Search results for: Abel Volterra Equations
Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 1280

Search results for: Abel Volterra Equations

1160 Application of the Central-Difference with Half- Sweep Gauss-Seidel Method for Solving First Order Linear Fredholm Integro-Differential Equations

Authors: E. Aruchunan, J. Sulaiman

Abstract:

The objective of this paper is to analyse the application of the Half-Sweep Gauss-Seidel (HSGS) method by using the Half-sweep approximation equation based on central difference (CD) and repeated trapezoidal (RT) formulas to solve linear fredholm integro-differential equations of first order. The formulation and implementation of the Full-Sweep Gauss-Seidel (FSGS) and Half- Sweep Gauss-Seidel (HSGS) methods are also presented. The HSGS method has been shown to rapid compared to the FSGS methods. Some numerical tests were illustrated to show that the HSGS method is superior to the FSGS method.

Keywords: Integro-differential equations, Linear fredholm equations, Finite difference, Quadrature formulas, Half-Sweep iteration.

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1159 Development Partitioning Intervalwise Block Method for Solving Ordinary Differential Equations

Authors: K.H.Khairul Anuar, K.I.Othman, F.Ishak, Z.B.Ibrahim, Z.Majid

Abstract:

Solving Ordinary Differential Equations (ODEs) by using Partitioning Block Intervalwise (PBI) technique is our aim in this paper. The PBI technique is based on Block Adams Method and Backward Differentiation Formula (BDF). Block Adams Method only use the simple iteration for solving while BDF requires Newtonlike iteration involving Jacobian matrix of ODEs which consumes a considerable amount of computational effort. Therefore, PBI is developed in order to reduce the cost of iteration within acceptable maximum error

Keywords: Adam Block Method, BDF, Ordinary Differential Equations, Partitioning Block Intervalwise

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1158 Behavior of Solutions of the System of Recurrence Equations Based on the Verhulst-Pearl Model

Authors: Vladislav N. Dumachev, Vladimir A. Rodin

Abstract:

By utilizing the system of the recurrence equations, containing two parameters, the dynamics of two antagonistically interconnected populations is studied. The following areas of the system behavior are detected: the area of the stable solutions, the area of cyclic solutions occurrence, the area of the accidental change of trajectories of solutions, and the area of chaos and fractal phenomena. The new two-dimensional diagram of the dynamics of the solutions change (the fractal cabbage) has been obtained. In the cross-section of this diagram for one of the equations the well-known Feigenbaum tree of doubling has been noted.Keywordsbifurcation, chaos, dynamics of populations, fractals

Keywords: bifurcation, chaos, dynamics of populations, fractals

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1157 Numerical Analysis of Hydrogen Transport using a Hydrogen-Enhanced Localized Plasticity Mechanism

Authors: Seul-Kee Kim, Chi-Seung Lee, Myung-Hyun Kim, Jae-Myung Lee

Abstract:

In this study, the hydrogen transport phenomenon was numerically evaluated by using hydrogen-enhanced localized plasticity (HELP) mechanisms. Two dominant governing equations, namely, the hydrogen transport model and the elasto-plastic model, were introduced. In addition, the implicitly formulated equations of the governing equations were implemented into ABAQUS UMAT user-defined subroutines. The simulation results were compared to published results to validate the proposed method.

Keywords: Hydrogen-enhanced localized plasticity (HELP), Hydrogen embrittlement, Hydrogen transport analysis, ABAQUS UMAT, Finite element method (FEM).

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1156 A Nonconforming Mixed Finite Element Method for Semilinear Pseudo-Hyperbolic Partial Integro-Differential Equations

Authors: Jingbo Yang, Hong Li, Yang Liu, Siriguleng He

Abstract:

In this paper, a nonconforming mixed finite element method is studied for semilinear pseudo-hyperbolic partial integrodifferential equations. By use of the interpolation technique instead of the generalized elliptic projection, the optimal error estimates of the corresponding unknown function are given.

Keywords: Pseudo-hyperbolic partial integro-differential equations, Nonconforming mixed element method, Semilinear, Error estimates.

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1155 On Positive Definite Solutions of Quaternionic Matrix Equations

Authors: Minghui Wang

Abstract:

The real representation of the quaternionic matrix is definited and studied. The relations between the positive (semi)define quaternionic matrix and its real representation matrix are presented. By means of the real representation, the relation between the positive (semi)definite solutions of quaternionic matrix equations and those of corresponding real matrix equations is established.

