Search results for: Analytical modeling
Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 2799

Search results for: Analytical modeling

2619 Building Information Modeling-Based Approach for Automatic Quantity Take-off and Cost Estimation

Authors: Lo Kar Yin, Law Ka Mei

Abstract:

Architectural, engineering, construction and operations (AECO) industry practitioners have been well adapting to the dynamic construction market from the fundamental training of its disciplines. As further triggered by the pandemic since 2019, great steps are taken in virtual environment and the best collaboration is strived with project teams without boundaries. With adoption of Building Information Modeling-based approach and qualitative analysis, this paper is to review quantity take-off (QTO) and cost estimation process through modeling techniques in liaison with suppliers, fabricators, subcontractors, contractors, designers, consultants and services providers in the construction industry value chain for automatic project cost budgeting, project cost control and cost evaluation on design options of in-situ reinforced-concrete construction and Modular Integrated Construction (MiC) at design stage, variation of works and cash flow/spending analysis at construction stage as far as practicable, with a view to sharing the findings for enhancing mutual trust and co-operation among AECO industry practitioners. It is to foster development through a common prototype of design and build project delivery method in NEC4 Engineering and Construction Contract (ECC) Options A and C.

Keywords: Building Information Modeling, cost estimation, quantity take-off, modeling techniques.

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2618 Cosastudio: A Software Architecture Modeling Tool

Authors: Adel Smeda, Adel Alti, Mourad Oussalah, Abdallah Boukerram

Abstract:

A key aspect of the design of any software system is its architecture. An architecture description provides a formal model of the architecture in terms of components and connectors and how they are composed together. COSA (Component-Object based Software Structures), is based on object-oriented modeling and component-based modeling. The model improves the reusability by increasing extensibility, evolvability, and compositionality of the software systems. This paper presents the COSA modelling tool which help architects the possibility to verify the structural coherence of a given system and to validate its semantics with COSA approach.

Keywords: Software Architecture, Architecture Description Languages, UML, Components, Connectors.

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2617 Dynamic Measurement System Modeling with Machine Learning Algorithms

Authors: Changqiao Wu, Guoqing Ding, Xin Chen

Abstract:

In this paper, ways of modeling dynamic measurement systems are discussed. Specially, for linear system with single-input single-output, it could be modeled with shallow neural network. Then, gradient based optimization algorithms are used for searching the proper coefficients. Besides, method with normal equation and second order gradient descent are proposed to accelerate the modeling process, and ways of better gradient estimation are discussed. It shows that the mathematical essence of the learning objective is maximum likelihood with noises under Gaussian distribution. For conventional gradient descent, the mini-batch learning and gradient with momentum contribute to faster convergence and enhance model ability. Lastly, experimental results proved the effectiveness of second order gradient descent algorithm, and indicated that optimization with normal equation was the most suitable for linear dynamic models.

Keywords: Dynamic system modeling, neural network, normal equation, second order gradient descent.

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2616 Evaluation of Minimization of Moment Ratio Method by Physical Modeling

Authors: Amin Eslami, Jafar Bolouri Bazaz

Abstract:

Under active stress conditions, a rigid cantilever retaining wall tends to rotate about a pivot point located within the embedded depth of the wall. For purely granular and cohesive soils, a methodology was previously reported called minimization of moment ratio to determine the location of the pivot point of rotation. The usage of this new methodology is to estimate the rotational stability safety factor. Moreover, the degree of improvement required in a backfill to get a desired safety factor can be estimated by the concept of the shear strength demand. In this article, the accuracy of this method for another type of cantilever walls called Contiguous Bored Pile (CBP) retaining wall is evaluated by using physical modeling technique. Based on observations, the results of moment ratio minimization method are in good agreement with the results of the carried out physical modeling.

Keywords: Cantilever Retaining Wall, Physical Modeling, Minimization of Moment Ratio Method, Pivot Point.

