Search results for: matrix swelling
547 Contextual SenSe Model: Word Sense Disambiguation Using Sense and Sense Value of Context Surrounding the Target
Authors: Vishal Raj, Noorhan Abbas
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Ambiguity in NLP (Natural Language Processing) refers to the ability of a word, phrase, sentence, or text to have multiple meanings. This results in various kinds of ambiguities such as lexical, syntactic, semantic, anaphoric and referential. This study is focused mainly on solving the issue of Lexical ambiguity. Word Sense Disambiguation (WSD) is an NLP technique that aims to resolve lexical ambiguity by determining the correct meaning of a word within a given context. Most WSD solutions rely on words for training and testing, but we have used lemma and Part of Speech (POS) tokens of words for training and testing. Lemma adds generality and POS adds properties of word into token. We have designed a method to create an affinity matrix to calculate the affinity between any pair of lemma_POS (a token where lemma and POS of word are joined by underscore) of given training set. Additionally, we have devised an algorithm to create the sense clusters of tokens using affinity matrix under hierarchy of POS of lemma. Furthermore, three different mechanisms to predict the sense of target word using the affinity/similarity value are devised. Each contextual token contributes to the sense of target word with some value and whichever sense gets higher value becomes the sense of target word. So, contextual tokens play a key role in creating sense clusters and predicting the sense of target word, hence, the model is named Contextual SenSe Model (CSM). CSM exhibits a noteworthy simplicity and explication lucidity in contrast to contemporary deep learning models characterized by intricacy, time-intensive processes, and challenging explication. CSM is trained on SemCor training data and evaluated on SemEval test dataset. The results indicate that despite the naivety of the method, it achieves promising results when compared to the Most Frequent Sense (MFS) model.
Keywords: Word Sense Disambiguation, WSD, Contextual SenSe Model, Most Frequent Sense, part of speech, POS, Natural Language Processing, NLP, OOV, out of vocabulary, ELMo, Embeddings from Language Model, BERT, Bidirectional Encoder Representations from Transformers, Word2Vec, lemma_POS, Algorithm.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 326546 Axisymmetric Vibrations of Layered Cylindrical Shells with Cracks
Authors: Larissa Roots
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Vibrations of circular cylindrical shells made of layered composite materials are considered. The shells are weakened by circumferential cracks. The influence of circumferential cracks with constant depth on the vibration of the shell is prescribed with the aid of a matrix of local flexibility coupled with the coefficient of the stress intensity known in the linear elastic fracture mechanics. Numerical results are presented for the case of the shell with one circular crack.
Keywords: Layered shell, axisymmetric vibration, crack.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1768545 Microscopic Analysis of Interfacial Transition Zone of Cementitious Composites Prepared by Various Mixing Procedures
Authors: Josef Fládr, Jiří Němeček, Veronika Koudelková, Petr Bílý
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Mechanical parameters of cementitious composites differ quite significantly based on the composition of cement matrix. They are also influenced by mixing times and procedure. The research presented in this paper was aimed at identification of differences in microstructure of normal strength (NSC) and differently mixed high strength (HSC) cementitious composites. Scanning electron microscopy (SEM) investigation together with energy dispersive X-ray spectroscopy (EDX) phase analysis of NSC and HSC samples was conducted. Evaluation of interfacial transition zone (ITZ) between the aggregate and cement matrix was performed. Volume share, thickness, porosity and composition of ITZ were studied. In case of HSC, samples obtained by several different mixing procedures were compared in order to find the most suitable procedure. In case of NSC, ITZ was identified around 40-50% of aggregate grains and its thickness typically ranged between 10 and 40 µm. Higher porosity and lower share of clinker was observed in this area as a result of increased water-to-cement ratio (w/c) and the lack of fine particles improving the grading curve of the aggregate. Typical ITZ with lower content of Ca was observed only in one HSC sample, where it was developed around less than 15% of aggregate grains. The typical thickness of ITZ in this sample was similar to ITZ in NSC (between 5 and 40 µm). In the remaining four HSC samples, no ITZ was observed. In general, the share of ITZ in HSC samples was found to be significantly smaller than in NSC samples. As ITZ is the weakest part of the material, this result explains to large extent the improved mechanical properties of HSC compared to NSC. Based on the comparison of characteristics of ITZ in HSC samples prepared by different mixing procedures, the most suitable mixing procedure from the point of view of properties of ITZ was identified.
