Search results for: Multi drug resistant

Authors: Sanghoon Park, Ki-Jin Kim, Kwang-Ho Ahn

Abstract:

This paper discusses the undesirable charge transfer through the parasitic capacitances of the input transistors in a multi-inputs voltage sense amplifier. Its intrinsic rail-to-rail voltage transitions at the output nodes inevitably disturb the input sides through the capacitive coupling between the outputs and inputs. Then, it can possible degrade the stabilities of the reference voltage levels. Moreover, it becomes more serious in multi-channel systems by altering them for other channels, and so degrades the linearity of the overall systems. In order to alleviate the internal node voltage transition, the internal node stabilization techniques are proposed. It achieves 45% and 40% improvements for node stabilization and input referred disturbance, respectively.

Keywords: Voltage sense amplifier, multi-inputs, voltage transition, node stabilization, and biasing circuits.

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Authors: M. Raissy, M. Shahrani

Abstract:

The present study was done to evaluate the presence of tetracycline resistance genes in Lactococcus garvieae isolated from cultured rainbow trout, West Iran. The isolates were examined for antimicrobial resistance using disc diffusion method. Of the 49 strains tested, 19 were resistant to tetracycline (38.7%), 32 to enrofloxacin (65.3%), 21 to erythromycin (42.8%), 20 to chloramphenicol and trimetoprim-sulfamethoxazole (40.8%). The strains were then characterized for their genotypic resistance profiles. The results revealed that all 49 isolates contained at least one of the tetracycline resistance genes. Tet (A) was found in 89.4% of tetracycline resistant isolates and the frequency of other gene were as follows: tet (E) 42.1%, tet (B) 47.3%, tet (D) 15.7%, tet (L) 26.3%, tet (K) 52.6%, tet (G) 36.8%, tet (34) 21%, tet (S) 63.1%, tet (C) 57.8%, tet (M) 73.6%, tet (O) 42.1%. The results revealed high levels of antibiotic resistance in L. garvieae strains which is a potential danger for trout culture as well as for public health.

Keywords: Lactococcus garvieae, rainbow trout, tetracycline resistance genes.

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Authors: S .A. Naeini, M. A. Jahanfar

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Compacted clay liners (CCLs) are the main materials used in waste disposal landfills due to their low permeability. In this study, the effect on the shear resistant of clays with inorganic salt solutions as permeate fluid was experimentally investigated. For this purpose, NaCl inorganic salt solution at concentrations of 2, 5, 10% and deionized water were used. Laboratory direct shear and Vane shear tests were conducted on three compacted clays with low, medium and high plasticity. Results indicated that the solutions type and its concentration affect the shear properties of the mixture. In the light of this study, the influence magnitude of these inorganic salts in varies concentrations in different clays were determined and more suitable compacted clay with the compare of plasticity were found.

Keywords: landfill liner, shear resistant, plasticity, salt solution

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Authors: Normi Abdul Hadi, Arsmah Ibrahim, Fatimah Yahya, Jamaludin Md. Ali

Abstract:

Beta-spline is built on G2 continuity which guarantees smoothness of generated curves and surfaces using it. This curve is preferred to be used in object design rather than reconstruction. This study however, employs the Beta-spline in reconstructing a 3- dimensional G2 image of the Stanford Rabbit. The original data consists of multi-slice binary images of the rabbit. The result is then compared with related works using other techniques.

Keywords: Beta-spline, multi-slice image, rectangular surface, 3D reconstruction

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Authors: M. Ali-Bey, N. Manamanni, S. Moughamir

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This paper focuses on the calibration problem of a multi-view shooting system designed for the production of 3D content for auto-stereoscopic visualization. The considered multiview camera is characterized by coplanar and decentered image sensors regarding to the corresponding optical axis. Based on the Faugéras and Toscani-s calibration approach, a calibration method is herein proposed for the case of multi-view camera with parallel and decentered image sensors. At first, the geometrical model of the shooting system is recalled and some industrial prototypes with some shooting simulations are presented. Next, the development of the proposed calibration method is detailed. Finally, some simulation results are presented before ending with some conclusions about this work.

