Search results for: Madari gold mine
58 Evaluation of the Environmental Risk from the Co-Deposition of Waste Rock Material and Fly Ash
Authors: A. Mavrikos, N. Petsas, E. Kaltsi, D. Kaliampakos
Abstract:
The lignite-fired power plants in the Western Macedonia Lignite Center produce more than 8106 t of fly ash per year. Approximately 90% of this quantity is used for restoration-reclamation of exhausted open-cast lignite mines and slope stabilization of the overburden. The purpose of this work is to evaluate the environmental behavior of the mixture of waste rock and fly ash that is being used in the external deposition site of the South Field lignite mine. For this reason, a borehole was made within the site and 86 samples were taken and subjected to chemical analyses and leaching tests. The results showed very limited leaching of trace elements and heavy metals from this mixture. Moreover, when compared to the limit values set for waste acceptable in inert waste landfills, only few excesses were observed, indicating only minor risk for groundwater pollution. However, due to the complexity of both the leaching process and the contaminant pathway, more boreholes and analyses should be made in nearby locations and a systematic groundwater monitoring program should be implemented both downstream and within the external deposition site.
Keywords: Co-deposition, fly ash, leaching tests, lignite, waste rock.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 188357 Investigating the Behavior of Underground Structures in the Event of an Earthquake
Authors: Davoud Beheshtizadeh, Farzin Malekpour
Abstract:
The progress of technology and producing new machinery have made a big change in excavation operations and construction of underground structures. The limitations of space and some other economic, politic and military considerations gained the attention of most developed and developing countries towards the construction of these structures for mine, military, and development objectives. Underground highways, tunnels, subways, oil reservoir resources, fuels, nuclear wastes burying reservoir and underground stores are increasingly developing and being used in these countries. The existence and habitability of the cities depend on these underground installations or in other words these vital arteries. Stopping the flow of water, gas leakage and explosion, collapsing of sewage paths, etc., resulting from the earthquake are among the factors that can severely harm the environment and increase the casualty. Lack of sewage network and complete stoppage of the flow of water in Bam (Iran) is a good example of this kind. In this paper, we investigate the effect of wave orientation on structures and deformation of them and the effect of faulting on underground structures, and then, we study resistance of reinforced concrete against earthquake, simulate two different samples, analyze the result and point out the importance of paying attention to underground installations.
Keywords: Earthquake, underground structures, underground installations.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 94856 On the Effectivity of Different Pseudo-Noise and Orthogonal Sequences for Speech Encryption from Correlation Properties
Authors: V. Anil Kumar, Abhijit Mitra, S. R. Mahadeva Prasanna
Abstract:
We analyze the effectivity of different pseudo noise (PN) and orthogonal sequences for encrypting speech signals in terms of perceptual intelligence. Speech signal can be viewed as sequence of correlated samples and each sample as sequence of bits. The residual intelligibility of the speech signal can be reduced by removing the correlation among the speech samples. PN sequences have random like properties that help in reducing the correlation among speech samples. The mean square aperiodic auto-correlation (MSAAC) and the mean square aperiodic cross-correlation (MSACC) measures are used to test the randomness of the PN sequences. Results of the investigation show the effectivity of large Kasami sequences for this purpose among many PN sequences.
Keywords: Speech encryption, pseudo-noise codes, maximallength, Gold, Barker, Kasami, Walsh-Hadamard, autocorrelation, crosscorrelation, figure of merit.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 203055 Phytoremediation Potential of Native Plants Growing on a Heavy Metals Contaminated Soil of Copper mine in Iran
Authors: B. Lorestani, M. Cheraghi, N. Yousefi
Abstract:
