Search results for: sensitivity theory
1179 Dynamic Anonymity
Authors: Emin Islam Tatlı, Dirk Stegemann, Stefan Lucks
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Encryption protects communication partners from disclosure of their secret messages but cannot prevent traffic analysis and the leakage of information about “who communicates with whom". In the presence of collaborating adversaries, this linkability of actions can danger anonymity. However, reliably providing anonymity is crucial in many applications. Especially in contextaware mobile business, where mobile users equipped with PDAs request and receive services from service providers, providing anonymous communication is mission-critical and challenging at the same time. Firstly, the limited performance of mobile devices does not allow for heavy use of expensive public-key operations which are commonly used in anonymity protocols. Moreover, the demands for security depend on the application (e.g., mobile dating vs. pizza delivery service), but different users (e.g., a celebrity vs. a normal person) may even require different security levels for the same application. Considering both hardware limitations of mobile devices and different sensitivity of users, we propose an anonymity framework that is dynamically configurable according to user and application preferences. Our framework is based on Chaum-s mixnet. We explain the proposed framework, its configuration parameters for the dynamic behavior and the algorithm to enforce dynamic anonymity.Keywords: Anonymity, context-awareness, mix-net, mobile business, policy management
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17081178 Experimental Study of the Metal Foam Flow Conditioner for Orifice Plate Flowmeters
Authors: B. Manshoor, N. Ihsak, Amir Khalid
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The sensitivity of orifice plate metering to disturbed flow (either asymmetric or swirling) is a subject of great concern to flow meter users and manufacturers. The distortions caused by pipe fittings and pipe installations upstream of the orifice plate are major sources of this type of non-standard flows. These distortions can alter the accuracy of metering to an unacceptable degree. In this work, a multi-scale object known as metal foam has been used to generate a predetermined turbulent flow upstream of the orifice plate. The experimental results showed that the combination of an orifice plate and metal foam flow conditioner is broadly insensitive to upstream disturbances. This metal foam demonstrated a good performance in terms of removing swirl and producing a repeatable flow profile within a short distance downstream of the device. The results of using a combination of a metal foam flow conditioner and orifice plate for non-standard flow conditions including swirling flow and asymmetric flow show this package can preserve the accuracy of metering up to the level required in the standards.Keywords: Metal foam flow conditioner, flow measurement, orifice plate.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 20601177 Implementation of Intuitionistic Fuzzy Approach in Maximizing Net Present Value
Authors: Gaurav Kumar, Rakesh Kumar Bajaj
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The applicability of Net Present Value (NPV) in an investment project is becoming more and more popular in the field of engineering economics. The classical NPV methodology involves only the precise and accurate data of the investment project. In the present communication, we give a new mathematical model for NPV which uses the concept of intuitionistic fuzzy set theory. The proposed model is based on triangular intuitionistic fuzzy number, which may be known as Intuitionistic Fuzzy Net Present Value (IFNPV). The model has been applied to an example and the results are presented.
Keywords: Net Present Value, Intuitionistic Fuzzy Set, Investment Projects.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 25141176 Bisymmetric, Persymmetric Matrices and Its Applications in Eigen-decomposition of Adjacency and Laplacian Matrices
Authors: Mahdi Nouri
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In this paper we introduce an efficient solution method for the Eigen-decomposition of bisymmetric and per symmetric matrices of symmetric structures. Here we decompose adjacency and Laplacian matrices of symmetric structures to submatrices with low dimension for fast and easy calculation of eigenvalues and eigenvectors. Examples are included to show the efficiency of the method.Keywords: Graphs theory, Eigensolution, adjacency and Laplacian matrix, Canonical forms, bisymmetric, per symmetric.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 24431175 Best Co-approximation and Best Simultaneous Co-approximation in Fuzzy Normed Spaces
Authors: J. Kavikumar, N. S. Manian, M.B.K. Moorthy
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The main purpose of this paper is to consider the t-best co-approximation and t-best simultaneous co-approximation in fuzzy normed spaces. We develop the theory of t-best co-approximation and t-best simultaneous co-approximation in quotient spaces. This new concept is employed us to improve various characterisations of t-co-proximinal and t-co-Chebyshev sets.
