Search results for: resource recovery from water
2924 Optimization of the Flexural Strength of Biocomposites Samples Reinforced with Resin for Engineering Applications
Authors: Stephen Akong Takim
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This study focused on the optimization of the flexural strength of bio-composite samples of palm kernel, whelks, clams, periwinkles shells and bamboo fiber reinforced with resin for engineering applications. The aim of the study was to formulate different samples of bio-composite reinforced with resin for engineering applications and to evaluate the flexural strength of the fabricated composite. The hand lay-up technique was used for the composites produced by incorporating different percentage compositions of the shells/fiber (10%, 15%, 20%, 25% and 30%) into varied proportions of epoxy resin and catalyst. The cured samples, after 24 hours, were subjected to tensile, impact, flexural and water absorption tests. The experiments were conducted using the Taguchi optimization method L25 (5x5) with five design parameters and five level combinations in Minitab 18 statistical software. The results showed that the average value of flexural was 114.87MPa when compared to the unreinforced 72.33MPa bio-composite. The study recommended that agricultural waste, like palm kernel shells, whelk shells, clams, periwinkle shells and bamboo fiber, should be converted into important engineering applications.Keywords: bio-composite, resin, palm kernel shells, welk shells, periwinkle shells, bamboo fiber, Taguchi techniques and engineering application
Procedia PDF Downloads 762923 Formulation Design and Optimization of Orodispersible Tablets of Diphenhydramine Hydrochloride Having Adequate Mechanical Strength
Authors: Jiwan P. Lavande, A. V. Chandewar
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In the present study, orodispersible tablets of diphenhydramine hydrochloride were prepared using croscarmellose sodium, crospovidone and camphor, menthol (as subliming agents) in different ratios and ODTs prepared with superdisintegrants were compared with ODTs prepared with camphor and menthol (subliming agents) for the following evaluation of in vitro disintegration time, dispersion time, wetting time, hardness and water absorption ratio. Results revealed that the tablets of all formulations have acceptable physical parameters. The drug and excipients compatibility study was evaluated using FTIR technique and has not detected any incompatibility. The in vitro release of drug from DC6 formulation was quick when compared to other formulations. Stability study was carried out as per ICH guidelines for three months and results revealed that upon storage disintegration time of tablets had not shown any significant difference. Microscopic study of different formulations of sublimed tablets showed formation of pores for the tablets prepared by sublimation method. Thus, conclusion can be made that the stable orodispersible tablets of diphenhydramine hydrochloride can be developed for the rapid release of diphenhydramine hydrochloride.Keywords: orodispersible tablet, subliming agent, super disintegrants, diphenhydramine hydrochloride
Procedia PDF Downloads 2352922 Teaching Continuities in the Great Books Tradition and Contemporary Popular Culture
Authors: Alex Kizuk
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This paper studies the trope or meme of the Siren in terms of what long-standing cultural continuities can be found in college classrooms today. Those who have raised children may remember reading from Hans Christian Anderson's 'The Little Mermaid' (1836), not to mention regaling them with colorful Disneyesque versions when they were younger. Though Anderson tempered the darker first ending of the story to give the little mermaid more agency in her salvation—a prognostic developed in Disney adaptations—nonetheless, the tale pivots on an image of a 'heavenly realm' that the mermaid may eventually come to know or comprehend as a beloved woman on dry land. Only after 300 years, however, may she hope to see that 'which lives forever' and 'rises through thin air, up to the shining stars. Just as [sea-people] rise through the water to see the lands on earth.' What students today can see in this example is a trope of the agonistic soul in a hard-won disembarkation at a harbour of knowledge--where the seeker after truth may come to know through persistence (300 years)—all that is good and true concerning human life. This paper discusses several such examples from the Great Books and popular culture to suggest that teaching in the world of the 21st century could do worse than accede to some such perennial seeking.Keywords: the Great Books, tradition, popular culture, 21st century directions in teaching
Procedia PDF Downloads 1572921 Gender Policies and Political Culture: An Examination of the Canadian Context
Authors: Chantal Maille
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This paper is about gender-based analysis plus (GBA+), an intersectional gender policy used in Canada to assess the impact of policies and programs for men and women from different origins. It looks at Canada’s political culture to explain the nature of its gender policies. GBA+ is defined as an analysis method that makes it possible to assess the eventual effects of policies, programs, services, and other initiatives on women and men of different backgrounds because it takes account of gender and other identity factors. The ‘plus’ in the name serves to emphasize that GBA+ goes beyond gender to include an examination of a wide range of other related identity factors, such as age, education, language, geography, culture, and income. The point of departure for GBA+ is that women and men are not homogeneous populations and gender is never the only factor in defining a person’s identity; rather, it interacts with factors such as ethnic origin, age, disabilities, where the person lives, and other aspects of individual and social identity. GBA+ takes account of these factors and thus challenges notions of similarity or homogeneity within populations of women and men. Comparative analysis based on sex and gender may serve as a gateway to studying a given question, but women, men, girls, and boys do not form homogeneous populations. In the 1990s, intersectionality emerged as a new feminist framework. The popularity of the notion of intersectionality corresponds to a time when, in hindsight, the damage done to minoritized groups by state disengagement policies in concert with global intensification of neoliberalism, and vice versa, can be measured. Although GBA+ constitutes a form of intersectionalization of GBA, it must be understood that the two frameworks do not spring from a similar logic. Intersectionality first emerged as a dynamic analysis of differences between women that was oriented toward change and social justice, whereas GBA is a technique developed by state feminists in a context of analyzing governmental policies and aiming to promote equality between men and women. It can nevertheless be assumed that there might be interest in such a policy and program analysis grid that is decentred from gender and offers enough flexibility to take account of a group of inequalities. In terms of methodology, the research is supported by a qualitative analysis of governmental documents about GBA+ in Canada. Research findings identify links between Canadian gender policies and its political culture. In Canada, diversity has been taken into account as an element at the basis of gendered analysis of public policies since 1995. The GBA+ adopted by the government of Canada conveys an opening to intersectionality and a sensitivity to multiculturalism. The Canadian Multiculturalism Act, adopted 1988, proposes to recognize the fact that multiculturalism is a fundamental characteristic of the Canadian identity and heritage and constitutes an invaluable resource for the future of the country. In conclusion, Canada’s distinct political culture can be associated with the specific nature of its gender policies.Keywords: Canada, gender-based analysis, gender policies, political culture
