound acts as a detector medium. Pursue to the preprocessing the extracted signal in cepstrum domain is registered. After classification of digestive diseases, the system selects random samples based on their features and generates the interest nonstationary, long-term signals via inverse transform in cepstral domain which is presented in digital and sonic form as the output. This structure is updatable or on the other word, by receiving a new signal the corresponding disease classification is updated in the feature domain.
Keywords: Cepstrum, databank, digestive disease, acousticsignal.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 155540 Universal Kinetic Modeling of RAFT Polymerization using Moment Equations
Authors: Mehdi Salami-Kalajahi, Pejman Ganjeh-Anzabi, Vahid Haddadi-Asl, Mohammad Najafi
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In the following text, we show that by introducing universal kinetic scheme, the origin of rate retardation and inhibition period which observed in dithiobenzoate-mediated RAFT polymerization can be described properly. We develop our model by utilizing the method of moments, then we apply our model to different monomer/RAFT agent systems, both homo- and copolymerization. The modeling results are in an excellent agreement with experiments and imply the validity of universal kinetic scheme, not only for dithiobenzoate-mediated systems, but also for different types of monomer/RAFT agent ones.Keywords: RAFT Polymerization, Mechanism, Kinetics, Moment Equations, Modeling.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 200339 SoC Communication Architecture Modeling
Authors: Ziaddin Daie Koozekanani, Mina Zolfy Lighvan
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One of the most challengeable issues in ESL (Electronic System Level) design is the lack of a general modeling scheme for on chip communication architecture. In this paper some of the mostly used methodologies for modeling and representation of on chip communication are investigated. Our goal is studying the existing methods to extract the requirements of a general representation scheme for communication architecture synthesis. The next step, will be introducing a modeling and representation method for being used in automatically synthesis process of on chip communication architecture.Keywords: Communication architecture, System on Chip, Communication Modeling and Representation
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 141538 Multiple Soliton Solutions of (2+1)-dimensional Potential Kadomtsev-Petviashvili Equation
Authors: Mohammad Najafi, Ali Jamshidi
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We employ the idea of Hirota-s bilinear method, to obtain some new exact soliton solutions for high nonlinear form of (2+1)-dimensional potential Kadomtsev-Petviashvili equation. Multiple singular soliton solutions were obtained by this method. Moreover, multiple singular soliton solutions were also derived.
Keywords: Hirota bilinear method, potential Kadomtsev-Petviashvili equation, multiple soliton solutions, multiple singular soliton solutions.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 137337 Promoting Collaborative Learning in Software Engineering by Adapting the PBL Strategy
Authors: Charlie Y. Shim, Mina Choi, Jung Y. Kim
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Software engineering education not only embraces technical skills of software development but also necessitates communication and interaction among learners. In this paper, it is proposed to adapt the PBL methodology that is especially designed to be integrated into software engineering classroom in order to promote collaborative learning environment. This approach helps students better understand the significance of social aspects and provides a systematic framework to enhance teamwork skills. The adaptation of PBL facilitates the transition to an innovative software development environment where cooperative learning can be actualized.Keywords: problem-based learning, software engineering, software process models, teamwork.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 171636 Nano-Alumina Sulfuric Acid: An Efficient Catalyst for the Synthesis of α-Aminonitriles Derivatives
Authors: Abbas Teimouri, Alireza Najafi Chermahini, Leila Ghorbanian
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An efficient and green protocol for the synthesis of α- aminonitriles derivatives by one-pot reaction of different aldehydes with amines and trimethylsilyl cyanides has been developed using natural alumina, alumina sulfuric acid (ASA), nano-γ-alumina, nanoalumina sulfuric acid (nano-ASA) under microwave irradiation and solvent-free conditions. The advantages of methods are short reaction times, high yields, milder conditions and easy work up. The catalysts can be recovered for the subsequent reactions and reused without any appreciable loss of efficiency.
Keywords: Nano-γ-alumina, nano-alumina sulfuric acid, green synthesis, microwave irradiation, α-aminonitriles derivatives.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 505135 Stability of a Self-Excited Machine Due to the Mechanical Coupling
Authors: M. Soltan Rezaee, M. R. Ghazavi, A. Najafi, W.-H. Liao
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Generally, different rods in shaft systems can be misaligned based on the mechanical system usages. These rods can be linked together via U-coupling easily. The system is self-stimulated and may cause instabilities due to the inherent behavior of the coupling. In this study, each rod includes an elastic shaft with an angular stiffness and structural damping. Moreover, the mass of shafts is considered via attached solid disks. The impact of the system architecture and shaft mass on the instability of such mechanism are studied. Stability charts are plotted via a method based on Floquet theory. Eventually, the unstable points have been found and analyzed in detail. The results show that stabilizing the driveline is feasible by changing the system characteristics which include shaft mass and architecture.