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2615 Ultrasound Mechanical Index as a Parameter Affecting of the Ability of Proliferation of Cells

Authors: Z. Hormozi Moghaddam, M. Mokhtari-Dizaji, M. Movahedin, M. E. Ravari

Abstract:

Mechanical index (MI) is used for quantifying acoustic cavitation and the relationship between acoustic pressure and the frequency. In this study, modeling of the MI was applied to provide treatment protocol and to understand the effective physical processes on reproducibility of stem cells. The acoustic pressure and MI equations are modeled and solved to estimate optimal MI for 28, 40, 150 kHz and 1 MHz frequencies. Radial and axial acoustic pressure distribution was extracted. To validate the results of the modeling, the acoustic pressure in the water and near field depth was measured by a piston hydrophone. Results of modeling and experiments show that the model is consistent well to experimental results with 0.91 and 0.90 correlation of coefficient (p<0.05) for 1 MHz and 40 kHz. Low intensity ultrasound with 0.40 MI is more effective on the proliferation rate of the spermatogonial stem cells during the seven days of culture, in contrast, high MI has a harmful effect on the spermatogonial stem cells. This model provides proper treatment planning in vitro and in vivo by estimating the cavitation phenomenon.

Keywords: Ultrasound, mechanical index, modeling, stem cell.

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2614 CFD Modeling of Reduction in NOX Emission Using HiTAC Technique

Authors: Abbas Khoshhal, Masoud Rahimi, Sayed Reza Shabanian, Ammar Abdulaziz Alsairafi

Abstract:

In the present study, the rate of NOx emission in a combustion chamber working in conventional combustion and High Temperature Air Combustion (HiTAC) system are examined using CFD modeling. The effect of peak temperature, combustion air temperature and oxygen concentration on NOx emission rate was undertaken. Results show that in a fixed oxygen concentration, increasing the preheated air temperature will increase the peak temperature and NOx emission rate. In addition, it was observed that the reduction of the oxygen concentration in the fixed preheated air temperature decreases the peak temperature and NOx emission rate. On the other hand, the results show that increase of preheated air temperature at various oxygen concentrations increases the NOx emission rate. However, the rate of increase in HiTAC conditions is quite lower than the conventional combustion. The modeling results show that the NOx emission rate in HiTAC combustion is 133% less than that of the conventional combustion.

Keywords: CFD Modeling, HiTAC, NOx, Combustion.

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2613 Real-Time Visual Simulation and Interactive Animation of Shadow Play Puppets Using OpenGL

Authors: Tan Kian Lam, Abdullah Zawawi bin Haji Talib, Mohd. Azam Osman

Abstract:

This paper describes a method of modeling to model shadow play puppet using sophisticated computer graphics techniques available in OpenGL in order to allow interactive play in real-time environment as well as producing realistic animation. This paper proposes a novel real-time method is proposed for modeling of puppet and its shadow image that allows interactive play of virtual shadow play using texture mapping and blending techniques. Special effects such as lighting and blurring effects for virtual shadow play environment are also developed. Moreover, the use of geometric transformations and hierarchical modeling facilitates interaction among the different parts of the puppet during animation. Based on the experiments and the survey that were carried out, the respondents involved are very satisfied with the outcomes of these techniques.

Keywords: Animation, blending, hierarchical modeling, interactive play, real-time, shadow play, visual simulation.

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2612 Dynamic Process Monitoring of an Ammonia Synthesis Fixed-Bed Reactor

Authors: Bothinah Altaf, Gary Montague, Elaine B. Martin

Abstract:

This study involves the modeling and monitoring of an ammonia synthesis fixed-bed reactor using partial least squares (PLS) and its variants. The process exhibits complex dynamic behavior due to the presence of heat recycling and feed quench. One limitation of static PLS model in this situation is that it does not take account of the process dynamics and hence dynamic PLS was used. Although it showed, superior performance to static PLS in terms of prediction, the monitoring scheme was inappropriate hence adaptive PLS was considered. A limitation of adaptive PLS is that non-conforming observations also contribute to the model, therefore, a new adaptive approach was developed, robust adaptive dynamic PLS. This approach updates a dynamic PLS model and is robust to non-representative data. The developed methodology showed a clear improvement over existing approaches in terms of the modeling of the reactor and the detection of faults.

