Search results for: Empiric Characteristic Function
Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 2691

Search results for: Empiric Characteristic Function

2661 The Core and Shapley Function for Games on Augmenting Systems with a Coalition Structure

Authors: Fan-Yong Meng

Abstract:

In this paper, we first introduce the model of games on augmenting systems with a coalition structure, which can be seen as an extension of games on augmenting systems. The core of games on augmenting systems with a coalition structure is defined, and an equivalent form is discussed. Meantime, the Shapley function for this type of games is given, and two axiomatic systems of the given Shapley function are researched. When the given games are quasi convex, the relationship between the core and the Shapley function is discussed, which does coincide as in classical case. Finally, a numerical example is given.

Keywords: Cooperative game, augmenting system, Shapley function, core.

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2660 On Figuring the City Characteristics and Landscape in Overall Urban Design: A Case Study in Xiangyang Central City, China

Authors: Guyue Zhu, Liangping Hong

Abstract:

Chinese overall urban design faces a large number of problems such as the neglect of urban characteristics, generalization of content, and difficulty in implementation. Focusing on these issues, this paper proposes the main points of shaping urban characteristics in overall urban design: focuses on core problems in city function and scale, landscape pattern, historical culture, social resources and modern city style and digs the urban characteristic genes. Then, we put forward “core problem location and characteristic gene enhancement” as a kind of overall urban design technical method. Firstly, based on the main problems in urban space as a whole, for the operability goal, the method extracts the key genes and integrates into the multi-dimension system in a targeted manner. Secondly, hierarchical management and guidance system is established which may be in line with administrative management. Finally, by converting the results, action plan is drawn up that can be dynamically implemented. Based on the above idea and method, a practical exploration has been performed in the case of Xiangyang central city.

Keywords: City characteristics, overall urban design, planning implementation, Xiangyang central city.

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2659 Optimization of Control Parameters for MRR in Injection Flushing Type of EDM on Stainless Steel 304 Workpiece

Authors: M. S. Reza, M. Hamdi, A.S. Hadi

Abstract:

The operating control parameters of injection flushing type of electrical discharge machining process on stainless steel 304 workpiece with copper tools are being optimized according to its individual machining characteristic i.e. material removal rate (MRR). Lower MRR during EDM machining process may decrease its- machining productivity. Hence, the quality characteristic for MRR is set to higher-the-better to achieve the optimum machining productivity. Taguchi method has been used for the construction, layout and analysis of the experiment for each of the machining characteristic for the MRR. The use of Taguchi method in the experiment saves a lot of time and cost of preparing and machining the experiment samples. Therefore, an L18 Orthogonal array which was the fundamental component in the statistical design of experiments has been used to plan the experiments and Analysis of Variance (ANOVA) is used to determine the optimum machining parameters for this machining characteristic. The control parameters selected for this optimization experiments are polarity, pulse on duration, discharge current, discharge voltage, machining depth, machining diameter and dielectric liquid pressure. The result had shown that the higher the discharge voltage, the higher will be the MRR.

Keywords: ANOVA, EDM, Injection Flushing, L18 OrthogonalArray, MRR, Stainless Steel 304

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2658 The Study and Practice of the Thermal Energy and Power Engineering Characteristic Specialty in China

Authors: Junjie Chen

Abstract:

According to the demand of the power and refrigeration industry, the theoretical and practical teachings of the Thermal Energy and Power Engineering characteristic specialty in china are studied. The teaching reform and practice of the Thermal Energy and Power Engineering specialty have been carried out, including construction and reform measures, teaching reform and practice, features, and achievements. Proved by practices, the theoretical and practical teaching effects are obvious. The study results can provides certain reference experience for theoretical and practical teachings of the related specialties in china.

Keywords: Theoretical teaching, practical teaching, Thermal Energy and Power Engineering, characteristic specialty, teaching reform.

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2657 Calculation of Wave Function at the Origin (WFO) for the Ground State of Doubly Heavy Mesons Based On the Variational Method

Authors: Maryam Momeni Feili, Mahvash Zandy Navgaran

Abstract:

The wave function at the origin is an important quantity in studying many physical problems concerning heavy quarkonia. This is because that it is using for calculating spin state hyperfine splitting and also crucial to evaluating the production and decay amplitude of the heavy quarkonium. In this paper, we present the variational method by using the single-parameter wave function to estimate the WFO for the ground state of heavy mesons.