Keywords: Auto-stereoscopic display, camera calibration, multi-view cameras, visual servoing

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Authors: R. Gary Black, Abolhassan Astaneh-Asl

Abstract:

The International Building Code (IBC) and the  California Building Code (CBC) both recognize four basic types of  steel seismic resistant frames; moment frames, concentrically braced  frames, shear walls and eccentrically braced frames. Based on  specified geometries and detailing, the seismic performance of these  steel frames is well understood. In 2011, the authors designed an  innovative steel braced frame system with tapering members in the  general shape of a branching tree as a seismic retrofit solution to an  existing four story “lift-slab” building. Located in the seismically  active San Francisco Bay Area of California, a frame of this  configuration, not covered by the governing codes, would typically  require model or full scale testing to obtain jurisdiction approval.  This paper describes how the theories, protocols, and code  requirements of eccentrically braced frames (EBFs) were employed  to satisfy the 2009 International Building Code (IBC) and the 2010  California Building Code (CBC) for seismically resistant steel frames  and permit construction of these nonconforming geometries.

 

Keywords: Eccentrically Braced Frame, Lift Slab Construction, Seismic Retrofit, Shear Link, Steel Design.

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Authors: Tanvir Ahmed, Thanh N. Long, Phan T. Huong, Donald E. Stewart

Abstract:

This paper presents views on condom use and the contexts of safe and unsafe sexual practices with different sexual partners and their relationships among Injecting Drug Users (IDUs) in Hai Phong, Vietnam. Fifteen IDUs participated and two local interviewers conducted qualitative semi-structured face-to-face interviews in September-October, 2012 in Vietnamese language. Data were analyzed thematically. Non-protective condom attitudes include negotiate or convince Female Sex Workers (FSW); not realizing risk, importance or necessity; partner doesn’t like, and having extra money/drug from clients. On the other hand, self-awareness, family-consciousness, suspicion of STI presence, fear of getting HIV, and client negotiation sometimes resulted in a safe-sex practice. A thematic diagram was developed to present the relationship (strong/weak) between condom attitude and sexual practice (safe/unsafe) by partner types. The experiences and views reflected in the qualitative information emphasize the heightened need for safe-sex education especially among young IDUs (male/female) highlighting sexual transmission risk.

Keywords: AIDS, HIV, injecting drug user, risk behaviors, Vietnam.

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Authors: Ching Louis Liu, Edmund Kazmierczak, Tim Miller

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Safety analysis for multi-agent systems is complicated by the, potentially nonlinear, interactions between agents. This paper proposes a method for analyzing the safety of multi-agent systems by explicitly focusing on interactions and the accident data of systems that are similar in structure and function to the system being analyzed. The method creates a Bayesian network using the accident data from similar systems. A feature of our method is that the events in accident data are labeled with HAZOP guide words. Our method uses an Ontology to abstract away from the details of a multi-agent implementation. Using the ontology, our methods then constructs an “Interaction Map,” a graphical representation of the patterns of interactions between agents and other artifacts. Interaction maps combined with statistical data from accidents and the HAZOP classifications of events can be converted into a Bayesian Network. Bayesian networks allow designers to explore “what it” scenarios and make design trade-offs that maintain safety. We show how to use the Bayesian networks, and the interaction maps to improve multi-agent system designs.

Keywords: Multi-agent system, safety analysis, safety model.

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Authors: Mandana Kariminejad, Ali Ghaffari

Abstract:

Today, the treatment of cancer, in a relatively short period, with minimum adverse effects is a great concern for oncologists. In this paper, based on a recently used mathematical model for cancer, a guideline has been proposed for the amount and duration of drug doses for cancer treatment by immunotherapy. Dynamically speaking, the mathematical ordinary differential equation (ODE) model of cancer has different equilibrium points; one of them is unstable, which is called the no tumor equilibrium point. In this paper, based on the number of tumor cells an intelligent soft computing controller (a combination of fuzzy logic controller and genetic algorithm), decides regarding the amount and duration of drug doses, to eliminate the tumor cells and stabilize the unstable point in a relatively short time. Two different immunotherapy approaches; active and adoptive, have been studied and presented. It is shown that the rate of decay of tumor cells is faster and the doses of drug are lower in comparison with the result of some other literatures. It is also shown that the period of treatment and the doses of drug in adoptive immunotherapy are significantly less than the active method. A recommendation to oncologists has also been presented.