Keywords: Matrix equation, Quaternionic matrix, Real representation, positive (semi)definite solutions.

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1154 Kalman Filter for Bilinear Systems with Application

Authors: Abdullah E. Al-Mazrooei

Abstract:

In this paper, we present a new kind of the bilinear systems in the form of state space model. The evolution of this system depends on the product of state vector by its self. The well known Lotak Volterra and Lorenz models are special cases of this new model. We also present here a generalization of Kalman filter which is suitable to work with the new bilinear model. An application to real measurements is introduced to illustrate the efficiency of the proposed algorithm.

Keywords: Bilinear systems, state space model, Kalman filter.

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1153 Ordinary Differential Equations with Inverted Functions

Authors: Thomas Kampke

Abstract:

Equations with differentials relating to the inverse of an unknown function rather than to the unknown function itself are solved exactly for some special cases and numerically for the general case. Invertibility combined with differentiability over connected domains forces solutions always to be monotone. Numerical function inversion is key to all solution algorithms which either are of a forward type or a fixed point type considering whole approximate solution functions in each iteration. The given considerations are restricted to ordinary differential equations with inverted functions (ODEIs) of first order. Forward type computations, if applicable, admit consistency of order one and, under an additional accuracy condition, convergence of order one.

Keywords: Euler method, fixed points, golden section, multi-step procedures, Runge Kutta methods.

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1152 An Efficient Collocation Method for Solving the Variable-Order Time-Fractional Partial Differential Equations Arising from the Physical Phenomenon

Authors: Haniye Dehestani, Yadollah Ordokhani

Abstract:

In this work, we present an efficient approach for solving variable-order time-fractional partial differential equations, which are based on Legendre and Laguerre polynomials. First, we introduced the pseudo-operational matrices of integer and variable fractional order of integration by use of some properties of Riemann-Liouville fractional integral. Then, applied together with collocation method and Legendre-Laguerre functions for solving variable-order time-fractional partial differential equations. Also, an estimation of the error is presented. At last, we investigate numerical examples which arise in physics to demonstrate the accuracy of the present method. In comparison results obtained by the present method with the exact solution and the other methods reveals that the method is very effective.

Keywords: Collocation method, fractional partial differential equations, Legendre-Laguerre functions, pseudo-operational matrix of integration.

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1151 A New Verified Method for Solving Nonlinear Equations

Authors: Taher Lotfi , Parisa Bakhtiari , Katayoun Mahdiani , Mehdi Salimi

Abstract:

In this paper, verified extension of the Ostrowski method which calculates the enclosure solutions of a given nonlinear equation is introduced. Also, error analysis and convergence will be discussed. Some implemented examples with INTLAB are also included to illustrate the validity and applicability of the scheme.

Keywords: Iinterval analysis, nonlinear equations, Ostrowski method.

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1150 Existence of Solution for Boundary Value Problems of Differential Equations with Delay

Authors: Xiguang Li

Abstract:

In this paper , by using fixed point theorem , upper and lower solution-s method and monotone iterative technique , we prove the existence of maximum and minimum solutions of differential equations with delay , which improved and generalize the result of related paper.

Keywords: Banach space, boundary value problem, differential equation, delay.

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1149 Comparison of Two Types of Preconditioners for Stokes and Linearized Navier-Stokes Equations

Authors: Ze-Jun Hu, Ting-Zhu Huang, Ning-Bo Tan

Abstract:

To solve saddle point systems efficiently, several preconditioners have been published. There are many methods for constructing preconditioners for linear systems from saddle point problems, for instance, the relaxed dimensional factorization (RDF) preconditioner and the augmented Lagrangian (AL) preconditioner are used for both steady and unsteady Navier-Stokes equations. In this paper we compare the RDF preconditioner with the modified AL (MAL) preconditioner to show which is more effective to solve Navier-Stokes equations. Numerical experiments indicate that the MAL preconditioner is more efficient and robust, especially, for moderate viscosities and stretched grids in steady problems. For unsteady cases, the convergence rate of the RDF preconditioner is slightly faster than the MAL perconditioner in some circumstances, but the parameter of the RDF preconditioner is more sensitive than the MAL preconditioner. Moreover the convergence rate of the MAL preconditioner is still quite acceptable. Therefore we conclude that the MAL preconditioner is more competitive than the RDF preconditioner. These experiments are implemented with IFISS package. 

