Search results for: equivalent dose

Authors: Kakali Bhadra

Abstract:

Harmalol administration caused remarkable reduction in proliferation of HepG₂ cells with GI₅₀ of 14.2 mM, without showing much cytotoxicity in embryonic liver cell line, WRL-68. Data from circular dichroism and differential scanning calorimetric analysis of harmalol-CT DNA complex shows conformational changes with prominent CD perturbation and stabilization of CT DNA by 8 ^oC. Binding constant and stoichiometry was also calculated using the above biophysical techniques. Further, dose dependent apoptotic induction ability of harmalol was studied in HepG₂ cells using different biochemical assays. Generation of ROS, DNA damage, changes in cellular external and ultramorphology, alteration of membrane, formation of comet tail, decreased mitochondrial membrane potential and a significant increase in Sub G_o/G₁ population made the cancer cell, HepG₂, prone to apoptosis. Up regulation of p53 and caspase 3 further indicated the apoptotic role of harmalol.

Keywords: Apoptosis, beta carboline alkaloid, comet assay, cytotoxicity, ROS.

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Authors: Václav Voltr, Jan Leština

Abstract:

The basis of examines is survey of 500 in the years 2002-2010, which was selected according to homogeneity of land cover and where 1090 revenues were evaluated. For achieved yields of winter wheat is obtained multicriterial regression function depending on the major factors influencing the consumption of nitrogen. The coefficient of discrimination of the established model is 0.722. The increase in efficiency of fertilization is involved in supply of organic nutrients, tillage, soil pH, past weather, the humus content in the subsoil and grain content to 0.001 mm. The decrease in efficiency was mainly influenced by the total dose of mineral nitrogen, although it was divided into multiple doses, the proportion loamy particles up to 0.01 mm, rainy, or conversely dry weather during the vegetation. The efficiency of nitrogen was found to be the smallest on undeveloped soils and the highest on chernozem and alluvial soils.

Keywords: Nitrogen efficiency, winter wheat, regression model

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Authors: Ahmad Seif, Karim Zare, Asadallah Boshra, Mehran Aghaie

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Density functional theory (DFT) calculations were performed to compute nitrogen-14 and boron-11 nuclear quadrupole resonance (NQR) spectroscopy parameters in the representative model of armchair boron nitride nanotube (BNNT) for the first time. The considered model consisting of 1 nm length of H-capped (5, 5) single-wall BNNT were first allowed to fully relax and then the NQR calculations were carried out on the geometrically optimized model. The evaluated nuclear quadrupole coupling constants and asymmetry parameters for the mentioned nuclei reveal that the model can be divided into seven layers of nuclei with an equivalent electrostatic environment where those nuclei at the ends of tubes have a very strong electrostatic environment compared to the other nuclei along the length of tubes. The calculations were performed via Gaussian 98 package of program.

Keywords: Armchair Nanotube, Density Functional Theory, Nuclear Quadrupole Resonance.

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Authors: Seow-Mun Hue, Amru Nasrulhaq Boyce, Chandran Somasundram

Abstract:

Ipomoea batatas (Sweetpotato) is currently ranked sixth in the total world food production and are planted mainly for their storage roots. The present study was undertaken to evaluate and compare the antioxidant properties of the leaf and carotenoids extract from the Ipomoea batatas var. Oren leaves. Total flavonoids in the leaf extract was 144.6 ± 40.5 μg/g compared to 114.86 ± 4.35 μg/g catechin equivalent in the carotenoids extract. Total polyphenols in the leaf extracts (3.470 ± 0.024 GAE g/100g DW) was slightly higher compared to carotenoids extract (2.994 ± 0.078 GAE g/100g DW). The carotenoids extract marked a higher radical scavenging capacity with the IC50= 491.86 μg/ml compared to leaf extract (IC50= 545.39 μg/ml). Concentration-dependent reducing activity was observed for both extracts. Thus, the carotenoids extraction process retained most of the antioxidant capacity from the leaves and can be made into potential natural yellow dye with antioxidant property.