Keywords: Energy dispersive X-ray spectroscopy, high strength concrete, interfacial transition zone, mixing procedure, normal strength concrete, scanning electron microscopy.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1261544 Parallel Multisplitting Methods for Singular Linear Systems
Authors: Guangbin Wang, Fuping Tan
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In this paper, we discuss convergence of the extrapolated iterative methods for linear systems with the coefficient matrices are singular H-matrices. And we present the sufficient and necessary conditions for convergence of the extrapolated iterative methods. Moreover, we apply the results to the GMAOR methods. Finally, we give one numerical example.
Keywords: Singular H-matrix, linear systems, extrapolated iterative method, GMAOR method, convergence.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1340543 The Riemann Barycenter Computation and Means of Several Matrices
Authors: Miklos Palfia
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An iterative definition of any n variable mean function is given in this article, which iteratively uses the two-variable form of the corresponding two-variable mean function. This extension method omits recursivity which is an important improvement compared with certain recursive formulas given before by Ando-Li-Mathias, Petz- Temesi. Furthermore it is conjectured here that this iterative algorithm coincides with the solution of the Riemann centroid minimization problem. Certain simulations are given here to compare the convergence rate of the different algorithms given in the literature. These algorithms will be the gradient and the Newton mehod for the Riemann centroid computation.
Keywords: Means, matrix means, operator means, geometric mean, Riemannian center of mass.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1778542 Fusion Filters Weighted by Scalars and Matrices for Linear Systems
Authors: Seok Hyoung Lee, Vladimir Shin
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An optimal mean-square fusion formulas with scalar and matrix weights are presented. The relationship between them is established. The fusion formulas are compared on the continuous-time filtering problem. The basic differential equation for cross-covariance of the local errors being the key quantity for distributed fusion is derived. It is shown that the fusion filters are effective for multi-sensor systems containing different types of sensors. An example demonstrating the reasonable good accuracy of the proposed filters is given.Keywords: Kalman filtering, fusion formula, multi-sensor, mean-square error.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1383541 Experimental Study on Thermomechanical Properties of New-Generation ODS Alloys
Authors: O. Khalaj, B. Mašek, H. Jirková, J. Svoboda
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By using a combination of new technologies together with an unconventional use of different types of materials, specific mechanical properties and structures of the material can be achieved. Some possibilities are enabled by a combination of powder metallurgy in the preparation of a metal matrix with dispersed stable particles achieved by mechanical alloying and hot consolidation. This paper explains the thermomechanical properties of new generation of Oxide Dispersion Strengthened alloys (ODS) within three ranges of temperature with specified deformation profiles. The results show that the mechanical properties of new ODS alloys are significantly affected by the thermomechanical treatment.
Keywords: Hot forming, ODS, alloys, thermomechanical, Fe-Al, Al2O3.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 921540 Relation between Significance of Attribute Set and Single Attribute
Authors: Xiuqin Ma, Norrozila Binti Sulaiman, Hongwu Qin
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In the research field of Rough Set, few papers concern the significance of attribute set. However, there is important relation between the significance of single attribute and that of attribute set, which should not be ignored. In this paper, we draw conclusions by case analysis that (1) the attribute set including single attributes with high significance is certainly significant, while, (2)the attribute set which consists of single attributes with low significance possibly has high significance. We validate the conclusions on discernibility matrix and the results demonstrate the contribution of our conclusions.
Keywords: relation, attribute set, single attribute, rough set, significance
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1731539 Globally Exponential Stability for Hopfield Neural Networks with Delays and Impulsive Perturbations
Authors: Adnene Arbi, Chaouki Aouiti, Abderrahmane Touati
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In this paper, we consider the global exponential stability of the equilibrium point of Hopfield neural networks with delays and impulsive perturbation. Some new exponential stability criteria of the system are derived by using the Lyapunov functional method and the linear matrix inequality approach for estimating the upper bound of the derivative of Lyapunov functional. Finally, we illustrate two numerical examples showing the effectiveness of our theoretical results.
