Search results for: Antibiotic & Heavy Metal Resistance.
1367 Experimental Study on the Hysteresis Properties in Operation of Vertical Axis Wind Turbines
Authors: Ching-Huei Lin, Yao-Pang Hsu, M. Z. Dosaev, Yu. D. Selyutskii, L. A. Klimina
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Hysteresis phenomenon has been observed in the operations of both horizontal-axis and vertical-axis wind turbines (HAWTs and VAWTs). In this study, wind tunnel experiments were applied to investigate the characters of hysteresis phenomena between the angular speed and the external resistance of electrical loading during the operation of a Darrieus type VAWT. Data of output voltage, output current, angular speed of wind turbine under different wind speeds are measured and analyzed. Results show that the range of external resistance changes with the wind speed. The range decreases as the wind speed increases following an exponential decay form. Experiments also indicate that the maximum output power of wind turbines is always inside the range where hysteresis happened. These results provide an important reference to the design of output control system of wind turbines.Keywords: Hysteresis phenomenon, Angular speed, Range ofexternal resistance
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 24631366 Ultimate Shear Resistance of Plate Girders Part 2- Höglund Theory
Authors: Ahmed S. Elamary
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Ultimate shear resistance (USR) of slender plate girders can be predicted theoretically using Cardiff theory or Höglund theory. This paper will be concerned with predicting the USR using Höglund theory and EC3. Two main factors can affect the USR, the panel width “b” and the web depth “d”, consequently, the panel aspect ratio (b/d) has to be identified by limits. In most of the previous study, there is no limit for panel aspect ratio indicated. In this paper theoretical analysis has been conducted to study the effect of (b/d) on the USR. The analysis based on ninety six test results of steel plate girders subjected to shear executed and collected by others. New formula proposed to predict the percentage of the distance between the plastic hinges form in the flanges “c” to panel width “b”. Conservative limits of (c/b) have been suggested to get a consistent value of USR.
Keywords: Ultimate shear resistance, Plate Girder, Höglund’s theory, EC3.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 49981365 miR-200c as a Biomarker for 5-FU Chemosensitivity in Colorectal Cancer
Authors: Rezvan Najafi, Korosh Heydari, Massoud Saidijam
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5-FU is a chemotherapeutic agent that has been used in colorectal cancer (CRC) treatment. However, it is usually associated with the acquired resistance, which decreases the therapeutic effects of 5-FU. miR-200c is involved in chemotherapeutic drug resistance, but its mechanism is not fully understood. In this study, the effect of inhibition of miR-200c in sensitivity of HCT-116 CRC cells to 5-FU was evaluated. HCT-116 cells were transfected with LNA-anti- miR-200c for 48 h. mRNA expression of miR-200c was evaluated using quantitative real- time PCR. The protein expression of phosphatase and tensin homolog (PTEN) and E-cadherin were analyzed by western blotting. Annexin V and propidium iodide staining assay were applied for apoptosis detection. The caspase-3 activation was evaluated by an enzymatic assay. The results showed LNA-anti-miR-200c inhibited the expression of PTEN and E-cadherin protein, apoptosis and activation of caspase 3 compared with control cells. In conclusion, these results suggest that miR-200c as a prognostic marker can overcome to 5-FU chemoresistance in CRC.
