@article{(Open Science Index):https://publications.waset.org/pdf/9998864,
	  title     = {Protective Effect of Hesperidin against Cyclophosphamide Hepatotoxicity in Rats},
	  author    = {Amr A. Fouad and  Waleed H. Albuali and  Iyad Jresat},
	  country	= {},
	  institution	= {},
	  abstract     = {The protective effect of hesperidin was investigated in
rats exposed to liver injury induced by a single intraperitoneal
injection of cyclophosphamide (CYP) at a dose of 150 mg kg-1.
Hesperidin treatment (100 mg kg-1/day, orally) was applied for seven
days, starting five days before CYP administration. Hesperidin
significantly decreased the CYP-induced elevations of serum alanine
aminotransferase, and hepatic malondialdehyde and myeloperoxidase
activity, significantly prevented the depletion of hepatic glutathione
peroxidase activity resulted from CYP administration. Also,
hesperidin ameliorated the CYP-induced liver tissue injury observed
by histopathological examination. In addition, hesperidin decreased
the CYP-induced expression of inducible nitric oxide synthase, tumor
necrosis factor-α, cyclooxygenase-2, Fas ligand, and caspase-9 in
liver tissue. It was concluded that hesperidin may represent a
potential candidate to protect against CYP-induced hepatotoxicity.
},
	    journal   = {International Journal of Bioengineering and Life Sciences},
	  volume    = {8},
	  number    = {7},
	  year      = {2014},
	  pages     = {730 - 733},
	  ee        = {https://publications.waset.org/pdf/9998864},
	  url   	= {https://publications.waset.org/vol/91},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 91, 2014},
	}