Keywords: antioxidants, carotenoids extract, Ipomoea batatas, sweetpotato leaves

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Authors: Jafar Khan Kasi, Ajab Khan Kasi, Muzamil Bokhari

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Carbon nanotube is one of the most attractive materials for the potential applications of nanotechnology due to its excellent mechanical, thermal, electrical and optical properties. In this paper we report a supercapacitor made of nickel foil electrodes, coated with multiwall carbon nanotubes (MWCNTs) thin film using electrophoretic deposition (EPD) method. Chemical vapor deposition method was used for the growth of MWCNTs and ethanol was used as a hydrocarbon source. High graphitic multiwall carbon nanotube was found at 750oC analyzing by Raman spectroscopy. We observed the electrochemical performance of supercapacitor by cyclic voltammetry. The electrodes of supercapacitor fabricated from MWCNTs exhibit considerably small equivalent series resistance (ESR), and a high specific power density. Electrophoretic deposition is an easy method in fabricating MWCNT electrodes for high performance supercapacitor.

Keywords: Carbon nanotube, chemical vapor deposition, catalyst, charge, cyclic voltammetry.

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Authors: Mahdi Sadeghian, Mahmoud Hassanlourad, Alireza Ardakani, Reza Dinarvand

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In this research, the behavior of monopiles, under lateral loads, was investigated with vertical and oblique piles by Finite Element Method. In engineering practice when soil-pile interaction comes to the picture some simplifications are applied to reduce the design time. As a simplified replacement of soil and pile interaction analysis, pile could be replaced by a column. The height of the column would be equal to the free length of the pile plus a portion of the embedded length of it. One of the important factors studied in this study was that columns with an equivalent length (free length plus a part of buried depth) could be used instead of soil and pile modeling. The results of the analysis show that the more internal friction angle of the soil increases, the more the bearing capacity of the soil is achieved. This additional length is 6 to 11 times of the pile diameter in dense soil although in loose sandy soil this range might increase.

Keywords: Lateral bearing capacity, pile group, oblique pile, soil-structure interaction, depth of fixity.

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Authors: Rusudan Sujashvili, Ekaterine Bakuradze, Irina Modebadze, Davit Dekanoidze

Abstract:

Extracellular ubiquitin in vivo effect on regenerative liver cells and liver histoarchitectonics has been studied. Experiments were performed on mature female white rats. Partial hepatectomy was made using the modified method of Higgins and Anderson. Standard histopathological assessment of liver tissue was used. Proliferative activity of hepatocytes was analyzed by colchicine mitotic index and immunohistochemical staining on ki67. We have found that regardless of number of injections and dose of extracellular ubiquitin liver histology has not been changed, so at tissue level no effect was observed. In vivo double injection of ubiquitin significantly decreases the mitotic activity at 32 hour point after partial hepatectomy. Thus, we can conclude that in vivo injected extracellular ubiquitin inhibits proliferative activity of hepatocytes in partially hepatectomyzed rats.

Keywords: Liver, regeneration, proliferation, ubiquitin.

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Authors: K. Manikandan, T. Viruthagiri

Abstract:

Studies on Simultaneous Saccharification and Fermentation (SSF) of corn flour, a major agricultural product as the substrate using starch digesting glucoamylase enzyme derived from Aspergillus niger and non starch digesting and sugar fermenting Saccharomyces cerevisiae in a batch fermentation. Experiments based on Central Composite Design (CCD) were conducted to study the effect of substrate concentration, pH, temperature, enzyme concentration on Ethanol Concentration and the above parameters were optimized using Response Surface Methodology (RSM). The optimum values of substrate concentration, pH, temperature and enzyme concentration were found to be 160 g/l, 5.5, 30°C and 50 IU respectively. The effect of inoculums age on ethanol concentration was also investigated. The corn flour solution equivalent to 16% initial starch concentration gave the highest ethanol concentration of 63.04 g/l after 48 h of fermentation at optimum conditions of pH and temperature. Monod model and Logistic model were used for growth kinetics and Leudeking – Piret model was used for product formation kinetics.

Keywords: Simultaneous Saccharification and Fermentation(SSF), Corn Starch, Ethanol, Logisitic Model.

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Authors: Hugo Rodríguez

Abstract:

The patenting of inventions is the result of an organized effort to achieve technological improvement and its consequent positive impact on the population's standard of living. Technology exports, either of high-tech goods or of Information and Communication Technology (ICT) services, represent the level of acceptance that world markets have of that technology acquired or developed by a country, either in public or private settings. A quantitative measure of the above variables is expected to have a positive and relevant impact on the level of economic development of the countries, measured on this first occasion through their level of Gross Domestic Product (GDP). And in that sense, it not only explains the performance of an economy but the difference between nations. We present an econometric model where we seek to explain the difference between the GDP levels of 178 countries through their different performance in the outputs of the technological production process. We take the variables of Patenting, ICT Exports and High Technology Exports as results of the innovation process. This model achieves an explanatory power for four annual cuts (2000, 2005, 2010 and 2015) equivalent to an adjusted r2 of 0.91, 0.87, 0.91 and 0.96, respectively.