Keywords: Colorectal cancer, miR-200c, 5-FU resistance, E-cadherin, PTEN.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 9171364 Tractive Performance Prediction for Intelligent Air-Cushion Track Vehicle: Fuzzy Logic Approach
Authors: Altab Hossain, Ataur Rahman, A. K. M. Mohiuddin, Yulfian Aminanda
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Fuzzy logic approach is used in this study to predict the tractive performance in terms of traction force, and motion resistance for an intelligent air cushion track vehicle while it operates in the swamp peat. The system is effective to control the intelligent air –cushion system with measuring the vehicle traction force (TF), motion resistance (MR), cushion clearance height (CH) and cushion pressure (CP). Sinkage measuring sensor, magnetic switch, pressure sensor, micro controller, control valves and battery are incorporated with the Fuzzy logic system (FLS) to investigate experimentally the TF, MR, CH, and CP. In this study, a comparison for tractive performance of an intelligent air cushion track vehicle has been performed with the results obtained from the predicted values of FLS and experimental actual values. The mean relative error of actual and predicted values from the FLS model on traction force, and total motion resistance are found as 5.58 %, and 6.78 % respectively. For all parameters, the relative error of predicted values are found to be less than the acceptable limits. The goodness of fit of the prediction values from the FLS model on TF, and MR are found as 0.90, and 0.98 respectively.Keywords: Cushion pressure, Fuzzy logic, Motion resistance, Traction force.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14991363 Protection of Transformers against Surge Voltage
Authors: Anil S. Khopkar, Umesh N. Soni
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Surge voltage arises in the system either by switching operations of heavy load or by natural lightning. Surge voltages cause significant failure of power system equipment if adequate protection not provided. The surge arrestor is device which is connected in a power system to protect the equipment against surge voltages. To protect the transformers against surge voltages, metal oxide surge arrestors (MOSA) are connected across each terminal. The Basic Insulation Level (BIL) of transformers has been defined in the national and international standards based on its voltage rating. While designing transformer insulation, factors such as BIL, surge arrestor ratings, and its operating voltage have to be considered. However, the performance of transformer insulation largely depends on the ratings of the surge arrestor ratings, their location, the margin considered in insulation design, the quantity of surge voltage strikes, etc. This paper demonstrates the role of surge arrestors in protecting transformers against overvoltage, transformer insulation design, the optimum location of surge arrestors and their connection lead length, insulation coordination for transformers, the protection margin in BIL, and methods of safeguarding transformers against surge voltages in detail.
Keywords: Surge voltage, surge arrestors, transformer, protection margin.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 781362 Resistance to Chloride Penetration of High Strength Self-Compacting Concretes: Pumice and Zeolite Effect
Authors: Kianoosh Samimi, Siham Kamali-Bernard, Ali Akbar Maghsoudi
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This paper aims to contribute to the characterization and the understanding of fresh state, compressive strength and chloride penetration tendency of high strength self-compacting concretes (HSSCCs) where Portland cement type II is partially substituted by 10% and 15% of natural pumice and zeolite. First, five concrete mixtures with a control mixture without any pozzolan are prepared and tested in both fresh and hardened states. Then, resistance to chloride penetration for all formulation is investigated in non-steady state and steady state by measurement of chloride penetration and diffusion coefficient. In non-steady state, the correlation between initial current and chloride penetration with diffusion coefficient is studied. Moreover, the relationship between diffusion coefficient in non-steady state and electrical resistivity is determined. The concentration of free chloride ions is also measured in steady state. Finally, chloride penetration for all formulation is studied in immersion and tidal condition. The result shows that, the resistance to chloride penetration for HSSCC in immersion and tidal condition increases by incorporating pumice and zeolite. However, concrete with zeolite displays a better resistance. This paper shows that the HSSCC with 15% pumice and 10% zeolite is suitable in fresh, hardened, and durability characteristics.Keywords: Chloride penetration, immersion, pumice, HSSCC, tidal, zeolite.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 8011361 Application of Four-electrode Method to Analysis Resistance Characteristics of Conductive Concrete
Authors: Chun-Yao Lee, Siang-Ren Wang