A research project dealing with the phytoremediation of a soil polluted by some heavy metals is currently running. The case study is represented by a mining area in Hamedan province in the central west part of Iran. The potential of phytoextraction and phytostabilization of plants was evaluated considering the concentration of heavy metals in the plant tissues and also the bioconcentration factor (BCF) and the translocation factor (TF). Also the several established criteria were applied to define hyperaccumulator plants in the studied area. Results showed that none of the collected plant species were suitable for phytoextraction of Cu, Zn, Fe and Mn, but among the plants, Euphorbia macroclada was the most efficient in phytostabilization of Cu and Fe, while, Ziziphora clinopodioides, Cousinia sp. and Chenopodium botrys were the most suitable for phytostabilization of Zn and Chondrila juncea and Stipa barbata had the potential for phytostabilization of Mn. Using the most common criterion, Euphorbia macroclada and Verbascum speciosum were Fe hyperaccumulator plants. Present study showed that native plant species growing on contaminated sites may have the potential for phytoremediation.Keywords: Bioconcentration factor, Heavy metals, Hyperaccumulator, Phytoremediation, Translocation factor
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 393154 Granularity Analysis for Spatio-Temporal Web Sensors
Authors: Shun Hattori
Abstract:
In recent years, many researches to mine the exploding Web world, especially User Generated Content (UGC) such as weblogs, for knowledge about various phenomena and events in the physical world have been done actively, and also Web services with the Web-mined knowledge have begun to be developed for the public. However, there are few detailed investigations on how accurately Web-mined data reflect physical-world data. It must be problematic to idolatrously utilize the Web-mined data in public Web services without ensuring their accuracy sufficiently. Therefore, this paper introduces the simplest Web Sensor and spatiotemporallynormalized Web Sensor to extract spatiotemporal data about a target phenomenon from weblogs searched by keyword(s) representing the target phenomenon, and tries to validate the potential and reliability of the Web-sensed spatiotemporal data by four kinds of granularity analyses of coefficient correlation with temperature, rainfall, snowfall, and earthquake statistics per day by region of Japan Meteorological Agency as physical-world data: spatial granularity (region-s population density), temporal granularity (time period, e.g., per day vs. per week), representation granularity (e.g., “rain" vs. “heavy rain"), and media granularity (weblogs vs. microblogs such as Tweets).Keywords: Granularity analysis, knowledge extraction, spatiotemporal data mining, Web credibility, Web mining, Web sensor.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 187453 Heavy Metal Pollution of the Soils around the Mining Area near Shamlugh Town (Armenia) and Related Risks to the Environment
Authors: G. A. Gevorgyan, K. A. Ghazaryan, T. H. Derdzyan
Abstract:
The heavy metal pollution of the soils around the mining area near Shamlugh town and related risks to human health were assessed. The investigations showed that the soils were polluted with heavy metals that can be ranked by anthropogenic pollution degree as follows: Cu>Pb>As>Co>Ni>Zn. The main sources of the anthropogenic metal pollution of the soils were the copper mining area near Shamlugh town, the Chochkan tailings storage facility and the trucks transferring ore from the mining area. Copper pollution degree in some observation sites was unallowable for agricultural production. The total non-carcinogenic chronic hazard index (THI) values in some places, including observation sites in Shamlugh town, were above the safe level (THI<1) for children living in this territory. Although the highest heavy metal enrichment degree in the soils was registered in case of copper, however, the highest health risks to humans especially children were posed by cobalt which is explained by the fact that heavy metals have different toxicity levels and penetration characteristics.
Keywords: Armenia, copper mine, heavy metal pollution of soil, health risks.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 237152 In silico Analysis of Isoniazid Resistance in Mycobacterium tuberculosis
Authors: A. Nusrath Unissa, Sameer Hassan, Luke Elizabeth Hanna
Abstract:
Altered drug binding may be an important factor in isoniazid (INH) resistance, rather than major changes in the enzyme’s activity as a catalase or peroxidase (KatG). The identification of structural or functional defects in the mutant KatGs responsible for INH resistance remains as an area to be explored. In this connection, the differences in the binding affinity between wild-type (WT) and mutants of KatG were investigated, through the generation of three mutants of KatG, Ser315Thr [S315T], Ser315Asn [S315N], Ser315Arg [S315R] and a WT [S315]) with the help of software-MODELLER. The mutants were docked with INH using the software-GOLD. The affinity is lower for WT than mutant, suggesting the tight binding of INH with the mutant protein compared to WT type. These models provide the in silico evidence for the binding interaction of KatG with INH and implicate the basis for rationalization of INH resistance in naturally occurring KatG mutant strains of Mycobacterium tuberculosis.
