Search results for: dynamic state estimation
1598 Determination of the Concentrated State Using Multiple EEG Channels
Authors: Tae Jin Choi, Jong Ok Kim, Sang Min Jin, Gilwon Yoon
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Analysis of EEG brainwave provides information on mental or emotional states. One of the particular states that can have various applications in human machine interface (HMI) is concentration. 8-channel EEG signals were measured and analyzed. The concentration index was compared during resting and concentrating periods. Among eight channels, locations the frontal lobe (Fp1 and Fp2) showed a clear increase of the concentration index during concentration regardless of subjects. The rest six channels produced conflicting observations depending on subjects. At this time, it is not clear whether individual difference or how to concentrate made these results for the rest six channels. Nevertheless, it is expected that Fp1 and Fp2 are promising locations for extracting control signal for HMI applications.
Keywords: Concentration, EEG, human machine interface.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 34371597 Resistive RAM Based on Hfox and its Temperature Instability Study
Authors: Z. Fang, H.Y. Yu, W.J. Liu, N. Singh, G.Q. Lo
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High performance Resistive Random Access Memory (RRAM) based on HfOx has been prepared and its temperature instability has been investigated in this work. With increasing temperature, it is found that: leakage current at high resistance state increases, which can be explained by the higher density of traps inside dielectrics (related to trap-assistant tunneling), leading to a smaller On/Off ratio; set and reset voltages decrease, which may be attributed to the higher oxygen ion mobility, in addition to the reduced potential barrier to create / recover oxygen ions (or oxygen vacancies); temperature impact on the RRAM retention degradation is more serious than electrical bias.Keywords: RRAM, resistive switching, temperature instability.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 24111596 Design of a Strain Sensor Based on Cascaded Fiber Bragg Grating for Remote Sensing Monitoring
Authors: Arafat A. A. Shabaneh
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Harsh environments require developed detection by an optical communication system to ensure a high level of security and safety. Fiber Bragg gratings (FBGs) are emerging sensing instruments that respond to variations in strain and temperature by varying wavelengths. In this study, a cascaded uniform FBG is designed as a strain sensor for 6 km length at 1550 nm wavelength with 30 °C temperature by analyzing dynamic strain and wavelength shifts. The FBG is placed in a small segment of an optical fiber that reflects light with a specific wavelength and passes on the remaining wavelengths. Consequently, periodic alteration occurs in the refractive index in the fiber core. The alteration in the modal index of the fiber is produced by strain effects on a Bragg wavelength. When the developed sensor is exposed to the strain (0.01) of the cascaded uniform FBG, the wavelength shifts by 0.0000144383 μm. The sensing accuracy of the developed sensor is 0.0012. Simulation results show the reliability and effectiveness of the strain monitoring sensor for remote sensing application.
Keywords: Remote sensing, cascaded fiber Bragg grating, strain sensor, wavelength shift.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 4781595 Optimization of Shear Frame Structures Applying Various Forms of Wavelet Transforms
Authors: Seyed Sadegh Naseralavi, Sohrab Nemati, Ehsan Khojastehfar, Sadegh Balaghi
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In the present research, various formulations of wavelet transform are applied on acceleration time history of earthquake. The mentioned transforms decompose the strong ground motion into low and high frequency parts. Since the high frequency portion of strong ground motion has a minor effect on dynamic response of structures, the structure is excited by low frequency part. Consequently, the seismic response of structure is predicted consuming one half of computational time, comparing with conventional time history analysis. Towards reducing the computational effort needed in seismic optimization of structure, seismic optimization of a shear frame structure is conducted by applying various forms of mentioned transformation through genetic algorithm.