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The purpose of this paper is to discuss the influence of resistance characteristic on the high conductive concrete considering the various voltage and environment. The four-electrode method is applied to the tailor-made high conductive concrete with appropriate proportion. The curve of resistivity with the changes of voltage and environment is plotted and the changes of resistivity are explored. The result based on the methods reveals that resistivity is less affected by the temperature factor, and the four-electrode method would be an applicable measurement method on a site inspection.Keywords: Conductive concrete, Resistivity.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16041360 The Gravitational Impact of the Sun and the Moon on Heavy Mineral Deposits and Dust Particles in Low Gravity Regions of the Earth
Authors: T. B. Karu Jayasundara
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The Earth’s gravity is not uniform. The satellite imageries of the Earth’s surface from NASA reveal a number of different gravity anomaly regions all over the globe. When the moon rotates around the earth, its gravity has a major physical influence on a number of regions on the earth. This physical change can be seen by the tides. The tides make sea levels high and low in coastal regions. During high tide, the gravitational force of the Moon pulls the Earth’s gravity so that the total gravitational intensity of Earth is reduced; it is further reduced in the low gravity regions of Earth. This reduction in gravity helps keep the suspended particles such as dust in the atmosphere, sand grains in the sea water for longer. Dramatic differences can be seen from the floating dust in the low gravity regions when compared with other regions. The above phenomena can be demonstrated from experiments. The experiments have to be done in high and low gravity regions of the earth during high and low tide, which will assist in comparing the final results. One of the experiments that can be done is by using a water filled cylinder about 80 cm tall, a few particles, which have the same density and same diameter (about 1 mm) and a stop watch. The selected particles were dropped from the surface of the water in the cylinder and the time taken for the particles to reach the bottom of the cylinder was measured using the stop watch. The times of high and low tide charts can be obtained from the regional government authorities. This concept is demonstrated by the particle drop times taken at high and low tides. The result of the experiment shows that the particle settlement time is less in low tide and high in high tide. The experiment for dust particles in air can be collected on filters, which are cellulose ester membranes and using a vacuum pump. The dust on filters can be used to make slides according to the NOHSC method. Counting the dust particles on the slides can be done using a phase contrast microscope. The results show that the concentration of dust is high at high tide and low in low tide. As a result of the high tides, a high concentration of heavy minerals deposit on placer deposits and dust particles retain in the atmosphere for longer in low gravity regions. These conditions are remarkably exhibited in the lowest low gravity region of the earth, mainly in the regions of India, Sri Lanka and in the middle part of the Indian Ocean. The biggest heavy mineral placer deposits are found in coastal regions of India and Sri Lanka and heavy dust particles are found in the atmosphere of India, particularly in the Delhi region.
Keywords: Dust particles, high and low tides, heavy minerals. low gravity.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 6231359 Enrichment of Cr, Mn, Ni and Zn in Surface Soil
Authors: Gitimoni Deka, Krishna G Bhattacharyya
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The textile industry produces highly coloured effluents containing polar and non-polar compounds. The textile mill run by the Assam Polyester Co-operative Society Limited (APOL) is situated at Rangia, about 55 km from Guwahati (26011' N, 91047' E) in the northern bank of the river Brahmaputra, Assam (India). This unit was commissioned in June 1988 and started commercial production in November 1988. The installed capacity of the weaving unit was 8000 m/day and that of the processing unit was 20,000 m/day. The mill has its own dyeing unit with a capacity of 1500-2000 kg/day. The western side of the mill consists of vast agricultural land and the far northern and southern side of the mill has scattered human population. The eastern side of the mill has a major road for thoroughfare. The mill releases its effluents into the agricultural land in the western side of the mill. The present study was undertaken to assess the impact of the textile mill on surface soil quality in and around the mill with particular reference to Cr, Mn, Ni and Zn. Surface soil samples, collected along different directions at 200, 500 and 1000 m were digested and the metals were estimated with Atomic Absorption Spectrophotometer. The metals were found in the range of: Cr 50.9 – 105.0 mg kg-1, Mn 19.2- 78.6 mg kg-1, Ni 41.9 – 50.6 mg kg-1 and Zn 187.8 – 1095.8 mg kg-1. The study reveals enrichment of Cr, Mn, Ni and Zn in the soil near the textile mill.Keywords: Cr, Mn, Ni, Zn, soil quality, heavy metal enrichment.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17031358 Deformation Mechanisms at Elevated Temperatures: Influence of Momenta and Energy in the Single Impact Test
