Search results for: Adel Mazloumi
172 Work Ability Index (WAI) and Its Health-Related Detriments among Iranian Farmers Working in the Small Farm Enterprises
Authors: Akbar Rostamabadi, Adel Mazloumi, Abbas Rahimi Foroushani
Abstract:
This study aimed to determine the Work Ability Index (WAI) and examine the influence of health dimensions and demographic variables on the work ability of Iranian farmers working in small farm enterprises. A cross-sectional study was conducted among 294 male farmers. The WAI and SF-36 questionnaires were used to determine work ability and health status. The effect of demographics variables on the work ability index was investigated with the independent samples t-test and one-way ANOVA. Also, multiple linear regression analysis was used to test the association between the mean WAI score and the SF-36 scales. The mean WAI score was 35.1 (SD=10.6). One-way ANOVA revealed a significant relationship between the mean WAI and age. Multiple linear regression analysis showed that work ability was more influenced by physical scales of the health dimensions, such as physical function, role-physical, and general health, whereas a lower association was found for mental scales such as mental health. The average WAI was at a moderate work ability level for the sample population of farmers in this study. Based on the WAI guidelines, improvement of work ability and identification of factors affecting it should be considered a priority in interventional programs. Given the influence of health dimensions on WAI, any intervention program for preservation and promotion work ability among the studied farmers should be based on balancing and optimizing the physical and psychosocial work environments, with a special focus on reducing physical work load.Keywords: farmers, SF-36, Work Ability Index (WAI), Iran
Procedia PDF Downloads 441171 Tram Track Deterioration Modeling
Authors: Mohammad Yousefikia, Sara Moridpour, Ehsan Mazloumi
Abstract:
Perceiving track geometry deterioration decisively influences the optimization of track maintenance operations. The effective management of this deterioration and increasingly utilized system with limited financial resources is a significant challenge. This paper provides a review of degradation models relevant for railroad tracks. Furthermore, due to the lack of long term information on the condition development of tram infrastructures, presents the methodology which will be used to derive degradation models from the data of Melbourne tram network.Keywords: deterioration modeling, asset management, railway, tram
Procedia PDF Downloads 381170 Groundwater Contamination Assessment and Mitigation Strategies for Water Resource Sustainability: A Concise Review
Authors: Khawar Naeem, Adel Elomri, Adel Zghibi
Abstract:
Contamination leakage from municipal solid waste (MSW) landfills is a serious environmental challenge that poses a threat to interconnected ecosystems. It not only contaminates the soil of the saturated zone, but it also percolates down the earth and contaminates the groundwater (GW). In this concise literature review, an effort is made to understand the environmental hazards posed by this contamination to the soil and groundwater, the type of contamination, and possible solutions proposed in the literature. In the study’s second phase, the MSW management practices are explored as the landfill site dump rate and type of MSW into the landfill site directly depend on the MSW management strategies. Case studies from multiple developed and underdeveloped countries are presented, and the complex MSW management system is investigated from an operational perspective to minimize the contamination of GW. One of the significant tools used in the literature was found to be Systems Dynamic Modeling (SDM), which is a simulation-based approach to study the stakeholder’s approach. By employing the SDM approach, the risk of GW contamination can be reduced by devising effective MSW management policies, ultimately resulting in water resource sustainability and regional sustainable development.Keywords: groundwater contamination, environmental risk, municipal solid waste management, system dynamic modeling, water resource sustainability, sustainable development
Procedia PDF Downloads 78169 Treatment of Interferograms Image of Perturbation Processes in Metallic Samples by Optical Method
Authors: Daira Radouane, Naim Boudmagh, Hamada Adel
Abstract:
The but of this handling is to use the technique of the shearing with a mechanism lapping machine of image: a prism of Wollaston. We want to characterize this prism in order to be able to employ it later on in an analysis by shearing. A prism of Wollaston is a prism produced in a birefringent material i.e. having two indexes of refraction. This prism is cleaved so as to present the directions associated with these indices in its face with entry. It should be noted that these directions are perpendicular between them.Keywords: non destructive control, aluminium, interferometry, treatment of image