Procedia PDF Downloads 2222920 Gasification of Trans-4-Hydroxycinnamic Acid with Ethanol at Elevated Temperatures
Authors: Shyh-Ming Chern, Wei-Ling Lin
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Lignin is a major constituent of woody biomass, and exists abundantly in nature. It is the major byproducts from the paper industry and bioethanol production processes. The byproducts are mainly used for low-valued applications. Instead, lignin can be converted into higher-valued gaseous fuel, thereby helping to curtail the ever-growing price of oil and to slow down the trend of global warming. Although biochemical treatment is capable of converting cellulose into liquid ethanol fuel, it cannot be applied to the conversion of lignin. Alternatively, it is possible to convert lignin into gaseous fuel thermochemically. In the present work, trans-4-hydroxycinnamic acid, a model compound for lignin, which closely resembles the basic building blocks of lignin, is gasified in an autoclave with ethanol at elevated temperatures and pressures, that are above the critical point of ethanol. Ethanol, instead of water, is chosen, because ethanol dissolves trans-4-hydroxycinnamic acid easily and helps to convert it into lighter gaseous species relatively well. The major operating parameters for the gasification reaction include temperature (673-873 K), reaction pressure (5-25 MPa) and feed concentration (0.05-0.3 M). Generally, more than 80% of the reactant, including trans-4-hydroxycinnamic acid and ethanol, were converted into gaseous products at an operating condition of 873 K and 5 MPa.Keywords: ethanol, gasification, lignin, supercritical
Procedia PDF Downloads 2392919 Bi-objective Network Optimization in Disaster Relief Logistics
Authors: Katharina Eberhardt, Florian Klaus Kaiser, Frank Schultmann
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Last-mile distribution is one of the most critical parts of a disaster relief operation. Various uncertainties, such as infrastructure conditions, resource availability, and fluctuating beneficiary demand, render last-mile distribution challenging in disaster relief operations. The need to balance critical performance criteria like response time, meeting demand and cost-effectiveness further complicates the task. The occurrence of disasters cannot be controlled, and the magnitude is often challenging to assess. In summary, these uncertainties create a need for additional flexibility, agility, and preparedness in logistics operations. As a result, strategic planning and efficient network design are critical for an effective and efficient response. Furthermore, the increasing frequency of disasters and the rising cost of logistical operations amplify the need to provide robust and resilient solutions in this area. Therefore, we formulate a scenario-based bi-objective optimization model that integrates pre-positioning, allocation, and distribution of relief supplies extending the general form of a covering location problem. The proposed model aims to minimize underlying logistics costs while maximizing demand coverage. Using a set of disruption scenarios, the model allows decision-makers to identify optimal network solutions to address the risk of disruptions. We provide an empirical case study of the public authorities’ emergency food storage strategy in Germany to illustrate the potential applicability of the model and provide implications for decision-makers in a real-world setting. Also, we conduct a sensitivity analysis focusing on the impact of varying stockpile capacities, single-site outages, and limited transportation capacities on the objective value. The results show that the stockpiling strategy needs to be consistent with the optimal number of depots and inventory based on minimizing costs and maximizing demand satisfaction. The strategy has the potential for optimization, as network coverage is insufficient and relies on very high transportation and personnel capacity levels. As such, the model provides decision support for public authorities to determine an efficient stockpiling strategy and distribution network and provides recommendations for increased resilience. However, certain factors have yet to be considered in this study and should be addressed in future works, such as additional network constraints and heuristic algorithms.Keywords: humanitarian logistics, bi-objective optimization, pre-positioning, last mile distribution, decision support, disaster relief networks
Procedia PDF Downloads 792918 Comparison of Growth and Biomass of Red Alga Cultured on Rope and Net
Authors: Esmaeil Kouhgardi, Saeedeh Dashti, Hakimeh Fekrandish
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This research has been conducted to study the method of culture and comparing growth and biomass of Gracilariacorticata cultured on rope and net for 50 days through two treatments (first treatment: culture of alga on net and the second treatment: culture of alga on rope and each treatment was repeated by four cases). During culture period, the water of aquariums was replaced once every two days for 40-50%. Also, 0.3-0.5 grams of Urea fertilizer was added to the culture environment for fertilization. Moreover, some of the environmental factors such as pH, salinity and temperature of the environment were measured on a daily basis. During the culture period, extent of longitudinal growth of the species of both treatments was equal. The said length was reached from 8-10 cm to 10.5-13 cm accordingly. The resulted weight in repetitions of the first treatment was higher than that of the second treatment in such a way as in the first treatment, its weight reached from 10 grams to 21.119 grams and in the second treatment, its weight reached from 10 grams to 17.663 grams. On a whole, it may be stated that that kind of alga being studied has a considerable growth with respect to its volume. The results have revealed that the percentage of daily growth and wet weight at the end of the first treatment was higher than that of the second treatment and it was registered as 0.934, 6.072 and 811.432 in the first treatment and 0.797, 4.990 and 758.071 in the second treatment respectively. This difference is significant (P < 0.05). Growth and biomass of G. corticata through culture on net was more emphasizing on numerous branches due to wider bed. Moreover, higher level of the species in this method was exposed to sunlight and this increased biosynthesis and eventually increases of growth and biomass.Keywords: red alga, growth, biomass, culture, net, rope
Procedia PDF Downloads 4372917 Central Solar Tower Model
Authors: Elmo Thiago Lins Cöuras Ford, Valentina Alessandra Carvalho do Vale