Keywords: Mycobacterium tuberculosis, KatG, INH resistance, Mutants, Modeling, Docking.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 296851 Development of Quasi-Two-Dimensional Nb2O5 for Functional Electrodes of Advanced Electrochemical Systems
Authors: S. Zhuiykov, E. Kats
Abstract:
In recent times there has been a growing interest in the development of quasi-two-dimensional niobium pentoxide (Nb2O5) as a semiconductor for the potential electronic applications such as capacitors, filtration, dye-sensitised solar cells and gas sensing platforms. Therefore once the purpose is established, Nb2O5 can be prepared in a number of nano- and sub-micron-structural morphologies that include rods, wires, belts and tubes. In this study films of Nb2O5 were prepared on gold plated silicon substrate using spin-coating technique and subsequently by mechanical exfoliation. The reason this method was employed was to achieve layers of less than 15nm in thickness. The sintering temperature of the specimen was 800oC. The morphology and structural characteristics of the films were analyzed by Atomic Force Microscopy (AFM), Raman Spectroscopy, X-ray Photoelectron Spectroscopy (XPS).Keywords: Mechanical exfoliation, niobium pentoxide, quazitwo- dimensional, semiconductor, sol-gel, spin-coating, two dimensional semiconductors.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 238750 Parameters Identification of Mathematical Model of the Fission Yeast Cell Cycle Control Using Evolutionary Strategy
Authors: A. Ghaffari, A. S. Mostafavi
Abstract:
Complex assemblies of interacting proteins carry out most of the interesting jobs in a cell, such as metabolism, DNA synthesis, mitosis and cell division. These physiological properties play out as a subtle molecular dance, choreographed by underlying regulatory networks that control the activities of cyclin-dependent kinases (CDK). The network can be modeled by a set of nonlinear differential equations and its behavior predicted by numerical simulation. In this paper, an innovative approach has been proposed that uses genetic algorithms to mine a set of behavior data output by a biological system in order to determine the kinetic parameters of the system. In our approach, the machine learning method is integrated with the framework of existent biological information in a wiring diagram so that its findings are expressed in a form of system dynamic behavior. By numerical simulations it has been illustrated that the model is consistent with experiments and successfully shown that such application of genetic algorithms will highly improve the performance of mathematical model of the cell division cycle to simulate such a complicated bio-system.Keywords: Cell cycle, Cyclin-dependent kinase, Fission yeast, Genetic algorithms, Mathematical modeling, Wiring diagram
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 149649 Spark Breakdown Voltage and Surface Degradation of Multiwalled Carbon Nanotube Electrode Surfaces
Authors: M. G. Rostedt, M. J. Hall, L. Shi, R. D. Matthews
Abstract:
Silicon substrates coated with multiwalled carbon nanotubes (MWCNTs) were experimentally investigated to determine spark breakdown voltages relative to uncoated surfaces, the degree of surface degradation associated with the spark discharge, and techniques to minimize the surface degradation. The results may be applicable to instruments or processes that use MWCNT as a means of increasing local electric field strength and where spark breakdown is a possibility that might affect the devices’ performance or longevity. MWCNTs were shown to reduce the breakdown voltage of a 1mm gap in air by 30-50%. The relative decrease in breakdown voltage was maintained over gap distances of 0.5 to 2mm and gauge pressures of 0 to 4 bar. Degradation of the MWCNT coated surfaces was observed. Several techniques to improve durability were investigated. These included: chromium and gold-palladium coatings, tube annealing, and embedding clusters of MWCNT in a ceramic matrix.
Keywords: Ionization sensor, spark, nanotubes, electrode, breakdown.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 241648 M2LGP: Mining Multiple Level Gradual Patterns
Authors: Yogi Satrya Aryadinata, Anne Laurent, Michel Sala
Abstract:
Gradual patterns have been studied for many years as they contain precious information. They have been integrated in many expert systems and rule-based systems, for instance to reason on knowledge such as “the greater the number of turns, the greater the number of car crashes”. In many cases, this knowledge has been considered as a rule “the greater the number of turns → the greater the number of car crashes” Historically, works have thus been focused on the representation of such rules, studying how implication could be defined, especially fuzzy implication. These rules were defined by experts who were in charge to describe the systems they were working on in order to turn them to operate automatically. More recently, approaches have been proposed in order to mine databases for automatically discovering such knowledge. Several approaches have been studied, the main scientific topics being: how to determine what is an relevant gradual pattern, and how to discover them as efficiently as possible (in terms of both memory and CPU usage). However, in some cases, end-users are not interested in raw level knowledge, and are rather interested in trends. Moreover, it may be the case that no relevant pattern can be discovered at a low level of granularity (e.g. city), whereas some can be discovered at a higher level (e.g. county). In this paper, we thus extend gradual pattern approaches in order to consider multiple level gradual patterns. For this purpose, we consider two aggregation policies, namely horizontal and vertical.Keywords: Gradual Pattern.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 148947 Electrical Characteristics of Biomodified Electrodes using Nonfaradaic Electrochemical Impedance Spectroscopy
Authors: Yusmeeraz Yusof, Yoshiyuki Yanagimoto, Shigeyasu Uno, Kazuo Nakazato
Abstract:
We demonstrate a nonfaradaic electrochemical impedance spectroscopy measurement of biochemically modified gold plated electrodes using a two-electrode system. The absence of any redox indicator in the impedance measurements provide more precise and accurate characterization of the measured bioanalyte at molecular resolution. An equivalent electrical circuit of the electrodeelectrolyte interface was deduced from the observed impedance data of saline solution at low and high concentrations. The detection of biomolecular interactions was fundamentally correlated to electrical double-layer variation at modified interface. The investigations were done using 20mer deoxyribonucleic acid (DNA) strands without any label. Surface modification was performed by creating mixed monolayer of the thiol-modified single-stranded DNA and a spacer thiol (mercaptohexanol) by a two-step self-assembly method. The results clearly distinguish between the noncomplementary and complementary hybridization of DNA, at low frequency region below several hundreds Hertz.