Keywords: Time history analysis, wavelet transform, optimization, earthquake.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 7981594 Smart Lean Manufacturing in the Context of Industry 4.0: A Case Study
Authors: M. Ramadan, B. Salah
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This paper introduces a framework to digitalize lean manufacturing tools to enhance smart lean-based manufacturing environments or Lean 4.0 manufacturing systems. The paper discusses the integration between lean tools and the powerful features of recent real-time data capturing systems with the help of Information and Communication Technologies (ICT) to develop an intelligent real-time monitoring and controlling system of production operations concerning lean targets. This integration is represented in the Lean 4.0 system called Dynamic Value Stream Mapping (DVSM). Moreover, the paper introduces the practice of Radio Frequency Identification (RFID) and ICT to smartly support lean tools and practices during daily production runs to keep the lean system alive and effective. This work introduces a practical description of how the lean method tools 5S, standardized work, and poka-yoke can be digitalized and smartly monitored and controlled through DVSM. A framework of the three tools has been discussed and put into practice in a German switchgear manufacturer.Keywords: Lean manufacturing, Industry 4.0, radio frequency identification, value stream mapping.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 31091593 Existence of Nano-Organic Carbon Particles below the Size Range of 10 nm in the Indoor Air Environment
Authors: Bireswar Paul, Amitava Datta
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Indoor air environment is a big concern in the last few decades in the developing countries, with increased focus on monitoring the air quality. In this work, an experimental study has been conducted to establish the existence of carbon nanoparticles below the size range of 10 nm in the non-sooting zone of a LPG/air partially premixed flame. Mainly, four optical techniques, UV absorption spectroscopy, fluorescence spectroscopy, dynamic light scattering and TEM have been used to characterize and measure the size of carbon nanoparticles in the sampled materials collected from the inner surface of the flame front. The existence of the carbon nanoparticles in the sampled material has been confirmed with the typical nature of the absorption and fluorescence spectra already reported in the literature. The band gap energy shows that the particles are made up of three to six aromatic rings. The size measurement by DLS technique also shows that the particles below the size range of 10 nm. The results of DLS are also corroborated by the TEM image of the same material.
Keywords: Indoor air, carbon nanoparticles, LPG, partially premixed flame, optical techniques.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 8801592 An Approach for Reducing the End-to-end Delay and Increasing Network Lifetime in Mobile Adhoc Networks
Authors: R. Asokan, A. M. Natarajan
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Mobile adhoc network (MANET) is a collection of mobile devices which form a communication network with no preexisting wiring or infrastructure. Multiple routing protocols have been developed for MANETs. As MANETs gain popularity, their need to support real time applications is growing as well. Such applications have stringent quality of service (QoS) requirements such as throughput, end-to-end delay, and energy. Due to dynamic topology and bandwidth constraint supporting QoS is a challenging task. QoS aware routing is an important building block for QoS support. The primary goal of the QoS aware protocol is to determine the path from source to destination that satisfies the QoS requirements. This paper proposes a new energy and delay aware protocol called energy and delay aware TORA (EDTORA) based on extension of Temporally Ordered Routing Protocol (TORA).Energy and delay verifications of query packet have been done in each node. Simulation results show that the proposed protocol has a higher performance than TORA in terms of network lifetime, packet delivery ratio and end-to-end delay.Keywords: EDTORA, Mobile Adhoc Networks, QoS, Routing, TORA
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 23901591 Reliability Factors Based Fuzzy Logic Scheme for Spectrum Sensing
Authors: Tallataf Rasheed, Adnan Rashdi, Ahmad Naeem Akhtar
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The accurate spectrum sensing is a fundamental requirement of dynamic spectrum access for deployment of Cognitive Radio Network (CRN). To acheive this requirement a Reliability factors based Fuzzy Logic (RFL) Scheme for Spectrum Sensing has been proposed in this paper. Cognitive Radio User (CRU) predicts the presence or absence of Primary User (PU) using energy detector and calculates the Reliability factors which are SNR of sensing node, threshold of energy detector and decision difference of each node with other nodes in a cooperative spectrum sensing environment. Then the decision of energy detector is combined with Reliability factors of sensing node using Fuzzy Logic. These Reliability Factors used in RFL Scheme describes the reliability of decision made by a CRU to improve the local spectrum sensing. This Fuzzy combining scheme provides the accuracy of decision made by sensornode. The simulation results have shown that the proposed technique provide better PU detection probability than existing Spectrum Sensing Techniques.Keywords: Cognitive radio, spectrum sensing, energy detector, reliability factors, fuzzy logic.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 10651590 An Induction Motor Drive System with Intelligent Supervisory Control for Water Networks Including Storage Tank