Keywords: Ammonia synthesis fixed-bed reactor, dynamic partial least squares modeling, recursive partial least squares, robust modeling.

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2611 Modeling of a Novel Dual-Belt Continuously Variable Transmission for Automobiles

Authors: Y. Q. Chen, P. K. Wong, Z. C. Xie, H. W. Wu, K. U. Chan, J., L. Huang

Abstract:

It is believed that continuously variable transmission (CVT) will dominate the automotive transmissions in the future. The most popular design is Van Doorne-s CVT with single metal pushing V-belt. However, it is only applicable to low power passenger cars because its major limitation is low torque capacity. Therefore, this research studies a novel dual-belt CVT system to overcome the limitation of traditional single-belt CVT, such that it can be applicable to the heavy-duty vehicles. This paper presents the mathematical model of the design and its experimental verification. Experimental and simulated results show that the model developed is valid and the proposed dual-belt CVT can really overcome the traditional limitation of single-belt Van Doorne-s CVT.

Keywords: Analytical model, CVT, Dual belts, Torque capacity.

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2610 Decision Tree Modeling in Emergency Logistics Planning

Authors: Yousef Abu Nahleh, Arun Kumar, Fugen Daver, Reham Al-Hindawi

Abstract:

Despite the availability of natural disaster related time series data for last 110 years, there is no forecasting tool available to humanitarian relief organizations to determine forecasts for emergency logistics planning. This study develops a forecasting tool based on identifying probability of disaster for each country in the world by using decision tree modeling. Further, the determination of aggregate forecasts leads to efficient pre-disaster planning. Based on the research findings, the relief agencies can optimize the various resources allocation in emergency logistics planning.

Keywords: Decision tree modeling, Forecasting, Humanitarian relief, emergency supply chain.

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2609 Laser Surface Hardening Considering Coupled Thermoelasticity using an Eulerian Formulations

Authors: Me. Sistaninia, G.H.Farrahi, Ma. Sistaninia

Abstract:

Thermoelastic temperature, displacement, and stress in heat transfer during laser surface hardening are solved in Eulerian formulation. In Eulerian formulations the heat flux is fixed in space and the workpiece is moved through a control volume. In the case of uniform velocity and uniform heat flux distribution, the Eulerian formulations leads to a steady-state problem, while the Lagrangian formulations remains transient. In Eulerian formulations the reduction to a steady-state problem increases the computational efficiency. In this study also an analytical solution is developed for an uncoupled transient heat conduction equation in which a plane slab is heated by a laser beam. The thermal result of the numerical model is compared with the result of this analytical model. Comparing the results shows numerical solution for uncoupled equations are in good agreement with the analytical solution.

Keywords: Coupled thermoelasticity, Finite element, Laser surface hardening, Eulerian formulation.

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2608 Adaptive Helmholtz Resonator in a Hydraulic System

Authors: Lari Kela

Abstract:

An adaptive Helmholtz resonator was designed and adapted to hydraulics. The resonator was controlled by open- and closed-loop controls so that 20 dB attenuation of the peak-to-peak value of the pulsating pressure was maintained. The closed-loop control was noted to be better, albeit it was slower because of its low pressure and temperature variation, which caused variation in the effective bulk modulus of the hydraulic system. Low-pressure hydraulics contains air, which affects the stiffness of the hydraulics, and temperature variation changes the viscosity of the oil. Thus, an open-loop control loses its efficiency if a condition such as temperature or the amount of air changes after calibration. The instability of the low-pressure hydraulic system reduced the operational frequency range of the Helmholtz resonator when compared with the results of an analytical model. Different dampers for hydraulics are presented. Then analytical models of a hydraulic pipe and a hydraulic pipe with a Helmholtz resonator are presented. The analytical models are based on the wave equation of sound pressure. Finally, control methods and the results of experiments are presented.