Keywords: Wave function at the origin, heavy mesons, bound states, variational method, non-relativistic quark model, potential model, trial wave function.

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2656 Real-time Laser Monitoring based on Pipe Detective Operation

Authors: Mongkorn Klingajay, Tawatchai Jitson

Abstract:

The pipe inspection operation is the difficult detective performance. Almost applications are mainly relies on a manual recognition of defective areas that have carried out detection by an engineer. Therefore, an automation process task becomes a necessary in order to avoid the cost incurred in such a manual process. An automated monitoring method to obtain a complete picture of the sewer condition is proposed in this work. The focus of the research is the automated identification and classification of discontinuities in the internal surface of the pipe. The methodology consists of several processing stages including image segmentation into the potential defect regions and geometrical characteristic features. Automatic recognition and classification of pipe defects are carried out by means of using an artificial neural network technique (ANN) based on Radial Basic Function (RBF). Experiments in a realistic environment have been conducted and results are presented.

Keywords: Artificial neural network, Radial basic function, Curve fitting, CCTV, Image segmentation, Data acquisition.

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2655 Fragility Analysis of Weir Structure Subjected to Flooding Water Damage

Authors: Oh Hyeon Jeon, WooYoung Jung

Abstract:

In this study, seepage analysis was performed by the level difference between upstream and downstream of weir structure for safety evaluation of weir structure against flooding. Monte Carlo Simulation method was employed by considering the probability distribution of the adjacent ground parameter, i.e., permeability coefficient of weir structure. Moreover, by using a commercially available finite element program (ABAQUS), modeling of the weir structure is carried out. Based on this model, the characteristic of water seepage during flooding was determined at each water level with consideration of the uncertainty of their corresponding permeability coefficient. Subsequently, fragility function could be constructed based on this response from numerical analysis; this fragility function results could be used to determine the weakness of weir structure subjected to flooding disaster. They can also be used as a reference data that can comprehensively predict the probability of failur,e and the degree of damage of a weir structure.

Keywords: Weir structure, seepage, flood disaster fragility, probabilistic risk assessment, Monte-Carlo Simulation, permeability coefficient.

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2654 A Transfer Function Representation of Thermo-Acoustic Dynamics for Combustors

Authors: Myunggon Yoon, Jung-Ho Moon

Abstract:

In this paper, we present a transfer function representation of a general one-dimensional combustor. The input of the transfer function is a heat rate perturbation of a burner and the output is a flow velocity perturbation at the burner. This paper considers a general combustor model composed of multiple cans with different cross sectional areas, along with a non-zero flow rate.

Keywords: Thermoacoustics, dynamics, combustor, transfer function.

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2653 Predicting Protein Function using Decision Tree

Authors: Manpreet Singh, Parminder Kaur Wadhwa, Surinder Kaur

Abstract:

The drug discovery process starts with protein identification because proteins are responsible for many functions required for maintenance of life. Protein identification further needs determination of protein function. Proposed method develops a classifier for human protein function prediction. The model uses decision tree for classification process. The protein function is predicted on the basis of matched sequence derived features per each protein function. The research work includes the development of a tool which determines sequence derived features by analyzing different parameters. The other sequence derived features are determined using various web based tools.

Keywords: Sequence Derived Features, decision tree.

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2652 Spatio-Temporal Orientation Development during the Physical Education Class, with 5th and 6th Form Pupils

Authors: Constantin Pehoiu

Abstract:

School physical education, through its objectives and contents, efficiently valorizes the pupils- abilities, developing them, especially the coordinative skill component, which is the basis of movement learning, of the development of the daily motility and also of the special, refined motility required by the practice of certain sports. Medium school age offers the nervous and motor substratum needed for the acquisition of complex motor habits, a substratum that is essential for the coordinative skill. Individuals differ as to the level at which this function is performed, the extent to which this function turns an individual into a person that is adapted and adaptable to complex and various situations. Spatio-temporal orientation, together with movement combination and coupling, and with kinesthetic, balance, motor reaction, movement transformation and rhythm differentiation form the coordinative skills. From our viewpoint, these are characteristic features with high levels of manifestation in a complex psychomotor act - valorizing the quality of one-s talent - as well as indices pertaining to one-s psychomotor intelligence and creativity.

Keywords: development, lesson, spatio-temporal orientation, physical education.