Authors: Harald Rojacz, Markus Varga, Horst Winkelmann
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Within this work High Temperature Single Impact Studies were performed to evaluate deformation mechanisms at different energy and momentum levels. To show the influence of different microstructures and hardness levels and their response to single impacts four different materials were tested at various temperatures up to 700°C. One carbide reinforced NiCrBSi based Metal Matrix Composite and three different steels were tested. The aim of this work is to determine critical energies for fracture appearance and the materials response at different energy and momenta levels. Critical impact loadings were examined at elevated temperatures to limit operating conditions in impact dominated regimes at elevated temperatures. The investigations on the mechanisms were performed using different means of microscopy at the surface and in metallographic cross sections. Results indicate temperature dependence of the occurrence of cracks in hardphase rich materials, such as Metal Matrix Composites High Speed Steels and the influence of different impact momenta at constant energies on the deformation of different steels.Keywords: Deformation, High Temperature, Metal Matrix Composite, Single Impact Test, Steel.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 20021357 Effects of Polymers and Alkaline on Recovery Improvement from Fractured Models
Authors: Payam Parvasi, Mohammad Hossein Sedaghat, Reza Janamiri, Amir Hatampour
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In this work, several ASP solutions were flooded into fractured models initially saturated with heavy oil at a constant flow rate and different geometrical characteristics of fracture. The ASP solutions are constituted from 2 polymers i.e. a synthetic polymer, hydrolyzed polyacrylamide as well as a biopolymer, a surfactant and 2types of alkaline. The results showed that using synthetic hydrolyzed polyacrylamide polymer increases ultimate oil recovery; however, type of alkaline does not play a significant rule on oil recovery. In addition, position of the injection well respect to the fracture system has remarkable effects on ASP flooding. For instance increasing angle of fractures with mean flow direction causes more oil recovery and delays breakthrough time. This work can be accounted as a comprehensive survey on ASP flooding which considers most of effective factors in this chemical EOR method.Keywords: ASP Flooding, Fractured System, Displacement, Heavy Oil.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18331356 Numerical Analysis on the Performance of Heatsink with Microchannels
Authors: Jer-Huan Jang, Han-Chieh Chiu, Wei-Chung Yeih, Jia-Jui Yang, Chien-Sheng Huang
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In this paper, numerical simulation is used to investigate the thermal performance of liquid cooling heatsink with microchannels due to geometric arrangement. Commercial software ICEPAK is utilized for the analysis. The considered parameters include aspect ratio, porosity and the length and height of microchannel. The aspect ratio varies from 3 to 16 and the length of microchannel is 10mm, 14mm, and 18mm. The height of microchannel is 2mm, 3mm and 4mm. It is found short channel have better thermal efficiency than long channel at 490Pa. No matter the length of channel the best aspect ratio is 4. It is also noted that pressure difference at 2940Pa the best aspect ratio from 4 to 8, it means pressure difference affect aspect ratio, effective thermal resistance at low pressure difference but lower effective thermal resistance at high pressure difference.Keywords: thermal resistance, liquid cooling, microchannels, numerical analysis, pressure difference
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 21601355 Removal of Pb (II) from Aqueous Solutions using Fuller's Earth
Authors: Tarun Kumar Naiya, Biswajit Singha, Ashim Kumar Bhattacharya, Sudip Kumar Das
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Fuller’s earth is a fine-grained, naturally occurring substance that has a substantial ability to adsorb impurities. In the present study Fuller’s earth has been characterized and used for the removal of Pb(II) from aqueous solution. The effect of various physicochemical parameters such as pH, adsorbent dosage and shaking time on adsorption were studied. The result of the equilibrium studies showed that the solution pH was the key factor affecting the adsorption. The optimum pH for adsorption was 5. Kinetics data for the adsorption of Pb(II) was best described by pseudo-second order model. The effective diffusion co-efficient for Pb(II) adsorption was of the order of 10-8 m2/s. The adsorption data for metal adsorption can be well described by Langmuir adsorption isotherm. The maximum uptake of metal was 103.3 mg/g of adsorbent. Mass transfer analysis was also carried out for the adsorption process. The values of mass transfer coefficients obtained from the study indicate that the velocity of the adsorbate transport from bulk to the solid phase was quite fast. The mean sorption energy calculated from Dubinin-Radushkevich isotherm indicated that the metal adsorption process was chemical in nature.