Keywords: adaptive, damper, hydraulics, pressure, pulsating

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2607 Modeling Prices of Electricity Futures at EEX

Authors: Robest Flasza, Milan Rippel, Jan Solc

Abstract:

The main aim of this paper is to develop and calibrate an econometric model for modeling prices of long term electricity futures contracts. The calibration of our model is performed on data from EEX AG allowing us to capture the specific features of German electricity market. The data sample contains several structural breaks which have to be taken into account for modeling. We model the data with an ARIMAX model which reveals high correlation between the price of electricity futures contracts and prices of LT futures contracts of fuels (namely coal, natural gas and crude oil). Besides this, also a share price index of representative electricity companies traded on Xetra, spread between 10Y and 1Y German bonds and exchange rate between EUR and USD appeared to have significant explanatory power over these futures contracts on EEX.

Keywords: electricity futures, EEX, ARIMAX, emissionallowances

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2606 E-Learning Methodology Development using Modeling

Authors: Sarma Cakula, Maija Sedleniece

Abstract:

Simulation and modeling computer programs are concerned with construction of models for analyzing different perspectives and possibilities in changing conditions environment. The paper presents theoretical justification and evaluation of qualitative e-learning development model in perspective of advancing modern technologies. There have been analyzed principles of qualitative e-learning in higher education, productivity of studying process using modern technologies, different kind of methods and future perspectives of e-learning in formal education. Theoretically grounded and practically tested model of developing e-learning methods using different technologies for different type of classroom, which can be used in professor-s decision making process to choose the most effective e-learning methods has been worked out.

Keywords: E-learning, modeling, E-learning methods development, personal knowledge management

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2605 Analytical Based Truncation Principle of Higher-Order Solution for a x1/3 Force Nonlinear Oscillator

Authors: Md. Alal Hosen

Abstract:

In this paper, a modified harmonic balance method based an analytical technique has been developed to determine higher-order approximate periodic solutions of a conservative nonlinear oscillator for which the elastic force term is proportional to x1/3. Usually, a set of nonlinear algebraic equations is solved in this method. However, analytical solutions of these algebraic equations are not always possible, especially in the case of a large oscillation. In this article, different parameters of the same nonlinear problems are found, for which the power series produces desired results even for the large oscillation. We find a modified harmonic balance method works very well for the whole range of initial amplitudes, and the excellent agreement of the approximate frequencies and periodic solutions with the exact ones has been demonstrated and discussed. Besides these, a suitable truncation formula is found in which the solution measures better results than existing solutions. The method is mainly illustrated by the x1/3 force nonlinear oscillator but it is also useful for many other nonlinear problems.

Keywords: Approximate solutions, Harmonic balance method, Nonlinear oscillator, Perturbation.

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2604 Load Modeling for Power Flow and Transient Stability Computer Studies at BAKHTAR Network

Authors: M. Sedighizadeh, A. Rezazadeh

Abstract:

A method has been developed for preparing load models for power flow and stability. The load modeling (LOADMOD) computer software transforms data on load class mix, composition, and characteristics into the from required for commonly–used power flow and transient stability simulation programs. Typical default data have been developed for load composition and characteristics. This paper defines LOADMOD software and describes the dynamic and static load modeling techniques used in this software and results of initial testing for BAKHTAR power system.

Keywords: Load Modelling, Static, Power Flow.

