Development and Optimization of Colon Targeted Drug Delivery System of Ayurvedic Churna Formulation Using Eudragit L100 and Ethyl Cellulose as Coating Material
The purpose of this study was to prepare time and pH dependent release tablets of Ayurvedic Churna formulation and evaluate their advantages as colon targeted drug delivery system. The Vidangadi Churna was selected for this study which contains Embelin and Gallic acid. Embelin is used in Helminthiasis as therapeutic agent. Embelin is insoluble in water and unstable in gastric environment so it was formulated in time and pH dependent tablets coated with combination of two polymers Eudragit L100 and ethyl cellulose. The 150mg of core tablet of dried extract and lactose were prepared by wet granulation method. The compression coating was used in the polymer concentration of 150mg for both the layer as upper and lower coating tablet was investigated. The results showed that no release was found in 0.1 N HCl and pH 6.8 phosphate buffers for initial 5 hours and about 98.97% of the drug was released in pH 7.4 phosphate buffer in total 17 Hours. The in vitro release profiles of drug from the formulation could be best expressed first order kinetics as highest linearity (r2= 0.9943). The results of the present study have demonstrated that the time and pH dependent tablets system is a promising vehicle for preventing rapid hydrolysis in gastric environment and improving oral bioavailability of Embelin and Gallic acid for treatment of Helminthiasis.
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 Anonymous, "The Ayurvedic Formulary of India”, Part-II, Govt. of India, Ministry of Health and Family Welfare, Dept. of Indian Systems of Medicine and Homeopathy, New Delhi, 128 .
 Goyal A., Kumar S., Nagpal M., Singh I., Arora S., " Potential of Novel Drug Delivery System for Herbal Drugs” Indian J. of Pharm. Edu. & Res. 2011, 45, 3.
 Atmakuri LR, Dathi S. "Current trends in herbal medicines” J Pharm Res 2010; 3(1):109-113.
 Brahmankar DM, Jaiswal SB. "Biopharmaceutics and st Pharmacokinetics A Treatise” 1 ed., New Delhi: Vallabh Prakashan; 1998 (reprint 2008):61, 359, 362.
 Lachman L, Lieberman HA, Kanig JL. "The Theory and Practice of Industrial Pharmacy” 3rd ed. Philadelphia: Lea & Febiger; 1996: 510-511.
 Ashord M, Fell JT, Attwood D, Sharma H, Woodhead P. "An evaluation of pectin as a carrier for drug targeting to the colon” J Control Rel 1993; 26:213- 220.
 Gazzaniga A, Iamartino P, Maffino G, Sangalli ME. "Oral delayed release system for colonic specific drug delivery” Int J Pharm 1994; 108:77-83.
 Fukui E, Miyamura N, Verma K, Kobayashi M. "Preparation of enteric coated time released press coated tablets and evaluation of their function by in vitro and in vivo tests for colon targeting” Int J Pharm 2000; 204:7-15.
 Watanabe S, Kawai H, Katsuma M, Fukui M. "Colon specific drug release system” U. S. Patent, 1998, 09/183339.
 Theeuwes F, Guittared G, Wong P. "Delivery of drugs to colon by oral dosage forms” U. S. Patent, 4904474.
 Pruthviraj S Pawar and M. A. Saleem "Formulation and evaluation of oral colon targeted tablet of budesonide” Der Pharmacia Lettre, 2013, 5 (3):1-12.
 M. A. Nasra, M. A. EL-Massik*, V. F. Naggar "Development of metronidazole colon-speciﬁc delivery systems” Asian Journal of Pharmaceutical Sciences 2007, 2 (1): 18-28.
 Preveen Singh M*, Manjula BP "Development and evaluation of compression coated tablets of metronidazole for colon targeted drug delivery” International journal of Pharmaceutical Research and Development 2013 Vol.5 July 70-78.
 Sumit Kumar*, Anurag Bhargava "Formulation and Evaluation of Compressed Coat Tablets of Naproxen for Colon Targeting” Asian Journal of Biomedical and Pharmaceutical Sciences 2(10) 2012, 33-37.
 Mukesh R. Patel *, K. R. Patel, N. M. Patel, T. J. Mehta and A. D. Patel "Development and optimization of colon targeted compression coated tablet of Methotrexate” J. Chem. Pharm. Res., 2011, 3(2):786-791.
 Parvin Zakeri-Milani "Preparation and In vitro Investigation of Chitosan Compressed Tablets for Colon Targeting” Advanced Pharmaceutical Bulletin, 2011, 1(2), 87-92.
 Chetan Singh Chauhan "Formulation and evaluation of Prednisolone tablet for colon targeted drug delivery system” J. Chem. Pharm. Res., 2010, 2(4):993-998