Keywords: Fuller's earth, Pseudo second order, Mass Transfer co-efficient, Langmuir
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18581354 Prediction of Metals Available to Maize Seedlings in Crude Oil Contaminated Soil
Authors: Stella O. Olubodun, George E. Eriyamremu
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The study assessed the effect of crude oil applied at rates, 0, 2, 5, and 10% on the fractional chemical forms and availability of some metals in soils from Usen, Edo State, with no known crude oil contamination and soil from a crude oil spill site in Ubeji, Delta State, Nigeria. Three methods were used to determine the bioavailability of metals in the soils: maize (Zea mays) plant, EDTA and BCR sequential extraction. The sequential extract acid soluble fraction of the BCR extraction (most labile fraction of the soils, normally associated with bioavailability) were compared with total metal concentration in maize seedlings as a means to compare the chemical and biological measures of bioavailability. Total Fe was higher in comparison to other metals for the crude oil contaminated soils. The metal concentrations were below the limits of 4.7% Fe, 190mg/kg Cu and 720mg/kg Zn intervention values and 36mg/kg Cu and 140mg/kg Zn target values for soils provided by the Department of Petroleum Resources (DPR) guidelines. The concentration of the metals in maize seedlings increased with increasing rates of crude oil contamination. Comparison of the metal concentrations in maize seedlings with EDTA extractable concentrations showed that EDTA extracted more metals than maize plant.Keywords: Availability, crude oil contamination, EDTA, maize, metals.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 13801353 New Insight into Fluid Mechanics of Lorenz Equations
Authors: Yu-Kai Ting, Jia-Ying Tu, Chung-Chun Hsiao
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New physical insights into the nonlinear Lorenz equations related to flow resistance is discussed in this work. The chaotic dynamics related to Lorenz equations has been studied in many papers, which is due to the sensitivity of Lorenz equations to initial conditions and parameter uncertainties. However, the physical implication arising from Lorenz equations about convectional motion attracts little attention in the relevant literature. Therefore, as a first step to understand the related fluid mechanics of convectional motion, this paper derives the Lorenz equations again with different forced conditions in the model. Simulation work of the modified Lorenz equations without the viscosity or buoyancy force is discussed. The time-domain simulation results may imply that the states of the Lorenz equations are related to certain flow speed and flow resistance. The flow speed of the underlying fluid system increases as the flow resistance reduces. This observation would be helpful to analyze the coupling effects of different fluid parameters in a convectional model in future work.
Keywords: Galerkin method, Lorenz equations, Navier-Stokes equations.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 23101352 Equilibrium, Kinetic and Thermodynamic Studies on Biosorption of Cd (II) and Pb (II) from Aqueous Solution Using a Spore Forming Bacillus Isolated from Wastewater of a Leather Factory
Authors: Sh. Kianfar, A. Moheb, H. Ghaforian
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The equilibrium, thermodynamics and kinetics of the biosorption of Cd (II) and Pb(II) by a Spore Forming Bacillus (MGL 75) were investigated at different experimental conditions. The Langmuir and Freundlich, and Dubinin-Radushkevich (D-R) equilibrium adsorption models were applied to describe the biosorption of the metal ions by MGL 75 biomass. The Langmuir model fitted the equilibrium data better than the other models. Maximum adsorption capacities q max for lead (II) and cadmium (II) were found equal to 158.73mg/g and 91.74 mg/g by Langmuir model. The values of the mean free energy determined with the D-R equation showed that adsorption process is a physiosorption process. The thermodynamic parameters Gibbs free energy (ΔG°), enthalpy (ΔH°), and entropy (ΔS°) changes were also calculated, and the values indicated that the biosorption process was exothermic and spontaneous. Experiment data were also used to study biosorption kinetics using pseudo-first-order and pseudo-second-order kinetic models. Kinetic parameters, rate constants, equilibrium sorption capacities and related correlation coefficients were calculated and discussed. The results showed that the biosorption processes of both metal ions followed well pseudo-second-order kinetics.Keywords: biosorption, kinetics, Metal ion removal, thermodynamics
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 20531351 3D Quantum Numerical Simulation of Horizontal Rectangular Dual Metal Gate\Gate All Around MOSFETs
Authors: M. Khaouani, A. Guen-Bouazza, B. Bouazza, Z. Kourdi
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The integrity and issues related to electrostatic performance associated with scaling Si MOSFET bulk sub 10nm channel length promotes research in new device architectures such as SOI, double gate and GAA MOSFET. In this paper, we present some novel characteristic of horizontal rectangular gate\gate all around MOSFETs with dual metal of gate we obtained using SILVACO TCAD tools. We will also exhibit some simulation results we obtained relating to the influence of some parameters variation on our structure, that having a direct impact on their threshold voltage and drain current. In addition, our TFET showed reasonable ION/IOFF ratio of (104) and low drain induced barrier lowering (DIBL) of 39 mV/V.