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It is presented a model of two subsystems of Central Solar Tower to produce steam in applications to help in energy consumption. The first subsystem consists of 24 heliostats constructed of adaptive and mobile metal structures to track the apparent movement of the sun on its focus and covered by 96 layers of mirror of 150 mm at width and 220 mm at length, totaling an area of concentration of 3.2 m². Thereby obtaining optical parameters essential to reflection of sunlight by the reflector surface and absorption of this light by focus located in the light receiver, which is inserted in the second subsystem, which is at the top of a tower. The tower was built in galvanized iron able to support the absorber, and a gas cylinder to cool the equipment. The area illuminated by the sun was 9 x 10-2m2, yielding a concentration factor of 35.22. It will be shown the processes of manufacture and assembly of the Mini-Central Tower proposal, which has as main characteristics the construction and assembly facilities, in addition to reduced cost. Data of tests to produce water vapor parameters are presented and determined to diagnose the efficiency of the mini-solar central tower. It will be demonstrated the thermal, economic and material viability of the proposed system.Keywords: solar oven, solar cooker, composite material, low cost, sustainable development
Procedia PDF Downloads 4172916 Study of Heat Exchangers in Small Modular Reactors
Authors: Harish Aryal, Roger Hague, Daniel Sotelo, Felipe Astete Salinas
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This paper presents a comparative study of different coolants, materials, and temperatures that can affect the effectiveness of heat exchangers that are used in small modular reactors. The corrugated plate heat exchangers were chosen out of different plate options for testing purposes because of their ease of access and better performance than other existing heat exchangers in recent years. SolidWorks enables us to see various results between water coolants and helium coolants acting upon different types of conducting metals, which were selected from different fluids that ultimately satisfied accessibility requirements and were compatible with the software. Though not every element, material, fluid, or method was used in the testing phase, their purpose is to help further research that is to come since the innovation of nuclear power is the future. The tests that were performed are to help better understand the constant necessities that are seen in heat exchangers and through every adjustment see what the breaking points or improvements in the machine are. Depending on consumers and researchers, the results may give further feedback as to show why different types of materials and fluids would be preferred and why it is necessary to keep failures to improve future research.Keywords: heat exchangers, Solidworks, coolants, small modular reactors, nuclear power, nanofluids, Nusselt number, friction factor, Reynolds number
Procedia PDF Downloads 722915 Economic Impact and Benefits of Integrating Augmented Reality Technology in the Healthcare Industry: A Systematic Review
Authors: Brenda Thean I. Lim, Safurah Jaafar
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Augmented reality (AR) in the healthcare industry has been gaining popularity in recent years, principally in areas of medical education, patient care and digital health solutions. One of the drivers in deciding to invest in AR technology is the potential economic benefits it could bring for patients and healthcare providers, including the pharmaceutical and medical technology sectors. Works of literature have shown that the benefits and impact of AR technologies have left trails of achievements in improving medical education and patient health outcomes. However, little has been published on the economic impact of AR in healthcare, a very resource-intensive industry. This systematic review was performed on studies focused on the benefits and impact of AR in healthcare to appraise if they meet the founded quality criteria so as to identify relevant publications for an in-depth analysis of the economic impact assessment. The literature search was conducted using multiple databases such as PubMed, Cochrane, Science Direct and Nature. Inclusion criteria include research papers on AR implementation in healthcare, from education to diagnosis and treatment. Only papers written in English language were selected. Studies on AR prototypes were excluded. Although there were many articles that have addressed the benefits of AR in the healthcare industry in the area of medical education, treatment and diagnosis and dental medicine, there were very few publications that identified the specific economic impact of technology within the healthcare industry. There were 13 publications included in the analysis based on the inclusion criteria. Out of the 13 studies, none comprised a systematically comprehensive cost impact evaluation. An outline of the cost-effectiveness and cost-benefit framework was made based on an AR article from another industry as a reference. This systematic review found that while the advancements of AR technology is growing rapidly and industries are starting to adopt them into respective sectors, the technology and its advancements in healthcare were still in their early stages. There are still plenty of room for further advancements and integration of AR into different sectors within the healthcare industry. Future studies will require more comprehensive economic analyses and costing evaluations to enable economic decisions for or against implementing AR technology in healthcare. This systematic review concluded that the current literature lacked detailed examination and conduct of economic impact and benefit analyses. Recommendations for future research would be to include details of the initial investment and operational costs for the AR infrastructure in healthcare settings while comparing the intervention to its conventional counterparts or alternatives so as to provide a comprehensive comparison on impact, benefit and cost differences.Keywords: augmented reality, benefit, economic impact, healthcare, patient care
Procedia PDF Downloads 2072914 Spatial Variation of Trace Elements in Suspended Sediments from Urban River
Authors: Daniel Macedo Neto, Sandro Froehner, Juan Sanez
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Suspended sediments (SS) are an environmental constituent able to represent the effects of land use changes on watersheds. One important consideration of land use change is its implication on trace element loading. Water bodies have the capacity to retain trace elements. Spatial variation in trace elements concentrations can be associated with land occupation and sources of pollution. In this work, the spatial variation of trace elements in suspended sediments from an urban river was assessed. Time-integrated fluvial suspended sediment samples were installed in three different sites of Barigui River. The suspend solids were collected every 30 days, from May 2015 to August 2015 (total samples 12). Site P1 covers 44 km2 drainage area and has low land occupation, whilst P2 cover an area of 87 km2 and it is totally urban as P3, which area is higher than 130 km2. Trace elements (As, Cd, Cr, P, Pb and Zn) were analysed by ICP-ES. All elements analyzed showed a similar pattern, i.e., the concentration raise with the urbanization, exception for As (P1=7.75; P2=5.75; P3=5.60mg/kg). There was increase in concentration for Cd (P1=0.75; P2=0.78; P3=1.45mg/kg), Cr (P1=59.50; P2=101.75; P3=102.00 mg/kg), Zn (P1=142.25; P2=152.50; P3=223.00mg/kg), P (P1=937.50; P2=1,545.00; P3=2,355.00 mg/kg) and for Pb (P1=31.25; P2=32.75; P3=39.17±2.56 mg/kg). The variation in concentrations were as follow -27.74% (As), +93.33% (Cd), +71.43% (Cr), +151.20% (P), +25.33% (Pb) e +56.77% (Zn). Cd, Cr, P, Pb and Zn presented a clear trend of increasing the concentration from upstream to downstream. Such variation is more notorious for P, Cd and Cr, possibly due the urbanization.Keywords: trace elements, erosion, urbanization, suspended sediments