Keywords: Tumor, immunotherapy, fuzzy controller, Genetic algorithm, mathematical model.

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Authors: Xin-Lei Feng, Ting-Zhu Huang

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According to conjugate gradient algorithm, a new consensus protocol algorithm of discrete-time multi-agent systems is presented, which can achieve finite-time consensus. Finally, a numerical example is given to illustrate our theoretical result.

Keywords: Consensus protocols; Graph theory; Multi-agent systems;Conjugate gradient algorithm; Finite-time.

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Authors: Jamal Moshtagh, Hassan Pourvali Souraki

Abstract:

In North America, Most power distribution systems employ a four-wire multi-grounded neutral (MGN) design. This paper has explained the inherent characteristics of multi-grounded three-phase four-wire distribution systems under unbalanced situations. As a result, the mechanism of voltage swell and voltage sag in MGN feeders becomes difficult to understand. The simulation tool that has been used in this paper is MATLAB under Windows software. In this paper the equivalent model of a full-scale multigrounded distribution system implemented by MATLAB is introduced. The results are expected to help utility engineers to understand the impact of MGN on distribution system operations.

Keywords: Distribution systems, multi- grounded, neutral, three-phase four-wire, ground.

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Authors: Mohamed Sanad, Noha Hassan

Abstract:

A multi-beam BTS (Base Transceiver Station) antenna has been developed using dual parabolic cylindrical reflectors. The ±45° polarization feeds are used in spatial diversity MIMO (Multi-Input Multi-Output). They can be replaced by single-port orthogonally polarized feeds. Then, with two sets of beams generated above each other, the ± 45° polarization ports of any conventional transceiver can be connected to two of these beam sets. Thus, with two-port transceivers, the system will be equivalent to 4x4 MIMO, instead of 2x2. Radio Frequency (RF) power combiners/splitters can also be used to combine the multiple beams into a single beam or any arbitrary number of beams/ports. The gain of the combined-beam will be more than 20-24 dBi instead of 17-18 dBi of conventional wide-beam antennas. Furthermore, the gain of the combined beam will be high over the whole beam angle. Moreover, the users will always be close to the peak gain value of the combined beam regardless of their location within the combined beam angle. The frequency bands of all the combined beams are adjusted such that they all have the same frequency band. Different configurations of RF power splitter/combiners can be used to provide any arbitrary number of beams/ports according to the requirements of any existing base station configuration.

Keywords: 5G mobile communications, BTS antennas, MIMO, orthogonally polarized antennas, multi-beam antennas.

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Authors: Konghe Xie

Abstract:

Two consensus problems are considered in this paper. One is the consensus of linear multi-agent systems with weakly connected directed communication topology. The other is the consensus of nonlinear multi-agent systems with strongly connected directed communication topology. For the first problem, a simplified consensus protocol is designed: Each child agent can only communicate with one of its neighbors. That is, the real communication topology is a directed spanning tree of the original communication topology and without any cycles. Then, the necessary and sufficient condition is put forward to the multi-agent systems can be reached consensus. It is worth noting that the given conditions do not need any eigenvalue of the corresponding Laplacian matrix of the original directed communication network. For the second problem, the feedback gain is designed in the nonlinear consensus protocol. Then, the sufficient condition is proposed such that the systems can be achieved consensus. Besides, the consensus interval is introduced and analyzed to solve the consensus problem. Finally, two numerical simulations are included to verify the theoretical analysis.

Keywords: Consensus, multi-agent systems, directed spanning tree, the Laplacian matrix.