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2651 The Effect of Prior Characteristic on Perceived Prosocial Content in Media

Authors: Pawit Monkolprasit, Proud Arunrangsiwed

Abstract:

It was important to understand the impact of media in young adolescents. The animated film, Khun Tong Dang the Inspirations (2015), was purposefully created for teaching young children to have a positive personal trait. The current study used this film as the case study. The objective is to understand the relationship between the good characteristic of movie audiences and their perception of the good characteristic of a movie character. One-hundred students from various age ranges responded to quantitative questionnaires. The questions included their age, gender, perception about their own personal traits, perception about their experiences with others, and perception about the bravery, intelligence, and gratefulness of the character. It was found that a good personal trait has a strong relationship with the perception of bravery, intelligence, and gratefulness of the character.

Keywords: Impact of media, children, personal trait, prosocial content.

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2650 Assessing the Function of Light and Colorin Architectural View

Authors: Gholam Hossein Naseri, Manucher Tamizi

Abstract:

Light is one of the most important qualitative and symbolic factors and has a special position in architecture and urban development in regard to practical function. The main function of light, either natural or artificial, is lighting up the environment and the constructional forms which is called lighting. However, light is used to redefine the urban spaces by architectural genius with regard to three aesthetic, conceptual and symbolic factors. In architecture and urban development, light has a function beyond lighting up the environment, and the designers consider it as one of the basic components. The present research aims at studying the function of light and color in architectural view and their effects in buildings.

Keywords: Architectural View , Color , Light

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2649 Particle Swarm Optimization and Quantum Particle Swarm Optimization to Multidimensional Function Approximation

Authors: Diogo Silva, Fadul Rodor, Carlos Moraes

Abstract:

This work compares the results of multidimensional function approximation using two algorithms: the classical Particle Swarm Optimization (PSO) and the Quantum Particle Swarm Optimization (QPSO). These algorithms were both tested on three functions - The Rosenbrock, the Rastrigin, and the sphere functions - with different characteristics by increasing their number of dimensions. As a result, this study shows that the higher the function space, i.e. the larger the function dimension, the more evident the advantages of using the QPSO method compared to the PSO method in terms of performance and number of necessary iterations to reach the stop criterion.

Keywords: PSO, QPSO, function approximation, AI, optimization, multidimensional functions.

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2648 Statistical Approach to Basis Function Truncation in Digital Interpolation Filters

Authors: F. Castillo, J. Arellano, S. Sánchez

Abstract:

In this paper an alternative analysis in the time domain is described and the results of the interpolation process are presented by means of functions that are based on the rule of conditional mathematical expectation and the covariance function. A comparison between the interpolation error caused by low order filters and the classic sinc(t) truncated function is also presented. When fewer samples are used, low-order filters have less error. If the number of samples increases, the sinc(t) type functions are a better alternative. Generally speaking there is an optimal filter for each input signal which depends on the filter length and covariance function of the signal. A novel scheme of work for adaptive interpolation filters is also presented.

Keywords: Interpolation, basis function, over-sampling.

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2647 Optimization of Control Parameters for EWR in Injection Flushing Type of EDM on Stainless Steel 304 Workpiece

Authors: M. S. Reza, M. Hamdi, S. H. Tomadi, A. R. Ismail

Abstract:

The operating control parameters of injection flushing type of electrical discharge machining process on stainless steel 304 workpiece using copper tools are being optimized according to its individual machining characteristic i.e. Electrode Wear Ratio (EWR). Higher EWR would give bad dimensional precision for the EDM machined workpiece because of high electrode wear. Hence, the quality characteristic for EWR is set to lower-the-better to achieve the optimum dimensional precision for the machined workpiece. Taguchi method has been used for the construction, layout and analysis of the experiment for EWR machining characteristic. The use of Taguchi method in the experiment saves a lot of time and cost of preparing and machining the experiment samples. Therefore, an L18 Orthogonal array which was the fundamental component in the statistical design of experiments has been used to plan the experiments and Analysis of Variance (ANOVA) is used to determine the optimum machining parameters for this machining characteristic. The control parameters selected for this optimization experiments are polarity, pulse on duration, discharge current, discharge voltage, machining depth, machining diameter and dielectric liquid pressure. The result had shown that negative polarity machining parameter setting will decreases EWR.