Keywords: Fuzzy best co-approximation, fuzzy quotient spaces, proximinality, Chebyshevity, best simultaneous co-approximation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16141174 Double Manifold Sliding Mode Observer for Sensorless Control of Multiphase Induction Machine under Fault Condition
Authors: Mohammad Jafarifar
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Multiphase Induction Machine (IM) is normally controlled using rotor field oriented vector control. Under phase(s) loss, the machine currents can be optimally controlled to satisfy certain optimization criteria. In this paper we discuss the performance of double manifold sliding mode observer (DM-SMO) in Sensorless control of multiphase induction machine under unsymmetrical condition (one phase loss). This observer is developed using the IM model in the stationary reference frame. DM-SMO is constructed by adding extra feedback term to conventional single mode sliding mode observer (SM-SMO) which proposed in many literature. This leads to a fully convergent observer that also yields an accurate estimate of the speed and stator currents. It will be shown by the simulation results that the estimated speed and currents by the method are very well and error between real and estimated quantities is negligible. Also parameter sensitivity analysis shows that this method is rather robust against parameter variation.Keywords: Multiphase induction machine, field oriented control, sliding mode, unsymmetrical condition, manifold.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18171173 Positive Solutions for Three-Point Boundary Value Problems of Third-Order Nonlinear Singular Differential Equations in Banach Space
Authors: Li Xiguang
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In this paper, by constructing a special set and utilizing fixed point index theory, we study the existence of solution for singular differential equation in Banach space, which improved and generalize the result of related paper.
Keywords: Banach space, cone, fixed point index, singular differential equation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14721172 A Necessary Condition for the Existence of Chaos in Fractional Order Delay Differential Equations
Authors: Sachin Bhalekar
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In this paper we propose a necessary condition for the existence of chaos in delay differential equations of fractional order. To explain the proposed theory, we discuss fractional order Liu system and financial system involving delay.
Keywords: Caputo derivative, delay, stability, chaos.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 26651171 Is It Important to Measure the Volumetric Mass Density of Nanofluids?
Authors: Z. Haddad, C. Abid, O. Rahli, O. Margeat, W. Dachraoui, A. Mataoui
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The present study aims to measure the volumetric mass density of NiPd-heptane nanofluids synthesized using a one step method known as thermal decomposition of metal-surfactant complexes. The particle concentration is up to 7.55g/l and the temperature range of the experiment is from 20°C to 50°C. The measured values were compared with the mixture theory and good agreement between the theoretical equation and measurement were obtained. Moreover, the available nanofluids volumetric mass density data in the literature is reviewed.
Keywords: NiPd nanoparticles, nanofluids, volumetric mass density, stability.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 26671170 Numerical Study of Airfoils Aerodynamic Performance in Heavy Rain Environment
Authors: M. Ismail, Cao Yihua, Zhao Ming, Abu Bakar
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Heavy rainfall greatly affects the aerodynamic performance of the aircraft. There are many accidents of aircraft caused by aerodynamic efficiency degradation by heavy rain. In this Paper we have studied the heavy rain effects on the aerodynamic efficiency of cambered NACA 64-210 and symmetric NACA 0012 airfoils. Our results show significant increase in drag and decrease in lift. We used preprocessing software gridgen for creation of geometry and mesh, used fluent as solver and techplot as postprocessor. Discrete phase modeling called DPM is used to model the rain particles using two phase flow approach. The rain particles are assumed to be inert. Both airfoils showed significant decrease in lift and increase in drag in simulated rain environment. The most significant difference between these two airfoils was the NACA 64-210 more sensitivity than NACA 0012 to liquid water content (LWC). We believe that the results showed in this paper will be useful for the designer of the commercial aircrafts and UAVs, and will be helpful for training of the pilots to control the airplanes in heavy rain.
Keywords: airfoil, discrete phase modeling, heavy rain, Reynolds
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 22731169 On Constructing a Cubically Convergent Numerical Method for Multiple Roots
Authors: Young Hee Geum
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We propose the numerical method defined by
xn+1 = xn − λ[f(xn − μh(xn))/]f'(xn) , n ∈ N,
and determine the control parameter λ and μ to converge cubically. In addition, we derive the asymptotic error constant. Applying this proposed scheme to various test functions, numerical results show a good agreement with the theory analyzed in this paper and are proven using Mathematica with its high-precision computability.