Procedia PDF Downloads 3142913 Prediction Compressive Strength of Self-Compacting Concrete Containing Fly Ash Using Fuzzy Logic Inference System
Authors: Belalia Douma Omar, Bakhta Boukhatem, Mohamed Ghrici
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Self-compacting concrete (SCC) developed in Japan in the late 80s has enabled the construction industry to reduce demand on the resources, improve the work condition and also reduce the impact of environment by elimination of the need for compaction. Fuzzy logic (FL) approaches has recently been used to model some of the human activities in many areas of civil engineering applications. Especially from these systems in the model experimental studies, very good results have been obtained. In the present study, a model for predicting compressive strength of SCC containing various proportions of fly ash, as partial replacement of cement has been developed by using Adaptive Neuro-Fuzzy Inference System (ANFIS). For the purpose of building this model, a database of experimental data were gathered from the literature and used for training and testing the model. The used data as the inputs of fuzzy logic models are arranged in a format of five parameters that cover the total binder content, fly ash replacement percentage, water content, super plasticizer and age of specimens. The training and testing results in the fuzzy logic model have shown a strong potential for predicting the compressive strength of SCC containing fly ash in the considered range.Keywords: self-compacting concrete, fly ash, strength prediction, fuzzy logic
Procedia PDF Downloads 3352912 Environmental Study on Urban Disinfection Using an On-site Generation System
Authors: Víctor Martínez del Rey, Kourosh Nasr Esfahani, Amir Masoud Samani Majd
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In this experimental study, the behaviors of Mixed Oxidant solution components (MOS) and sodium hypochlorite (HYPO) as the most commonly applied surface disinfectant were compared through the effectiveness of chlorine disinfection as a function of the contact time and residual chlorine. In this regard, the variation of pH, free available chlorine (FAC) concentration, and electric conductivity (EC) of disinfection solutions in different concentrations were monitored over 48 h contact time. In parallel, the plant stress activated by chlorine-based disinfectants was assessed by comparing MOS and HYPO. The elements of pH and EC in the plant-soil and their environmental impacts, spread by disinfection solutions were analyzed through several concentrations of FAC including 500 mg/L, 1000 mg/L, and 5000 mg/L in irrigated water. All the experiments were carried out at the service station of Sant Cugat, Spain. The outcomes indicated lower pH and higher durability of MOS than HYPO at the same concentration of FAC which resulted in promising stability of FAC within MOS. Furthermore, the pH and EC value of plant-soil irrigated by NaOCl solution were higher than that of MOS solution at the same FAC concentration. On-site generation of MOS as a safe chlorination option might be considered an imaginary future of smart cities.Keywords: disinfection, free available chlorine, on-site generation, sodium hypochlorite
Procedia PDF Downloads 1182911 Influence of Metakaolin and Cements Types on Compressive Strength and Transport Properties of Self-Consolidating Concrete
Authors: Kianoosh Samimi, Farhad Estakhr, Mahdi Mahdikhani, Faramaz Moodi
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The self-consolidating concrete (SCC) performance over ordinary concrete is generally related to the ingredients used. The metakaolin can modify various properties of concrete, due to high pozzolanic reactions and also makes a denser microstructure. The objective of this paper is to examine the influence of three types of Portland cement and metakaolin on compressive strength and transport properties of SCC at early ages and up to 90 days. Six concrete mixtures were prepared with three types of different cements and substitution of 15% metakaolin. The results show that the highest value of compressive strength was achieved for Portland Slag Cement (PSC) and without any metakaolin at age of 90 days. Conversely, the lowest level of compressive strength at all ages of conservation was obtained for Pozzolanic Portland Cement (PPC) and containing 15% metakaolin. As can be seen in the results, compressive strength in SCC containing Portland cement type II with metakaolin is higher compared to that relative to SCC without metakaolin from 28 days of age. On the other hand, the samples containing PSC and PPC with metakaolin had a lower compressive strength than the plain samples. Therefore, it can be concluded that metakaolin has a negative effect on the compressive strength of SCC containing PSC and PPC. In addition, results show that metakaolin has enhanced chloride durability of SCCs and reduced capillary water absorption at 28, 90 days.Keywords: SCC, metakaolin, cement type, compressive strength, chloride diffusion
Procedia PDF Downloads 2202910 Forecasting of the Mobility of Rainfall-Induced Slow-Moving Landslides Using a Two-Block Model
Authors: Antonello Troncone, Luigi Pugliese, Andrea Parise, Enrico Conte
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The present study deals with the landslides periodically reactivated by groundwater level fluctuations owing to rainfall. The main type of movement which generally characterizes these landslides consists in sliding with quite small-displacement rates. Another peculiar characteristic of these landslides is that soil deformations are essentially concentrated within a thin shear band located below the body of the landslide, which, consequently, undergoes an approximately rigid sliding. In this context, a simple method is proposed in the present study to forecast the movements of this type of landslides owing to rainfall. To this purpose, the landslide body is schematized by means of a two-block model. Some analytical solutions are derived to relate rainfall measurements with groundwater level oscillations and these latter, in turn, to landslide mobility. The proposed method is attractive for engineering applications since it requires few parameters as input data, many of which can be obtained from conventional geotechnical tests. To demonstrate the predictive capability of the proposed method, the application to a well-documented landslide periodically reactivated by rainfall is shown.Keywords: rainfall, water level fluctuations, landslide mobility, two-block model
Procedia PDF Downloads 1212909 Spatial Assessment of Soil Contamination from Informal E-Waste Recycling Site in Agbogbloshie, Ghana
Authors: Kyere Vincent Nartey, Klaus Greve, Atiemo Sampson
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E-waste is discarded electrical electronic equipment inclusive of all components, sub-assemblies and consumables which are part of the product at the time of discarding and known to contain both hazardous and valuable fractions. E-waste is recycled within the proposed ecological restoration of the Agbogbloshie enclave using crude and rudimental recycling procedures such as open burning and manual dismantling which result in pollution and contamination of soil, water and air. Using GIS, this study was conducted to examine the spatial distribution and extent of soil contamination by heavy metals from the e-waste recycling site in Agbogbloshie. From the month of August to November 2013, 146 soil samples were collected in addition to their coordinates using GPS. Elemental analysis performed on the collected soil samples using X-Ray fluorescence revealed over 30 elements including, Ni, Cr, Zn, Cu, Pb and Mn. Using geostatistical techniques in ArcGIS 10.1 spatial assessment and distribution maps were generated. Mathematical models or equations were used to estimate the degree of contamination and pollution index. Results from soil analysis from the Agbogbloshie enclave showed that levels of measured or observed elements were significantly higher than the Canadian EPA and Dutch environmental standards.Keywords: e-waste, geostatistics, soil contamination, spatial distribution