Keywords: ANOVA, EDM, Injection Flushing, L18Orthogonal Array, EWR, Stainless Steel 304

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2646 A Case Study to Assess the Validity of Function Points

Authors: Neelam Bawane nee' Singhal, C. V. Srikrishna

Abstract:

Many metrics were proposed to evaluate the characteristics of the analysis and design model of a given product which in turn help to assess the quality of the product. Function point metric is a measure of the 'functionality' delivery by the software. This paper presents an analysis of a set of programs of a project developed in Cµ through Function Points metric. Function points are measured for a Data Flow Diagram (DFD) of the case developed at initial stage. Lines of Codes (LOCs) and possible errors are calculated with the help of measured Function Points (FPs). The calculations are performed using suitable established functions. Calculated LOCs and errors are compared with actual LOCs and errors found at the time of analysis & design review, implementation and testing. It has been observed that actual found errors are more than calculated errors. On the basis of analysis and observations, authors conclude that function point provides useful insight and helps to analyze the drawbacks in the development process.

Keywords: Function Points, Data Flow Diagram, Lines ofCodes.

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2645 The Genesis of the Art of the Kazakh Sals, Seris and Paluans in Characteristic Comparison to European Histriones and Russian Skomorkhs

Authors: D. Dosbatyrov

Abstract:

This article is a piece of the doctoral thesis "Syncretism of traditional Kazakh culture in the light of the innovation direction of circus and choreographic art of Kazakhstan and its integration into the world civilization", and reveals the features of the creative personalities of the traditional culture of shamans, sals, seris, paluans in the comparative characteristic of the European histriones and Russian skomorokhs.

Keywords: circus, histriones, shamans, skomorkhs

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2644 Subclasses of Bi-Univalent Functions Associated with Hohlov Operator

Authors: Rashidah Omar, Suzeini Abdul Halim, Aini Janteng

Abstract:

The coefficients estimate problem for Taylor-Maclaurin series is still an open problem especially for a function in the subclass of bi-univalent functions. A function f ϵ A is said to be bi-univalent in the open unit disk D if both f and f-1 are univalent in D. The symbol A denotes the class of all analytic functions f in D and it is normalized by the conditions f(0) = f’(0) – 1=0. The class of bi-univalent is denoted by  The subordination concept is used in determining second and third Taylor-Maclaurin coefficients. The upper bound for second and third coefficients is estimated for functions in the subclasses of bi-univalent functions which are subordinated to the function φ. An analytic function f is subordinate to an analytic function g if there is an analytic function w defined on D with w(0) = 0 and |w(z)| < 1 satisfying f(z) = g[w(z)]. In this paper, two subclasses of bi-univalent functions associated with Hohlov operator are introduced. The bound for second and third coefficients of functions in these subclasses is determined using subordination. The findings would generalize the previous related works of several earlier authors.

Keywords: Analytic functions, bi-univalent functions, Hohlov operator, subordination.

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2643 The Study of Chain Initiation Effect on the Direct Initiation of Detonation

Authors: Masoud Afrand, Saeid Farahat, Mehdi Alamkar

Abstract:

In this research, effect of combustion reaction mechanism on direct initiation of detonation has been studied numerically. For this purpose, reaction mechanism has been simulated by using a three-step chemical kinetics model. The reaction scheme consists sequentially of a chain-initiation and chainbranching step, followed by a temperature -independent chaintermination. In a previous research, the effect of chain-branching on the direct initiation of detonation is studied. In this research effect of chain-initiation on direct initiation of detonation is investigated. For the investigation, first a characteristic time (τ) for each step of mechanism, which includes effect of different kinetics parameters, is defined. Then the effect of characteristic time of chain-initiation (τI) on critical initiation energy is studied. It is seen that increasing τI, causes critical initiation energy to be increased. Drawing detonation's shock pressure diagrams for different cases, shows that in small value of τI , kinetics has more important effect on the behavior of the wave.

Keywords: Detonation initiation, Initiation energy, Reaction rate, Characteristic time.

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2642 Explicit Chain Homotopic Function to Compute Hochschild Homology of the Polynomial Algebra

Authors: Z. Altawallbeh

Abstract:

In this paper, an explicit homotopic function is constructed to compute the Hochschild homology of a finite dimensional free k-module V. Because the polynomial algebra is of course fundamental in the computation of the Hochschild homology HH and the cyclic homology CH of commutative algebras, we concentrate our work to compute HH of the polynomial algebra, by providing certain homotopic function.

Keywords: Exterior algebra, free resolution, free and projective modules, Hochschild homology, homotopic function, symmetric algebra.