Keywords: Biosensor, electrical double-layer, impedance spectroscopy, label free DNA.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 307346 Structural and Electronic Characterization of Supported Ni and Au Catalysts used in Environment Protection Determined by XRD,XAS and XPS methods
Authors: N. Aldea, V. Rednic, F. Matei, Tiandou Hu, M. Neumann
Abstract:
The nickel and gold nanoclusters as supported catalysts were analyzed by XAS, XRD and XPS in order to determine their local, global and electronic structure. The present study has pointed out a strong deformation of the local structure of the metal, due to its interaction with oxide supports. The average particle size, the mean squares of the microstrain, the particle size distribution and microstrain functions of the supported Ni and Au catalysts were determined by XRD method using Generalized Fermi Function for the X-ray line profiles approximation. Based on EXAFS analysis we consider that the local structure of the investigated systems is strongly distorted concerning the atomic number pairs. Metal-support interaction is confirmed by the shape changes of the probability densities of electron transitions: Ni K edge (1s → continuum and 2p), Au LIII-edge (2p3/2 → continuum, 6s, 6d5/2 and 6d3/2). XPS investigations confirm the metal-support interaction at their interface.Keywords: local and global structure, metal-support interaction, supported metal catalysts, synchrotron radiation, X-ray absorptionspectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 176845 Hydrogeological Risk and Mining Tunnels: the Fontane-Rodoretto Mine Turin (Italy)
Authors: Paola Gattinoni, Laura Scesi, Elena Cerino Adbin, Daniele Cremonesi
Abstract:
The interaction of tunneling or mining with groundwater has become a very relevant problem not only due to the need to guarantee the safety of workers and to assure the efficiency of the tunnel drainage systems, but also to safeguard water resources from impoverishment and pollution risk. Therefore it is very important to forecast the drainage processes (i.e., the evaluation of drained discharge and drawdown caused by the excavation). The aim of this study was to know better the system and to quantify the flow drained from the Fontane mines, located in Val Germanasca (Turin, Italy). This allowed to understand the hydrogeological local changes in time. The work has therefore been structured as follows: the reconstruction of the conceptual model with the geological, hydrogeological and geological-structural study; the calculation of the tunnel inflows (through the use of structural methods) and the comparison with the measured flow rates; the water balance at the basin scale. In this way it was possible to understand what are the relationships between rainfall, groundwater level variations and the effect of the presence of tunnels as a means of draining water. Subsequently, it the effects produced by the excavation of the mining tunnels was quantified, through numerical modeling. In particular, the modeling made it possible to observe the drawdown variation as a function of number, excavation depth and different mines linings.Keywords: Groundwater, Italy, numerical model, tunneling.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 191244 Investigation of Thermal and Mechanical Loading on Functional Graded Material Plates
Authors: Mine Uslu Uysal
Abstract:
This paper interested in the mechanical deformation behavior of shear deformable functionally graded ceramic-metal (FGM) plates. Theoretical formulations are based on power law theory when build up functional graded material. The mechanical properties of the plate are graded in the thickness direction according to a power-law Displacement and stress is obtained using finite element method (FEM). The load is supposed to be a uniform distribution over the plate surface (XY plane) and varied in the thickness direction only. An FGM’s gradation in material properties allows the designer to tailor material response to meet design criteria. An FGM made of ceramic and metal can provide the thermal protection and load carrying capability in one material thus eliminating the problem of thermo-mechanical deformation behavior. This thesis will explore analysis of FGM flat plates and shell panels, and their applications to r structural problems. FGMs are first characterized as flat plates under pressure in order to understand the effect variation of material properties has on structural response. In addition, results are compared to published results in order to show the accuracy of modeling FGMs using ABAQUS software.
Keywords: Functionally graded material, finite element method, thermal and structural loading.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 355143 Statistical Measures and Optimization Algorithms for Gene Selection in Lung and Ovarian Tumor
Authors: C. Gunavathi, K. Premalatha
Abstract:
Microarray technology is universally used in the study of disease diagnosis using gene expression levels. The main shortcoming of gene expression data is that it includes thousands of genes and a small number of samples. Abundant methods and techniques have been proposed for tumor classification using microarray gene expression data. Feature or gene selection methods can be used to mine the genes that directly involve in the classification and to eliminate irrelevant genes. In this paper statistical measures like T-Statistics, Signal-to-Noise Ratio (SNR) and F-Statistics are used to rank the genes. The ranked genes are used for further classification. Particle Swarm Optimization (PSO) algorithm and Shuffled Frog Leaping (SFL) algorithm are used to find the significant genes from the top-m ranked genes. The Naïve Bayes Classifier (NBC) is used to classify the samples based on the significant genes. The proposed work is applied on Lung and Ovarian datasets. The experimental results show that the proposed method achieves 100% accuracy in all the three datasets and the results are compared with previous works.