Procedia PDF Downloads 5152908 Controlled Release of Curcumin from a Thermoresponsive Polypeptide Hydrogel for Anti-Tumor Therapy
Authors: Chieh-Nan Chen, Ji-Yu Lin, I-Ming Chu
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Polypeptide thermosensitive hydrogel is an excellent candidate as a smart device to deliver drugs and cells due to its remarkable biocompatibility, low gelation concentration, and respond to temperature stimuli, it can be easily injected as a polymer solution into the patient’s body where it undergoes gelation due to an elevation in temperature. Poly (ethylene glycol) monomethyl ether-poly (ethyl-l-glutamate) (mPEG-PELG) contains a hydrophobic side chain –C2H5 which is useful in encapsulating and stabilizing hydrophobic drugs. In this study, we plan to focus on the hydrophobic anti-carcinogenic and anti-inflammatory drug curcumin, which due its insolubility in water, requires a proper carrier for delivery into the body. Our main concept is to use mPEG-PELG to stabilize curcumin, inject the curcumin-loaded hydrogel into the tumor site, and allow the enzymatically-sensitive hydrogel to be degraded by bodily fluids and release the drug. The polymers of interest have been successfully synthesized and characterized by 1H-NMR, FT-IR, SEM, and CMC. Curcumin loading content and drug release were assayed using HPLC. Preliminary results show that these materials have potential as a delivery vehicle for poorly soluble drugs.Keywords: curcumin, drug release, hydrogel, polypeptide material
Procedia PDF Downloads 2932907 Urea Treatment of Low Dry Matter Oat Silage
Authors: Noor-ul-Ain, Muhammad Tahir Khan, Kashif Khan, Adeela Ajmal, Hamid Mustafa
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The objective of this study was to evaluate the preservative and upgrading potential of urea (70g/kg DM) added to high moisture oat silage at laboratory scale trial and urea was hydrolysed 95%. Microbial activity measured by pH and volatile fatty acids (VFA) and lactate production was reduced (p<0.001) by the urea addition. The pH of oat silage (without treated) was measured 5.7 and increased up to 8.00 on average while; volatile fatty acids (VFA) concentration was decreased. Relative proportions of fermentation acids changed after urea addition, increasing the acetate and butyrate and decreasing the propionate and lactate proportions. The addition of urea to oat silages increased (P<0.001) water soluble and ammonium nitrogen of the forage. These nitrogen fractions represented more than 40% of total nitrogen. After urea addition, total nitrogen content of oat silages increased from 21.0 g/kg DM to 28 g/kg DM. Application of urea at a rate of 70 g/kg DM significantly increased (P<0.001) the in situ degradation of neutral-detergent fibre after 48h of rumen incubation (NDF-situ). The NDF-situ was 200 g/kg NDF higher on oat forages ensiled with urea than on oat forages ensiled without urea. Oat silages can be effectively preserved and upgraded by ensiling with 70 g urea/kg dry matter. Further studies are required to evaluate voluntary intake of this forage.Keywords: oat, silage, urea, pH, forage
Procedia PDF Downloads 4702906 Taleghan Dam Break Numerical Modeling
Authors: Hamid Goharnejad, Milad Sadeghpoor Moalem, Mahmood Zakeri Niri, Leili Sadeghi Khalegh Abadi
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While there are many benefits to using reservoir dams, their break leads to destructive effects. From the viewpoint of International Committee of Large Dams (ICOLD), dam break means the collapse of whole or some parts of a dam; thereby the dam will be unable to hold water. Therefore, studying dam break phenomenon and prediction of its behavior and effects reduces losses and damages of the mentioned phenomenon. One of the most common types of reservoir dams is embankment dam. Overtopping in embankment dams occurs because of flood discharge system inability in release inflows to reservoir. One of the most important issues among managers and engineers to evaluate the performance of the reservoir dam rim when sliding into the storage, creating waves is large and long. In this study, the effects of floods which caused the overtopping of the dam have been investigated. It was assumed that spillway is unable to release the inflow. To determine outflow hydrograph resulting from dam break, numerical model using Flow-3D software and empirical equations was used. Results of numerical models and their comparison with empirical equations show that numerical model and empirical equations can be used to study the flood resulting from dam break.Keywords: embankment dam break, empirical equations, Taleghan dam, Flow-3D numerical model
Procedia PDF Downloads 3212905 Analysis of Distance Travelled by Plastic Consumables Used in the First 24 Hours of an Intensive Care Admission: Impacts and Methods of Mitigation
Authors: Aidan N. Smallwood, Celestine R. Weegenaar, Jack N. Evans
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The intensive care unit (ICU) is a particularly resource heavy environment, in terms of staff, drugs and equipment required. Whilst many areas of the hospital are attempting to cut down on plastic use and minimise their impact on the environment, this has proven challenging within the confines of intensive care. Concurrently, as globalization has progressed over recent decades, there has been a tendency towards centralised manufacturing with international distribution networks for products, often covering large distances. In this study, we have modelled the standard consumption of plastic single-use items over the course of the first 24-hours of an average individual patient’s stay in a 12 bed ICU in the United Kingdom (UK). We have identified the country of manufacture and calculated the minimum possible distance travelled by each item from factory to patient. We have assumed direct transport via the shortest possible straight line from country of origin to the UK and have not accounted for transport within either country. Assuming an intubated patient with invasive haemodynamic monitoring and central venous access, there are a total of 52 distincts, largely plastic, disposable products which would reasonably be required in the first 24-hours after admission. Each product type has only been counted once to account for multiple items being shipped as one package. Travel distances from origin were summed to give the total distance combined for all 52 products. The minimum possible total distance travelled from country of origin to the UK for all types of product was 273,353 km, equivalent to 6.82 circumnavigations of the globe, or 71% of the way to the moon. The mean distance travelled was 5,256 km, approximately the distance from London to Mecca. With individual packaging for each item, the total weight of consumed products was 4.121 kg. The CO2 produced shipping these items by air freight would equate to 30.1 kg, however doing the same by sea would produce 0.2 kg CO2. Extrapolating these results to the 211,932 UK annual ICU admissions (2018-2019), even with the underestimates of distance and weight of our assumptions, air freight would account for 6586 tons CO2 emitted annually, approximately 130 times that of sea freight. Given the drive towards cost saving within the UK health service, and the decline of the local manufacturing industry, buying from intercontinental manufacturers is inevitable However, transporting all consumables by sea where feasible would be environmentally beneficial, as well as being less costly than air freight. At present, the NHS supply chain purchases from medical device companies, and there is no freely available information as to the transport mode used to deliver the product to the UK. This must be made available to purchasers in order to give a fuller picture of life cycle impact and allow for informed decision making in this regard.Keywords: CO2, intensive care, plastic, transport