Authors: O. S. Ebrahim, K. O. Shawky, M. A. Badr, P. K. Jain
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This paper describes an efficient; low-cost; high-availability; induction motor (IM) drive system with intelligent supervisory control for water distribution networks including storage tank. To increase the operational efficiency and reduce cost, the IM drive system includes main pumping unit and an auxiliary voltage source inverter (VSI) fed unit. The main unit comprises smart star/delta starter, regenerative fluid clutch, switched VAR compensator, and hysteresis liquid-level controller. Three-state energy saving mode (ESM) is defined at no-load and a logic algorithm is developed for best energetic cost reduction. To reduce voltage sag, the supervisory controller operates the switched VAR compensator upon motor starting. To provide smart star/delta starter at low cost, a method based on current sensing is developed for interlocking, malfunction detection, and life–cycles counting and used to synthesize an improved fuzzy logic (FL) based availability assessment scheme. Furthermore, a recurrent neural network (RNN) full state estimator is proposed to provide sensor fault-tolerant algorithm for the feedback control. The auxiliary unit is working at low flow rates and improves the system efficiency and flexibility for distributed generation during islanding mode. Compared with doubly-fed IM, the proposed one ensures 30% working throughput under main motor/pump fault conditions, higher efficiency, and marginal cost difference. This is critically important in case of water networks. Theoretical analysis, computer simulations, cost study, as well as efficiency evaluation, using timely cascaded energy-conservative systems, are performed on IM experimental setup to demonstrate the validity and effectiveness of the proposed drive and control.
Keywords: Artificial Neural Network, ANN, Availability Assessment, Cloud Computing, Energy Saving, Induction Machine, IM, Supervisory Control, Fuzzy Logic, FL, Pumped Storage.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 6301589 A Survey on Positive Real and Strictly Positive Real Scalar Transfer Functions
Authors: Mojtaba Hakimi-Moghaddam
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Positive real and strictly positive real transfer functions are important concepts in the control theory. In this paper, the results of researches in these areas are summarized. Definitions together with their graphical interpretations are mentioned. The equivalent conditions in the frequency domain and state space representations are reviewed. Their equivalent electrical networks are explained. Also, a comprehensive discussion about a difference between behavior of real part of positive real and strictly positive real transfer functions in high frequencies is presented. Furthermore, several illustrative examples are given.Keywords: Real rational transfer functions, positive realness property, strictly positive realness property, equivalent conditions.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 23861588 Experimental and Numerical Study of The Shock-Accelerated Elliptic Heavy Gas Cylinders
Authors: Jing S. Bai, Li Y. Zou, Tao Wang, Kun Liu, Wen B. Huang, Jin H. Liu, Ping Li, Duo W. Tan, CangL. Liu
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We studied the evolution of elliptic heavy SF6 gas cylinder surrounded by air when accelerated by a planar Mach 1.25 shock. A multiple dynamics imaging technology has been used to obtain one image of the experimental initial conditions and five images of the time evolution of elliptic cylinder. We compared the width and height of the circular and two kinds of elliptic gas cylinders, and analyzed the vortex strength of the elliptic ones. Simulations are in very good agreement with the experiments, but due to the different initial gas cylinder shapes, a certain difference of the initial density peak and distribution exists between the circular and elliptic gas cylinders, and the latter initial state is more sensitive and more inenarrable.Keywords: About four key words or phrases in alphabeticalorder, separated by commas.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15131587 Enhancement of Stereo Video Pairs Using SDNs To Aid In 3D Reconstruction
Authors: Lewis E. Hibell, Honghai Liu, David J. Brown
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This paper presents the results of enhancing images from a left and right stereo pair in order to increase the resolution of a 3D representation of a scene generated from that same pair. A new neural network structure known as a Self Delaying Dynamic Network (SDN) has been used to perform the enhancement. The advantage of SDNs over existing techniques such as bicubic interpolation is their ability to cope with motion and noise effects. SDNs are used to generate two high resolution images, one based on frames taken from the left view of the subject, and one based on the frames from the right. This new high resolution stereo pair is then processed by a disparity map generator. The disparity map generated is compared to two other disparity maps generated from the same scene. The first is a map generated from an original high resolution stereo pair and the second is a map generated using a stereo pair which has been enhanced using bicubic interpolation. The maps generated using the SDN enhanced pairs match more closely the target maps. The addition of extra noise into the input images is less problematic for the SDN system which is still able to out perform bicubic interpolation.
