%0 Journal Article %A E. Aboutaleb and R. Dinarvand %D 2012 %J International Journal of Pharmacological and Pharmaceutical Sciences %B World Academy of Science, Engineering and Technology %I Open Science Index 67, 2012 %T Vincristine-Dextran Complex Loaded Solid Lipid Nanoparticles for Drug Delivery to the Brain %U https://publications.waset.org/pdf/15432 %V 67 %X The purpose of this work was to inspect the potential of vincristine-dextran complex loaded solid lipid nanoparticles for drug delivery to the brain. The nanoparticles were stained with a fluorescence dye and their plasma pharmacokinetic and brain concentrations were investigated following injection to rats. The result revealed a significant improvement in the plasma concentration profile of the SLN injected animals as well as a sharp increased concentration in the brains. %P 295 - 299