Keywords: Development, exports, patents, technology.

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Authors: Mohd Azman A. Nurul, Husni Shafik, Almajano P. Maria, Gallego G. Maria

Abstract:

The potential of using herbal Betula alba (BA) and Convolvulus arvensis (CA) as a natural antioxidant for food applications were investigated. Each plant extract was prepared by using pure ethanol, different concentration of ethanol aqueous solutions, including 50% and 75%, 50% methanol aqueous and water. Total phenolic content (TPC) was determined using Folin–Ciocalteau method and antioxidant activity were analyzed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals, trolox equivalent antioxidant capacity (TEAC), Oxygen radical absorbance capacity (ORAC) and ferric reducing antioxidant power (FRAP) respectively. Ethanol extract of CA exhibited the highest TPC and antioxidant activity; however BA showed varies of antioxidant activity value in each assay. The BA and CA exhibit the potential sources of natural antioxidant for food commodities.

Keywords: Solvent effect, Antioxidant activity, Betula Alba, Convolvulus arvensis, Total Phenolic Content.

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Authors: Nihit Madireddi, P. A. Mahanwar

Abstract:

We have aimed to produce a self-cleaning transparent polymer coating with polyurethane (PU) matrix as the latter is highly solvent, chemical and weather resistant having good mechanical properties. Nano-silica modified by 1H, 1H, 2H, 2Hperflurooctyltriethoxysilane was incorporated into the PU matrix for attaining self-cleaning ability through hydrophobicity. The modification was confirmed by particle size analysis and scanning electron microscopy (SEM). Thermo-gravimetric (TGA) studies were carried to ascertain the grafting of silane onto the silica. Several coating formulations were prepared by varying the silica loading content and compared to a commercial equivalent. The effect of dispersion and the morphology of the coated films were assessed by SEM analysis. All coating standardized tests like solvent resistance, adhesion, flexibility, acid, alkali, gloss etc. have been performed as per ASTM standards. Water contact angle studies were conducted to analyze the hydrophobic character of the coating. In addition, the coatings were also subjected to salt spray and accelerated weather testing to analyze the durability of the coating.

Keywords: FAS, nano-silica, PU clear coat, self-cleaning.

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Authors: A. Eman Mohammed

Abstract:

Algae-based fuel are considered a promising sources of clean energy, and because it has many advantages over traditional biofuel, research and business ventures have driven into developing and producing Algal-biofuel. But its production stages create a cost structure that it is not competitive with traditional fuels. Therefore, cost becomes the main obstacle in commercial production purpose. However, the present research which aims at using cost structure model, and designed MS-Dose program, to investigate the a mount of production cost and determined the parameter had great effect on it, second to measured the amount of contribution rate of algae in process the pollution by capturing Co2 from air . The result generated from the model shows that the production cost of biomass is between $0.137 /kg for 100 ha and $0.132 /kg for 500 ha which was less than cost of other studies, while gallon costs between $3.4 - 3.5, more than traditional sources of oil about $1 ,which regarded as a rate of contribution of algal in capturing CO2 from air.

Keywords: Cost Structure Model, Operation Costs(Production Cost), Capital Costs, Algae.

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Authors: K. E. McPHEE, A. Kahraman, M. Onder, E. Ceyhan, B. Tashtemirov

Abstract:

Water is the main component of biological processes. Water management is important to obtain higher productivity. In this study, some of the yield components were investigated together with different drought levels. Four chickpea genotypes (CDC Frontier, CDC Luna, Sawyer and Sierra) were grown in pots with 3 different irrigation levels (a dose of 17.5 ml, 35 ml and 70 ml for each pot per day) after three weeks from sowing. In the research, flowering, pod set, pod per plant, fertile pod, double seed/pod, stem diameter, plant weight, seed per plant, 1000 seed weight, seed diameter, vegetation length and weekly plant height were measured. Consequently, significant differences were observed on all the investigated characteristics owing to genotypes (except double seed/pod and stem diameter), water levels (except first pod, seed weight and height on 3rd week) and genotype x water level interaction (except first pod, double seed/pod, seed weight and height).