Keywords: Microarray, T-Statistics, Signal-to-Noise Ratio, FStatistics, Particle Swarm Optimization, Shuffled Frog Leaping, Naïve Bayes Classifier.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 193642 Artificial Neural Networks Technique for Seismic Hazard Prediction Using Seismic Bumps
Authors: Belkacem Selma, Boumediene Selma, Samira Chouraqui, Hanifi Missoum, Tourkia Guerzou
Abstract:
Natural disasters have occurred and will continue to cause human and material damage. Therefore, the idea of "preventing" natural disasters will never be possible. However, their prediction is possible with the advancement of technology. Even if natural disasters are effectively inevitable, their consequences may be partly controlled. The rapid growth and progress of artificial intelligence (AI) had a major impact on the prediction of natural disasters and risk assessment which are necessary for effective disaster reduction. Earthquake prediction to prevent the loss of human lives and even property damage is an important factor; that, is why it is crucial to develop techniques for predicting this natural disaster. This study aims to analyze the ability of artificial neural networks (ANNs) to predict earthquakes that occur in a given area. The used data describe the problem of high energy (higher than 104 J) seismic bumps forecasting in a coal mine using two long walls as an example. For this purpose, seismic bumps data obtained from mines have been analyzed. The results obtained show that the ANN is able to predict earthquake parameters with high accuracy; the classification accuracy through neural networks is more than 94%, and the models developed are efficient and robust and depend only weakly on the initial database.
Keywords: Earthquake prediction, artificial intelligence, AI, Artificial Neural Network, ANN, seismic bumps.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 115441 The Investigation of Enzymatic Activity in the Soils under the Impact of Metallurgical Industrial Activity in Lori Marz, Armenia
Authors: T. H. Derdzyan, K. A. Ghazaryan, G. A. Gevorgyan
Abstract:
Beta-glucosidase, chitinase, leucine-aminopeptidase, acid phosphomonoesterase and acetate-esterase enzyme activities in the soils under the impact of metallurgical industrial activity in Lori marz (district) were investigated. The results of the study showed that the activities of the investigated enzymes in the soils decreased with increasing distance from the Shamlugh copper mine, the Chochkan tailings storage facility and the ore transportation road. Statistical analysis revealed that the activities of the enzymes were positively correlated (significant) to each other according to the observation sites which indicated that enzyme activities were affected by the same anthropogenic factor. The investigations showed that the soils were polluted with heavy metals (Cu, Pb, As, Co, Ni, Zn) due to copper mining activity in this territory. The results of Pearson correlation analysis revealed a significant negative correlation between heavy metal pollution degree (Nemerow integrated pollution index) and soil enzyme activity. All of this indicated that copper mining activity in this territory causing the heavy metal pollution of the soils resulted in the inhabitation of the activities of the enzymes which are considered as biological catalysts to decompose organic materials and facilitate the cycling of nutrients.
Keywords: Armenia, metallurgical industrial activity, heavy metal pollutionl, soil enzyme activity.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 255940 An Energy Efficient Digital Baseband for Batteryless Remote Control
Authors: Wei-Da Toh, Yuan Gao, Minkyu Je
Abstract:
In this paper, an energy efficient digital baseband circuit for piezoelectric (PE) harvester powered batteryless remote control system is presented. Pulse mode PE harvester, which provides short duration of energy, is adopted to replace conventional chemical battery in wireless remote controller. The transmitter digital baseband repeats the control command transmission once the digital circuit is initiated by the power-on-reset. A power efficient data frame format is proposed to maximize the transmission repetition time. By using the proposed frame format and receiver clock and data recovery method, the receiver baseband is able to decode the command even when the received data has 20% error. The proposed transmitter and receiver baseband are implemented using FPGA and simulation results are presented.