Procedia PDF Downloads 1782904 A Comparison between the Results of Hormuz Strait Wave Simulations Using WAVEWATCH-III and MIKE21-SW and Satellite Altimetry Observations
Authors: Fatemeh Sadat Sharifi
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In the present study, the capabilities of WAVEWATCH-III and MIKE21-SW for predicting the characteristics of wind waves in Hormuz Strait are evaluated. The GFS wind data (Global Forecast System) were derived. The bathymetry of gride with 2 arc-minute resolution, also were extracted from the ETOPO1. WAVEWATCH-III findings illustrate more valid prediction of wave features comparing to the MIKE-21 SW in deep water. Apparently, in shallow area, the MIKE-21 provides more uniformities with altimetry measurements. This may be due to the merits of the unstructured grid which are used in MIKE-21, leading to better representations of the coastal area. The findings on the direction of waves generated by wind in the modeling area indicate that in some regions, despite the increase in wind speed, significant wave height stays nearly unchanged. This is fundamental because of swift changes in wind track over the Strait of Hormuz. After discussing wind-induced waves in the region, the impact of instability of the surface layer on wave growth has been considered. For this purpose, the average monthly mean air temperature has been used. The results in cold months, when the surface layer is unstable, indicates an acceptable increase in the accuracy of prediction of the indicator wave height.Keywords: numerical modeling, WAVEWATCH-III, Strait of Hormuz, MIKE21-SW
Procedia PDF Downloads 2072903 Aquaporin-1 as a Differential Marker in Toxicant-Induced Lung Injury
Authors: Ekta Yadav, Sukanta Bhattacharya, Brijesh Yadav, Ariel Hus, Jagjit Yadav
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Background and Significance: Respiratory exposure to toxicants (chemicals or particulates) causes disruption of lung homeostasis leading to lung toxicity/injury manifested as pulmonary inflammation, edema, and/or other effects depending on the type and extent of exposure. This emphasizes the need for investigating toxicant type-specific mechanisms to understand therapeutic targets. Aquaporins, aka water channels, are known to play a role in lung homeostasis. Particularly, the two major lung aquaporins AQP5 and AQP1 expressed in alveolar epithelial and vasculature endothelia respectively allow for movement of the fluid between the alveolar air space and the associated vasculature. In view of this, the current study is focused on understanding the regulation of lung aquaporins and other targets during inhalation exposure to toxic chemicals (Cigarette smoke chemicals) versus toxic particles (Carbon nanoparticles) or co-exposures to understand their relevance as markers of injury and intervention. Methodologies: C57BL/6 mice (5-7 weeks old) were used in this study following an approved protocol by the University of Cincinnati Institutional Animal Care and Use Committee (IACUC). The mice were exposed via oropharyngeal aspiration to multiwall carbon nanotube (MWCNT) particles suspension once (33 ugs/mouse) followed by housing for four weeks or to Cigarette smoke Extract (CSE) using a daily dose of 30µl/mouse for four weeks, or to co-exposure using the combined regime. Control groups received vehicles following the same dosing schedule. Lung toxicity/injury was assessed in terms of homeostasis changes in the lung tissue and lumen. Exposed lungs were analyzed for transcriptional expression of specific targets (AQPs, surfactant protein A, Mucin 5b) in relation to tissue homeostasis. Total RNA from lungs extracted using TRIreagent kit was analyzed using qRT-PCR based on gene-specific primers. Total protein in bronchoalveolar lavage (BAL) fluid was determined by the DC protein estimation kit (BioRad). GraphPad Prism 5.0 (La Jolla, CA, USA) was used for all analyses. Major findings: CNT exposure alone or as co-exposure with CSE increased the total protein content in the BAL fluid (lung lumen rinse), implying compromised membrane integrity and cellular infiltration in the lung alveoli. In contrast, CSE showed no significant effect. AQP1, required for water transport across membranes of endothelial cells in lungs, was significantly upregulated in CNT exposure but downregulated in CSE exposure and showed an intermediate level of expression for the co-exposure group. Both CNT and CSE exposures had significant downregulating effects on Muc5b, and SP-A expression and the co-exposure showed either no significant effect (Muc5b) or significant downregulating effect (SP-A), suggesting an increased propensity for infection in the exposed lungs. Conclusions: The current study based on the lung toxicity mouse model showed that both toxicant types, particles (CNT) versus chemicals (CSE), cause similar downregulation of lung innate defense targets (SP-A, Muc5b) and mostly a summative effect when presented as co-exposure. However, the two toxicant types show differential induction of aquaporin-1 coinciding with the corresponding differential damage to alveolar integrity (vascular permeability). Interestingly, this implies the potential of AQP1 as a differential marker of toxicant type-specific lung injury.Keywords: aquaporin, gene expression, lung injury, toxicant exposure
Procedia PDF Downloads 1842902 3D Printing for Maritime Cultural Heritage: A Design for All Approach to Public Interpretation
Authors: Anne Eugenia Wright
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This study examines issues in accessibility to maritime cultural heritage. Using the Pillar Dollar Wreck in Biscayne National Park, Florida, this study presents an approach to public outreach based on the concept of Design for All. Design for All advocates creating products that are accessible and functional for all users, including those with visual, hearing, learning, mobility, or economic impairments. As a part of this study, a small exhibit was created that uses 3D products as a way to bring maritime cultural heritage to the public. It was presented to the public at East Carolina University’s Joyner Library. Additionally, this study presents a methodology for 3D printing scaled photogrammetry models of archaeological sites in full color. This methodology can be used to present a realistic depiction of underwater archaeological sites to those who are incapable of accessing them in the water. Additionally, this methodology can be used to present underwater archaeological sites that are inaccessible to the public due to conditions such as visibility, depth, or protected status. This study presents a practical use for 3D photogrammetry models, as well as an accessibility strategy to expand the outreach potential for maritime archaeology.Keywords: Underwater Archaeology, 3D Printing, Photogrammetry, Design for All