Keywords: GAA, SILVACO, QUANTUM, MOSFETs.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 29041350 Hole Configuration Effect on Turbine Blade Cooling
Authors: A.Hasanpour, M. Farhadi, H.R. Ashorynejad
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In this paper a numerical technique is used to predict the metal temperature of a gas turbine vane. The Rising combustor exit temperatures in gas turbine engines necessitate active cooling for the downstream turbine section to avoid thermal failure. This study is performed the solution of external flow, internal convection, and conduction within the metal vane. Also the trade-off between the cooling performances in four different hole shapes and configurations is performed. At first one of the commonly used cooling hole geometry is investigated; cylindrical holes and then two other configurations are simulated. The average temperature magnitude in mid-plan section of each configuration is obtained and finally the lower temperature value is selected such as best arrangement.Keywords: Forced Convection, Gas Turbine Blade, Hole Configuration
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 25971349 Operational Challenges of Marine Fiber Reinforced Polymer Composite Structures Coupled with Piezoelectric Transducers
Authors: H. Ucar, U. Aridogan
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Composite structures become intriguing for the design of aerospace, automotive and marine applications due to weight reduction, corrosion resistance and radar signature reduction demands and requirements. Studies on piezoelectric ceramic transducers (PZT) for diagnostics and health monitoring have gained attention for their sensing capabilities, however PZT structures are prone to fail in case of heavy operational loads. In this paper, we develop a piezo-based Glass Fiber Reinforced Polymer (GFRP) composite finite element (FE) model, validate with experimental setup, and identify the applicability and limitations of PZTs for a marine application. A case study is conducted to assess the piezo-based sensing capabilities in a representative marine composite structure. A FE model of the composite structure combined with PZT patches is developed, afterwards the response and functionality are investigated according to the sea conditions. Results of this study clearly indicate the blockers and critical aspects towards industrialization and wide-range use of PZTs for marine composite applications.
Keywords: FRP, marine composite, piezoelectric transducer, sea state, wave-induced loads.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 4861348 Effects of Temperature-Dependent Material Properties on Stress and Temperature in Cracked Metal Plate under Electric Current Load
Authors: Thomas Jin-Chee Liu
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Using the finite element analyses, this paper discusses the effects of temperature-dependent material properties on the stress and temperature fields in a cracked metal plate under the electric current load. The practical and complicated results are obtained when the temperature-dependent material properties are adopted in the analysis. If the simplified (temperature-independent) material properties are used, incorrect results will be obtained.
Keywords: Joule heating, temperature-dependent, crack tip, finite element.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 20031347 In silico Studies on Selected Drug Targets for Combating Drug Resistance in Plasmodium falcifarum
Authors: D. Bhaskar, N. R. Wadehra, M. Gulati, A. Narula, R. Vishnu, G. Katyal
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With drug resistance becoming widespread in Plasmodium falciparum infections, the development of the alternative drugs is the desired strategy for prevention and cure of malaria. Three drug targets were selected to screen promising drug molecules from the GSK library of 13469 molecules. Using an in silico structure-based drug designing approach, the differences in binding energies of the substrate and inhibitor were exploited between target sites of parasite and human to design a drug molecule against Plasmodium. The docking studies have shown several promising molecules from GSK library with more effective binding as compared to the already known inhibitors for the drug targets. Though stronger interaction has been shown by several molecules as compared to the reference, few molecules have shown the potential as drug candidates though in vitro studies are required to validate the results. In case of thymidylate synthase-dihydrofolatereductase (TS-DHFR), three compounds have shown promise for future studies as potential drugs.
Keywords: Drug resistance, Drug targets, In silico studies, Plasmodium falciparum.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 19411346 The Effect of Four-Week Resistance Exercise along with Milk Consumption on NT-proBNP and Plasma Troponin I
Authors: Rostam Abdi, Ahmad Abdi, Zahra Vahedi Langrodi
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The aim of this study is to investigate four-week resistance exercise and milk supplement on NT-proBNP and plasma troponin I of male students. Concerning the methodology of the study, 21 senior high school students of Ardebil city were selected. The selected subjects were randomly shared in three groups of control, exercise- water and exercise- milk. The exercise program includes resistance exercise for a big muscle group. The subjects of control group rested during the study and did not participate in any training. The subjects of exercise- water experimental group immediately received 400 cc water after exercise and exercise- milk group immediately received 400 cc low fat milk. Control-water groups consumed the same amount of water. 48 hours before and after the last exercise session, the blood sample of the subjects were taken for measuring the variables. NT-proBNP and Troponin I concentrations were measured by ELISA. For data analysis, one-way variance analysis test, correlated t-test and Bonferroni post hoc test were used. The significant difference of p ≤ 0.05 was accepted. Resistance training along with milk consumption leads to increase of plasma NT-proBNP, however; this increase has not reached the significant level. Furthermore, meaningful increase was observed in plasma NT–proBNP in exercise group between pretest and posttest values. Furthermore, no meaningful difference was observed between groups in terms of Troponin I after milk consumption. It seems that endurance exercises lead to change in the structure of heart muscle and is along with an increase of NT-proBNP. Furthermore, there is the possibility that milk consumption can lead to release of heart troponin I. The mechanism through which protein supplements have been put on heart troponin I is unknown and requires more research.