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Authors: Teerapun Saeheaw, Nivit Charoenchai, Wichai Chattinnawat

Abstract:

This paper proposes a meta-heuristic called Ant Colony Optimization to solve multi-objective production problems. The multi-objective function is to minimize lead time and work in process. The problem is related to the decision variables, i.e.; distance and process time. According to decision criteria, the mathematical model is formulated. In order to solve the model an ant colony optimization approach has been developed. The proposed algorithm is parameterized by the number of ant colonies and the number of pheromone trails. One example is given to illustrate the effectiveness of the proposed model. The proposed formulations; Max-Min Ant system are then used to solve the problem and the results evaluate the performance and efficiency of the proposed algorithm using simulation.

Keywords: Ant colony optimization, multi-objective problems.

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Authors: D. Moser, D. Pinto, A. Cipriano

Abstract:

A Disaster Management System (DMS) is very important for countries with multiple disasters, such as Chile. In the world (also in Chile)different disasters (earthquakes, tsunamis, volcanic eruption, fire or other natural or man-made disasters) happen and have an effect on the population. It is also possible that two or more disasters occur at the same time. This meansthata multi-risk situation must be mastered. To handle such a situation a Decision Support System (DSS) based on multiagents is a suitable architecture. The most known DMSs are concernedwith only a singledisaster (sometimes thecombination of earthquake and tsunami) and often with a particular disaster. Nevertheless, a DSS helps for a better real-time response. Analyze the existing systems in the literature and expand them for multi-risk disasters to construct a well-organized system is the proposal of our work. The here shown work is an approach of a multi-risk system, which needs an architecture and well defined aims. In this moment our study is a kind of case study to analyze the way we have to follow to create our proposed system in the future.

Keywords: Decision Support System, Disaster Management System, Multi-Risk, Multiagent System.

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Authors: Simona Dostalova, Ana Maria Jimenez Jimenez, Marketa Vaculovicova, Vojtech Adam, Rene Kizek

Abstract:

Various nanomaterials can be used as a drug delivery vehicles in nanomedicine, called nanocarriers. They can either be organic or inorganic, synthetic or natural-based. Although synthetic nanocarriers are easier to produce, they can often be toxic for the organism and thus not suitable for use in treatment. From naturalbased nanocarriers, the most commonly used are protein cages or viral capsids. In this work, virus bacteriophage λ was used for delivery of different cytotoxic drugs (cisplatin, carboplatin, oxaliplatin and doxorubicin). Large quantities of phage λ were obtained from phage λ-producing strain of E. coli cultivated in medium with 0.2% maltose. After killing of E. coli with chloroform and its removal by centrifugation, the phage was concentrated by ultracentrifugation at 130 000×g and 4°C for 3 h. The encapsulation of the drugs was performed by infusion method and four different concentrations of the drugs were encapsulated (200; 100; 50; 25 μg·mL-1). Free drug molecules were removed by filtration. The encapsulation was verified using the absorbance for doxorubicin and atomic absorption spectrometry for platinum cytostatics. The amount of encapsulated drug linearly increased with the increasing concentration of applied drug with the determination coefficient R2=0.989 for doxorubicin; R2=0.967 for cisplatin; R2=0.989 for carboplatin and R2=0.996 for oxaliplatin. The overall encapsulation efficiency was calculated as 50% for doxorubicin; 8% for cisplatin; 6% for carboplatin and 10% for oxaliplatin.

Keywords: Bacteriophage λ, doxorubicin, platinum cytostatics, protein-based nanocarrier, viral capsid.

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Authors: F. Sarhaddi, S. Farahat, M .A. Alavi, F. Sobhnamayan

Abstract:

In this paper, an attempt has been made to obtain nonsensitive solutions in the multi-objective optimization of a photovoltaic/thermal (PV/T) air collector. The selected objective functions are overall energy efficiency and exergy efficiency. Improved thermal, electrical and exergy models are used to calculate the thermal and electrical parameters, overall energy efficiency, exergy components and exergy efficiency of a typical PV/T air collector. A computer simulation program is also developed. The results of numerical simulation are in good agreement with the experimental measurements noted in the previous literature. Finally, multi-objective optimization has been carried out under given climatic, operating and design parameters. The optimized ranges of inlet air velocity, duct depth and the objective functions in optimal Pareto front have been obtained. Furthermore, non-sensitive solutions from energy or exergy point of view in the results of multi-objective optimization have been shown.