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2603 Modeling Language for Constructing Solvers in Machine Learning: Reductionist Perspectives

Authors: Tsuyoshi Okita

Abstract:

For a given specific problem an efficient algorithm has been the matter of study. However, an alternative approach orthogonal to this approach comes out, which is called a reduction. In general for a given specific problem this reduction approach studies how to convert an original problem into subproblems. This paper proposes a formal modeling language to support this reduction approach in order to make a solver quickly. We show three examples from the wide area of learning problems. The benefit is a fast prototyping of algorithms for a given new problem. It is noted that our formal modeling language is not intend for providing an efficient notation for data mining application, but for facilitating a designer who develops solvers in machine learning.

Keywords: Formal language, statistical inference problem, reduction.

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2602 Performance Boundaries for Interactive Finite Element Applications

Authors: Jaewon Jang, Gregory R. Miller

Abstract:

This paper presents work characterizing finite element performance boundaries within which live, interactive finite element modeling is feasible on current and emerging systems. These results are based on wide-ranging tests performed using a prototype finite element program implemented specifically for this study, thereby enabling the unified investigation of numerous direct and iterative solver strategies and implementations in a variety of modeling contexts. The results are intended to be useful for researchers interested in interactive analysis by providing baseline performance estimates, to give guidance in matching solution strategies to problem domains, and to spur further work addressing the challenge of extending the present boundaries.

Keywords: Finite Elements, Interactive Modeling, NumericalAnalysis.

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2601 Containment/Penetration Analysis for the Protection of Aircraft Engine External Configuration and Nuclear Power Plant Structures

Authors: Dong Wook Lee, Adrian Mistreanu

Abstract:

The authors have studied a method for analyzing containment and penetration using an explicit nonlinear Finite Element Analysis. This method may be used in the stage of concept design for the protection of external configurations or components of aircraft engines and nuclear power plant structures. This paper consists of the modeling method, the results obtained from the method and the comparison of the results with those calculated from simple analytical method. It shows that the containment capability obtained by proposed method matches well with analytically calculated containment capability.

Keywords: Computer Aided Engineering, CAE, containment analysis, Finite Element Analysis, FEA, impact analysis, penetration analysis.

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2600 Mobile Ad Hoc Networks and It’s Routing Protocols

Authors: Rakesh Kumar, Piush Verma, Yaduvir Singh

Abstract:

A mobile ad hoc network (MANET) is a self configuring network, without any centralized control. The topology of this network is not always defined. The main objective of this paper is to introduce the fundamental concepts of MANETs to the researchers and practitioners, who are involved in the work in the area of modeling and simulation of MANETs. This paper begins with an overview of mobile ad hoc networks. Then it proceeds with the overview of routing protocols used in the MANETS, their properties and simulation methods. A brief tabular comparison between the routing protocols is also given in this paper considering different routing protocol parameters. This paper introduces a new routing scheme developed by the use of evolutionary algorithms (EA) and analytical hierarchy process (AHP) which will be used for getting the optimized output of MANET. In this paper cryptographic technique, ceaser cipher is also employed for making the optimized route secure.

Keywords: AHP, AODV, Cryptography, EA, MANET, Optimized output.

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2599 Marangoni Convection in a Fluid Layer with Internal Heat Generation

Authors: Norfifah Bachok, Norihan Md. Arifin

Abstract:

In this paper we use classical linear stability theory to investigate the effects of uniform internal heat generation on the onset of Marangoni convection in a horizontal layer of fluid heated from below. We use a analytical technique to obtain the close form analytical expression for the onset of Marangoni convection when the lower boundary is conducting with free-slip condition. We show that the effect of increasing the internal heat generation is always to destabilize the layer.