Keywords: Clock and Data Recovery (CDR), Correlator, Digital Baseband, Gold Code, Power-On-Reset.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 200839 Subjective Versus Objective Assessment for Magnetic Resonance Images
Authors: Heshalini Rajagopal, Li Sze Chow, Raveendran Paramesran
Abstract:
Magnetic Resonance Imaging (MRI) is one of the most important medical imaging modality. Subjective assessment of the image quality is regarded as the gold standard to evaluate MR images. In this study, a database of 210 MR images which contains ten reference images and 200 distorted images is presented. The reference images were distorted with four types of distortions: Rician Noise, Gaussian White Noise, Gaussian Blur and DCT compression. The 210 images were assessed by ten subjects. The subjective scores were presented in Difference Mean Opinion Score (DMOS). The DMOS values were compared with four FR-IQA metrics. We have used Pearson Linear Coefficient (PLCC) and Spearman Rank Order Correlation Coefficient (SROCC) to validate the DMOS values. The high correlation values of PLCC and SROCC shows that the DMOS values are close to the objective FR-IQA metrics.Keywords: Medical Resonance (MR) images, Difference Mean Opinion Score (DMOS), Full Reference Image Quality Assessment (FR-IQA).
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 220538 Data Mining Classification Methods Applied in Drug Design
Authors: Mária Stachová, Lukáš Sobíšek
Abstract:
Data mining incorporates a group of statistical methods used to analyze a set of information, or a data set. It operates with models and algorithms, which are powerful tools with the great potential. They can help people to understand the patterns in certain chunk of information so it is obvious that the data mining tools have a wide area of applications. For example in the theoretical chemistry data mining tools can be used to predict moleculeproperties or improve computer-assisted drug design. Classification analysis is one of the major data mining methodologies. The aim of thecontribution is to create a classification model, which would be able to deal with a huge data set with high accuracy. For this purpose logistic regression, Bayesian logistic regression and random forest models were built using R software. TheBayesian logistic regression in Latent GOLD software was created as well. These classification methods belong to supervised learning methods. It was necessary to reduce data matrix dimension before construct models and thus the factor analysis (FA) was used. Those models were applied to predict the biological activity of molecules, potential new drug candidates.Keywords: data mining, classification, drug design, QSAR
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 283737 Precious and Rare Metals in Overburden Carbonaceous Rocks: Methods of Extraction
Authors: Tatyana Alexandrova, Alexandr Alexandrov, Nadezhda Nikolaeva
Abstract:
A problem of complex mineral resources development is urgent and priority, it is aimed at realization of the processes of their ecologically safe development, one of its components is revealing the influence of the forms of element compounds in raw materials and in the processing products. In view of depletion of the precious metal reserves at the traditional deposits in the XXI century the large-size open cast deposits, localized in black shale strata begin to play the leading role. Carbonaceous (black) shales carry a heightened metallogenic potential. Black shales with high content of carbon are widely distributed within the scope of Bureinsky massif. According to academician Hanchuk`s data black shales of Sutirskaya series contain generally PGEs native form. The presence of high absorptive towards carbonaceous matter gold and PGEs compounds in crude ore results in decrease of valuable components extraction because of their sorption into dissipated carbonaceous matter.Keywords: Сarbonaceous rocks, bitumens, precious metals, concentration, extraction.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 164036 Decision Trees for Predicting Risk of Mortality using Routinely Collected Data
Authors: Tessy Badriyah, Jim S. Briggs, Dave R. Prytherch
Abstract:
It is well known that Logistic Regression is the gold standard method for predicting clinical outcome, especially predicting risk of mortality. In this paper, the Decision Tree method has been proposed to solve specific problems that commonly use Logistic Regression as a solution. The Biochemistry and Haematology Outcome Model (BHOM) dataset obtained from Portsmouth NHS Hospital from 1 January to 31 December 2001 was divided into four subsets. One subset of training data was used to generate a model, and the model obtained was then applied to three testing datasets. The performance of each model from both methods was then compared using calibration (the χ2 test or chi-test) and discrimination (area under ROC curve or c-index). The experiment presented that both methods have reasonable results in the case of the c-index. However, in some cases the calibration value (χ2) obtained quite a high result. After conducting experiments and investigating the advantages and disadvantages of each method, we can conclude that Decision Trees can be seen as a worthy alternative to Logistic Regression in the area of Data Mining.Keywords: Decision Trees, Logistic Regression, clinical outcome, risk of mortality.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 250835 Fluorescence Spectroscopy of Lysozyme-Silver Nanoparticles Complex
Authors: S. Ashrafpour, T. Tohidi Moghadam, B. Ranjbar
Abstract:
Identifying the nature of protein-nanoparticle interactions and favored binding sites is an important issue in functional characterization of biomolecules and their physiological responses. Herein, interaction of silver nanoparticles with lysozyme as a model protein has been monitored via fluorescence spectroscopy. Formation of complex between the biomolecule and silver nanoparticles (AgNPs) induced a steady state reduction in the fluorescence intensity of protein at different concentrations of nanoparticles. Tryptophan fluorescence quenching spectra suggested that silver nanoparticles act as a foreign quencher, approaching the protein via this residue. Analysis of the Stern-Volmer plot showed quenching constant of 3.73 μM−1. Moreover, a single binding site in lysozyme is suggested to play role during interaction with AgNPs, having low affinity of binding compared to gold nanoparticles. Unfolding studies of lysozyme showed that complex of lysozyme- AgNPs has not undergone structural perturbations compared to the bare protein. Results of this effort will pave the way for utilization of sensitive spectroscopic techniques for rational design of nanobiomaterials in biomedical applications.