Keywords: Navier-Stokes equations, Krylov subspace method, preconditioner, dimensional splitting, augmented Lagrangian preconditioner.

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1148 Modeling of a Small Unmanned Aerial Vehicle

Authors: A. Elsayed Ahmed, A. Hafez, A. N. Ouda, H. Eldin Hussein Ahmed, H. Mohamed Abd-Elkader

Abstract:

Unmanned aircraft systems (UAS) are playing increasingly prominent roles in defense programs and defense strategies around the world. Technology advancements have enabled the development of it to do many excellent jobs as reconnaissance, surveillance, battle fighters, and communications relays. Simulating a small unmanned aerial vehicle (SUAV) dynamics and analyzing its behavior at the preflight stage is too important and more efficient. The first step in the UAV design is the mathematical modeling of the nonlinear equations of motion. . In this paper, a survey with a standard method to obtain the full non-linear equations of motion is utilized, and then the linearization of the equations according to a steady state flight condition (trimming) is derived. This modeling technique is applied to an Ultrastick-25e fixed wing UAV to obtain the valued linear longitudinal and lateral models. At the end the model is checked by matching between the behavior of the states of the nonlinear UAV and the resulted linear model with doublet at the control surfaces.

Keywords: Equations of motion, linearization, modeling, nonlinear model, UAV.

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1147 Thermal and Mechanical Buckling of Short and Long Functionally Graded Cylindrical Shells Using First Order Shear Deformation Theory

Authors: O. Miraliyari, M.M. Najafizadeh, A.R. Rahmani, A. Momeni Hezaveh

Abstract:

This paper presents the buckling analysis of short and long functionally graded cylindrical shells under thermal and mechanical loads. The shell properties are assumed to vary continuously from the inner surface to the outer surface of the shell. The equilibrium and stability equations are derived using the total potential energy equations, Euler equations and first order shear deformation theory assumptions. The resulting equations are solved for simply supported boundary conditions. The critical temperature and pressure loads are calculated for both short and long cylindrical shells. Comparison studies show the effects of functionally graded index, loading type and shell geometry on critical buckling loads of short and long functionally graded cylindrical shells.

Keywords: Buckling, Functionally graded materials, Short and long cylindrical shell, Thermal and mechanical loads.

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1146 Representing Collective Unconsciousness Using Neural Networks

Authors: Pierre Abou-Haila, Richard Hall, Mark Dawes

Abstract:

Instead of representing individual cognition only, population cognition is represented using artificial neural networks whilst maintaining individuality. This population network trains continuously, simulating adaptation. An implementation of two coexisting populations is compared to the Lotka-Volterra model of predator-prey interaction. Applications include multi-agent systems such as artificial life or computer games.

Keywords: Collective unconsciousness, neural networks, adaptation, predator-prey simulation.

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1145 Strict Stability of Fuzzy Differential Equations by Lyapunov Functions

Authors: Mustafa Bayram Gücen, Coşkun Yakar

Abstract:

In this study, we have investigated the strict stability of fuzzy differential systems and we compare the classical notion of strict stability criteria of ordinary differential equations and the notion of strict stability of fuzzy differential systems. In addition that, we present definitions of stability and strict stability of fuzzy differential equations and also we have some theorems and comparison results. Strict Stability is a different stability definition and this stability type can give us an information about the rate of decay of the solutions. Lyapunov’s second method is a standard technique used in the study of the qualitative behavior of fuzzy differential systems along with a comparison result that allows the prediction of behavior of a fuzzy differential system when the behavior of the null solution of a fuzzy comparison system is known. This method is a usefull for investigating strict stability of fuzzy systems. First of all, we present definitions and necessary background material. Secondly, we discuss and compare the differences between the classical notion of stability and the recent notion of strict stability. And then, we have a comparison result in which the stability properties of the null solution of the comparison system imply the corresponding stability properties of the fuzzy differential system. Consequently, we give the strict stability results and a comparison theorem. We have used Lyapunov second method and we have proved a comparison result with scalar differential equations.

Keywords: Fuzzy systems, fuzzy differential equations, fuzzy stability, strict stability.

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1144 On Some Properties of Interval Matrices

Authors: K. Ganesan

Abstract:

By using a new set of arithmetic operations on interval numbers, we discuss some arithmetic properties of interval matrices which intern helps us to compute the powers of interval matrices and to solve the system of interval linear equations.

Keywords: Interval arithmetic, Interval matrix, linear equations.