Procedia PDF Downloads 1382901 α-Amylase Inhibitory Activity of Some Tunisian Aromatic and Medicinal Plants
Authors: Hamdi Belfeki, Belgacem Chandoul, Mnasser Hassouna, Mondher Mejri
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Aqueous and ethanolic extracts of eight Tunisian aromatic and medicinal plants (TAMP) were characterized by studying their composition in polyphenols and also their antiradical and antioxidant capacities. In absence and in the presence of the various extracts, α-amylase from Bacillus subtlis activity, was measured in order to detect a potential inhibition. The total contents of polyphenols and flavonoid vary in function of TAMP and the mobile phase used for the extraction (distilled water or ethanol). The ethanolic extracts showed the most significant antiradical and antioxidant activities. Only the extracts from Coriandrum sativum showed a significant inhibiting effect on the α-amylase activity. This inhibiting capacity could be correlated with the chemical profile of the two extracts, due to the fact that they have the greatest amount of total flavonoid. The ethanolic extract has the most important antioxidant and anti-radicalizing activities among the sixteen extracts studied. The inhibition kinetics of the two coriander extracts were evaluated by pre-incubation method, using Lineweaver-Burk’s equation, obtained by linearization of Michaeilis-Menten’s expression. The results showed that both extracts exercised a competitive inhibition mechanism.Keywords: α-amylase, antioxidant activity, aromatic and medicinal plants, inhibition
Procedia PDF Downloads 4492900 Study of Radioactivity of Oil and Gas
Authors: Harish Aryal, Thalia Balderas, Alondra Rodriguez
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Radioactivity present in nature possess a major challenge to public health and occupational concerns. Even at low doses, NORM can cause radiation-induced cancers, heritable diseases, genetic defects, etc. There have not been enough radiological studies and consequently, there is a lack of supportive data. In addition, there is no universal medical surveillance program for low-level doses and there is a need for NORM management guidelines for appropriate control. Naturally Occurring Radioactive Material (NORM) is present everywhere during oil/gas exploration. Currently, there is limited data available to quantify radioactivity. This research presents the study of radioactivity in different areas in the United States to be encouraged to be used for further study in Texas or similar areas within the oil and gas industry. Many materials that are found in the oil and gas industry are NORM (Naturally Occurring Radioactive Materials). The NORM is made of various types of materials, including Radium 226, Radium 228, and Radon 222. Efforts to characterize the geographic distribution of NORM have been limited by poor statistical representation in this area of study. In addition, the fate of NORM in the environment has not been fully defined, and few human health risk assessments have been conducted. To further comprehend how to measure radioactivity in oil and gas, it will be essential to understand the amount and type of radioactivity that is wasted on the water and soil of the industry.Keywords: NORM, radium 226, radon 222, radionuclides, geological formations
Procedia PDF Downloads 882899 Enhanced Functional Production of a Crucial Biomolecule Human Serum Albumin in Escherichia coli
Authors: Ashima Sharma
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Human Serum Albumin (HSA)- one of the most demanded therapeutic proteins with immense biotechnological applications- is a large multidomain protein containing 17 disulfide bonds. The current source of HSA is human blood plasma which is a limited and unsafe source. Thus, there exists an indispensable need to promote non-animal derived recombinant HSA (rHSA) production. Escherichia coli is one of the most convenient hosts which had contributed to the production of more than 30% of the FDA approved recombinant pharmaceuticals. It grows rapidly and reaches high cell density using inexpensive and simple substrates. E. coli derived recombinant products have more economic potential as fermentation processes are cheaper compared to the other expression hosts. The major bottleneck in exploiting E. coli as a host for a disulfide-rich multidomain protein is the formation of aggregates of overexpressed protein. The majority of the expressed HSA forms inclusion bodies (more than 90% of the total expressed rHSA) in the E. coli cytosol. Recovery of functional rHSA from inclusion bodies is not preferred because it is difficult to obtain a large multidomain disulfide bond rich protein like rHSA in its functional native form. Purification is tedious, time-consuming, laborious and expensive. Because of such limitations, the E. coli host system was neglected for rHSA production for the past few decades despite its numerous advantages. In the present work, we have exploited the capabilities of E. coli as a host for the enhanced functional production of rHSA (~60% of the total expressed rHSA in the soluble fraction). Parameters like intracellular environment, temperature, induction type, duration of induction, cell lysis conditions etc. which play an important role in enhancing the level of production of the desired protein in its native form in vivo have been optimized. We have studied the effect of assistance of different types of exogenously employed chaperone systems on the functional expression of rHSA in the E. coli host system. Different aspects of cell growth parameters during the production of rHSA in presence and absence of molecular chaperones in E. coli have also been studied. Upon overcoming the difficulties to produce functional rHSA in E. coli, it has been possible to produce significant levels of functional protein through engineering the biological system of protein folding in the cell, the E. coli-derived rHSA has been purified to homogeneity. Its detailed physicochemical characterization has been performed by monitoring its conformational properties, secondary and tertiary structure elements, surface properties, ligand binding properties, stability issues etc. These parameters of the recombinant protein have been compared with the naturally occurring protein from the human source. The outcome of the comparison reveals that the recombinant protein resembles exactly the same as the natural one. Hence, we propose that the E. coli-derived rHSA is an ideal biosimilar for human blood plasma-derived serum albumin. Therefore, in the present study, we have introduced and promoted the E. coli- derived rHSA as an alternative to the preparation from a human source, pHSA.Keywords: recombinant human serum albumin, Escherichia coli, biosimilar, chaperone assisted protein folding
Procedia PDF Downloads 2092898 Parametric and Analysis Study of the Melting in Slabs Heated by a Laminar Heat Transfer Fluid in Downward and Upward Flows
Authors: Radouane Elbahjaoui, Hamid El Qarnia