Keywords: Nanocarrier, Nanoparticles, Surface Plasmon Resonance, Quenching Fluorescence.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 256034 Effect of Rotating Electrode
Authors: S. Gnapowski, H. Akiyama, S. Hamid R. Hosseini, C. Yamabe
Abstract:
A gold coated copper rotating electrode was used to eliminate surface oxidation effect. This study examined the effect of electrode rotation on the ozone generation process and showed that an ozonizer with an electrode rotating system might be a possible way to increase ozone-synthesis efficiency. Two new phenomena appeared during experiments with the rotating electrode. First was that ozone concentration increased to about two times higher than that of the case with no rotation. Second, input power and discharge area were found to increase with the rotation speed. Both ozone concentration and ozone production efficiency improved in the case of rotating electrode compared to the case with a non-rotating electrode. One possible reason for this was the increase in discharge length of micro-discharges during electrode rotation. The rotating electrode decreased onset voltage, while reactor capacitance increased with rotation. Use of a rotating-type electrode allowed earlier observation of the ozone zero phenomena compared with a non-rotating electrode because, during rotation, the entire electrode surface was functional, allowing nitrogen on the electrode surface to be evenly consumed. Nitrogen demand increased with increasing rotation s
Keywords: Rotating electrode, input power, onset voltage, discharge canal.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 212833 Optimization of Air Pollution Control Model for Mining
Authors: Zunaira Asif, Zhi Chen
Abstract:
The sustainable measures on air quality management are recognized as one of the most serious environmental concerns in the mining region. The mining operations emit various types of pollutants which have significant impacts on the environment. This study presents a stochastic control strategy by developing the air pollution control model to achieve a cost-effective solution. The optimization method is formulated to predict the cost of treatment using linear programming with an objective function and multi-constraints. The constraints mainly focus on two factors which are: production of metal should not exceed the available resources, and air quality should meet the standard criteria of the pollutant. The applicability of this model is explored through a case study of an open pit metal mine, Utah, USA. This method simultaneously uses meteorological data as a dispersion transfer function to support the practical local conditions. The probabilistic analysis and the uncertainties in the meteorological conditions are accomplished by Monte Carlo simulation. Reasonable results have been obtained to select the optimized treatment technology for PM2.5, PM10, NOx, and SO2. Additional comparison analysis shows that baghouse is the least cost option as compared to electrostatic precipitator and wet scrubbers for particulate matter, whereas non-selective catalytical reduction and dry-flue gas desulfurization are suitable for NOx and SO2 reduction respectively. Thus, this model can aid planners to reduce these pollutants at a marginal cost by suggesting control pollution devices, while accounting for dynamic meteorological conditions and mining activities.
Keywords: Air pollution, linear programming, mining, optimization, treatment technologies.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 159232 Fluorometric Aptasensor: Evaluation of Stability and Comparison to Standard ELISA Assay
Authors: J. Carlos Kuri, Varun Vij, Raymond J. Turner, Orly Yadid-Pecht
Abstract:
Celiac disease (CD) is an immune system disorder that is related to eating gluten. As gluten-free (GF) diet has become a concern of many people for health reasons, a gold standard had to be nominated. Enzyme-linked immunosorbent assay (ELISA) has taken the seat of this role. However, multiple limitations were discovered, and with that, the desire for an alternative method now exists. Nucleic acid based aptamers have become of great interest due to their selectivity, specificity, simplicity, and rapid-testing advantages. However, fluorescence-based aptasensors have been tagged as unstable, but lifespan details are rarely stated. In this work, the lifespan stability of a fluorescence-based aptasensor is shown over a 8-week long study displaying the accuracy of the sensor and false negatives. This study follows 22 different samples, including GF and gluten-rich (GR) and soy sauce products, off-the-shelf products, and reference material from laboratories; giving a total of 836 tests. The analysis shows an accuracy of correctly classifying GF and GR products of 96.30% and 100%, respectively, when the protocol is augmented with molecular sieves. The overall accuracy remains around 94% within the first 4 weeks and then decays to 63%.