Keywords: Asymptotic error constant, iterative method , multiple root, root-finding.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15071168 A Simple Epidemiological Model for Typhoid with Saturated Incidence Rate and Treatment Effect
Authors: Steady Mushayabasa
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Typhoid fever is a communicable disease, found only in man and occurs due to systemic infection mainly by Salmonella typhi organism. The disease is endemic in many developing countries and remains a substantial public health problem despite recent progress in water and sanitation coverage. Globally, it is estimated that typhoid causes over 16 million cases of illness each year, resulting in over 600,000 deaths. A mathematical model for assessing the impact of educational campaigns on controlling the transmission dynamics of typhoid in the community, has been formulated and analyzed. The reproductive number has been computed. Stability of the model steady-states has been examined. The impact of educational campaigns on controlling the transmission dynamics of typhoid has been discussed through the basic reproductive number and numerical simulations. At its best the study suggests that targeted education campaigns, which are effective at stopping transmission of typhoid more than 40% of the time, will be highly effective at controlling the disease in the community.
Keywords: Mathematical model, Typhoid, saturated incidence rate, treatment, reproductive number, sensitivity analysis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 35171167 Performance Improvement of Information System of a Banking System Based on Integrated Resilience Engineering Design
Authors: S. H. Iranmanesh, L. Aliabadi, A. Mollajan
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Integrated resilience engineering (IRE) is capable of returning banking systems to the normal state in extensive economic circumstances. In this study, information system of a large bank (with several branches) is assessed and optimized under severe economic conditions. Data envelopment analysis (DEA) models are employed to achieve the objective of this study. Nine IRE factors are considered to be the outputs, and a dummy variable is defined as the input of the DEA models. A standard questionnaire is designed and distributed among executive managers to be considered as the decision-making units (DMUs). Reliability and validity of the questionnaire is examined based on Cronbach's alpha and t-test. The most appropriate DEA model is determined based on average efficiency and normality test. It is shown that the proposed integrated design provides higher efficiency than the conventional RE design. Results of sensitivity and perturbation analysis indicate that self-organization, fault tolerance, and reporting culture respectively compose about 50 percent of total weight.
Keywords: Banking system, data envelopment analysis, DEA, integrated resilience engineering, IRE, performance evaluation, perturbation analysis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 8411166 On the Relationship between Language Output and Second Language Acquisition
Authors: Haiyan Wang
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Many researchers have been discussing the importance of language input in second language acquisition. The author holds that the bigger problem lies in how to activate language learners' language knowledge and raise their language output consciousness and competence. Analyzing the importance of language output based on theory and reality, this paper mainly explores the essence of language output and its revelation for second language acquisition in order to make second language learners really raise their communicative competence.
Keywords: Language output, second language acquisition, communicative competence.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 37041165 Aligning IS Development with Users- Work Habits
Authors: Abbas Moshref Razavi, Rodina Ahmad
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As a primitive assumption, if a new information system is able to remind users their old work habits, it should have a better opportunity to be accepted, adopted and finally, utilized. In this paper some theoretical concepts borrowed from psychodynamic theory e.g. ego defenses are discussed to show how such resemblance can be made without necessarily affecting the performance of the new system. The main assertion is a new system should somehow imitate old work habits, not literally, but through following their paces in terms of the order of habitual tensional states including stimulation, defensive actions and satisfactions.Keywords: information Systems, users' habits, psychodynamic
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 13481164 Evolutionary Design of Polynomial Controller
Authors: R. Matousek, S. Lang, P. Minar, P. Pivonka
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In the control theory one attempts to find a controller that provides the best possible performance with respect to some given measures of performance. There are many sorts of controllers e.g. a typical PID controller, LQR controller, Fuzzy controller etc. In the paper will be introduced polynomial controller with novel tuning method which is based on the special pole placement encoding scheme and optimization by Genetic Algorithms (GA). The examples will show the performance of the novel designed polynomial controller with comparison to common PID controller.Keywords: Evolutionary design, Genetic algorithms, PID controller, Pole placement, Polynomial controller
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 21571163 Market Segmentation and Conjoint Analysis for Apple Family Design
Authors: Abbas Al-Refaie, Nour Bata
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A distributor of Apple products' experiences numerous difficulties in developing marketing strategies for new and existing mobile product entries that maximize customer satisfaction and the firm's profitability. This research, therefore, integrates market segmentation in platform-based product family design and conjoint analysis to identify iSystem combinations that increase customer satisfaction and business profits. First, the enhanced market segmentation grid is created. Then, the estimated demand model is formulated. Finally, the profit models are constructed then used to determine the ideal product family design that maximizes profit. Conjoint analysis is used to explore customer preferences with their satisfaction levels. A total of 200 surveys are collected about customer preferences. Then, simulation is used to determine the importance values for each attribute. Finally, sensitivity analysis is conducted to determine the product family design that maximizes both objectives. In conclusion, the results of this research shall provide great support to Apple distributors in determining the best marketing strategies that enhance their market share.