Procedia PDF Downloads 332168 Successful Treatment of Multifocal XDR Tuberculosis Osteomyelitis
Authors: Abeer N. Alshukairi, Abdulrahman A. Alrajhi, Abdulfattah W. Alamri, Adel F. Alothman
Abstract:
We described the nosocomial transmission of a pre-XDR or an MDR case of pulmonary tuberculosis in a HIV negative health care worker in an area endemic for MDR & XDR tuberculosis. With inadequate therapy and non-compliance, his strain developed acquired resistance and he presented with extra-pulmonary XDR tuberculosis in the form of multi-focal osteomyelitis and encysted pleural effusion. He was cured after 2 years of therapy with various anti-tuberculous drugs in addition to interferon gamma.Keywords: osteomyelitis, treatment, XDR tuberculosis, successful treatment
Procedia PDF Downloads 483167 Design, Synthesis and in-vitro Antitumor Evaluation of Some Novel Substituted Quinazoline Derivatives
Authors: Adel S. El-Azab, Alaa A. M. Abdel-Aziz, Ibrahim A. Al-Suwaidan, Amer M. Alanazi
Abstract:
A novel series of 2,3,6-trisubstitute quinazolinone were designed, synthesized, and evaluated for their in-vitro antitumor activity. 3 (Benzylideneamino)-6-chloro-2-p-tolylquinazolin-4(3H)-One, 2-[(4-oxo-3-phenethyl-3,4-dihydroquinazolin-2-yl)thio]-N-(3,4;5-trimethoxyphenyl) acetamide and 3-(3-benzyl-6-methyl-4-oxo-3, 4-dihydroquinazolin-2-ylthio)-N-(3,4,5-trimethoxyphenyl) propanamide have shown amazing broad spectrum antitumor activity with mean GI50; 15.8, 3.16, and 7.4 μM respectively compared to known Quinazoline Derivatives antitumor drug 5-FU mean GI50=22.6 μM.Keywords: quinazoline derivatives, in vitro antitumor, synthesis, 5-FU, NCI
Procedia PDF Downloads 544166 Potential Energy Expectation Value for Lithium Excited State (1s2s3s)
Authors: Khalil H. Al-Bayati, G. Nasma, Hussein Ban H. Adel
Abstract:
The purpose of the present work is to calculate the expectation value of potential energyKeywords: lithium excited state, potential energy, 1s2s3s, mathematical physics
Procedia PDF Downloads 491165 Saudi Twitter Corpus for Sentiment Analysis
Authors: Adel Assiri, Ahmed Emam, Hmood Al-Dossari
Abstract:
Sentiment analysis (SA) has received growing attention in Arabic language research. However, few studies have yet to directly apply SA to Arabic due to lack of a publicly available dataset for this language. This paper partially bridges this gap due to its focus on one of the Arabic dialects which is the Saudi dialect. This paper presents annotated data set of 4700 for Saudi dialect sentiment analysis with (K= 0.807). Our next work is to extend this corpus and creation a large-scale lexicon for Saudi dialect from the corpus.Keywords: Arabic, sentiment analysis, Twitter, annotation
Procedia PDF Downloads 633164 Types of Feedback and Their Effectiveness in an EFL Context in Iran
Authors: Adel Ebrahimpourtaher, Saeede Eisaie
Abstract:
This study was an attempt to investigate the types of feedback most frequently provided to the students and their effectiveness based on the students’ preferences established through the interview conducted after the treatment. For this purpose, some class sessions of the students of the institute who were studying general English (pre-intermediate level) were recorded by the teacher for the analysis of the feed backs. The results of the analysis and transcriptions indicated that recast is the most frequent feedback type used by the teacher. In addition, the interview indicated that most of the students prefer recast as well as elicitation and explicit correction to some extent.Keywords: EFL, elicitation, explicit, recast, feedback
Procedia PDF Downloads 366163 On the Efficiency of the Algerian FRR Sovereign Fund
Authors: Abdelkader Guendouz, Fatima Zohra Adel
Abstract:
Since about two decades, the Algerian government created a new instrument in the field of its fiscal policy, which is the FRR (Fonds de Régulation des Recettes). The FRR is a sovereign fund, which the initial role was saving the surplus generated by the fixation of a referential oil price to establish the state budget in the aim equilibrium between budgetary incomes and public expenditures. After a while, the government turns to use this instrument in boosting the public investment more than keeping for funding a deficit budget in periods of crisis. This lead to ask some justified questions about the efficiency of this sovereign fund and its real role.Keywords: FRR sovereign fund, public expenditures, public investment, efficiency
Procedia PDF Downloads 338162 Static Study of Piezoelectric Bimorph Beams with Delamination Zone
Authors: Zemirline Adel, Ouali Mohammed, Mahieddine Ali
Abstract:
The FOSDT (First Order Shear Deformation Theory) is taking into consideration to study the static behavior of a bimorph beam, with a delamination zone between the upper and the lower layer. The effect of limit conditions and lengths of the delamination zone are presented in this paper, with a PVDF piezoelectric material application. A FEM “Finite Element Method” is used to discretize the beam. In the axial displacement, a displacement field appears in the debonded zone with inverse effect between the upper and the lower layer was observed.Keywords: static, piezoelectricity, beam, delamination
