Minh T. N. Le and Cathleen Teh and Ng Shyh-Chang and Vladimir Korzh and Harvey F. Lodish and Bing Lim
Function of miR125b in Zebrafish Neurogenesis
156 - 161
2010
4
2
International Journal of Bioengineering and Life Sciences
https://publications.waset.org/pdf/9625
https://publications.waset.org/vol/38
World Academy of Science, Engineering and Technology
MicroRNAs are an important class of gene expression
regulators that are involved in many biological processes including
embryogenesis. miR125b is a conserved microRNA that is enriched
in the nervous system. We have previously reported the function of
miR125b in neuronal differentiation of human cell lines. We also
discovered the function of miR125b in regulating p53 in human and
zebrafish. Here we further characterize the brain defects in zebrafish
embryos injected with morpholinos against miR125b. Our data
confirm the essential role of miR125b in brain morphogenesis
particularly in maintaining the balance between proliferation, cell
death and differentiation. We identified lunatic fringe (lfng) as an
additional target of miR125b in human and zebrafish and suggest
that lfng may mediate the function of miR125b in neurogenesis.
Together, this report reveals new insights into the function of miR
125b during neural development of zebrafish.
Open Science Index 38, 2010