@article{(Open Science Index):https://publications.waset.org/pdf/6918,
	  title     = {Evaluation of the Immunoregulatory Activity of rFip-gts Purified from Baculovirus-infected Insect Cells},
	  author    = {Tzong Yuan Wu and  Sheng Kuo Hsieh and  Tzyy Rong Jinn},
	  country	= {},
	  institution	= {},
	  abstract     = {Fip-gts, an immunomodulatory protein purified from Ganoderma tsugae, has been reported to possess therapeutic effects in the treatment of cancer and autoimmune disease. For medicinal application, a recombinant Fip-gts was successfully expressed and purified in Sf21 insect cells by our previously work. It is important to evaluate the immunomodulatory activity of the rFip-gts. To assess the immunomodulatory potential of rFip-gts, the T lymphocytes of murine splenocytes were used in the present study. Results revealed that rFip-gts induced cellular aggregation formation. Additionally, the expression of IL-2 and IFN-r were up-regulated after the treatment of rFip-gts, and a corresponding increased production of IL-2 and IFN-r in a dose-dependent manner. The results showed that rFip-gts has an immunomodulatory activity in inducing Th1 lymphocytes from murine splenocytes released IL-2 and IFN-γ, thus suggest that rFip-gts may have therapeutic potential in vivo as an immune modulator.
},
	    journal   = {International Journal of Medical and Health Sciences},
	  volume    = {4},
	  number    = {5},
	  year      = {2010},
	  pages     = {205 - 207},
	  ee        = {https://publications.waset.org/pdf/6918},
	  url   	= {https://publications.waset.org/vol/41},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 41, 2010},
	}