Keywords: Agronomical characteristics, Cicer arietinum, water levels.

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Authors: Mohd K. Yunus, Murni M. Ahmad, Abrar Inayat, Suzana Yusup

Abstract:

Due to the environmental and price issues of current energy crisis, scientists and technologists around the globe are intensively searching for new environmentally less-impact form of clean energy that will reduce the high dependency on fossil fuel. Particularly hydrogen can be produced from biomass via thermochemical processes including pyrolysis and gasification due to the economic advantage and can be further enhanced through in-situ carbon dioxide removal using calcium oxide. This work focuses on the synthesis and development of the flowsheet for the enhanced biomass gasification process in PETRONAS-s iCON process simulation software. This hydrogen prediction model is conducted at operating temperature between 600 to 1000oC at atmospheric pressure. Effects of temperature, steam-to-biomass ratio and adsorbent-to-biomass ratio were studied and 0.85 mol fraction of hydrogen is predicted in the product gas. Comparisons of the results are also made with experimental data from literature. The preliminary economic potential of developed system is RM 12.57 x 106 which equivalent to USD 3.77 x 106 annually shows economic viability of this process.

Keywords: Biomass, Gasification, Hydrogen, iCON.

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Authors: Amr A. Fouad, Waleed H. Albuali, Iyad Jresat

Abstract:

The protective effect of hesperidin was investigated in rats exposed to liver injury induced by a single intraperitoneal injection of cyclophosphamide (CYP) at a dose of 150 mg kg-1. Hesperidin treatment (100 mg kg-1/day, orally) was applied for seven days, starting five days before CYP administration. Hesperidin significantly decreased the CYP-induced elevations of serum alanine aminotransferase, and hepatic malondialdehyde and myeloperoxidase activity, significantly prevented the depletion of hepatic glutathione peroxidase activity resulted from CYP administration. Also, hesperidin ameliorated the CYP-induced liver tissue injury observed by histopathological examination. In addition, hesperidin decreased the CYP-induced expression of inducible nitric oxide synthase, tumor necrosis factor-α, cyclooxygenase-2, Fas ligand, and caspase-9 in liver tissue. It was concluded that hesperidin may represent a potential candidate to protect against CYP-induced hepatotoxicity.

Keywords: Cyclophosphamide, hesperidin, liver, rats.

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Authors: Bu Seog Ju, Woo Young Jung

Abstract:

A multi-panel PMC infilled system, using polymer matrix composite (PMC) material, was introduced as new conceptual design for seismic retrofitting. A proposed multi panel PMC infilled system was composed of two basic structural components: inner PMC sandwich infills and outer FRP damping panels. The PMC material had high stiffness-to-weight and strength-to-weight ratios. Therefore, the addition of PMC infill panels into existing structures would not significantly alter the weight of the structure, while providing substantial structural enhancement.

In this study, an equivalent linearized dynamic analysis for a proposed multi-panel PMC infilled frame was performed, in order to assess their effectiveness and their responses under the simulated earthquake loading. Upon comparing undamped (without PMC panel) and damped (with PMC panel) structures, numerical results showed that structural damping with passive interface damping layer could significantly enhance the seismic response.

Keywords: Polymer Matrix Composite (PMC), Panel, Piece-wise linear, Earthquake, FRP.

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Authors: Mohammad Rakibul Islam

Abstract:

In this paper, a Gaussian multiple input multiple output multiple eavesdropper (MIMOME) channel is considered where a transmitter communicates to a receiver in the presence of an eavesdropper. We present a technique for determining the secrecy capacity of the multiple input multiple output (MIMO) channel under Gaussian noise. We transform the degraded MIMOME channel into multiple single input multiple output (SIMO) Gaussian wire-tap channels and then use scalar approach to convert it into two equivalent multiple input single output (MISO) channels. The secrecy capacity model is then developed for the condition where the channel state information (CSI) for main channel only is known to the transmitter. The results show that the secret communication is possible when the eavesdropper channel noise is greater than a cutoff noise level. The outage probability is also analyzed of secrecy capacity is also analyzed. The effect of fading and outage probability is also analyzed.

Keywords: Secrecy capacity, MIMO, wiretap channel, covariance matrix, fading.