Keywords: Marangoni convection, heat generation, free-slip

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2598 Mathematical Modeling of Current Harmonics Caused by Personal Computers

Authors: Rana Abdul Jabbar Khan, Muhammad Akmal

Abstract:

Personal computers draw non-sinusoidal current with odd harmonics more significantly. Power Quality of distribution networks is severely affected due to the flow of these generated harmonics during the operation of electronic loads. In this paper, mathematical modeling of odd harmonics in current like 3rd, 5th, 7th and 9th influencing the power quality has been presented. Live signals have been captured with the help of power quality analyzer for analysis purpose. The interesting feature is that Total Harmonic Distortion (THD) in current decreases with the increase of nonlinear loads has been verified theoretically. The results obtained using mathematical expressions have been compared with the practical results and exciting results have been found.

Keywords: Harmonic Distortion, Mathematical Modeling, Power Quality.

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2597 Modeling of a Small Unmanned Aerial Vehicle

Authors: A. Elsayed Ahmed, A. Hafez, A. N. Ouda, H. Eldin Hussein Ahmed, H. Mohamed Abd-Elkader

Abstract:

Unmanned aircraft systems (UAS) are playing increasingly prominent roles in defense programs and defense strategies around the world. Technology advancements have enabled the development of it to do many excellent jobs as reconnaissance, surveillance, battle fighters, and communications relays. Simulating a small unmanned aerial vehicle (SUAV) dynamics and analyzing its behavior at the preflight stage is too important and more efficient. The first step in the UAV design is the mathematical modeling of the nonlinear equations of motion. . In this paper, a survey with a standard method to obtain the full non-linear equations of motion is utilized, and then the linearization of the equations according to a steady state flight condition (trimming) is derived. This modeling technique is applied to an Ultrastick-25e fixed wing UAV to obtain the valued linear longitudinal and lateral models. At the end the model is checked by matching between the behavior of the states of the nonlinear UAV and the resulted linear model with doublet at the control surfaces.

Keywords: Equations of motion, linearization, modeling, nonlinear model, UAV.

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2596 Modeling and Analysis of a Cruise Control System

Authors: Anthony Spiteri Staines

Abstract:

This paper examines the modeling and analysis of a cruise control system using a Petri net based approach, task graphs, invariant analysis and behavioral properties. It shows how the structures used can be verified and optimized.

Keywords: Software Engineering, Real Time Analysis andDesign, Petri Nets, Task Graphs, Parallelism.

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2595 Modeling and Optimization of Process Parameters in PMEDM by Genetic Algorithm

Authors: Farhad Kolahan, Mohammad Bironro

Abstract:

This paper addresses modeling and optimization of process parameters in powder mixed electrical discharge machining (PMEDM). The process output characteristics include metal removal rate (MRR) and electrode wear rate (EWR). Grain size of Aluminum powder (S), concentration of the powder (C), discharge current (I) pulse on time (T) are chosen as control variables to study the process performance. The experimental results are used to develop the regression models based on second order polynomial equations for the different process characteristics. Then, a genetic algorithm (GA) has been employed to determine optimal process parameters for any desired output values of machining characteristics.

Keywords: Regression modeling, PMEDM, GeneticAlgorithm, Optimization.

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2594 Topic Modeling Using Latent Dirichlet Allocation and Latent Semantic Indexing on South African Telco Twitter Data

Authors: Phumelele P. Kubheka, Pius A. Owolawi, Gbolahan Aiyetoro

Abstract:

Twitter is one of the most popular social media platforms where users share their opinions on different subjects. Twitter can be considered a great source for mining text due to the high volumes of data generated through the platform daily. Many industries such as telecommunication companies can leverage the availability of Twitter data to better understand their markets and make an appropriate business decision. This study performs topic modeling on Twitter data using Latent Dirichlet Allocation (LDA). The obtained results are benchmarked with another topic modeling technique, Latent Semantic Indexing (LSI). The study aims to retrieve topics on a Twitter dataset containing user tweets on South African Telcos. Results from this study show that LSI is much faster than LDA. However, LDA yields better results with higher topic coherence by 8% for the best-performing model in this experiment. A higher topic coherence score indicates better performance of the model.

Keywords: Big data, latent Dirichlet allocation, latent semantic indexing, Telco, topic modeling, Twitter.