Procedia PDF Downloads 418161 Understand the Concept of Agility for the Manufacturing SMEs
Authors: Adel H. Hejaaji
Abstract:
The need for organisations to be flexible to meet the rapidly changing requirements of their customers is now well appreciated and can be witnessed within companies with their use of techniques such as single-minute exchange of die (SMED) for machine change-over or Kanban as the visual production and inventory control for Just-in-time manufacture and delivery. What is not so well appreciated by companies is the need for agility. Put simply it is the need to be alert for a new and unexpected opportunity and quick to respond with the changes necessary in order to profit from it. This paper aims to study the literature of agility in manufacturing to understand the concept of agility and how it is important and critical for the small and medium size manufacturing organisations (SMEs), and to defined the specific benefits of moving towards agility, and thus what benefit it can bring to an organisation.Keywords: SMEs, agile manufacturing, manufacturing, industrial engineering
Procedia PDF Downloads 608160 Design of a Rectifier with Enhanced Efficiency and a High-gain Antenna for Integrated and Compact-size Rectenna Circuit
Authors: Rawaa Maher, Ahmed Allam, Haruichi Kanaya, Adel B. Abdelrahman
Abstract:
In this paper, a compact, high-efficiency integrated rectenna is presented to operate in the 2.45 GHz band. A comparison between two rectifier topologies is performed to verify the benefits of removing the matching network from the rectifier. A rectifier high conversion efficiency of 74.1% is achieved. To complete the rectenna system, a novel omnidirectional antenna with high gain (3.72 dB) and compact size (25 mm * 29 mm) is designed and fabricated. The same antenna is used with a reflector for raising the gain to nearly 8.3 dB. The simulation and measurement results of the antenna are in good agreement.Keywords: internet of things, integrated rectenna, rectenna, RF energy harvesting, wireless sensor networks(WSN)
Procedia PDF Downloads 183159 Compact Ultra-Wideband Printed Monopole Antenna with Inverted L-Shaped Slots for Data Communication and RF Energy Harvesting
Authors: Mohamed Adel Sennouni, Jamal Zbitou, Benaissa Abboud, Abdelwahed Tribak, Hamid Bennis, Mohamed Latrach
Abstract:
A compact UWB planar antenna fed with a microstrip-line is proposed. The new design is composed of a rectangular patch with symmetric L-shaped slots and fed by 50 Ω microstrip transmission line and a reduced ground-plane which have a periodic slots with an overall size of 47 mm x 20 mm. It is intended to be used in wireless applications that cover the ultra-wideband (UWB) frequency band. A wider impedance bandwidth of around 116.5% (1.875Keywords: UWB planar antenna, L-shaped slots, wireless applications, impedance band-width, radiation pattern, CST
Procedia PDF Downloads 488158 High Voltage Magnetic Pulse Generation Using Capacitor Discharge Technique
Authors: Mohamed Adel Abdallah
Abstract:
A high voltage magnetic pulse is designed by applying an electrical pulse to the coil. Capacitor banks are developed to generate a pulse current. Switching circuit consisting of DPDT switches, thyristor, and triggering circuit is built and tested. The coil current is measured using a Hall-effect current sensor. The magnetic pulse created is measured and tabulated in the graph. Simulation using FEMM is done to compare the results obtained between experiment and simulation. This technology can be applied to area such as medical equipment, measuring instrument, and military equipment.Keywords: high voltage, magnetic pulse, capacitor discharge, coil
Procedia PDF Downloads 680157 Dynamic Study of a Two Phase Thermosyphon Loop
Authors: Selva Georgena D., Videcoq Etienne, Caner Julien, Benselama Adel, Girault Manu
Abstract:
A Two-Phase Thermosyphon Loop (TPTL) is a passive cooling system which does not require a pump to function. Therefore, TPTL is a simple and robust device and its physics is complex to describe because of the coupled phenomena: heat flux, nucleation, fluid dynamics and gravitational effects. Moreover, the dynamic behavior of TPTL shows some physical instabilities and the actual occurrence of such a behavior remains unknown. The aim of this study is to propose a thermal balance of the TPTL to better identify the fundamental reasons for the appearance of the instabilities.Keywords: Two-phase flow, passive cooling system, thermal reliability, thermal experimental study, liquid-vapor phase change
Procedia PDF Downloads 112156 Settlement of Group of Stone Columns
Authors: Adel Hanna, Tahar Ayadat, Mohammad Etezad, Cyrille Cros
Abstract:
A number of theoretical methods have been developed over the years to calculate the amount settlement of the soil reinforced with group of stone columns. The results deduced from these methods sometimes show large disagreement with the experimental observations. The reason of this divergence might be due to the fact that many of the previous methods assumed the deform shape of the columns which is different with the actual case. A new method to calculate settlement of the ground reinforced with group of stone columns is presented in this paper which overcomes the restrictions made by previous theories. This method is based on results deduced from numerical modeling. Results obtained from the model are validated.Keywords: stone columns, group, soft soil, settlement, prediction
Procedia PDF Downloads 508155 Molecular Junctions between Graphene Strips: Electronic and Transport Properties
Authors: Adel Belayadi, Ahmed Mougari, Boualem Bourahla
Abstract:
Molecular junctions are currently considered a promising style in the miniaturization of electronic devices. In this contribution, we provide a tight-binding model to investigate the quantum transport properties across-molecular junctions sandwiched between 2D-graphene nanoribbons in the zigzag direction. We investigate, in particular, the effect of embedded atoms such as Gold and Silicon across the molecular junction. The results exhibit a resonance behavior in terms of incident Fermi levels, depending on the molecular junction type. Additionally, the transport properties under a perpendicular magnetic field exhibit an oscillation for the transmittance versus the magnetic field strength.Keywords: molecular junction, 2D-graphene nanoribbons, quantum transport properties, magnetic field
Procedia PDF Downloads 97154 Easy Method of Synthesis and Functionalzation of Zno Nanoparticules With 3 Aminopropylthrimethoxysilane (APTES)
Authors: Haythem Barrak, Gaetan Laroche, Adel M’nif, Ahmed Hichem Hamzaoui
Abstract:
The use of semiconductor oxides, as chemical or biological, requires their functionalization with appropriate dependent molecules of the substance to be detected. generally, the support materials used are TiO2 and SiO2. In the present work, we used zinc oxide (ZnO) known for its interesting physical properties. The synthesis of nano scale ZnO was performed by co-precipitation at low temperature (60 ° C).To our knowledge, the obtaining of this material at this temperature was carried out for the first time. This shows the low cost of this operation. On the other hand, the surface functionalization of ZnO was performed with (3-aminopropyl) triethoxysilane (APTES) by using a specific method using ethanol for the first time. In addition, the duration of this stage is very low compared to literature. The samples obtained were analyzed by XRD, TEM, DLS, FTIR, and TGA shows that XPS that the operation of grafting of APTES on our support was carried out with success.Keywords: functionalization, nanoparticle, ZnO, APTES, caractérisation
Procedia PDF Downloads 362153 A Spin and Valley Modulating Device in Grapheme heterostructure: Controlling Valley and Spin Current
Authors: Adel Belayadi
Abstract:
The investigation of two-dimensional (2D) heterostructures, whether in the presence or the absence of magnetic substrates that sustain several induced spin-orbit couplings, has shown a promising/essential application for advancing the emerging fields of spintronics and valleytronics. In this contribution, we study spin/valley transport in graphene-like substrates in the presence of one or several locally induced spin-orbit coupling (SOC) terms resulting from graphene-based heterostructures. The models we proposed are based on the tight-binding approach, and our findings imply an alternative approach for conducting valley-polarized currents and suggest a corresponding mechanism for valley-dependent electron optics and optoelectronic devices.Keywords: graphene-heterostructures, tight binding pproch, Spintronics, Valleytronics
Procedia PDF Downloads 28152 Potential Distribution and Electric Field Analysis around a Polluted Outdoor Polymeric Insulator with Broken Sheds
Authors: Adel Kara, Abdelhafid Bayadi, Hocine Terrab
Abstract:
This paper presents a study of electric field distribution along of 72 kV polymeric outdoor insulators with broken sheds. Different cases of damaged insulators are modeled and both of clean and polluted cases. By 3D finite element analysis using the software package COMSOL Multiphysics 4.3b. The obtained results of potential and the electrical field distribution around insulators by 3D simulation proved that finite element computations is useful tool for studying insulation electrical field distribution.Keywords: electric field distributions, insulator, broken sheds, potential distributions
Procedia PDF Downloads 513151 Vehicle to Vehicle Communication: Collision Avoidance Scenarios
Authors: Ahmed Emad, Ahmed Salah, Abdelrahman Magdy, Omar Rashid, Mohammed Adel
Abstract:
This research paper discusses vehicle-to-vehicle technology as an important application of linear algebra. This communication technology represents an efficient and promising application to help to ensure the safety of the drivers by warning them when a crash possibility is close. The major link that combines our topic with linear algebra is the Laplacian matrix. Some main definitions used in the V2V were illustrated, such as VANET and its characteristics. The V2V technology could be applied in different applications with different traffic scenarios and various ways to warn car drivers. These scenarios were simulated programs such as MATLAB and Python to test how the V2V system would respond to the different scenarios and warn the car drivers exposed to the threat of collisions.Keywords: V2V communication, vehicle to vehicle scenarios, VANET, FCW, EEBL, IMA, Laplacian matrix
Procedia PDF Downloads 166150 Mathematical Modeling of District Cooling Systems
Authors: Dana Alghool, Tarek ElMekkawy, Mohamed Haouari, Adel Elomari
Abstract:
District cooling systems have captured the attentions of many researchers recently due to the enormous benefits offered by such system in comparison with traditional cooling technologies. It is considered a major component of urban cities due to the significant reduction of energy consumption. This paper aims to find the optimal design and operation of district cooling systems by developing a mixed integer linear programming model to minimize the annual total system cost and satisfy the end-user cooling demand. The proposed model is experimented with different cooling demand scenarios. The results of the very high cooling demand scenario are only presented in this paper. A sensitivity analysis on different parameters of the model was performed.Keywords: Annual Cooling Demand, Compression Chiller, Mathematical Modeling, District Cooling Systems, Optimization
Procedia PDF Downloads 202149 A Hybrid Heuristic for the Team Orienteering Problem
Authors: Adel Bouchakhchoukha, Hakim Akeb
Abstract:
In this work, we propose a hybrid heuristic in order to solve the Team Orienteering Problem (TOP). Given a set of points (or customers), each with associated score (profit or benefit), and a team that has a fixed number of members, the problem to solve is to visit a subset of points in order to maximize the total collected score. Each member performs a tour starting at the start point, visiting distinct customers and the tour terminates at the arrival point. In addition, each point is visited at most once, and the total time in each tour cannot be greater than a given value. The proposed heuristic combines beam search and a local optimization strategy. The algorithm was tested on several sets of instances and encouraging results were obtained.Keywords: team orienteering problem, vehicle routing, beam search, local search
Procedia PDF Downloads 418148 Robust Diagnosis Efficiency by Bond-Graph Approach
Authors: Benazzouz Djamel, Termeche Adel, Touati Youcef, Alem Said, Ouziala Mahdi
Abstract:
This paper presents an approach which detect and isolate efficiently a fault in a system. This approach avoids false alarms, non-detections and delays in detecting faults. A study case have been proposed to show the importance of taking into consideration the uncertainties in the decision-making procedure and their effect on the degradation diagnostic performance and advantage of using Bond Graph (BG) for such degradation. The use of BG in the Linear Fractional Transformation (LFT) form allows generating robust Analytical Redundancy Relations (ARR’s), where the uncertain part of ARR’s is used to generate the residuals adaptive thresholds. The study case concerns an electromechanical system composed of a motor, a reducer and an external load. The aim of this application is to show the effectiveness of the BG-LFT approach to robust fault detection.Keywords: bond graph, LFT, uncertainties, detection and faults isolation, ARR
Procedia PDF Downloads 306147 A Compared Approach between Moderate Islamic Values and Basic Human Values
Authors: Adel Bessadok
Abstract:
The theory of values postulates that each human has a set of values, or attractive and trans-situational goals, that drive their actions. The Basic Human Values as an incentive construct that apprehends human's values have been shown to govern a wide range of human behaviors. Individuals within and within societies have very different value preferences that reflect their enculturation, their personal experiences, their social places and their genetic heritage. Using a focus group composed by Islamic religious Preachers and a sample of 800 young students; this ongoing study will establish Moderate Islamic Values parameters. We analyze later, for the same students sample the difference between Moderate Islamic Values and Schwartz’s Basic Human Values. Keywords—Moderate Islamic Values, Basic Human Values, Exploratory Factor Analysis and Confirmatory Factor Analysis.Keywords: moderate Islamic values, basic human values, exploratory factor analysis, confirmatory factor analysis