Keywords: Genetic Evolution, Image Enhancement, Neuron Networks, Stereo Vision
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14241586 A 24-Bit, 8.1-MS/s D/A Converter for Audio Baseband Channel Applications
Authors: N. Ben Ameur, M. Loulou
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This paper study the high-level modelling and design of delta-sigma (ΔΣ) noise shapers for audio Digital-to-Analog Converter (DAC) so as to eliminate the in-band Signal-to-Noise- Ratio (SNR) degradation that accompany one channel mismatch in audio signal. The converter combines a cascaded digital signal interpolation, a noise-shaping single loop delta-sigma modulator with a 5-bit quantizer resolution in the final stage. To reduce sensitivity of Digital-to-Analog Converter (DAC) nonlinearities of the last stage, a high pass second order Data Weighted Averaging (R2DWA) is introduced. This paper presents a MATLAB description modelling approach of the proposed DAC architecture with low distortion and swing suppression integrator designs. The ΔΣ Modulator design can be configured as a 3rd-order and allows 24-bit PCM at sampling rate of 64 kHz for Digital Video Disc (DVD) audio application. The modeling approach provides 139.38 dB of dynamic range for a 32 kHz signal band at -1.6 dBFS input signal level.Keywords: DVD-audio, DAC, Interpolator and Interpolation Filter, Single-Loop ΔΣ Modulation, R2DWA, Clock Jitter
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 26231585 The Characteristics of the Factors that Govern the Preferred Force in the Social Force Model of Pedestrian Movement
Authors: Zarita Zainuddin, Mohammed Mahmod Shuaib, Ibtesam M. Abu-Sulyman
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The social force model which belongs to the microscopic pedestrian studies has been considered as the supremacy by many researchers and due to the main feature of reproducing the self-organized phenomena resulted from pedestrian dynamic. The Preferred Force which is a measurement of pedestrian-s motivation to adapt his actual velocity to his desired velocity is an essential term on which the model was set up. This Force has gone through stages of development: first of all, Helbing and Molnar (1995) have modeled the original force for the normal situation. Second, Helbing and his co-workers (2000) have incorporated the panic situation into this force by incorporating the panic parameter to account for the panic situations. Third, Lakoba and Kaup (2005) have provided the pedestrians some kind of intelligence by incorporating aspects of the decision-making capability. In this paper, the authors analyze the most important incorporations into the model regarding the preferred force. They make comparisons between the different factors of these incorporations. Furthermore, to enhance the decision-making ability of the pedestrians, they introduce additional features such as the familiarity factor to the preferred force to let it appear more representative of what actually happens in reality.Keywords: Pedestrian movement, social force model, preferredforce, familiarity.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 12471584 Calibrations and Effect of Different Operating Conditions on the Performance of a Fluid Power Control System with Servo Solenoid Valve
Authors: Tahany W. Sadak, Fouly, A. Anwer, M. Rizk
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The current investigation presents a study on the hydraulic performance of an electro-hydraulic servo solenoid valve controlled linear piston used in hydraulic systems. Advanced methods have been used to measure and record laboratory experiments, to ensure accurate analysis and evaluation. Experiments have been conducted under different values of temperature (28, 40 and 50 °C), supply pressure (10, 20, 30, 40 and 50 bar), system stiffness (32 N/mm), and load (0.0 & 5560 N). It is concluded that increasing temperature of hydraulic oil increases the quantity of flow rate, so it achieves an increase of the quantity of flow by 5.75 % up to 48.8 % depending on operating conditions. The values of pressure decay at low temperature are less than the values at high temperature. The frequency increases with the increase of the temperature. When we connect the springs to the system, it decreases system frequency. These results are very useful in the process of packing and manufacturing of fluid products, where the properties are not affected by 50 °C, so energy and time are saved.
