Vincristine-Dextran Complex Loaded Solid Lipid Nanoparticles for Drug Delivery to the Brain

Authors: E. Aboutaleb, R. Dinarvand

Abstract:

The purpose of this work was to inspect the potential of vincristine-dextran complex loaded solid lipid nanoparticles for drug delivery to the brain. The nanoparticles were stained with a fluorescence dye and their plasma pharmacokinetic and brain concentrations were investigated following injection to rats. The result revealed a significant improvement in the plasma concentration profile of the SLN injected animals as well as a sharp increased concentration in the brains.

Keywords: Brain, Coumarin-6, Nanoparticles, SLN.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1085024

References:

[1] What You Need To Know About Brain Tumors National Cancer Institute booklet (Publication No. 09-1558).
[2] Shah, G.D. and L.E. Abrey, Chemotherapy for Brain Metastases: Breast, Gynecologic and Non-Melanoma Skin Malignancies, in Brain Metastases, J.J. Raizer and L.E. Abrey, Editors. 2007, Springer US. p. 185-197.
[3] Victor Tse, Brain Metastasis. Medscape 2011.
[4] Pardridge, W.M., Drug targeting to the brain. Pharm Res, 2007. 24(9): p. 1733-44.
[5] Yang, S.C., et al., Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain. Journal of Controlled Release, 1999. 59(3): p. 299-307.
[6] Bondì, M.L., et al., Brain-targeted solid lipid nanoparticles containing riluzole: Preparation, characterization and biodistribution. Nanomedicine, 2010. 5(1): p. 25-32.
[7] Göppert, T.M. and R.H. M├╝ller, Polysorbate-stabilized solid lipid nanoparticles as colloidal carriers for intravenous targeting of drugs to the brain: Comparison of plasma protein adsorption patterns. Journal of Drug Targeting, 2005. 13(3): p. 179-187.
[8] Kaur, I.P., et al., Potential of solid lipid nanoparticles in brain targeting. J Control Release, 2008. 127(2): p. 97-109.
[9] Zhang, H., et al., Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats. Arch Pharm Res, 2003. 26(9): p. 768-772.
[10] Collnot, E.-M., et al., Vitamin E TPGS P-Glycoprotein Inhibition Mechanism: Influence on Conformational Flexibility, Intracellular ATP Levels, and Role of Time and Site of Access. Mol. Pharmaceutics, 2010. 7(3): p. 642-651.
[11] Dalwadi, G. and B. Sunderland, An ion pairing approach to increase the loading of hydrophilic and lipophilic drugs into PEGylated PLGA nanoparticles. Eur J Pharm Biopharm, 2009. 71(2): p. 231-42.
[12] Gaudana, R., et al., Development and characterization of nanoparticulate formulation of a water soluble prodrug of dexamethasone by HIP complexation. Journal of Microencapsulation, 2011. 28(1): p. 10-20.
[13] Lu, E., et al., Preparation of aminoglycoside-loaded chitosan nanoparticles using dextran sulphate as a counterion. J Microencapsul, 2009. 26(4): p. 346-54.
[14] Wang, F., et al., Influence of blood-brain barrier efflux pumps on the distribution of vincristine in brain and brain tumors. Neuro Oncol, 2010. 12(10): p. 1043-9.
[15] Greig, N.H., et al., Brain uptake and anticancer activities of vincristine and vinblastine are restricted by their low cerebrovascular permeability and binding to plasma constituents in rat. Cancer Chemotherapy and Pharmacology, 1990. 26(4): p. 263-268.
[16] Boyle, F.M., S.L. Eller, and S.A. Grossman, Penetration of intraarterially administered vincristine in experimental brain tumor. Neuro Oncol, 2004. 6(4): p. 300-5.
[17] E Aboutaleb, "Optimization and Invivo evaluation of vincristine-dextran sulfate complex loaded Solid lipid nanoparticles" Unpublished.
[18] Zhang, P., et al., Poly(caprolactone)-block-poly(ethyl ethylene phosphate) micelles for brain-targeting drug delivery: in vitro and in vivo valuation. Pharm Res, 2010. 27(12): p. 2657-69.
[19] Gualbert, J., et al., Solid Lipid Nanoparticles (SLNs): Preparation and Properties of Calix
[4]resorcinarene Derived Systems. Journal of Inclusion Phenomena, 2004. 48(1/2): p. 37-44.
[20] Neto, C., et al., In Situ Study of Soft Matter with Atomic Force Microscopy and Light Scattering, in Trends in Colloid and Interface Science XIV, V. Buckin, Editor 2000, Springer Berlin Heidelberg: Berlin, Heidelberg. p. 295-299.
[21] Volcke, C., et al., Influence of DNA condensation state on transfection efficiency in DNA/polymer complexes: an AFM and DLS comparative study. J Biotechnol, 2006. 125(1): p. 11-21.