Keywords: Coupling, mechanical systems, oscillations, rotating shafts.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 76234 Using Multi-Objective Particle Swarm Optimization for Bi-objective Multi-Mode Resource-Constrained Project Scheduling Problem
Authors: Fatemeh Azimi, Razeeh Sadat Aboutalebi, Amir Abbas Najafi
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In this paper the multi-mode resource-constrained project scheduling problem with discounted cash flows is considered. Minimizing the makespan and maximization the net present value (NPV) are the two common objectives that have been investigated in the literature. We apply one evolutionary algorithm named multiobjective particle swarm optimization (MOPSO) to find Pareto front solutions. We used standard sets of instances from the project scheduling problem library (PSPLIB). The results are computationally compared respect to different metrics taken from the literature on evolutionary multi-objective optimization.
Keywords: Evolutionary multi-objective optimization makespan, multi-mode, resource constraint, net present value.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 229333 Convective Interactions and Heat Transfer in a Czochralski Melt with a Model Phase Boundary of Two Different Shapes
Authors: R. Faiez, M. Mashhoudi, F. Najafi
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Implicit in most large-scale numerical analyses of the crystal growth from the melt is the assumption that the shape and position of the phase boundary are determined by the transport phenomena coupled strongly to the melt hydrodynamics. In the present numerical study, the interface shape-effect on the convective interactions in a Czochralski oxide melt is described. It was demonstrated that thermocapillary flow affects inversely the phase boundaries of distinct shapes. The inhomogenity of heat flux and the location of the stagnation point at the crystallization front were investigated. The forced convection effect on the point displacement at the boundary found to be much stronger for the flat plate interface compared to the cone-shaped one with and without the Marangoni flow.
Keywords: Computer simulation, fluid flow, interface shape, thermocapillary effect.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 214632 A Finite Element Model for Estimating Young-s Modulus of Carbon Nanotube Reinforced Composites Incorporating Elastic Cross-Links
Authors: Kaveh PourAkbar Saffar, Nima JamilPour, Ahmad Raeisi Najafi, Gholamreza Rouhi, Ahmad Reza Arshi, Abdolhossein Fereidoon
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The presence of chemical bonding between functionalized carbon nanotubes and matrix in carbon nanotube reinforced composites is modeled by elastic beam elements representing covalent bonding characteristics. Neglecting other reinforcing mechanisms in the composite such as relatively weak interatomic Van der Waals forces, this model shows close results to the Rule of Mixtures model-s prediction for effective Young-s modulus of a Representative Volume Element of composite for small volume fractions (~1%) and high aspect ratios (L/D>200) of CNTs.
Keywords: Beam Element, Carbon Nanotube Reinforced Composite, Cross-link, Young's modulus.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 232431 Geometrical Based Unequal Droplet Splitting Using Microfluidic Y-Junction
Authors: Bahram Talebjedi, Amirmohammad Sattari, Ahmed Zoher Sihorwala, Mina Hoorfar
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Among different droplet manipulations, controlled droplet-splitting is of great significance due to its ability to increase throughput and operational capability. Furthermore, unequal droplet-splitting can provide greater flexibility and a wider range of dilution factors. In this study, we developed two-dimensional, time-dependent complex fluid dynamics simulations to model droplet formation in a flow focusing device, followed by splitting in a Y-shaped junction with sub-channels of unequal widths. From the results obtained from the numerical study, we correlated the diameters of the droplets in the sub-channels to the Weber number, thereby demarcating the droplet splitting and non-splitting regimes.