Keywords: Electro Hydraulic Servo Valve, fluid power control system, system stiffness, static and dynamic performance.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 6801583 Seismic Behavior Evaluation of Semi-Rigid Steel Frames with Knee Bracing by Modal Pushover Analysis (MPA)
Authors: Farzan Namvari, Panam Zarfam
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Nowadays use of a new structural bracing system called 'Knee Bracing System' have taken the specialists attention too much. On the other hand nonlinear static analysis procedures in estimate structures performance in earthquake time have taken attention too much. One of these procedure is modal pushover analysis (MPA) procedure. The accuracy of MPA procedure for simple steel moment resisting frame has been verified and considered in Chintanapakdee and Chopra-s article in 2003. Since the accuracy of MPA procedure has not verified for semi-rigid steel frames with knee bracing, we are going to get through with this matter in this study. For this purpose, the selected structures are four frames with different heights, 5 to 20 stories, will be designed according to AISC criteria. Then MPA procedure is used for the same frames with different rigidity percentiles of connections. The results of seismic responses are compared with dynamic nonlinear response history analysis as exact procedure and accuracy of MPA procedure is evaluated. It seems that MPA procedure accuracy will come down by reduction of the rigidity percentiles of semi-rigid connections.Keywords: Knee Bracing, Modal Pushover Analysis, SeismicBehavior, Semi-Rigid Connections.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 21351582 Bond Graph and Bayesian Networks for Reliable Diagnosis
Authors: Abdelaziz Zaidi, Belkacem Ould Bouamama, Moncef Tagina
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Bond Graph as a unified multidisciplinary tool is widely used not only for dynamic modelling but also for Fault Detection and Isolation because of its structural and causal proprieties. A binary Fault Signature Matrix is systematically generated but to make the final binary decision is not always feasible because of the problems revealed by such method. The purpose of this paper is introducing a methodology for the improvement of the classical binary method of decision-making, so that the unknown and identical failure signatures can be treated to improve the robustness. This approach consists of associating the evaluated residuals and the components reliability data to build a Hybrid Bayesian Network. This network is used in two distinct inference procedures: one for the continuous part and the other for the discrete part. The continuous nodes of the network are the prior probabilities of the components failures, which are used by the inference procedure on the discrete part to compute the posterior probabilities of the failures. The developed methodology is applied to a real steam generator pilot process.Keywords: Redundancy relations, decision-making, Bond Graph, reliability, Bayesian Networks.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 25251581 Low Cost Real Time Robust Identification of Impulsive Signals
Authors: R. Biondi, G. Dys, G. Ferone, T. Renard, M. Zysman
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This paper describes an automated implementable system for impulsive signals detection and recognition. The system uses a Digital Signal Processing device for the detection and identification process. Here the system analyses the signals in real time in order to produce a particular response if needed. The system analyses the signals in real time in order to produce a specific output if needed. Detection is achieved through normalizing the inputs and comparing the read signals to a dynamic threshold and thus avoiding detections linked to loud or fluctuating environing noise. Identification is done through neuronal network algorithms. As a setup our system can receive signals to “learn” certain patterns. Through “learning” the system can recognize signals faster, inducing flexibility to new patterns similar to those known. Sound is captured through a simple jack input, and could be changed for an enhanced recording surface such as a wide-area recorder. Furthermore a communication module can be added to the apparatus to send alerts to another interface if needed.
Keywords: Sound Detection, Impulsive Signal, Background Noise, Neural Network.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 23341580 Left Ventricular Model to Study the Combined Viscoelastic, Heart Rate, and Size Effects
Authors: Elie H. Karam, Antoine B. Abche
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It is known that the heart interacts with and adapts to its venous and arterial loading conditions. Various experimental studies and modeling approaches have been developed to investigate the underlying mechanisms. This paper presents a model of the left ventricle derived based on nonlinear stress-length myocardial characteristics integrated over truncated ellipsoidal geometry, and second-order dynamic mechanism for the excitation-contraction coupling system. The results of the model presented here describe the effects of the viscoelastic damping element of the electromechanical coupling system on the hemodynamic response. Different heart rates are considered to study the pacing effects on the performance of the left-ventricle against constant preload and afterload conditions under various damping conditions. The results indicate that the pacing process of the left ventricle has to take into account, among other things, the viscoelastic damping conditions of the myofilament excitation-contraction process. The effects of left ventricular dimensions on the hemdynamic response have been examined. These effects are found to be different at different viscoelastic and pacing conditions.Keywords: Myocardial sarcomere, cardiac pump, excitationcontractioncoupling, viscoelasicity
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16551579 Optimum Tuning Capacitors for Wireless Charging of Electric Vehicles Considering Variation in Coil Distances
Authors: Muhammad Abdullah Arafat, Nahrin Nowrose
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Wireless charging of electric vehicles is becoming more and more attractive as large amount of power can now be transferred to a reasonable distance using magnetic resonance coupling method. However, proper tuning of the compensation network is required to achieve maximum power transmission. Due to the variation of coil distance from the nominal value as a result of change in tire condition, change in weight or uneven road condition, the tuning of the compensation network has become challenging. In this paper, a tuning method has been described to determine the optimum values of the compensation network in order to maximize the average output power. The simulation results show that 5.2% increase in average output power is obtained for 10% variation in coupling coefficient using the optimum values without the need of additional space and electro-mechanical components. The proposed method is applicable to both static and dynamic charging of electric vehicles.