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Authors: Guohua Cao, Xu Dong

Abstract:

X-ray Fluorescence Molecular Imaging (XFMI) holds great promise as a low-cost molecular imaging modality for biomedical applications with high chemical sensitivity. However, for in vivo biomedical applications, a key technical bottleneck is the relatively low chemical sensitivity of XFMI, especially at a reasonably low radiation dose. In laboratory x-ray source based XFMI, one of the main factors that limits the chemical sensitivity of XFMI is the scattered x-rays. We will present our latest findings on improving the chemical sensitivity of XFMI using excitation beam spectrum optimization. XFMI imaging experiments on two mouse-sized phantoms were conducted at three different excitation beam spectra. Our results show that the minimum detectable concentration (MDC) of iodine can be readily increased by five times via excitation spectrum optimization. Findings from this investigation could find use for in vivo pre-clinical small-animal XFMI in the future.

Keywords: Molecular imaging, X-ray fluorescence, chemical sensitivity, X-ray scattering.

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Authors: N. H. Hamid, N. D. Hadi, K. D. Ghani

Abstract:

This paper presents the retrofitting of beam-column joint using CFRP (Carbon Fiber Reinforced Polymer) and steel plate. This specimen was tested until failure up to 1.0% drift. This joint suffered severe damages and diagonal cracks at upper crack at upper column before retrofitted. CFRP were wrapped at corbel, bottom and top of the column. Steel plates with bonding were attached to the two beams and the jointing system. This retrofitted specimen is tested again under lateral cyclic loading up 1.75% drift. Visual observations show that the cracks started at joint when 0.5% drift applied at top of column. Damage of retrofitted beam-column joint occurred inside the CFRP and it cannot be seen from outside. Analysis of elastic stiffness, lateral strength, ductility, hysteresis loops and equivalent viscous damping shows that these values are higher than before retrofitting. Therefore, it is recommended to use this type of retrofitting method for beam-column joint with corbel which suffers severe damage after the earthquake.

Keywords: Beam-Column joint, ductility, stiffness, retrofitting.

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Authors: Tzong Yuan Wu, Sheng Kuo Hsieh, Tzyy Rong Jinn

Abstract:

Fip-gts, an immunomodulatory protein purified from Ganoderma tsugae, has been reported to possess therapeutic effects in the treatment of cancer and autoimmune disease. For medicinal application, a recombinant Fip-gts was successfully expressed and purified in Sf21 insect cells by our previously work. It is important to evaluate the immunomodulatory activity of the rFip-gts. To assess the immunomodulatory potential of rFip-gts, the T lymphocytes of murine splenocytes were used in the present study. Results revealed that rFip-gts induced cellular aggregation formation. Additionally, the expression of IL-2 and IFN-r were up-regulated after the treatment of rFip-gts, and a corresponding increased production of IL-2 and IFN-r in a dose-dependent manner. The results showed that rFip-gts has an immunomodulatory activity in inducing Th1 lymphocytes from murine splenocytes released IL-2 and IFN-γ, thus suggest that rFip-gts may have therapeutic potential in vivo as an immune modulator.

Keywords: Fungal immunomodulatory protein, Ganodermatsugae, Interleukin 2, Interferon γ, Lingzhi.

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Authors: K. M. Aldossari, W. A. Elsaigh, M. J. Shannag

Abstract:

An experimental study was conducted to investigate the effect of hooked-end steel fibers on the flexural behavior of normal and high strength concrete matrices. The fibers content appropriate for the concrete matrices investigated was also determined based on flexural tests on standard prisms. Parameters investigated include: matrix compressive strength ranging from 45 MPa to 70 MPa, corresponding to normal and high strength concrete matrices respectively; fibers volume fraction including 0, 0.5%, 0.76% and 1%, equivalent to 0, 40, 60, and 80 kg/m³ of hooked-end steel fibers respectively. Test results indicated that flexural strength and toughness of normal and high strength concrete matrices were significantly improved with the increase in the fibers content added; whereas a slight improvement in compressive strength was observed for the same matrices. Furthermore, the test results indicated that the effect of increasing the fibers content was more pronounced on increasing the flexural strength of high strength concrete than that of normal concrete.

Keywords: Concrete, flexural strength, toughness, steel fibers.