Keywords: Market segmentation, conjoint analysis, market strategies, optimization.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 25181162 Reasoning with Dynamic Domains and Computer Security
Authors: Yun Bai
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Representing objects in a dynamic domain is essential in commonsense reasoning under some circumstances. Classical logics and their nonmonotonic consequences, however, are usually not able to deal with reasoning with dynamic domains due to the fact that every constant in the logical language denotes some existing object in the static domain. In this paper, we explore a logical formalization which allows us to represent nonexisting objects in commonsense reasoning. A formal system named N-theory is proposed for this purpose and its possible application in computer security is briefly discussed.Keywords: knowledge representation and reasoning, commonsensereasoning, computer security
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14431161 Bifurcation Analysis for a Physiological Control System with Delay
Authors: Kejun Zhuang
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In this paper, a delayed physiological control system is investigated. The sufficient conditions for stability of positive equilibrium and existence of local Hopf bifurcation are derived. Furthermore, global existence of periodic solutions is established by using the global Hopf bifurcation theory. Finally, numerical examples are given to support the theoretical analysis.
Keywords: Physiological control system, global Hopf bifurcation, periodic solutions.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15581160 Global Existence of Periodic Solutions in a Delayed Tri–neuron Network
Authors: Kejun Zhuang, Zhaohui Wen
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In this paper, a tri–neuron network model with time delay is investigated. By using the Bendixson-s criterion for high– dimensional ordinary differential equations and global Hopf bifurcation theory for functional differential equations, sufficient conditions for existence of periodic solutions when the time delay is sufficiently large are established.Keywords: Delay, global Hopf bifurcation, neural network, periodicsolutions.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14831159 New Algorithms for Finding Short Reset Sequences in Synchronizing Automata
Authors: Adam Roman
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Finding synchronizing sequences for the finite automata is a very important problem in many practical applications (part orienters in industry, reset problem in biocomputing theory, network issues etc). Problem of finding the shortest synchronizing sequence is NP-hard, so polynomial algorithms probably can work only as heuristic ones. In this paper we propose two versions of polynomial algorithms which work better than well-known Eppstein-s Greedy and Cycle algorithms.
Keywords: Synchronizing words, reset sequences, Černý Conjecture
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16001158 A Comparison of Fuzzy Clustering Algorithms to Cluster Web Messages
Authors: Sara El Manar El Bouanani, Ismail Kassou
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Our objective in this paper is to propose an approach capable of clustering web messages. The clustering is carried out by assigning, with a certain probability, texts written by the same web user to the same cluster based on Stylometric features and using fuzzy clustering algorithms. Focus in the present work is on comparing the most popular algorithms in fuzzy clustering theory namely, Fuzzy C-means, Possibilistic C-means and Fuzzy Possibilistic C-Means.