Keywords: Coupling coefficient, electric vehicles, magnetic resonance coupling, tuning capacitor, wireless power transfer.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2471578 Finite Element Analysis of Cooling Time and Residual Strains in Cold Spray Deposited Titanium Particles
Authors: Thanh-Duoc Phan, Saden H. Zahiri, S. H. Masood, Mahnaz Jahedi
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In this article, using finite element analysis (FEA) and an X-ray diffractometer (XRD), cold-sprayed titanium particles on a steel substrate is investigated in term of cooling time and the development of residual strains. Three cooling-down models of sprayed particles after deposition stage are simulated and discussed: the first model (m1) considers conduction effect to the substrate only, the second model (m2) considers both conduction as well as convection effect to the environment, and the third model (m3) which is the same as the second model but with the substrate heated to a near particle temperature before spraying. Thereafter, residual strains developed in the third model is compared with the experimental measurement of residual strains, which involved a Bruker D8 Advance Diffractometer using CuKa radiation (40kV, 40mA) monochromatised with a graphite sample monochromator. For deposition conditions of this study, a good correlation was found to exist between the FEA results and XRD measurements of residual strains.Keywords: cold gas dynamic spray, X-ray diffraction, explicit finite element analysis, residual strain, titanium, particle impact, deformation behavior.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17561577 Molecular Dynamic Simulation and Receptor-based Pharmacophore Modeling on Human Renin for Discovery of Novel Inhibitors
Authors: Chanin Park, Sundarapandian Thangapandian, Yuno Lee, Minky Son, Shalini John, Young-sik Sohn, Keun Woo Lee
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Hypertension is characterized with stress on the heart and blood vessels thus increasing the risk of heart attack and renal diseases. The Renin angiotensin system (RAS) plays a major role in blood pressure control. Renin is the enzyme that controls the RAS at the rate-limiting step. Our aim is to develop new drug-like leads which can inhibit renin and thereby emerge as therapeutics for hypertension. To achieve this, molecular dynamics (MD) simulation and receptor-based pharmacophore modeling were implemented, and three rennin-inhibitor complex structures were selected based on IC50 value and scaffolds of inhibitors. Three pharmacophore models were generated considering conformations induced by inhibitor. The compounds mapped to these models were selected and subjected to drug-like screening. The identified hits were docked into the active site of renin. Finally, hit1 satisfying the binding mode and interaction energy was selected as possible lead candidate to be used in novel renin inhibitors.
Keywords: Renin inhibitor, Molecular dynamics simulation, Structure-based pharmacophore modeling
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 19681576 Vision Based Hand Gesture Recognition Using Generative and Discriminative Stochastic Models
Authors: Mahmoud Elmezain, Samar El-shinawy
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Many approaches to pattern recognition are founded on probability theory, and can be broadly characterized as either generative or discriminative according to whether or not the distribution of the image features. Generative and discriminative models have very different characteristics, as well as complementary strengths and weaknesses. In this paper, we study these models to recognize the patterns of alphabet characters (A-Z) and numbers (0-9). To handle isolated pattern, generative model as Hidden Markov Model (HMM) and discriminative models like Conditional Random Field (CRF), Hidden Conditional Random Field (HCRF) and Latent-Dynamic Conditional Random Field (LDCRF) with different number of window size are applied on extracted pattern features. The gesture recognition rate is improved initially as the window size increase, but degrades as window size increase further. Experimental results show that the LDCRF is the best in terms of results than CRF, HCRF and HMM at window size equal 4. Additionally, our results show that; an overall recognition rates are 91.52%, 95.28%, 96.94% and 98.05% for CRF, HCRF, HMM and LDCRF respectively.