Keywords: Hopfield Neural Networks, Exponential stability.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2338538 On Modified Numerical Schemes in Vortex Element Method for 2D Flow Simulation Around Airfoils
Authors: Ilia Marchevsky, Victoriya Moreva
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The problem of incompressible steady flow simulation around an airfoil is discussed. For some simplest airfoils (circular, elliptical, Zhukovsky airfoils) the exact solution is known from complex analysis. It allows to compute the intensity of vortex layer which simulates the airfoil. Some modifications of the vortex element method are proposed and test computations are carried out. It-s shown that the these approaches are much more effective in comparison with the classical numerical scheme.
Keywords: Vortex element method, vortex layer, integral equation, ill-conditioned matrix.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1664537 Fuel Cell/DC-DC Convertor Control by Sliding Mode Method
Authors: Farzad Abdous
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Fuel cell's system requires regulating circuit for voltage and current in order to control power in case of connecting to other generative devices or load. In this paper Fuel cell system and convertor, which is a multi-variable system, are controlled using sliding mode method. Use of weighting matrix in design procedure made it possible to regulate speed of control. Simulation results show the robustness and accuracy of proposed controller for controlling desired of outputs.Keywords: DC-DC converter, Fuel cell, PEM, Slides mode control.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1597536 Influence of Temperature Variations on Calibrated Cameras
Authors: Peter Podbreznik, Božidar Potocnik
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The camera parameters are changed due to temperature variations, which directly influence calibrated cameras accuracy. Robustness of calibration methods were measured and their accuracy was tested. An error ratio due to camera parameters change with respect to total error originated during calibration process was determined. It pointed out that influence of temperature variations decrease by increasing distance of observed objects from cameras.Keywords: camera calibration, perspective projection matrix, epipolar geometry, temperature variation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1846535 An Immunosensor for Bladder Cancer Screening
Authors: Congo Tak Shing Ching, Hong-Sheng Chen, Tai-Ping Sun, Hsiu-Li Shieh
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Nuclear matrix protein 22 (NMP22) is a FDA approved biomarker for bladder cancer. The objective of this study is to develop a simple NMP22 immumosensor (NMP22-IMS) for accurate measurement of NMP22. The NMP22-IMS was constructed with NMP22 antibody immobilized on screen-printed carbon electrodes. The construction procedures and antibody immobilization are simple. Results showed that the NMP22-IMS has an excellent (r2³0.95) response range (20 – 100 ng/mL). In conclusion, a simple and reliable NMP22-IMS was developed, capable of precisely determining urine NMP22 level.Keywords: Bladder Cancer, Immunosensor, Impedance, NMP22
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1646534 Education of Purchasing Professionals in Austria: Competence Based View
Authors: Volker Koch
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This paper deals with the education of purchasing professionals in Austria. In this education, equivalent and measurable criteria are collected in order to create a comparison. The comparison shows the problem. To make the aforementioned comparison possible, methodologies such as KODE-Competence Atlas or presentations in a matrix form are used. The result shows the content taught and whether there are any similarities or interesting differences in the current Austrian purchasers’ formations. Purchasing professionals learning competencies are also illustrated in the study result.Keywords: Competencies, education, purchasing professional, technological-oriented.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1053533 Polymer Mediated Interaction between Grafted Nanosheets
Authors: Supriya Gupta, Paresh Chokshi
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Polymer-particle interactions can be effectively utilized to produce composites that possess physicochemical properties superior to that of neat polymer. The incorporation of fillers with dimensions comparable to polymer chain size produces composites with extra-ordinary properties owing to very high surface to volume ratio. The dispersion of nanoparticles is achieved by inducing steric repulsion realized by grafting particles with polymeric chains. A comprehensive understanding of the interparticle interaction between these functionalized nanoparticles plays an important role in the synthesis of a stable polymer nanocomposite. With the focus on incorporation of clay sheets in a polymer matrix, we theoretically construct the polymer mediated interparticle potential for two nanosheets grafted with polymeric chains. The self-consistent field theory (SCFT) is employed to obtain the inhomogeneous composition field under equilibrium. Unlike the continuum models, SCFT is built from the microscopic description taking in to account the molecular interactions contributed by both intra- and inter-chain potentials. We present the results of SCFT calculations of the interaction potential curve for two grafted nanosheets immersed in the matrix of polymeric chains of dissimilar chemistry to that of the grafted chains. The interaction potential is repulsive at short separation and shows depletion attraction for moderate separations induced by high grafting density. It is found that the strength of attraction well can be tuned by altering the compatibility between the grafted and the mobile chains. Further, we construct the interaction potential between two nanosheets grafted with diblock copolymers with one of the blocks being chemically identical to the free polymeric chains. The interplay between the enthalpic interaction between the dissimilar species and the entropy of the free chains gives rise to a rich behavior in interaction potential curve obtained for two separate cases of free chains being chemically similar to either the grafted block or the free block of the grafted diblock chains.