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2641 Some Solitary Wave Solutions of Generalized Pochhammer-Chree Equation via Exp-function Method

Authors: Kourosh Parand, Jamal Amani Rad

Abstract:

In this paper, Exp-function method is used for some exact solitary solutions of the generalized Pochhammer-Chree equation. It has been shown that the Exp-function method, with the help of symbolic computation, provides a very effective and powerful mathematical tool for solving nonlinear partial differential equations. As a result, some exact solitary solutions are obtained. It is shown that the Exp-function method is direct, effective, succinct and can be used for many other nonlinear partial differential equations.

Keywords: Exp-function method, generalized Pochhammer- Chree equation, solitary wave solution, ODE's.

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2640 A New Approach to Solve Blasius Equation using Parameter Identification of Nonlinear Functions based on the Bees Algorithm (BA)

Authors: E. Assareh, M.A. Behrang, M. Ghalambaz, A.R. Noghrehabadi, A. Ghanbarzadeh

Abstract:

In this paper, a new approach is introduced to solve Blasius equation using parameter identification of a nonlinear function which is used as approximation function. Bees Algorithm (BA) is applied in order to find the adjustable parameters of approximation function regarding minimizing a fitness function including these parameters (i.e. adjustable parameters). These parameters are determined how the approximation function has to satisfy the boundary conditions. In order to demonstrate the presented method, the obtained results are compared with another numerical method. Present method can be easily extended to solve a wide range of problems.

Keywords: Bees Algorithm (BA); Approximate Solutions; Blasius Differential Equation.

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2639 Stability Analysis of Fractional Order Systems with Time Delay

Authors: Hong Li, Shou-Ming Zhong, Hou-Biao Li

Abstract:

In this paper, we mainly study the stability of linear and interval linear fractional systems with time delay. By applying the characteristic equations, a necessary and sufficient stability condition is obtained firstly, and then some sufficient conditions are deserved. In addition, according to the equivalent relationship of fractional order systems with order 0 < α ≤ 1 and with order 1 ≤ β < 2, one may get more relevant theorems. Finally, two examples are provided to demonstrate the effectiveness of our results.

Keywords: Fractional order systems, Time delay, Characteristic equation.

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2638 Extremal Properties of Generalized Class of Close-to-convex Functions

Authors: Norlyda Mohamed, Daud Mohamad, Shaharuddin Cik Soh

Abstract:

Let Gα ,β (γ ,δ ) denote the class of function f (z), f (0) = f ′(0)−1= 0 which satisfied e δ {αf ′(z)+ βzf ′′(z)}> γ i Re in the open unit disk D = {z ∈ı : z < 1} for some α ∈ı (α ≠ 0) , β ∈ı and γ ∈ı (0 ≤γ <α ) where δ ≤ π and α cosδ −γ > 0 . In this paper, we determine some extremal properties including distortion theorem and argument of f ′( z ) .

Keywords: Argument of f ′(z) , Carathéodory Function, Closeto- convex Function, Distortion Theorem, Extremal Properties

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2637 The Study of the Discrete Risk Model with Random Income

Authors: Peichen Zhao

Abstract:

In this paper, we extend the compound binomial model to the case where the premium income process, based on a binomial process, is no longer a linear function. First, a mathematically recursive formula is derived for non ruin probability, and then, we examine the expected discounted penalty function, satisfy a defect renewal equation. Third, the asymptotic estimate for the expected discounted penalty function is then given. Finally, we give two examples of ruin quantities to illustrate applications of the recursive formula and the asymptotic estimate for penalty function.

Keywords: Discounted penalty function, compound binomial process, recursive formula, discrete renewal equation, asymptotic estimate.

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2636 Investigation of the Unbiased Characteristic of Doppler Frequency to Different Antenna Array Geometries

Authors: Somayeh Komeylian

Abstract:

Array signal processing techniques have been recently developing in a variety application of the performance enhancement of receivers by refraining the power of jamming and interference signals. In this scenario, biases induced to the antenna array receiver degrade significantly the accurate estimation of the carrier phase. Owing to the integration of frequency becomes the carrier phase, we have obtained the unbiased doppler frequency for the high precision estimation of carrier phase. The unbiased characteristic of Doppler frequency to the power jamming and the other interference signals allows achieving the highly accurate estimation of phase carrier. In this study, we have rigorously investigated the unbiased characteristic of Doppler frequency to the variation of the antenna array geometries. The simulation results have efficiently verified that the Doppler frequency remains also unbiased and accurate to the variation of antenna array geometries.