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1143 Approximate Solution to Non-Linear Schrödinger Equation with Harmonic Oscillator by Elzaki Decomposition Method

Authors: Emad K. Jaradat, Ala’a Al-Faqih

Abstract:

Nonlinear Schrödinger equations are regularly experienced in numerous parts of science and designing. Varieties of analytical methods have been proposed for solving these equations. In this work, we construct an approximate solution for the nonlinear Schrodinger equations, with harmonic oscillator potential, by Elzaki Decomposition Method (EDM). To illustrate the effects of harmonic oscillator on the behavior wave function, nonlinear Schrodinger equation in one and two dimensions is provided. The results show that, it is more perfectly convenient and easy to apply the EDM in one- and two-dimensional Schrodinger equation.

Keywords: Non-linear Schrodinger equation, Elzaki decomposition method, harmonic oscillator, one and two- dimensional Schrodinger equation.

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1142 Exact Solutions of Steady Plane Flows of an Incompressible Fluid of Variable Viscosity Using (ξ, ψ)- Or (η, ψ)- Coordinates

Authors: Rana Khalid Naeem, Asif Mansoor, Waseem Ahmed Khan, Aurangzaib

Abstract:

The exact solutions of the equations describing the steady plane motion of an incompressible fluid of variable viscosity for an arbitrary state equation are determined in the (ξ,ψ) − or (η,ψ )- coordinates where ψ(x,y) is the stream function, ξ and η are the parts of the analytic function, ϖ =ξ( x,y )+iη( x,y ). Most of the solutions involve arbitrary function/ functions indicating  that the flow equations possess an infinite set of solutions. 

Keywords: Exact solutions, Fluid of variable viscosity, Navier-Stokes equations, Steady plane flows

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1141 Solitary Wave Solutions for Burgers-Fisher type Equations with Variable Coefficients

Authors: Amit Goyal, Alka, Rama Gupta, C. Nagaraja Kumar

Abstract:

We have solved the Burgers-Fisher (BF) type equations, with time-dependent coefficients of convection and reaction terms, by using the auxiliary equation method. A class of solitary wave solutions are obtained, and some of which are derived for the first time. We have studied the effect of variable coefficients on physical parameters (amplitude and velocity) of solitary wave solutions. In some cases, the BF equations could be solved for arbitrary timedependent coefficient of convection term.

Keywords: Solitary wave solution, Variable coefficient Burgers- Fisher equation, Auxiliary equation method.

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1140 Matrix Valued Difference Equations with Spectral Singularities

Authors: Serifenur Cebesoy, Yelda Aygar, Elgiz Bairamov

Abstract:

In this study, we examine some spectral properties of non-selfadjoint matrix-valued difference equations consisting of a polynomial-type Jost solution. The aim of this study is to investigate the eigenvalues and spectral singularities of the difference operator L which is expressed by the above-mentioned difference equation. Firstly, thanks to the representation of polynomial type Jost solution of this equation, we obtain asymptotics and some analytical properties. Then, using the uniqueness theorems of analytic functions, we guarantee that the operator L has a finite number of eigenvalues and spectral singularities.

Keywords: Difference Equations, Jost Functions, Asymptotics, Eigenvalues, Continuous Spectrum, Spectral Singularities.

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1139 Numerical Simulation of Tidal Currents in Persian Gulf

Authors: Ameleh Aghajanloo, Moharam Dolatshahi Pirouz, Masoud Montazeri Namin

Abstract:

In this paper, a two-dimensional (2D) numerical model for the tidal currents simulation in Persian Gulf is presented. The model is based on the depth averaged equations of shallow water which consider hydrostatic pressure distribution. The continuity equation and two momentum equations including the effects of bed friction, the Coriolis effects and wind stress have been solved. To integrate the 2D equations, the Alternative Direction Implicit (ADI) technique has been used. The base of equations discritization was finite volume method applied on rectangular mesh. To evaluate the model validation, a dam break case study including analytical solution is selected and the comparison is done. After that, the capability of the model in simulation of tidal current in a real field is represented by modeling the current behavior in Persian Gulf. The tidal fluctuations in Hormuz Strait have caused the tidal currents in the area of study. Therefore, the water surface oscillations data at Hengam Island on Hormoz Strait are used as the model input data. The check point of the model is measured water surface elevations at Assaluye port. The comparison between the results and the acceptable agreement of them showed the model ability for modeling marine hydrodynamic.