Keywords: Solar photovoltaic thermal (PV/T) air collector, Overall energy efficiency, Exergy efficiency, Multi-objectiveoptimization, Sensitivity analysis.

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Authors: Jānis Zuters

Abstract:

There are a lot of extensions made to the classic model of multi-layer perceptron (MLP). A notable amount of them has been designed to hasten the learning process without considering the quality of generalization. The paper proposes a new MLP extension based on exploiting topology of the input layer of the network. Experimental results show the extended model to improve upon generalization capability in certain cases. The new model requires additional computational resources to compare to the classic model, nevertheless the loss in efficiency isn-t regarded to be significant.

Keywords: Learning algorithm, multi-layer perceptron, topology.

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Authors: Janos Hamar, Peter Bartal, Daniel T. Sepsi

Abstract:

Consumer electronics are pervasive. It is impossible to imagine a household or office without DVD players, digital cameras, printers, mobile phones, shavers, electrical toothbrushes, etc. All these devices operate at different voltage levels ranging from 1.8 to 20 VDC, in the absence of universal standards. The voltages available are however usually 120/230 VAC at 50/60 Hz. This situation makes an individual electrical energy conversion system necessary for each device. Such converters usually involve several conversion stages and often operate with excessive losses and poor reliability. The aim of the project presented in this paper is to design and implement a multi-channel DC/DC converter system, customizing the output voltage and current ratings according to the requirements of the load. Distributed, multi-agent techniques will be applied for the control of the DC/DC converters.

Keywords: DC/DC converter, energy efficiency, multi-agentcontrol, parallel converters.

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Authors: Ho Phu TRAN, Frédéric PLOURDE

Abstract:

The ongoing effort to develop an in-house compressible solver with multi-disciplinary physics is presented in this paper. Basic compressible solver combined with IBM technique provides us an effective numerical tool able to tackle the physics phenomena and especially physic phenomena involved in Solid Rocket Motors (SRMs). Main principles are introduced step by step describing its implementation. This paper sheds light on the whole potentiality of our proposed numerical model and we strongly believe a way to introduce multi-physics mechanisms strongly coupled is opened to ablation in nozzle, fluid/structure interaction and burning propellant surface with time.

Keywords: Compressible Flow, Immersed Boundary Method, Multi-disciplinary physics, Solid Rocket Motors.

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Authors: S. Shahrooi, I. H. Metselaar, Z. Huda

Abstract:

When considering the development of constitutive equations describing the behavior of materials under cyclic plastic strains, different kinds of formulations can be adopted. The primary intention of this study is to develop computer programming of plasticity models to accurately predict the life of engineering components. For this purpose, the energy or cyclic strain is computed in multi-surface plasticity models in non-proportional loading and to present their procedures and codes results.

Keywords: Strain energy, cyclic plasticity model, multi-surface model, codes result.

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Authors: Anil Bhandari, Imran Khan Pathan, Peeyush K. Sharma, Rakesh K. Patel, Suresh Purohit

Abstract:

The purpose of this study was to prepare time and pH dependent release tablets of Ayurvedic Churna formulation and evaluate their advantages as colon targeted drug delivery system. The Vidangadi Churna was selected for this study which contains Embelin and Gallic acid. Embelin is used in Helminthiasis as therapeutic agent. Embelin is insoluble in water and unstable in gastric environment so it was formulated in time and pH dependent tablets coated with combination of two polymers Eudragit L100 and ethyl cellulose. The 150mg of core tablet of dried extract and lactose were prepared by wet granulation method. The compression coating was used in the polymer concentration of 150mg for both the layer as upper and lower coating tablet was investigated. The results showed that no release was found in 0.1 N HCl and pH 6.8 phosphate buffers for initial 5 hours and about 98.97% of the drug was released in pH 7.4 phosphate buffer in total 17 Hours. The in vitro release profiles of drug from the formulation could be best expressed first order kinetics as highest linearity (r²= 0.9943). The results of the present study have demonstrated that the time and pH dependent tablets system is a promising vehicle for preventing rapid hydrolysis in gastric environment and improving oral bioavailability of Embelin and Gallic acid for treatment of Helminthiasis.