Keywords: Microfluidics, unequal droplet splitting, two phase flow, flow focusing device.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 77330 Monte Carlo Simulation of Copolymer Heterogeneity in Atom Transfer Radical Copolymerization of Styrene and N-Butyl Acrylate
Authors: Mohammad Najafi, Hossein Roghani-Mamaqani, Mehdi Salami-Kalajahi, Vahid Haddadi-Asl
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A high-performance Monte Carlo simulation, which simultaneously takes diffusion-controlled and chain-length-dependent bimolecular termination reactions into account, is developed to simulate atom transfer radical copolymerization of styrene and nbutyl acrylate. As expected, increasing initial feed fraction of styrene raises the fraction of styrene-styrene dyads (fAA) and reduces that of n-butyl acrylate dyads (fBB). The trend of variation in randomness parameter (fAB) during the copolymerization also varies significantly. Also, there is a drift in copolymer heterogeneity and the highest drift occurs in the initial feeds containing lower percentages of styrene, i.e. 20% and 5%.Keywords: Atom Transfer Radical Copolymerization, MonteCarlo Simulation, Copolymer Heterogeneity, Styrene n-ButylAcrylate
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 160029 A Scenario Oriented Supplier Selection by Considering a Multi Tier Supplier Network
Authors: Mohammad Najafi Nobar, Bahareh Pourmehr, Mehdi Hajimirarab
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One of the main processes of supply chain management is supplier selection process which its accurate implementation can dramatically increase company competitiveness. In presented article model developed based on the features of second tiers suppliers and four scenarios are predicted in order to help the decision maker (DM) in making up his/her mind. In addition two tiers of suppliers have been considered as a chain of suppliers. Then the proposed approach is solved by a method combined of concepts of fuzzy set theory (FST) and linear programming (LP) which has been nourished by real data extracted from an engineering design and supplying parts company. At the end results reveal the high importance of considering second tier suppliers features as criteria for selecting the best supplier.Keywords: Supply Chain Management (SCM), SupplierSelection, Second Tier Supplier, Scenario Planning, Green Factor, Linear Programming, Fuzzy Set Theory
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 180628 Application of GIS and Statistical Multivariate Techniques for Estimation of Soil Erosion and Sediment Yield
Authors: Masoud Nasri, Ali Gholami, Ali Najafi
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In recent years, most of the regions in the world are exposed to degradation and erosion caused by increasing population and over use of land resources. The understanding of the most important factors on soil erosion and sediment yield are the main keys for decision making and planning. In this study, the sediment yield and soil erosion were estimated and the priority of different soil erosion factors used in the MPSIAC method of soil erosion estimation is evaluated in AliAbad watershed in southwest of Isfahan Province, Iran. Different information layers of the parameters were created using a GIS technique. Then, a multivariate procedure was applied to estimate sediment yield and to find the most important factors of soil erosion in the model. The results showed that land use, geology, land and soil cover are the most important factors describing the soil erosion estimated by MPSIAC model.Keywords: land degradation, Soil erosion, Sediment yield, Aliabad, GIS technique, Land use.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 169027 Non-Linear Vibration and Stability Analysis of an Axially Moving Beam with Rotating-Prismatic Joint
Authors: M. Najafi, F. Rahimi Dehgolan
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In this paper, the dynamic modeling of a single-link flexible beam with a tip mass is given by using Hamilton's principle. The link has been rotational and translational motion and it was assumed that the beam is moving with a harmonic velocity about a constant mean velocity. Non-linearity has been introduced by including the non-linear strain to the analysis. Dynamic model is obtained by Euler-Bernoulli beam assumption and modal expansion method. Also, the effects of rotary inertia, axial force, and associated boundary conditions of the dynamic model were analyzed. Since the complex boundary value problem cannot be solved analytically, the multiple scale method is utilized to obtain an approximate solution. Finally, the effects of several conditions on the differences among the behavior of the non-linear term, mean velocity on natural frequencies and the system stability are discussed.
Keywords: Non-linear vibration, stability, axially moving beam, bifurcation, multiple scales method.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 133926 The Inverse Problem of Nonsymmetric Matrices with a Submatrix Constraint and its Approximation
Authors: Yongxin Yuan, Hao Liu
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In this paper, we first give the representation of the general solution of the following least-squares problem (LSP): Given matrices X ∈ Rn×p, B ∈ Rp×p and A0 ∈ Rr×r, find a matrix A ∈ Rn×n such that XT AX − B = min, s. t. A([1, r]) = A0, where A([1, r]) is the r×r leading principal submatrix of the matrix A. We then consider a best approximation problem: given an n × n matrix A˜ with A˜([1, r]) = A0, find Aˆ ∈ SE such that A˜ − Aˆ = minA∈SE A˜ − A, where SE is the solution set of LSP. We show that the best approximation solution Aˆ is unique and derive an explicit formula for it. Keyw
Keywords: Inverse problem, Least-squares solution, model updating, Singular value decomposition (SVD), Optimal approximation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 164625 miR-200c as a Biomarker for 5-FU Chemosensitivity in Colorectal Cancer
Authors: Rezvan Najafi, Korosh Heydari, Massoud Saidijam
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5-FU is a chemotherapeutic agent that has been used in colorectal cancer (CRC) treatment. However, it is usually associated with the acquired resistance, which decreases the therapeutic effects of 5-FU. miR-200c is involved in chemotherapeutic drug resistance, but its mechanism is not fully understood. In this study, the effect of inhibition of miR-200c in sensitivity of HCT-116 CRC cells to 5-FU was evaluated. HCT-116 cells were transfected with LNA-anti- miR-200c for 48 h. mRNA expression of miR-200c was evaluated using quantitative real- time PCR. The protein expression of phosphatase and tensin homolog (PTEN) and E-cadherin were analyzed by western blotting. Annexin V and propidium iodide staining assay were applied for apoptosis detection. The caspase-3 activation was evaluated by an enzymatic assay. The results showed LNA-anti-miR-200c inhibited the expression of PTEN and E-cadherin protein, apoptosis and activation of caspase 3 compared with control cells. In conclusion, these results suggest that miR-200c as a prognostic marker can overcome to 5-FU chemoresistance in CRC.
Keywords: Colorectal cancer, miR-200c, 5-FU resistance, E-cadherin, PTEN.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 916