Keywords: Resistance exercise, milk, NT-proBNP, Troponin I.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 7141345 Rotor Side Speed Control Methods Using MATLAB/Simulink for Wound Induction Motor
Authors: Rajesh Kumar, Roopali Dogra, Puneet Aggarwal
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In recent advancements in electric machine and drives, wound rotor motor is extensively used. The merit of using wound rotor induction motor is to control speed/torque characteristics by inserting external resistance. Wound rotor induction motor can be used in the cases such as (a) low inrush current, (b) load requiring high starting torque, (c) lower starting current is required, (d) loads having high inertia, and (e) gradual built up of torque. Examples include conveyers, cranes, pumps, elevators, and compressors. This paper includes speed control of wound induction motor using MATLAB/Simulink for rotor resistance and slip power recovery method. The characteristics of these speed control methods are hence analyzed.
Keywords: Wound rotor induction motor, MATLAB/Simulink, rotor resistance method, slip power recovery method.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 24171344 Induction of alpha-Amylase in Wheat Grain Cultivars as an Indicator of Resistance to Pre-harvest Sprouting
Authors: Aidar A. Khakimzhanov, Vladimir A. Kuzovlev, Nurgul S. Mamytova, Dinara A. Shansharova, Oleg V. Fursov
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The influence of humidity and low temperature on the α- amylase activity and isoenzyme composition of grains of different wheat varieties have been studied. The identified samples of varieties have significant difference in the level of enzyme induction under the impact of high humidity and low temperature. It is proposed to use this methodological approach for testing genotypes and wheat breeding lines for resistance to pre-harvest sprouting (PHS).
Keywords: α-Amylase, isoenzymes, wheat, pre-harvest sprouting.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18521343 Preparation of Protective Coating Film on Metal Alloy
Authors: Rana Th. A. Al-Rubaye
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A novel chromium-free protective coating films based on a zeolite coating was growing onto a FeCrAlloy metal using in – situ hydrothermal method. The zeolite film was obtained using in-situ crystallization process that is capable of coating large surfaces with complex shape and in confined spaces has been developed. The zeolite coating offers an advantage of a high mechanical stability and thermal stability. The physicochemical properties were investigated using X-ray diffraction (XRD), Electron Microscopy (SEM), Energy Dispersive X–ray Analysis (EDX) and Thermogravimetric Analysis (TGA). The transition from oxide-on-alloy wires to hydrothermally synthesised uniformly zeolite coated surfaces was followed using SEM and XRD. In addition, the robustness of the prepared coating was confirmed by subjecting these to thermal cycling (ambient to 550oC).Keywords: FeCrAlloy, Zeolite ZSM-5. Zeolite coating.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18421342 Experimental Investigation and Optimization of Nanoparticle Mass Concentration and Heat Input of Loop Heat Pipe
Authors: P. Gunnasegaran, M. Z. Abdullah, M. Z. Yusoff, Nur Irmawati
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This study presents experimental and optimization of nanoparticle mass concentration and heat input based on the total thermal resistance (Rth) of loop heat pipe (LHP), employed for PCCPU cooling. In this study, silica nanoparticles (SiO2) in water with particle mass concentration ranged from 0% (pure water) to 1% is considered as the working fluid within the LHP. The experimental design and optimization is accomplished by the design of experimental tool, Response Surface Methodology (RSM). The results show that the nanoparticle mass concentration and the heat input have significant effect on the Rth of LHP. For a given heat input, the Rth is found to decrease with the increase of the nanoparticle mass concentration up to 0.5% and increased thereafter. It is also found that the Rth is decreased when the heat input is increased from 20W to 60W. The results are optimized with the objective of minimizing the Rth, using Design-Expert software, and the optimized nanoparticle mass concentration and heat input are 0.48% and 59.97W, respectively, the minimum thermal resistance being 2.66 (ºC/W).Keywords: Loop heat pipe, nanofluid, optimization, thermal resistance.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18231341 Optimization of Carbon Nanotube Content of Asphalt Nanocomposites with Regard to Resistance to Permanent Deformation
Authors: João V. Staub de Melo, Glicério Trichês, Liseane P. Thives
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This paper presents the results of the development of asphalt nanocomposites containing carbon nanotubes (CNTs) with high resistance to permanent deformation, aiming to increase the performance of asphalt surfaces in relation to the rutting problem. Asphalt nanocomposites were prepared with the addition of different proportions of CNTs (1%, 2% and 3%) in relation to the weight of asphalt binder. The base binder used was a conventional binder (50-70 penetration) classified as PG 58-22. The optimum percentage of CNT addition in the asphalt binder (base) was determined through the evaluation of the rheological and empirical characteristics of the nanocomposites produced. In order to evaluate the contribution and the effects of the nanocomposite (optimized) in relation to the rutting, the conventional and nanomodified asphalt mixtures were tested in a French traffic simulator (Orniéreur). The results obtained demonstrate the efficient contribution of the asphalt nanocomposite containing CNTs to the resistance to permanent deformation of the asphalt mixture.