Keywords: Aptasensor, PEG, rGO, FAM, RM, ELISA.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 40131 Using Field Indices of Rill and Gully in order to Erosion Estimating and Sediment Analysis (Case Study: Menderjan Watershed in Isfahan Province, Iran)
Authors: Masoud Nasri, Sadat Feiznia, Mohammad Jafari, Hasan Ahmadi
Abstract:
Today, incorrect use of lands and land use changes, excessive grazing, no suitable using of agricultural farms, plowing on steep slopes, road construct, building construct, mine excavation etc have been caused increasing of soil erosion and sediment yield. For erosion and sediment estimation one can use statistical and empirical methods. This needs to identify land unit map and the map of effective factors. However, these empirical methods are usually time consuming and do not give accurate estimation of erosion. In this study, we applied GIS techniques to estimate erosion and sediment of Menderjan watershed at upstream Zayandehrud river in center of Iran. Erosion faces at each land unit were defined on the basis of land use, geology and land unit map using GIS. The UTM coordinates of each erosion type that showed more erosion amounts such as rills and gullies were inserted in GIS using GPS data. The frequency of erosion indicators at each land unit, land use and their sediment yield of these indices were calculated. Also using tendency analysis of sediment yield changes in watershed outlet (Menderjan hydrometric gauge station), was calculated related parameters and estimation errors. The results of this study according to implemented watershed management projects can be used for more rapid and more accurate estimation of erosion than traditional methods. These results can also be used for regional erosion assessment and can be used for remote sensing image processing.Keywords: Erosion and sedimentation, Gully, Rill, GIS, GPS, Menderjan Watershed
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 189930 Arsenic Mobility from Mining Tailings of Monte San Nicolas to Presa de Mata in Guanajuato, Mexico
Authors: I. Cano-Aguilera, B. E. Rubio-Campos, G. De la Rosa, A. F. Aguilera-Alvarado
Abstract:
Mining tailings represent a generating source of rich heavy metal material with a potential danger the public health and the environment, since these metals, under certain conditions, can leach and contaminate aqueous systems that serve like supplying potable water sources. The strategy for this work is based on the observation, experimentation and the simulation that can be obtained by binding real answers of the hydrodynamic behavior of metals leached from mining tailings, and the applied mathematics that provides the logical structure to decipher the individual effects of the general physicochemical phenomenon. The case of study presented herein focuses on mining tailings deposits located in Monte San Nicolas, Guanajuato, Mexico, an abandoned mine. This was considered the contamination source that under certain physicochemical conditions can favor the metal leaching, and its transport towards aqueous systems. In addition, the cartography, meteorology, geology and the hydrodynamics and hydrological characteristics of the place, will be helpful in determining the way and the time in which these systems can interact. Preliminary results demonstrated that arsenic presents a great mobility, since this one was identified in several superficial aqueous systems of the micro watershed, as well as in sediments in concentrations that exceed the established maximum limits in the official norms. Also variations in pH and potential oxide-reduction were registered, conditions that favor the presence of different species from this element its solubility and therefore its mobility.
Keywords: Arsenic, mining tailings, transport.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 167729 A Nanosensor System Based On Disuccinimydyl–CYP2E1 for Amperometric Detection of the Anti-Tuberculosis Drug, Pyrazinamide
Authors: R. F. Ajayi, U. Sidwaba, U. Feleni, S. F. Douman, E. Nxusani, L. Wilson, C. Rassie, O. Tovide, P. G. L. Baker, S. L. Vilakazi, R. Tshikhudo, E. I. Iwuoha
Abstract:
Pyrazinamide (PZA) is among the first-line pro-drugs in the tuberculosis (TB) combination chemotherapy used to treat Mycobacterium tuberculosis. Numerous reports have suggested that hepatotoxicity due to pyrazinamide in patients is due to inappropriate dosing. It is, therefore necessary to develop sensitive and reliable techniques for determining the PZA metabolic profile of diagnosed patients promptly and at point-of-care. This study reports the determination of PZA based on nanobiosensor systems developed from disuccinimidyl octanedioate modified Cytochrome P450-2E1 (CYP2E1) electrodeposited on gold substrates derivatised with (poly(8-anilino-1-napthalene sulphonic acid) PANSA/PVP-AgNPs nanocomposites. The rapid and sensitive amperometric PZA detection gave a dynamic linear range of 2µM to 16µM revealing a limit of detection of 0.044µM and a sensitivity of 1.38µA/µM. The Michaelis-Menten parameters; KM, KM app and IMAX were calculated to be 6.0µM, 1.41µM and 1.51x10-6 A, respectively, indicating a nanobiosensor suitable for use in serum.
Keywords: Cytochrome P450-2E1, Disuccinimidyl octanedioate, Pyrazinamide, Tuberculosis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2208