Keywords: Clay nanosheets, polymer brush, polymer nanocomposites, self-consistent field theory.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1457532 Semi-Blind Two-Dimensional Code Acquisition in CDMA Communications
Authors: Rui Wu, Tapani Ristaniemi
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In this paper, we propose a new algorithm for joint time-delay and direction-of-arrival (DOA) estimation, here called two-dimensional code acquisition, in an asynchronous directsequence code-division multiple-access (DS-CDMA) array system. This algorithm depends on eigenvector-eigenvalue decomposition of sample correlation matrix, and requires to know desired user-s training sequence. The performance of the algorithm is analyzed both analytically and numerically in uncorrelated and coherent multipath environment. Numerical examples show that the algorithm is robust with unknown number of coherent signals.
Keywords: Two-Dimensional Code Acquisition, EV-t, DSCDMA
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1512531 Adaptive MPC Using a Recursive Learning Technique
Authors: Ahmed Abbas Helmy, M. R. M. Rizk, Mohamed El-Sayed
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A model predictive controller based on recursive learning is proposed. In this SISO adaptive controller, a model is automatically updated using simple recursive equations. The identified models are then stored in the memory to be re-used in the future. The decision for model update is taken based on a new control performance index. The new controller allows the use of simple linear model predictive controllers in the control of nonlinear time varying processes.
Keywords: Adaptive control, model predictive control, dynamic matrix control, online model identification
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1765530 Controlled Synchronization of an Array of Nonlinear System with Time Delays
Authors: S.M. Lee, J.H. Koo, J.H. Park, S.C. Won
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In this paper, we propose synchronization of an array of nonlinear systems with time delays. The array of systems is decomposed into isolated systems to establish appropriate Lyapunov¬Krasovskii functional. Using the Lyapunov-Krasovskii functional, a sufficient condition for the synchronization is derived in terms of LMIs(Linear Matrix Inequalities). Delayed feedback control gains are obtained by solving the sufficient condition. Numerical examples are given to show the validity the proposed method.
Keywords: Synchronization, Delay, Lyapunov method, LMI.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1430529 Proposal of Solidification/Stabilisation Process of Chosen Hazardous Waste by Cementation
Authors: Bozena Dohnalkova
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This paper presents a part of the project solving which is dedicated to the identification of the hazardous waste with the most critical production within the Czech Republic with the aim to study and find the optimal composition of the cement matrix that will ensure maximum content disposal of chosen hazardous waste. In the first stage of project solving – which represents this paper – a specific hazardous waste was chosen, its properties were identified and suitable solidification agents were chosen. Consequently solidification formulas and testing methodology was proposed.
Keywords: Cementation, solidification, waste, binder.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1861528 Existence and Exponential Stability of Almost Periodic Solution for Cohen-Grossberg SICNNs with Impulses
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In this paper, based on the estimation of the Cauchy matrix of linear impulsive differential equations, by using Banach fixed point theorem and Gronwall-Bellman-s inequality, some sufficient conditions are obtained for the existence and exponential stability of almost periodic solution for Cohen-Grossberg shunting inhibitory cellular neural networks (SICNNs) with continuously distributed delays and impulses. An example is given to illustrate the main results.