Keywords: Asphalt nanocomposites, asphalt mixtures, carbon nanotubes, nanotechnology, permanent deformation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14891340 Lead in The Soil-Plant System Following Aged Contamination from Ceramic Wastes
Authors: F. Pedron, M. Grifoni, G. Petruzzelli, M. Barbafieri, I. Rosellini, B. Pezzarossa
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Lead contamination of agricultural land mainly vegetated with perennial ryegrass (Lolium perenne) has been investigated. The metal derived from the discharge of sludge from a ceramic industry in the past had used lead paints. The results showed very high values of lead concentration in many soil samples. In order to assess the lead soil contamination, a sequential extraction with H2O, KNO3, EDTA was performed, and the chemical forms of lead in the soil were evaluated. More than 70% of lead was in a potentially bioavailable form. Analysis of Lolium perenne showed elevated lead concentration. A Freundlich-like model was used to describe the transferability of the metal from the soil to the plant.
Keywords: Bioavailability, Freundlich-like equation, sequential extraction, soil lead contamination.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 9641339 Studying the Theoretical and Laboratory Design of a Concrete Frame and Optimizing Its Design for Impact and Earthquake Resistance
Authors: Mehrdad Azimzadeh, Seyed Mohammadreza Jabbari, Mohammadreza Hosseinzadeh Alherd
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This paper includes experimental results and analytical studies about increasing resistance of single-span reinforced concreted frames against impact factor and their modeling according to optimization methods and optimizing the behavior of these frames under impact loads. During this study, about 30 designs for different frames were modeled and made using specialized software like ANSYS and Sap and their behavior were examined under variable impacts. Then suitable strategies were offered for frames in terms of concrete mixing in order to optimize frame modeling. To reduce the weight of the frames, we had to use fine-grained stones. After designing about eight types of frames for each type of frames, three samples were designed with the aim of controlling the impact strength parameters, and a good shape of the frame was created for the impact resistance, which was a solid frame with muscular legs, and as a bond away from each other as much as possible with a 3 degree gradient in the upper part of the beam.
Keywords: Optimization, reinforced concrete, single-span frames, optimization methods of impact load.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 6021338 Investigation about Mechanical Equipment Needed to Break the Molecular Bonds of Heavy Oil by Using Hydrodynamic Cavitation
Authors: Mahdi Asghari
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The cavitation phenomenon is the formation and production of micro-bubbles and eventually the bursting of the micro-bubbles inside the liquid fluid, which results in localized high pressure and temperature, causing physical and chemical fluid changes. This pressure and temperature are predicted to be 2000 atmospheres and 5000 °C, respectively. As a result of small bubbles bursting from this process, temperature and pressure increase momentarily and locally, so that the intensity and magnitude of these temperatures and pressures provide the energy needed to break the molecular bonds of heavy compounds such as fuel oil. In this paper, we study the theory of cavitation and the methods of cavitation production by acoustic and hydrodynamic methods and the necessary mechanical equipment and reactors for industrial application of the hydrodynamic cavitation method to break down the molecular bonds of the fuel oil and convert it into useful and economical products.
Keywords: Cavitation, hydrodynamic cavitation, cavitation reactor, fuel oil.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 579