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2593 Process Modeling and Problem Solving: Connecting Two Worlds by BPMN

Authors: Gionata Carmignani, Mario G. C. A. Cimino, Franco Failli

Abstract:

Business Processes (BPs) are the key instrument to understand how companies operate at an organizational level, taking an as-is view of the workflow, and how to address their issues by identifying a to-be model. In last year’s, the BP Model and Notation (BPMN) has become a de-facto standard for modeling processes. However, this standard does not incorporate explicitly the Problem- Solving (PS) knowledge in the Process Modeling (PM) results. Thus, such knowledge cannot be shared or reused. To narrow this gap is today a challenging research area. In this paper we present a framework able to capture the PS knowledge and to improve a workflow. This framework extends the BPMN specification by incorporating new general-purpose elements. A pilot scenario is also presented and discussed.

Keywords: Business Process Management, BPMN, Problem Solving, Process mapping.

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2592 A Method to Saturation Modeling of Synchronous Machines in d-q Axes

Authors: Mohamed A. Khlifi, Badr M. Alshammari

Abstract:

This paper discusses the general methods to saturation in the steady-state, two axis (d & q) frame models of synchronous machines. In particular, the important role of the magnetic coupling between the d-q axes (cross-magnetizing phenomenon), is demonstrated. For that purpose, distinct methods of saturation modeling of dumper synchronous machine with cross-saturation are identified, and detailed models synthesis in d-q axes. A number of models are given in the final developed form. The procedure and the novel models are verified by a critical application to prove the validity of the method and the equivalence between all developed models is reported. Advantages of some of the models over the existing ones and their applicability are discussed.

Keywords: Cross-magnetizing, models synthesis, synchronous machine, saturated modeling, state-space vectors.

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2591 Research on the Correlation of the Fluctuating Density Gradient of the Compressible Flows

Authors: Yasuo Obikane

Abstract:

This work is to study a roll of the fluctuating density gradient in the compressible flows for the computational fluid dynamics (CFD). A new anisotropy tensor with the fluctuating density gradient is introduced, and is used for an invariant modeling technique to model the turbulent density gradient correlation equation derived from the continuity equation. The modeling equation is decomposed into three groups: group proportional to the mean velocity, and that proportional to the mean strain rate, and that proportional to the mean density. The characteristics of the correlation in a wake are extracted from the results by the two dimensional direct simulation, and shows the strong correlation with the vorticity in the wake near the body. Thus, it can be concluded that the correlation of the density gradient is a significant parameter to describe the quick generation of the turbulent property in the compressible flows.

Keywords: Turbulence Modeling , Density Gradient Correlation, Compressible

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2590 Mathematical modeling of Bi-Substrate Enzymatic Reactions with Ping-Pong Mechanism in the Presence of Competitive Inhibitors

Authors: Rafayel A. Azizyan, Aram E. Gevogyan, Valeri B. Arakelyan, Emil S. Gevorgyan

Abstract:

The mathematical modeling of different biological processes is usually used to predict or assess behavior of systems in which these processes take place. This study deals with mathematical and computer modeling of bi-substrate enzymatic reactions with ping-pong mechanism, which play an important role in different biochemical pathways. Besides that, three models of competitive inhibition were designed using different software packages. The main objective of this study is to represent the results from in silico investigation of bi-substrate enzymatic reactions with ordered pingpong mechanism in the presence of competitive inhibitors, as well as to describe in details the inhibition effects. The simulation of the models with certain kinetic parameters allowed investigating the behavior of reactions as well as determined some interesting aspects concerning influence of different cases of competitive inhibition. Simultaneous presence of two inhibitors, competitive to the S1 and S2 substrates have been studied. Moreover, we have found the pattern of simultaneous influence of both inhibitors.

Keywords: Mathematical modeling, bi-substrate enzymatic reactions, ping-pong mechanism, competitive inhibition.

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