Keywords: Almost periodic solution, exponential stability, neural networks, impulses.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14322527 Preconditioned Jacobi Method for Fuzzy Linear Systems
Authors: Lina Yan, Shiheng Wang, Ke Wang
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A preconditioned Jacobi (PJ) method is provided for solving fuzzy linear systems whose coefficient matrices are crisp Mmatrices and the right-hand side columns are arbitrary fuzzy number vectors. The iterative algorithm is given for the preconditioned Jacobi method. The convergence is analyzed with convergence theorems. Numerical examples are given to illustrate the procedure and show the effectiveness and efficiency of the method.
Keywords: preconditioning, M-matrix, Jacobi method, fuzzy linear system (FLS).
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1894526 Characterization of Indoor Power Lines as Data Communication Channels Experimental Details and Results
Authors: Sheroz Khan, A. F. Salami, W. A. Lawal, AHM Zahirul Alam, Shihab Abdel Hameed, M. J. E.Salami
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In this paper, a multi-branch power line is modeled using ABCD matrix to show its worth as a communication channel. The model is simulated using MATLAB in an effort to investigate the effects of multiple loading, multipath, and those as a result of load mismatching. The channel transfer function is obtained and investigated using different cable lengths, and different number of bridge taps under given loading conditions.
Keywords: Power line Communication, Transfer Function, Channel Modeling, Signal Transmission.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1923525 Evaluation of Corrosion by Impedance Spectroscopy of Embedded Steel in an Alternative Concrete Exposed to the Chloride Ion
Authors: Erika J. Ruíz, Jairo R. Cortes, Willian A. Aperador
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In this article was evaluated the protective effect of the alternative concrete obtained from the binary mixture of fly ash, and iron and steel slag. After mixing the cement with aggregates, structural steel was inserted in the matrix cementitious. The study was conducted comparatively with specimens exposed to natural conditions free of chloride ion. The chloride ion effect on the specimens accelerated under controlled conditions (3.5% NaCl and 25°C temperature). The impedance data were acquired in a range of 1 mHz to 100 kHz.
Keywords: Alternative concrete, corrosion, alkaline activation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1408524 Weighted Harmonic Arnoldi Method for Large Interior Eigenproblems
Authors: Zhengsheng Wang, Jing Qi, Chuntao Liu, Yuanjun Li
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The harmonic Arnoldi method can be used to find interior eigenpairs of large matrices. However, it has been shown that this method may converge erratically and even may fail to do so. In this paper, we present a new method for computing interior eigenpairs of large nonsymmetric matrices, which is called weighted harmonic Arnoldi method. The implementation of the method has been tested by numerical examples, the results show that the method converges fast and works with high accuracy.
Keywords: Harmonic Arnoldi method, weighted harmonic Arnoldi method, eigenpair, interior eigenproblem, non symmetric matrix.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1539523 Mathematical Modeling of the Influence of Hydrothermal Processes in the Water Reservoir
Authors: Alibek Issakhov
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In this paper presents the mathematical model of hydrothermal processes in thermal power plant with different wind direction scenarios in the water reservoir, which is solved by the Navier - Stokes and temperature equations for an incompressible fluid in a stratified medium. Numerical algorithm based on the method of splitting by physical parameters. Three dimensional Poisson equation is solved with Fourier method by combination of tridiagonal matrix method (Thomas algorithm).Keywords: thermal power plant, hydrothermal process, large eddy simulation, water reservoir
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1634522 Affine Projection Algorithm with Variable Data-Reuse Factor
Authors: ChangWoo Lee, Young Kow Lee, Sung Jun Ban, SungHoo Choi, Sang Woo Kim
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This paper suggests a new Affine Projection (AP) algorithm with variable data-reuse factor using the condition number as a decision factor. To reduce computational burden, we adopt a recently reported technique which estimates the condition number of an input data matrix. Several simulations show that the new algorithm has better performance than that of the conventional AP algorithm.