Keywords: Embelin, Gallic acid, Vidangadi Churna, Colon targeted drug delivery.

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Authors: Visit Hirankitti, Vuong Tran Xuan

Abstract:

Meta-reasoning is essential for multi-agent communication. In this paper we propose a framework of multi-agent communication in which agents employ meta-reasoning to reason with agent and ontology locations in order to communicate semantic information with other agents on the semantic web and also reason with multiple distributed ontologies. We shall argue that multi-agent communication of Semantic Web information cannot be realized without the need to reason with agent and ontology locations. This is because for an agent to be able to communicate with another agent, it must know where and how to send a message to that agent. Similarly, for an agent to be able to reason with an external semantic web ontology, it must know where and how to access to that ontology. The agent framework and its communication mechanism are formulated entirely in meta-logic.

Keywords: Semantic Web, agent communication, ontologies.

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Authors: Zong Chen, Li Zhang

Abstract:

Median filter is widely used to remove impulse noise without blurring sharp edges. However, when noise level increased, or with thin edges, median filter may work poorly. This paper proposes a new filter, which will detect edges along four possible directions, and then replace noise corrupted pixel with estimated noise-free edge median value. Simulations show that the proposed multi-stage directional median filter can provide excellent performance of suppressing impulse noise in all situations.

Keywords: Impulse noise, Median filter, Multi-stage, Edgepreserving

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Authors: Shilpi Tyagi, D. K. Nauriyal

Abstract:

This study investigates the firm level determinants of profitability of Indian drug and pharmaceutical industry. The study uses inflation adjusted panel data for a period 2000-2013 and applies OLS regression model with Driscoll-Kraay standard errors. It has been found that export intensity, A&M intensity, firm’s market power and stronger patent regime dummy have exercised positive influence on profitability. The negative and statistically significant influence of R&D intensity and raw material import intensity points to the need for firms to adopt suitable investment strategies. The study suggests that firms are required to pay far more attention to optimize their operating expenditures, advertisement and marketing expenditures and improve their export orientation, as part of the long term strategy.

Keywords: Indian drug and pharmaceutical industry, trade related intellectual property rights, research and development, food and drug administration.

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Authors: E. R. Arakelova, S. G. Grigoryan, F. G. Arsenyan, N. S. Babayan, R. M. Grigoryan, N. K. Sarkisyan

Abstract:

The nanotechnology offers some exciting possibilities in cancer treatment, including the possibility of destroying tumors with minimal damage to healthy tissue and organs by targeted drug delivery systems. Considerable achievements in investigations aimed at the use of ZnO nanoparticles and nanocontainers in diagnostics and antitumor therapy were described. However, there are substantial obstacles to the purposes to be achieved by the use of zinc oxide nanosize materials in antitumor therapy. Among the serious problems are the techniques of obtaining ZnO nanosize materials. The article presents a new vector delivery system for the known antitumor drug, doxorubicin in the form of polymeric (PEO, starch-NaCMC) hydrogels, in which nanosize ZnO film of a certain thickness are deposited directly on the drug surface on glass substrate by DC-magnetron sputtering of a zinc target. Anticancer activity in vitro and in vivo of those nanosize zinc oxide composites is shown.

Keywords: Anticancer activity, cancer specificity, doxorubicin, zinc oxide.

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Authors: E. Aboutaleb, R. Dinarvand

Abstract:

The purpose of this work was to inspect the potential of vincristine-dextran complex loaded solid lipid nanoparticles for drug delivery to the brain. The nanoparticles were stained with a fluorescence dye and their plasma pharmacokinetic and brain concentrations were investigated following injection to rats. The result revealed a significant improvement in the plasma concentration profile of the SLN injected animals as well as a sharp increased concentration in the brains.