Keywords: Authorship detection, fuzzy clustering, profiling, stylometric features.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 20521157 Fung’s Model Constants for Intracranial Blood Vessel of Human Using Biaxial Tensile Test Results
Authors: Mohammad Shafigh, Nasser Fatouraee, Amirsaied Seddighi
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Mechanical properties of cerebral arteries are, due to their relationship with cerebrovascular diseases, of clinical worth. To acquire these properties, eight samples were obtained from middle cerebral arteries of human cadavers, whose death were not due to injuries or diseases of cerebral vessels, and tested within twelve hours after resection, by a precise biaxial tensile test device specially developed for the present study considering the dimensions, sensitivity and anisotropic nature of samples. The resulting stress-stretch curve was plotted and subsequently fitted to a hyperelastic three-parameter Fung model. It was found that the arteries were noticeably stiffer in circumferential than in axial direction. It was also demonstrated that the use of multi-parameter hyperelastic constitutive models is useful for mathematical description of behavior of cerebral vessel tissue. The reported material properties are a proper reference for numerical modeling of cerebral arteries and computational analysis of healthy or diseased intracranial arteries.
Keywords: Anisotropic Tissue, Cerebral Blood Vessels, Fung Model, Nonlinear Material, Plain Stress.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 33581156 Positive Periodic Solutions for a Neutral Impulsive Delay Competition System
Authors: Daiming Wang
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In this paper, a neutral impulsive competition system with distributed delays is studied by using Mawhin-s coincidence degree theory and the mean value theorem of differential calculus. Sufficient conditions on the existence of positive periodic solution of the system are obtained.
Keywords: Neutral impulsive delay system, competitive system, coincidence degree, periodic solution, existence.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15071155 Airfoils Aerodynamic Efficiency Study in Heavy Rain via Two Phase Flow Approach
Authors: M. Ismail, Cao Yihua, Zhao Ming
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Heavy rainfall greatly affects the aerodynamic performance of the aircraft. There are many accidents of aircraft caused by aerodynamic efficiency degradation by heavy rain. In this Paper we have studied the heavy rain effects on the aerodynamic efficiency of NACA 64-210 & NACA 0012 airfoils. For our analysis, CFD method and preprocessing grid generator are used as our main analytical tools, and the simulation of rain is accomplished via two phase flow approach-s Discrete Phase Model (DPM). Raindrops are assumed to be non-interacting, non-deforming, non-evaporating and non-spinning spheres. Both airfoil sections exhibited significant reduction in lift and increase in drag for a given lift condition in simulated rain. The most significant difference between these two airfoils was the sensitivity of the NACA 64-210 to liquid water content (LWC), while NACA 0012 performance losses in the rain environment is not a function of LWC . It is expected that the quantitative information gained in this paper will be useful to the operational airline industry and greater effort such as small scale and full scale flight tests should put in this direction to further improve aviation safety.
Keywords: airfoil, discrete phase modeling, heavy rain, Reynolds number
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 36411154 End-to-End Pyramid Based Method for MRI Reconstruction
Authors: Omer Cahana, Maya Herman, Ofer Levi
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Magnetic Resonance Imaging (MRI) is a lengthy medical scan that stems from a long acquisition time. Its length is mainly due to the traditional sampling theorem, which defines a lower boundary for sampling. However, it is still possible to accelerate the scan by using a different approach such as Compress Sensing (CS) or Parallel Imaging (PI). These two complementary methods can be combined to achieve a faster scan with high-fidelity imaging. To achieve that, two conditions must be satisfied: i) the signal must be sparse under a known transform domain, and ii) the sampling method must be incoherent. In addition, a nonlinear reconstruction algorithm must be applied to recover the signal. While the rapid advances in Deep Learning (DL) have had tremendous successes in various computer vision tasks, the field of MRI reconstruction is still in its early stages. In this paper, we present an end-to-end method for MRI reconstruction from k-space to image. Our method contains two parts. The first is sensitivity map estimation (SME), which is a small yet effective network that can easily be extended to a variable number of coils. The second is reconstruction, which is a top-down architecture with lateral connections developed for building high-level refinement at all scales. Our method holds the state-of-art fastMRI benchmark, which is the largest, most diverse benchmark for MRI reconstruction.