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Authors: Lei Yao, Jia Hao Cheong, Rui-Feng Xue, Minkyu Je

Abstract:

A closed-loop controlled wireless power transmission circuit block for implantable biomedical applications is described in this paper. The circuit consists of one front-end rectifier, power management sub-block including bandgap reference and low drop-out regulators (LDOs) as well as transmission power detection / feedback circuits. Simulation result shows that the front-end rectifier achieves 80% power efficiency with 750-mV single-end peak-to-peak input voltage and 1.28-V output voltage under load current of 4 mA. The power management block can supply 1.8mA average load current under 1V consuming only 12μW power, which is equivalent to 99.3% power efficiency. The wireless power transmission block described in this paper achieves a maximum power efficiency of 80%. The wireless power transmission circuit block is designed and implemented using UMC 65-nm CMOS/RF process. It occupies 1 mm × 1.2 mm silicon area.

Keywords: Implantable biomedical devices, wireless power transfer, LDO, rectifier, closed-loop power control

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Authors: Seyed Abolhasan Naeini, Saeideh Mohammadi

Abstract:

Site response has a profound effect on earthquake damages. Seismic interaction of urban tunnels with surface structures could also affect seismic site response. Here, we use FLAC 2D to investigate the interaction of a single tunnel and twin tunnels-surface structures on the site response. Soil stratification and properties are selected based on Line. No 7 of the Tehran subway. The effect of surface structure is considered in two ways: Equivalent surcharge and geometrical modeling of the structure. Comparison of the results shows that consideration of the structure geometry is vital in dynamic analysis and leads to the changes in the magnitude of displacements, accelerations and response spectrum. Therefore it is necessary for the surface structures to be wholly modeled and not just considered as a surcharge in dynamic analysis. The use of twin tunnel also leads to the reduction of dynamic residual settlement.

Keywords: Superstructure, tunnel, site response, surcharge, interaction.

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Authors: Victor A. Naumenko, Yuriy A. Tyulenev, Alla A. Kushch

Abstract:

The objective of current issue was to develop a model of testicular herpes simplex virus (HSV) type I infection for assessment of viral effect on fertility. 56 male mice were inoculated intraperitoneally with different concentrations of HSV on 8 day post partum. It was revealed that the optimal dose was 100 plaque forming units per mice as it provided testicular infection in 100% of survivors. HSV proteins were detected both in somatic and germ cells (spermatogonia, spermatocytes, spermatides). Although DNA load in testis was descending from 3 to 28 days post infection only 12.5% of infected males had offspring after mating with uninfected females comparing to 87.5% in control (p=0.012). These results are the first direct evidence for HSV impact in male sterility. Prepuberal mice appeared to be a suitable model for investigation of pathogenesis of virus-associated fertility disorders.

Keywords: Herpes simplex virus type I, male fertility, prepuberal mice, spermatogenesis.

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Authors: Hyung-Jin Jang, Kwang-Bok Shin, Sung-Ho Han

Abstract:

This paper describes the crashworthiness assessment and improvement of tlting train made of sandwich composites. The crashworhiness assessment of tilting train was conducted according to four collision scenarios of the Korean railway safety law. Collision analysis was carried out using explicit finite element analysis code LS-DYNA 3D. The finite element model consists of 3-D finite element model and 1-D equivalent model to save the finite element modeling and calculation time. It found that the crashworthiness analysis results were satisfied with the performance requirements except the crash scenario-2. In order to meet the crashworthiness requirements for crash scenario-2, the stiffness reinforcement for the laminate composite cover and metal frames of cabmask structure were proposed. Consequentially, it has satisfied the requirement for crash scenario-2.

Keywords: Crashworthiness, collision scenario, Korean railway safety law, sandwich composite, tilting train.

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Authors: Yashar Haghighatfar, Shahrzad Mirhosseini

Abstract:

Pull-in instability is a nonlinear and crucial effect that is important for the design of microelectromechanical system devices. In this paper, the appropriate electrostatic voltage range is determined by measuring fluid flow pressure via micro pressure sensor based microbeam. The microbeam deflection contains two parts, the static and perturbation deflection of static. The second order equation regarding the equivalent stiffness, mass and damping matrices based on Galerkin method is introduced to predict pull-in instability due to the external voltage. Also the reduced order method is used for solving the second order nonlinear equation of motion. Furthermore, in the present study, the micro capacitive pressure sensor is designed for measuring special fluid flow pressure range. The results show that the measurable pressure range can be optimized, regarding damping field and external voltage.

Keywords: MEMS, pull-in instability, electrostatically actuated microbeam, reduced order method.