Keywords: Brain, Coumarin-6, Nanoparticles, SLN.

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Authors: Prakash Singh

Abstract:

Many schools throughout the world are facing constant pressure to cope with the violence and drug abuse of learners who show little or no respect for acceptable and desirable social norms. These delinquent learners tend to harbour feelings of being beyond reproach because they strongly believe that it is well within their rights to engage in violent and destructive behaviour. Knives, guns, and other weapons appear to be more readily used by them on the school premises than before. It is known that learners smoke, drink alcohol, and use drugs during school hours, hence, their ability to concentrate, work, and learn, is affected. They become violent and display disruptive behaviour in their classrooms as well as on the school premises, and this atrocious behaviour makes it possible for drug dealers and gangsters to gain access onto the school premises. The primary purpose of this exploratory quantitative study was therefore to establish how tobephobia (TBP), caused by school violence and drug abuse, affects teaching and learning in schools. The findings of this study affirmed that poor discipline resulted in producing poor quality education. Most of the teachers in this study agreed that educating learners who consumed alcohol and other drugs on the school premises resulted in them suffering from TBP. These learners are frequently abusive and disrespectful, and resort to violence to seek attention. As a result, teachers feel extremely demotivated and suffer from high levels of anxiety and stress. The word TBP will surely be regarded as a blessing by many teachers throughout the world because finally, there is a word that will make people sit up and listen to their problems that cause real fear and anxiety in schools.

Keywords: Aims and objectives of quality education, Debilitating effects of tobephobia, Fear of failure associated with education, learners’ violent behaviour and drug abuse.

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Authors: Rodolfo Lorbieski, Silvia Modesto Nassar

Abstract:

Many supervised machine learning tasks require decision making across numerous different classes. Multi-class classification has several applications, such as face recognition, text recognition and medical diagnostics. The objective of this article is to analyze an adapted method of Stacking in multi-class problems, which combines ensembles within the ensemble itself. For this purpose, a training similar to Stacking was used, but with three levels, where the final decision-maker (level 2) performs its training by combining outputs from the tree-based pair of meta-classifiers (level 1) from Bayesian families. These are in turn trained by pairs of base classifiers (level 0) of the same family. This strategy seeks to promote diversity among the ensembles forming the meta-classifier level 2. Three performance measures were used: (1) accuracy, (2) area under the ROC curve, and (3) time for three factors: (a) datasets, (b) experiments and (c) levels. To compare the factors, ANOVA three-way test was executed for each performance measure, considering 5 datasets by 25 experiments by 3 levels. A triple interaction between factors was observed only in time. The accuracy and area under the ROC curve presented similar results, showing a double interaction between level and experiment, as well as for the dataset factor. It was concluded that level 2 had an average performance above the other levels and that the proposed method is especially efficient for multi-class problems when compared to binary problems.

Keywords: Stacking, multi-layers, ensemble, multi-class.

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Authors: Sunil Kamboj, Suman Bala, Vipin Saini

Abstract:

Niosomes were formulated with an aim of enhancing the oral bioavailability of losartan potassium and formulated in different molar ratios of surfactant, cholesterol and dicetyl phosphate. The formulated niosomes were found in range of 54.98 µm to 107.85 µm in size. Formulations with 1:1 ratio of surfactant and cholesterol have shown maximum entrapment efficiencies. Niosomes with sorbitan monostearate showed maximum drug release and zero order release kinetics, at the end of 24 hours. The in vivo study has shown the significant enhancement in oral bioavailability of losartan potassium in rats, after a dose of 10 mg/kg. The average relative bioavailability in relation with pure drug solution was found 2.56, indicates more than two fold increase in oral bioavailability. A significant increment in MRT reflects the release retarding ability of the vesicles. In conclusion, niosomes could be a promising delivery of losartan potassium with improved oral bioavailability and prolonged release profiles.

Keywords: Non-ionic surfactant vesicles, losartan potassium, oral bioavailability, controlled release.

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