Keywords: Persian Gulf, Tidal Currents, Shallow Water Equations, Finite Volumes

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1138 Simulation of a Multi-Component Transport Model for the Chemical Reaction of a CVD-Process

Authors: J. Geiser, R. Röhle

Abstract:

In this paper we present discretization and decomposition methods for a multi-component transport model of a chemical vapor deposition (CVD) process. CVD processes are used to manufacture deposition layers or bulk materials. In our transport model we simulate the deposition of thin layers. The microscopic model is based on the heavy particles, which are derived by approximately solving a linearized multicomponent Boltzmann equation. For the drift-process of the particles we propose diffusionreaction equations as well as for the effects of heat conduction. We concentrate on solving the diffusion-reaction equation with analytical and numerical methods. For the chemical processes, modelled with reaction equations, we propose decomposition methods and decouple the multi-component models to simpler systems of differential equations. In the numerical experiments we present the computational results of our proposed models.

Keywords: Chemical reactions, chemical vapor deposition, convection-diffusion-reaction equations, decomposition methods, multi-component transport.

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1137 A Fully Implicit Finite-Difference Solution to One Dimensional Coupled Nonlinear Burgers’ Equations

Authors: Vineet K. Srivastava, Mukesh K. Awasthi, Mohammad Tamsir

Abstract:

A fully implicit finite-difference method has been proposed for the numerical solutions of one dimensional coupled nonlinear Burgers’ equations on the uniform mesh points. The method forms a system of nonlinear difference equations which is to be solved at each iteration. Newton’s iterative method has been implemented to solve this nonlinear assembled system of equations. The linear system has been solved by Gauss elimination method with partial pivoting algorithm at each iteration of Newton’s method. Three test examples have been carried out to illustrate the accuracy of the method. Computed solutions obtained by proposed scheme have been compared with analytical solutions and those already available in the literature by finding L2 and L∞ errors.

Keywords: Burgers’ equation, Implicit Finite-difference method, Newton’s method, Gauss elimination with partial pivoting.

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1136 Assessment of Analytical Equations for the Derivation of Young’s Modulus of Bonded Rubber Materials

Authors: Z. N. Haji, S. O. Oyadiji, H. Samami, O. Farrell

Abstract:

The prediction of the vibration response of rubber products by analytical or numerical method depends mainly on the predefined intrinsic material properties such as Young’s modulus, damping factor and Poisson’s ratio. Such intrinsic properties are determined experimentally by subjecting a bonded rubber sample to compression tests. The compression tests on such a sample yield an apparent Young’s modulus which is greater in magnitude than the intrinsic Young’s modulus of the rubber. As a result, many analytical equations have been developed to determine Young’s modulus from an apparent Young’s modulus of bonded rubber materials. In this work, the applicability of some of these analytical equations is assessed via experimental testing. The assessment is based on testing of vulcanized nitrile butadiene rubber (NBR70) samples using tensile test and compression test methods. The analytical equations are used to determine the intrinsic Young’s modulus from the apparent modulus that is derived from the compression test data of the bonded rubber samples. Then, these Young’s moduli are compared with the actual Young’s modulus that is derived from the tensile test data. The results show significant discrepancy between the Young’s modulus derived using the analytical equations and the actual Young’s modulus.

Keywords: Bonded rubber, quasi-static test, shape factor, apparent Young’s modulus.

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1135 MEGSOR Iterative Scheme for the Solution of 2D Elliptic PDE's

Authors: J. Sulaiman, M. Othman, M. K. Hasan

Abstract:

Recently, the findings on the MEG iterative scheme has demonstrated to accelerate the convergence rate in solving any system of linear equations generated by using approximation equations of boundary value problems. Based on the same scheme, the aim of this paper is to investigate the capability of a family of four-point block iterative methods with a weighted parameter, ω such as the 4 Point-EGSOR, 4 Point-EDGSOR, and 4 Point-MEGSOR in solving two-dimensional elliptic partial differential equations by using the second-order finite difference approximation. In fact, the formulation and implementation of three four-point block iterative methods are also presented. Finally, the experimental results show that the Four Point MEGSOR iterative scheme is superior as compared with the existing four point block schemes.

Keywords: MEG iteration, second-order finite difference, weighted parameter.