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The present work aims to investigate numerically the thermal and flow characteristics of a rectangular latent heat storage unit (LHSU) during the melting process of a phase change material (PCM). The LHSU consists of a number of vertical and identical plates of PCM separated by rectangular channels. The melting process is initiated when the LHSU is heated by a heat transfer fluid (HTF: water) flowing in channels in a downward or upward direction. The proposed study is motivated by the need to optimize the thermal performance of the LHSU by accelerating the charging process. A mathematical model is developed and a fixed-grid enthalpy formulation is adopted for modeling the melting process coupling with convection-conduction heat transfer. The finite volume method was used for discretization. The obtained numerical results are compared with experimental, analytical and numerical ones found in the literature and reasonable agreement is obtained. Thereafter, the numerical investigations were carried out to highlight the effects of the HTF flow direction and the aspect ratio of the PCM slabs on the heat transfer characteristics and thermal performance enhancement of the LHSU.Keywords: PCM, TES, LHSU, melting
Procedia PDF Downloads 2612897 Numerical Study for the Estimation of Hydrodynamic Current Drag Coefficients for the Colombian Navy Frigates Using Computational Fluid Dynamics
Authors: Mauricio Gracia, Luis Leal, Bharat Verma
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Computational fluid dynamics (CFD) has become nowadays an important tool in the process of hydrodynamic design of modern ships. CFD is used to model any phenomena related to fluid flow in a control volume like a ship or any offshore structure in the sea. In the present study, the current force drag coefficients for a Colombian Navy Frigate in deep and shallow water are estimated through the application of CFD. The study shows the process of simulating the ship current drag coefficients using the CFD simulations method, which is conducted using STAR-CCM+ software package. The Almirante Padilla class Frigate ship scale model is investigated. The results show the ship current drag coefficient calculated considering a current speed of 1 knot with a 90° drift angle for the full-scale ship. Predicted results were compared against the current drag coefficients published in the Lloyds register OCIMF report. It is shown that the simulation results agree fairly well with the published results and that STAR-CCM+ code can predict current drag coefficients.Keywords: CFD, current draft coefficient, STAR-CCM+, OCIMF, Bollard pull
Procedia PDF Downloads 1742896 The Quranic Case for Resurrection
Authors: Maira Farooq Maneka
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Death has increasingly caused humans to investigate its reality and what lies after it, if something at all, with personal conviction and concern. Till date it remains a matter of speculation. We do not encounter arguments other than ‘faith’ from major world religions when justifying claims about life after death (LAD) as it is an unseen phenomenon. This paper attempts to analyse the Islamic idea of resurrection (after death) and its justification that is distinct from faith but instead contemplative in nature. To do this a legal lens was adopted which allowed the categorisation of selected Quranic arguments under the heading of direct evidence, indirect evidence and intuitive reasoning. Results: Four kinds of direct evidences are discussed under the themes of sleep, droughts, predictions and Quranic challenge. The section of indirect evidences narrows its scope only to two, out of many, broad possible signs that pointed towards the reality of resurrection. These include the signs found in nature such as sun and water as well as signs one finds within the human body such as the creation and function of human fingertips. Finally the last section tries to amalgamate Quran’s appeal to human rationality that facilitates the reader in accepting the possibility of resurrection and hence a final Day of Judgement. These include the notion of accountability, pleasure, pain and human agency.Keywords: Islam, life after death, Quran, resurrection
Procedia PDF Downloads 952895 Metal Contamination in an E-Waste Recycling Community in Northeastern Thailand
Authors: Aubrey Langeland, Richard Neitzel, Kowit Nambunmee
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Electronic waste, ‘e-waste’, refers generally to discarded electronics and electrical equipment, including products from cell phones and laptops to wires, batteries and appliances. While e-waste represents a transformative source of income in low- and middle-income countries, informal e-waste workers use rudimentary methods to recover materials, simultaneously releasing harmful chemicals into the environment and creating a health hazard for themselves and surrounding communities. Valuable materials such as precious metals, copper, aluminum, ferrous metals, plastic and components are recycled from e-waste. However, persistent organic pollutants such as polychlorinated biphenyls (PCBs) and some polybrominated diphenyl ethers (PBDEs), and heavy metals are toxicants contained within e-waste and are of great concern to human and environmental health. The current study seeks to evaluate the environmental contamination resulting from informal e-waste recycling in a predominantly agricultural community in northeastern Thailand. To accomplish this objective, five types of environmental samples were collected and analyzed for concentrations of eight metals commonly associated with e-waste recycling during the period of July 2016 through July 2017. Rice samples from the community were collected after harvest and analyzed using inductively coupled plasma mass spectrometry (ICP-MS) and gas furnace atomic spectroscopy (GF-AS). Soil samples were collected and analyzed using methods similar to those used in analyzing the rice samples. Surface water samples were collected and analyzed using absorption colorimetry for three heavy metals. Environmental air samples were collected using a sampling pump and matched-weight PVC filters, then analyzed using Inductively Coupled Argon Plasma-Atomic Emission Spectroscopy (ICAP-AES). Finally, surface wipe samples were collected from surfaces in homes where e-waste recycling activities occur and were analyzed using ICAP-AES. Preliminary1 results indicate that some rice samples have concentrations of lead and cadmium significantly higher than limits set by the United States Department of Agriculture (USDA) and the World Health Organization (WHO). Similarly, some soil samples show levels of copper, lead and cadmium more than twice the maximum permissible level set by the USDA and WHO, and significantly higher than other areas of Thailand. Surface water samples indicate that areas near e-waste recycling activities, particularly the burning of e-waste products, result in increased levels of cadmium, lead and copper in surface waters. This is of particular concern given that many of the surface waters tested are used in irrigation of crops. Surface wipe samples measured concentrations of metals commonly associated with e-waste, suggesting a danger of ingestion of metals during cooking and other activities. Of particular concern is the relevance of surface contamination of metals to child health. Finally, air sampling showed that the burning of e-waste presents a serious health hazard to workers and the environment through inhalation and deposition2. Our research suggests a need for improved methods of e-waste recycling that allows workers to continue this valuable revenue stream in a sustainable fashion that protects both human and environmental health. 1Statistical analysis to be finished in October 2017 due to follow-up field studies occurring in July and August 2017. 2Still awaiting complete analytic results.Keywords: e-waste, environmental contamination, informal recycling, metals
Procedia PDF Downloads 362