Keywords: Affine projection algorithm, variable data-reuse factor, condition number, convergence rate, misalignment.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1533521 Using Fly Ash as a Reinforcement to Increase Wear Resistance of Pure Magnesium
Authors: E. Karakulak, R. Yamanoğlu, M. Zeren
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In the current study, fly ash obtained from a thermal power plant was used as reinforcement in pure magnesium. The composite materials with different fly ash contents were produced with powder metallurgical methods. Powder mixtures were sintered at 540oC under 30 MPa pressure for 15 minutes in a vacuum assisted hot press. Results showed that increasing ash content continuously increases hardness of the composite. On the other hand, minimum wear damage was obtained at 2 wt. % ash content. Addition of higher level of fly ash results with formation of cracks in the matrix and increases wear damage of the material.Keywords: Mg composite, fly ash, wear, powder metallurgy.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1389520 Delay-Dependent Stability Analysis for Neural Networks with Distributed Delays
Authors: Qingqing Wang, Shouming Zhong
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This paper deals with the problem of delay-dependent stability for neural networks with distributed delays. Some new sufficient condition are derived by constructing a novel Lyapunov-Krasovskii functional approach. The criteria are formulated in terms of a set of linear matrix inequalities, this is convenient for numerically checking the system stability using the powerful MATLAB LMI Toolbox. Moreover, in order to show the stability condition in this paper gives much less conservative results than those in the literature, numerical examples are considered.
Keywords: Neural networks, Globally asymptotic stability , LMI approach, Distributed delays.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1559519 Formulation and in vitro Evaluation of Ondansetron Hydrochloride Matrix Transdermal Systems Using Ethyl Cellulose/Polyvinyl Pyrrolidone Polymer Blends
Authors: Rajan Rajabalaya, Li-Qun Tor, Sheba David
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Transdermal delivery of ondansetron hydrochloride (OdHCl) can prevent the problems encountered with oral ondansetron. In previously conducted studies, effect of amount of polyvinyl pyrrolidone, permeation enhancer and casting solvent on the physicochemical properties on OdHCl were investigated. It is feasible to develop ondansetron transdermal patch by using ethyl cellulose and polyvinyl pyrrolidone with dibutyl pthalate as plasticizer, however, the desired flux is not achieved. The primary aim of this study is to use dimethyl succinate (DMS) and propylene glycol that are not incorporated in previous studies to determine their effect on the physicochemical properties of an OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone. This study also investigates the effect of permeation enhancer (eugenol and phosphatidylcholine) on the release of OdHCl. The results showed that propylene glycol is a more suitable plasticizer compared to DMS in the fabrication of OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone as polymers. Propylene glycol containing patch has optimum drug content, thickness, moisture content and water absorption, tensile strength, and a better release profile than DMS. Eugenol and phosphatidylcholine can increase release of OdHCl from the patches. From the physicochemical result and permeation profile, a combination of 350mg of ethyl cellulose, 150mg polyvinyl pyrrolidone, 3% of total polymer weight of eugenol, and 40% of total polymer weight of propylene glycol is the most suitable formulation to develop an OdHCl patch. OdHCl release did not increase with increasing the percentage of plasticiser. DMS 4, PG 4, DMS 9, PG 9, DMS 14, and PG 14 gave better release profiles where using 300mg: 0mg, 300mg: 100mg, and 350mg: 150mg of EC: PVP. Thus, 40% of PG or DMS appeared to be the optimum amount of plasticiser when the above combination where EC: PVP was used. It was concluded from the study that a patch formulation containing 350mg EC, 150mg PVP, 40% PG and 3% eugenol is the best transdermal matrix patch compositions for the uniform and continuous release/permeation of OdHCl over an extended period. This patch design can be used for further pharmacokinetic and pharmacodynamic studies in suitable animal models.
Keywords: Ondansetron hydrochloride, dimethyl succinate, eugenol.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2450518 Robust BIBO Stabilization Analysis for Discrete-time Uncertain System
Authors: Zixin Liu, Shu Lü, Shouming Zhong, Mao Ye
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The discrete-time uncertain system with time delay is investigated for bounded input bounded output (BIBO). By constructing an augmented Lyapunov function, three different sufficient conditions are established for BIBO stabilization. These conditions are expressed in the form of linear matrix inequalities (LMIs), whose feasibility can be easily checked by using Matlab LMI Toolbox. Two numerical examples are provided to demonstrate the effectiveness of the derived results.
Keywords: Robust BIBO stabilization, delay-dependent stabilization, discrete-time system, time delay.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1580