Keywords: Accelerate MRI scans, image reconstruction, pyramid network, deep learning.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3341153 Persistence of Termination for Non-Overlapping Term Rewriting Systems
Authors: Munehiro Iwami
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A property is called persistent if for any many-sorted term rewriting system , has the property if and only if term rewriting system , which results from by omitting its sort information, has the property. In this paper,we show that termination is persistent for non-overlapping term rewriting systems and we give the example as application of this result. Furthermore we obtain that completeness is persistent for non-overlapping term rewriting systems.Keywords: Theory of computing, Model-based reasoning, termrewriting system, termination
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 13911152 High Strain Rate Characteristics of the Advanced Blast Energy Absorbers
Authors: Martina Drdlová, Michal Frank, Jaroslav Buchar, Josef Krátký
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The main aim of the presented experiments is to improve behaviour of sandwich structures under dynamic loading, such as crash or explosion. Several cellular materials are widely used as core of the sandwich structures and their properties influence the response of the entire element under impact load. To optimize their performance requires the characterisation of the core material behaviour at high strain rates and identification of the underlying mechanism. This work presents the study of high strain-rate characteristics of a specific porous lightweight blast energy absorbing foam using a Split Hopkinson Pressure Bar (SHPB) technique adapted to perform tests on low strength materials. Two different velocities, 15 and 30 m.s-1 were used to determine the strain sensitivity of the material. Foams were designed using two types of porous lightweight spherical raw materials with diameters of 30- 100 *m, combined with polymer matrix. Cylindrical specimens with diameter of 15 mm and length of 7 mm were prepared and loaded using a Split Hopkinson Pressure Bar apparatus to assess the relation between the composition of the material and its shock wave attenuation capacity.
Keywords: Blast, foam, microsphere, resin.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 24831151 A Nanosensor System Based On Disuccinimydyl–CYP2E1 for Amperometric Detection of the Anti-Tuberculosis Drug, Pyrazinamide
Authors: R. F. Ajayi, U. Sidwaba, U. Feleni, S. F. Douman, E. Nxusani, L. Wilson, C. Rassie, O. Tovide, P. G. L. Baker, S. L. Vilakazi, R. Tshikhudo, E. I. Iwuoha
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Pyrazinamide (PZA) is among the first-line pro-drugs in the tuberculosis (TB) combination chemotherapy used to treat Mycobacterium tuberculosis. Numerous reports have suggested that hepatotoxicity due to pyrazinamide in patients is due to inappropriate dosing. It is, therefore necessary to develop sensitive and reliable techniques for determining the PZA metabolic profile of diagnosed patients promptly and at point-of-care. This study reports the determination of PZA based on nanobiosensor systems developed from disuccinimidyl octanedioate modified Cytochrome P450-2E1 (CYP2E1) electrodeposited on gold substrates derivatised with (poly(8-anilino-1-napthalene sulphonic acid) PANSA/PVP-AgNPs nanocomposites. The rapid and sensitive amperometric PZA detection gave a dynamic linear range of 2µM to 16µM revealing a limit of detection of 0.044µM and a sensitivity of 1.38µA/µM. The Michaelis-Menten parameters; KM, KM app and IMAX were calculated to be 6.0µM, 1.41µM and 1.51x10-6 A, respectively, indicating a nanobiosensor suitable for use in serum.
Keywords: Cytochrome P450-2E1, Disuccinimidyl octanedioate, Pyrazinamide, Tuberculosis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 22241150 Effect of Damping on Performance of Magnetostrictive Vibration Energy Harvester
Authors: Mojtaba Ghodsi, Hamidreza Ziaifar, Morteza Mohammadzaheri, Payam Soltani
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This article presents an analytical model to estimate the harvested power from a Magnetostrictive cantilevered beam with tip excitation. Furthermore, the effects of internal and external damping on harvested power are investigated. The magnetostrictive material in this harvester is Galfenol. In comparison to other popular smart materials like Terfenol-D, Galfenol has higher strength and machinability. In this article, first, a mechanical model of the Euler-Bernoulli beam is employed to calculate the deflection of the harvester. Then, the magneto-mechanical equation of Galfenol is combined with Faraday's law to calculate the generated voltage of the Magnetostrictive cantilevered beam harvester. Finally, the beam model is incorporated in the aforementioned combination. The results show that a 30×8.5×1 mm Galfenol cantilever beam harvester with 80 turn pickup coil can generate up to 3.7 mV and 9 mW. Furthermore, sensitivity analysis made by Response Surface Method (RSM) shows that the harvested power is only sensitive to the internal damping coefficient.
Keywords: Internal damping coefficient, external damping coefficient, Euler-Bernoulli, energy harvester, Galfenol, magnetostrictive, response surface method.
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