@article{(Open Science Index):https://publications.waset.org/pdf/1938, title = {Herpes Simplex Virus Type I Infection of Mice Testis and Effect on Fertility}, author = {Victor A. Naumenko and Yuriy A. Tyulenev and Alla A. Kushch}, country = {}, institution = {}, abstract = {The objective of current issue was to develop a model of testicular herpes simplex virus (HSV) type I infection for assessment of viral effect on fertility. 56 male mice were inoculated intraperitoneally with different concentrations of HSV on 8 day post partum. It was revealed that the optimal dose was 100 plaque forming units per mice as it provided testicular infection in 100% of survivors. HSV proteins were detected both in somatic and germ cells (spermatogonia, spermatocytes, spermatides). Although DNA load in testis was descending from 3 to 28 days post infection only 12.5% of infected males had offspring after mating with uninfected females comparing to 87.5% in control (p=0.012). These results are the first direct evidence for HSV impact in male sterility. Prepuberal mice appeared to be a suitable model for investigation of pathogenesis of virus-associated fertility disorders.}, journal = {International Journal of Medical and Health Sciences}, volume = {6}, number = {12}, year = {2012}, pages = {703 - 706}, ee = {https://publications.waset.org/pdf/1938}, url = {https://publications.waset.org/vol/72}, bibsource = {https://publications.waset.org/}, issn = {eISSN: 1307-6892}, publisher = {World Academy of Science, Engineering and Technology}, index = {Open Science Index 72, 2012}, }