Keywords: Array signal processing, unbiased Doppler frequency, GNSS, carrier phase, slowly fluctuating point target.

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2635 Clustering Unstructured Text Documents Using Fading Function

Authors: Pallav Roxy, Durga Toshniwal

Abstract:

Clustering unstructured text documents is an important issue in data mining community and has a number of applications such as document archive filtering, document organization and topic detection and subject tracing. In the real world, some of the already clustered documents may not be of importance while new documents of more significance may evolve. Most of the work done so far in clustering unstructured text documents overlooks this aspect of clustering. This paper, addresses this issue by using the Fading Function. The unstructured text documents are clustered. And for each cluster a statistics structure called Cluster Profile (CP) is implemented. The cluster profile incorporates the Fading Function. This Fading Function keeps an account of the time-dependent importance of the cluster. The work proposes a novel algorithm Clustering n-ary Merge Algorithm (CnMA) for unstructured text documents, that uses Cluster Profile and Fading Function. Experimental results illustrating the effectiveness of the proposed technique are also included.

Keywords: Clustering, Text Mining, Unstructured TextDocuments, Fading Function.

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2634 A Dual Fitness Function Genetic Algorithm: Application on Deterministic Identical Machine Scheduling

Authors: Saleem Z. Ramadan, Gürsel A. Süer

Abstract:

In this paper a genetic algorithm (GA) with dual-fitness function is proposed and applied to solve the deterministic identical machine scheduling problem. The mating fitness function value was used to determine the mating for chromosomes, while the selection fitness function value was used to determine their survivals. The performance of this algorithm was tested on deterministic identical machine scheduling using simulated data. The results obtained from the proposed GA were compared with classical GA and integer programming (IP). Results showed that dual-fitness function GA outperformed the classical single-fitness function GA with statistical significance for large problems and was competitive to IP, particularly when large size problems were used.

Keywords: Machine scheduling, Genetic algorithms, Due dates, Number of tardy jobs, Number of early jobs, Integer programming, Dual Fitness functions.

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2633 Software-Defined Radio Based Channel Measurement System of Wideband HF Communication System in Low-Latitude Region

Authors: P. H. Mukti, I. Kurniawati, F. Oktaviansyah, A. D. Adhitya, N. Rachmadani, R. Corputty, G. Hendrantoro, T. Fukusako

Abstract:

HF Communication system is one of the attractive fields among many researchers since it can be reached long-distance areas with low-cost. This long-distance communication can be achieved by exploiting the ionosphere as a transmission medium for the HF radio wave. However, due to the dynamic nature of ionosphere, the channel characteristic of HF communication has to be investigated in order to gives better performances. Many techniques to characterize HF channel are available in the literature. However, none of those techniques describe the HF channel characteristic in low-latitude regions, especially equatorial areas. Since the ionosphere around equatorial region has an ESF phenomenon, it becomes an important investigation to characterize the wideband HF Channel in low-latitude region. On the other sides, the appearance of software-defined radio attracts the interest of many researchers. Accordingly, in this paper a SDR-based channel measurement system is proposed to be used for characterizing the HF channel in low-latitude region.

Keywords: Channel Characteristic, HF Communication System, LabVIEW, Software-Defined Radio, Universal Software Radio Pheripheral.

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2632 Function of miR-125b in Zebrafish Neurogenesis

Authors: Minh T. N. Le, Cathleen Teh, Ng Shyh-Chang, Vladimir Korzh, Harvey F. Lodish, Bing Lim

Abstract:

MicroRNAs are an important class of gene expression regulators that are involved in many biological processes including embryogenesis. miR-125b is a conserved microRNA that is enriched in the nervous system. We have previously reported the function of miR-125b in neuronal differentiation of human cell lines. We also discovered the function of miR-125b in regulating p53 in human and zebrafish. Here we further characterize the brain defects in zebrafish embryos injected with morpholinos against miR-125b. Our data confirm the essential role of miR-125b in brain morphogenesis particularly in maintaining the balance between proliferation, cell death and differentiation. We identified lunatic fringe (lfng) as an additional target of miR-125b in human and zebrafish and suggest that lfng may mediate the function of miR-125b in neurogenesis. Together, this report reveals new insights into the function of miR- 125b during neural development of zebrafish.

Keywords: microRNA, miR-125b, neurogenesis, zebrafish.

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