Keywords: Statistical Pattern Recognition, Generative Model, Discriminative Model, Human Computer Interaction.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 29361575 Intelligent Caching in on-demand Routing Protocol for Mobile Adhoc Networks
Authors: Shobha.K.R., K. Rajanikanth
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An on-demand routing protocol for wireless ad hoc networks is one that searches for and attempts to discover a route to some destination node only when a sending node originates a data packet addressed to that node. In order to avoid the need for such a route discovery to be performed before each data packet is sent, such routing protocols must cache routes previously discovered. This paper presents an analysis of the effect of intelligent caching in a non clustered network, using on-demand routing protocols in wireless ad hoc networks. The analysis carried out is based on the Dynamic Source Routing protocol (DSR), which operates entirely on-demand. DSR uses the cache in every node to save the paths that are learnt during route discovery procedure. In this implementation, caching these paths only at intermediate nodes and using the paths from these caches when required is tried. This technique helps in storing more number of routes that are learnt without erasing the entries in the cache, to store a new route that is learnt. The simulation results on DSR have shown that this technique drastically increases the available memory for caching the routes discovered without affecting the performance of the DSR routing protocol in any way, except for a small increase in end to end delay.Keywords: Caching, DSR, on demand routing, MANET.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 19911574 Cercarial Diversity in Freshwater Snails from Selected Freshwater Bodies and Its Implication for Veterinary and Public Health in Kaduna State, Nigeria
Authors: Fatima Muhammad Abdulkadir, D. B. Maikaje, Y. A. Umar
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A study conducted to determine cercariae diversity and prevalence of trematode infection in freshwater snails from six freshwater bodies selected by systematic random sampling in Kaduna State was carried from January 2013 to December 2013. Freshwater snails and cercariae harvested from the study sites were morphologically identified. A total of 23,823 freshwater snails were collected from the six freshwater bodies: Bagoma dam, Gimbawa dam, Kangimi dam, Kubacha dam, Manchok water intake and Saminaka water intake. The observed freshwater snail species were: Melanoides tuberculata, Biomphalaria pfeifferi, Bulinus globosus, Lymnaea natalensis, Physa sp., Cleopatra bulimoides, Bellamya unicolor and Lanistes varicus. The freshwater snails were exposed to artificial bright light from a 100 Watt electric bulb in the laboratory to induce cercarial shedding. Of the total freshwater snails collected, 10.55% released one or more types of cercariae. Seven morphological types of cercariae were shed by six freshwater snail species namely: Brevifurcate-apharyngeate distome, Amphistome, Gymnocephalus, Longifurcate-pharyngeate monostome, Longifurcate-pharyngeate distome, Echinostome and Xiphidio cercariae. Infection was monotype in most of the freshwater snails collected; however, Physa species presented a mixed infection with Gymnocephalus and Longifurcate-pharyngeate distome cercariae. B. globosus and B. pfeifferi were the most preferred intermediate hosts with the prevalence of 13.48% and 13.46%, respectively. The diversity and prevalence of cercariae varied among the six freshwater bodies with Manchok water intake having the highest infestation (14.3%) and the least recorded in Kangimi dam (3.9%). There was a correlation trend between the number of freshwater snails and trematode infection with Manchok exhibiting the highest and Bagoma none. The highest cercarial diversity was observed in B. pfeifferi and B. globosus with four morphotypes each, and the lowest was in M. tuberculata with one morphotype. The general distribution of freshwater snails and the trematode cercariae they shed suggests the risk of human and animals to trematodiasis in Manchok community. Public health education to raise awareness on individual and communal action that may control snail breeding sites, prevent transmission and provide access to treatment should be intensified.