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Authors: O. Benaziz, A. Dorbane, S. Djeraba

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The objective of this work is to formulate a dry dispersible form of furosemide in the context of pediatric dose adjustment. To achieve this, we have produced a set of formulas that will be tested in process and after compression. The formula with the best results will be improved to optimize the final shape of the product. Furosemide is the most widely used pediatric diuretic because of its low toxicity. The manufacturing process was chosen taking into account all the data relating to the active ingredient and the excipients used and complying with the specifications and requirements of dispersible tablets. The process used to prepare these tablets was wet granulation. Different excipients were used: lactose, maize starch, magnesium stearate and two superdisintegrants. The mode of incorporation of super-disintegrant changes with each formula. The use of super-disintegrant in the formula allowed optimization of the disintegration time. Prepared tablets were evaluated for weight, content uniformity, hardness, disintegration time, friability and in vitro dissolution test. 

Keywords: Formulation, dispersible tablets, wet granulation, superdisintegrants, disintegration.

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Authors: Behzad Moeini Sam, Sara Mohammadi Avandi

Abstract:

Ancient scribes usually wrote an Akkadian word in Akkadian, spelling it out syllable by syllable. Sometimes, however, they wrote down the equivalent word in Sumerian for the Akkadians held Sumerian culture, from which they had inherited the cuneiform script, in high esteem. ‘Syllabic’ vs. ‘Sumerographic’ are the two forms of cuneiform writing. The Assyrian language was a branch of the Akkadian one that used the script and language of Aramaic throughout the whole of the empire. It caused the Aramaic language to apply as an Interlingua until the following periods. This paper aims to compare Sumerograms in Akkadian texts and Arameograms in Middle Persian texts to find a continuous written system that continued to apply from Akkadian to the Middle Persian. It will firstly introduce Sumerograms which are the earliest Akkadian texts, and will finally explain the Aramaic language, which continues its use by the Parthians and Sasanians as Arameograms. Thus, the main conclusion to be drawn is that just as the Akkadians who applied Sumerograms, Parthian and Pahlavi (including the inscriptions and the Psalter), too, employed a large number of, and more or less faithfully rendered, Aramaic words, also called Arameograms.

Keywords: Sumerogram, Mesopotamian, Akkadian. Aramaic, Middle Persian.

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Authors: Athirah Nur Amirulhusni, Navindra Kumari Palanisamy, Zaini Mohd-Zain, Liew Jian Ping, R.Durairaj

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Multidrug resistant organisms have been taunting the medical world for the last few decades. Even with new antibiotics developed, resistant strains have emerged soon after. With the advancement of nanotechnology, we investigated colloidal silver nanoparticles for its antimicrobial activity against Pseudomonas aeruginosa. This organism is a multidrug resistant which contributes to the high morbidity and mortality in immunocompromised patients. Five multidrug resistant strains were used in this study. The antimicrobial effect was studied using the disc diffusion and broth dilution techniques. An inhibition zone of 11 mm was observed with 10 μg dose of the nanoparticles. The nanoparticles exhibited MIC of 50 μg/ml when added at the lag phase and the subinhibitory concentration was measured as 100 μg/ml. The MIC50 value showed to be 15 μg/ml. This study suggests that silver nanoparticles can be further developed as an antimicrobial agent, hence decreasing the burden of the multidrug resistance phenomena.

Keywords: Antimirobial activity, Multidrug resistance, Pseudomonas aeruginosa, Silver nanoparticles

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Authors: Mohammad Ali Zazouli, Farzaneh Veisi, Amir Veisi

Abstract:

Bisphenol A (BPA) is an organic synthetic compound that has many applications in various industries and is known as persistent pollutant. The aim of this research was to evaluate the efficiency of bone ash and banana peel as adsorbents for BPA adsorption from aqueous solution by using Response Surface Methodology. The effects of some variables such as sorbent dose, detention time, solution pH, and BPA concentration on the sorption efficiency was examined. All analyses were carried out according to Standard Methods. The sample size was performed using Box-Benken design and also optimization of BPA removal was done using response surface methodology (RSM). The results showed that the BPA adsorption increases with increasing of contact time and BPA concentration. However, it decreases with higher pH. More adsorption efficiency of a banana peel is very smaller than a bone ash so that BPA removal for bone ash and banana peel is 62 and 28 percent, respectively. It is concluded that a bone ash has a good ability for the BPA adsorption.

Keywords: Adsorbent, banana peel, bisphenol A (BPA), bone ash, wastewater treatment.

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