Procedia PDF Downloads 384146 On Direct Matrix Factored Inversion via Broyden's Updates
Authors: Adel Mohsen
Abstract:
A direct method based on the good Broyden's updates for evaluating the inverse of a nonsingular square matrix of full rank and solving related system of linear algebraic equations is studied. For a matrix A of order n whose LU-decomposition is A = LU, the multiplication count is O (n3). This includes the evaluation of the LU-decompositions of the inverse, the lower triangular decomposition of A as well as a “reduced matrix inverse”. If an explicit value of the inverse is not needed the order reduces to O (n3/2) to compute to compute inv(U) and the reduced inverse. For a symmetric matrix only O (n3/3) operations are required to compute inv(L) and the reduced inverse. An example is presented to demonstrate the capability of using the reduced matrix inverse in treating ill-conditioned systems. Besides the simplicity of Broyden's update, the method provides a mean to exploit the possible sparsity in the matrix and to derive a suitable preconditioner.Keywords: Broyden's updates, matrix inverse, inverse factorization, solution of linear algebraic equations, ill-conditioned matrices, preconditioning
Procedia PDF Downloads 480145 Water Use Efficiency of Sunflower Genotypes Under Drip Irrigation
Authors: Adel M. Mahmoud
Abstract:
This Investigation was conducted to determine the productivity and water use efficiency for new sunflower genotypes. Ten sunflower genotypes were evaluated under drip irrigation using two treatments of. Results indicate that decreasing the amount of irrigation water from 1500 to 1130 mm/hectar significantly reduced all studied traits. Mutation (M1-63) surpassed all the other one genotypes in seed yield and WUE. Lines which gave the highest yield of the seed have water use efficiency under drought conditions higher than water use efficiency under normal irrigation. The lowest depression in seed yield due to drought conditions has been registered for Line 20, Line M1-63 and Sakha 53 genotypes (11 , 18 and 16 %, respectively). Genotypes (Line 20 , Line M1-63 and Sakha 53) are more tolerant to drought than others and we can used its in breeding program to develop sunflower hybrids suitable for cultivation under drought condition.Keywords: sunflower genotypes, water use efficiency, mutation, inbred lines
Procedia PDF Downloads 379144 Characterization of Leakage Current on the Surface of Porcelain Insulator under Contaminated Conditions
Authors: Hocine Terrab , Abdelhafid Bayadi, Adel Kara, Ayman El-Hag
Abstract:
Insulator flashover under polluted conditions has been a serious threat on the reliability of power systems. It is known that the flashover process is mainly affected by the environmental conditions such as; the pollution level and humidity. Those are the essential parameters influencing the wetting process. This paper presents an investigation of the characteristics of leakage current (LC) developed on the surface of porcelain insulator at contaminated conditions under AC voltage. The study is done in an artificial fog chamber and the LC is characterized for different stages; dry, wetted and presence of discharge activities. Time-frequency and spectral analysis are adopted to calculate the evolution of LC characteristics with various stages prior to flashover occurrence. The preliminary results could be used in analysing the LC to develop more effective diagnosis of early signs of dry band arcing as an indication for insulation washing.Keywords: flashover, harmonic components, leakage current, phase angle, statistical analysis
Procedia PDF Downloads 435143 Comparing Spontaneous Hydrolysis Rates of Activated Models of DNA and RNA
Authors: Mohamed S. Sasi, Adel M. Mlitan, Abdulfattah M. Alkherraz
Abstract:
This research project aims to investigate difference in relative rates concerning phosphoryl transfer relevant to biological catalysis of DNA and RNA in the pH-independent reactions. Activated Models of DNA and RNA for alkyl-aryl phosphate diesters (with 4-nitrophenyl as a good leaving group) have successfully been prepared to gather kinetic parameters. Eyring plots for the pH–independent hydrolysis of 1 and 2 were established at different temperatures in the range 100–160 °C. These measurements have been used to provide a better estimate for the difference in relative rates between the reactivity of DNA and RNA cleavage. Eyring plot gave an extrapolated rate of kH2O = 1 × 10-10 s -1 for 1 (RNA model) and 2 (DNA model) at 25°C. Comparing the reactivity of RNA model and DNA model shows that the difference in relative rates in the pH-independent reactions is surprisingly very similar at 25°. This allows us to obtain chemical insights into how biological catalysts such as enzymes may have evolved to perform their current functions.Keywords: DNA and RNA models, relative rates, reactivity, phosphoryl transfe
Procedia PDF Downloads 423