Keywords: Cercariae, diversity, freshwater snails, prevalence, trematodiasis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15471573 Fatigue Crack Initiation of Al-Alloys “Effect of Heat Treatment Condition”
Authors: M. Benachour, N. Benachour, M. Benguediab
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In this investigation an empirical study was made on fatigue crack initiation on 7075 T6 and 7075 T71 Al-alloys under constant amplitude loading. In initiation stage, local strain approach at the notch was applied. Single Edge Notch Tensile specimen with semi circular notch is used. Based on experimental results, effect of mean stress, is highlights on fatigue initiation life. Results show that fatigue life initiation is affected by notch geometry and mean stress.
Keywords: Fatigue crack initiation, Al-Alloy, mean stress, heat treatment state.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 29701572 An Efficient Feature Extraction Algorithm for the Recognition of Handwritten Arabic Digits
Authors: Ahmad T. Al-Taani
Abstract:
In this paper, an efficient structural approach for recognizing on-line handwritten digits is proposed. After reading the digit from the user, the slope is estimated and normalized for adjacent nodes. Based on the changing of signs of the slope values, the primitives are identified and extracted. The names of these primitives are represented by strings, and then a finite state machine, which contains the grammars of the digits, is traced to identify the digit. Finally, if there is any ambiguity, it will be resolved. Experiments showed that this technique is flexible and can achieve high recognition accuracy for the shapes of the digits represented in this work.Keywords: Digits Recognition, Pattern Recognition, FeatureExtraction, Structural Primitives, Document Processing, Handwritten Recognition, Primitives Selection.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 26421571 Exponential Stability Analysis for Switched Cellular Neural Networks with Time-varying Delays and Impulsive Effects
Authors: Zixin Liu, Fangwei Chen
Abstract:
In this Letter, a class of impulsive switched cellular neural networks with time-varying delays is investigated. At the same time, parametric uncertainties assumed to be norm bounded are considered. By dividing the network state variables into subgroups according to the characters of the neural networks, some sufficient conditions guaranteeing exponential stability for all admissible parametric uncertainties are derived via constructing appropriate Lyapunov functional. One numerical example is provided to illustrate the validity of the main results obtained in this paper.
Keywords: Switched systems, exponential stability, cellular neural networks.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14171570 Reliability Analysis for Cyclic Fatigue Life Prediction in Railroad Bolt Hole
Authors: Hasan Keshavarzian, Tayebeh Nesari
Abstract:
Bolted rail joint is one of the most vulnerable areas in railway track. A comprehensive approach was developed for studying the reliability of fatigue crack initiation of railroad bolt hole under random axle loads and random material properties. The operation condition was also considered as stochastic variables. In order to obtain the comprehensive probability model of fatigue crack initiation life prediction in railroad bolt hole, we used FEM, response surface method (RSM), and reliability analysis. Combined energy-density based and critical plane based fatigue concept is used for the fatigue crack prediction. The dynamic loads were calculated according to the axle load, speed, and track properties. The results show that axle load is most sensitive parameter compared to Poisson’s ratio in fatigue crack initiation life. Also, the reliability index decreases slowly due to high cycle fatigue regime in this area.Keywords: Rail-wheel tribology, rolling contact mechanic, finite element modeling, reliability analysis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 11101569 Study of the Particle Size Effect on Bubble Rise Velocities in a Three-Phase Bubble Column
Authors: Weiling Li, Wenqi Zhong, Baosheng Jin, Rui Xiao, Yong Lu, Tingting He
Abstract:
Experiments were performed in a three-phase bubble column to study variations of bubble rise velocities. The dynamic gas disengagement (DGD) technique and the fast response pressure transducers were utilized to investigate the bubble rise in the column. The superficial gas velocity of large bubbles and small bubbles, the rise velocities of larger and small bubble fractions were studied considering the effect of particle sizes. The results show that the superficial gas velocity associated with large bubbles linearly increase as superficial gas velocity increasing. Particle size has little effect on the both large and small bubble superficial gas velocities. The rise velocities of larger bubble fractions are larger than that of small bubble fractions, and it had different tendency at low and high superficial gas velocities when changing the particle sizes. The rise velocities of small bubble fractions increased and then had a decrease tendency when the particle size became greater.
Keywords: Bubble rise velocity, gas–liquid–solid, particle size effect, three–phase bubble column.
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