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1134 Using Lagrange Equations to Study the Relative Motion of a Mechanism

Authors: R. A. Petre, S. E. Nichifor, A. Craifaleanu, I. Stroe

Abstract:

The relative motion of a robotic arm formed by homogeneous bars of different lengths and masses, hinged to each other is investigated. The first bar of the mechanism is articulated on a platform, considered initially fixed on the surface of the Earth, while for the second case the platform is considered to be in rotation with respect to the Earth. For both analyzed cases the motion equations are determined using the Lagrangian formalism, applied in its traditional form, valid with respect to an inertial reference system, conventionally considered as fixed. However, in the second case, a generalized form of the formalism valid with respect to a non-inertial reference frame will also be applied. The numerical calculations were performed using a MATLAB program.

Keywords: Lagrange equations, relative motion, inertial or non-inertial reference frame.

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1133 The Effects of Various Boundary Conditions on Thermal Buckling of Functionally Graded Beamwith Piezoelectric Layers Based on Third order Shear Deformation Theory

Authors: O. Miraliyari

Abstract:

This article attempts to analyze functionally graded beam thermal buckling along with piezoelectric layers applying based on the third order shearing deformation theory considering various boundary conditions. The beam properties are assumed to vary continuously from the lower surface to the upper surface of the beam. The equilibrium equations are derived using the total potential energy equations, Euler equations, piezoelectric material constitutive equations and third order shear deformation theory assumptions. In order to fulfill such an aim, at first functionally graded beam with piezoelectric layers applying the third order shearing deformation theory along with clamped -clamped boundary conditions are thoroughly analyzed, and then following making sure of the correctness of all the equations, the very same beam is analyzed with piezoelectric layers through simply-simply and simply-clamped boundary conditions. In this article buckling critical temperature for functionally graded beam is derived in two different ways, without piezoelectric layer and with piezoelectric layer and the results are compared together. Finally, all the conclusions obtained will be compared and contrasted with the same samples in the same and distinguished conditions through tables and charts. It would be noteworthy that in this article, the software MAPLE has been applied in order to do the numeral calculations.

Keywords: Thermal buckling, functionally graded beam, piezoelectric layer, various boundary conditions.

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1132 Tsunami Inundation Modeling in a Boundary Fitted Curvilinear Grid Model Using the Method of Lines Technique

Authors: M. Ashaque Meah, M. Shah Noor, M Asif Arefin, Md. Fazlul Karim

Abstract:

A numerical technique in a boundary-fitted curvilinear grid model is developed to simulate the extent of inland inundation along the coastal belts of Peninsular Malaysia and Southern Thailand due to 2004 Indian ocean tsunami. Tsunami propagation and run-up are also studied in this paper. The vertically integrated shallow water equations are solved by using the method of lines (MOL). For this purpose the boundary-fitted grids are generated along the coastal and island boundaries and the other open boundaries of the model domain. A transformation is used to the governing equations so that the transformed physical domain is converted into a rectangular one. The MOL technique is applied to the transformed shallow water equations and the boundary conditions so that the equations are converted into ordinary differential equations initial value problem. Finally the 4th order Runge-Kutta method is used to solve these ordinary differential equations. The moving boundary technique is applied instead of fixed sea side wall or fixed coastal boundary to ensure the movement of the coastal boundary. The extent of intrusion of water and associated tsunami propagation are simulated for the 2004 Indian Ocean tsunami along the west coast of Peninsular Malaysia and southern Thailand. The simulated results are compared with the results obtained from a finite difference model and the data available in the USGS website. All simulations show better approximation than earlier research and also show excellent agreement with the observed data.

Keywords: Open boundary condition, moving boundary condition, boundary-fitted curvilinear grids, far field tsunami, Shallow Water Equations, tsunami source, Indonesian tsunami of 2004.

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1131 Error Estimates for Calculated Glomerular Filtration Rates

Authors: Simon Brown

Abstract:

Glomerular filtration rate (GFR) is a measure of kidney function. It is usually estimated from serum concentrations of cystatin C or creatinine although there has been considerable debate in the literature about (i) the best equation to use and (ii) the variability in the correlation between the concentrations of creatinine and cystatin C. The equations for GFR can be written in a general form and from these I calculate the error of the GFR estimates associated with analyte measurement error. These show that the error of the GFR estimates is such that it is not possible to distinguish between the equations over much of the concentration range of either analyte. The general forms of the equations are also used to derive an expression for the concentration of cystatin C as a function of the concentration of creatinine. This equation shows that these analyte concentrations are not linearly related. Clinical reports of cystatin C and creatinine concentration are consistent with the expression derived.

Keywords: creatinine, cystatin C, error analysis, glomerularfiltration rate, measurement error.

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