Search results for: dynamic competitive advantage
1905 Lean Changeability – Evaluation and Design of Lean and Transformable Factories
Authors: Tim Klemke, Peter Nyhuis
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In today-s turbulent environment, companies are faced with two principal challenges. On the one hand, it is necessary to produce ever more cost-effectively to remain competitive. On the other hand, factories need to be transformable in order to manage unpredictable changes in the corporate environment. To deal with these different challenges, companies use the philosophy of lean production in the first case, in the second case the philosophy of transformability. To a certain extent these two approaches follow different directions. This can cause conflicts when designing factories. Therefore, the Institute of Production Systems and Logistics (IFA) of the Leibniz University of Hanover has developed a procedure to allow companies to evaluate and design their factories with respect to the requirements of both philosophies.
Keywords: Factory planning, lean production, transformability
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 21881904 Comparison of Rheological Properties for Polymer Modified Asphalt Produced in Riyadh
Authors: Ali M. Babalghaith, Hamad A. Alsoliman, Abdulrahman S. Al-Suhaibani
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Flexible pavement made with neat asphalt binder is not enough to resist heavy traffic loads as well as harsh environmental condition found in Riyadh region. Therefore, there is a need to modify asphalt binder with polymers to satisfy such conditions. There are several types of polymers that are used to modify asphalt binder. The objective of this paper is to compare the rheological properties of six polymer modified asphalt binders (Lucolast7010, Anglomak2144, Paveflex140, SBS KTR401, EE-2 and Crumb rubber) obtained from asphalt manufacturer plants. The rheological properties of polymer modified asphalt binders were tested using conventional tests such as penetration, softening point and viscosity; and SHRP tests such as dynamic shear rheometer and bending beam rheometer. The results have indicated that the polymer modified asphalt binders have lower penetration and higher softening point than neat asphalt indicating an improvement in stiffness of asphalt binder, and as a result, more resistant to rutting. Moreover, the dynamic shear rheometer results have shown that all modifiers used in this study improved the binder properties and satisfied the Superpave specifications except SBS KTR401 which failed to satisfy the rutting parameter (G*/sinδ).Keywords: Polymer modified asphalt, rheological properties, SBS, crumb rubber, EE-2.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 24071903 Cardiac Function and Morphological Adaptations in Endurance and Resistance Athletes: Evaluation using a new Method
Authors: K. Hosseini, MD., R. Mazaheri, MD., H.R. Khoddami Vishteh, MD., M.A. Mansournia, MD., H. Angoorani, MD
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Background: Tissue Doppler Echocardiography (TDE) assesses diastolic function more accurately than routine pulse Doppler echo. Assessment of the effects of dynamic and static exercises on the heart by using TDE can provides new information about the athlete-s heart syndrome. Methods: This study was conducted on 20 elite wrestlers, 14 endurance runners at national level and 21 non-athletes as the control group. Participants underwent two-dimensional echocardiography, standard Doppler and TDE. Results: Wrestlers had the highest left ventricular mass index, enddiastolic inter-ventricular septum thickness and left ventricular Posterior wall thickness. Runners had the highest Left ventricular end-diastolic volume, LV ejection fraction, stroke volume and cardiac output. In TDE, the early diastolic velocity of mitral annulus to the late diastolic velocity ratio in athletic groups was greater than the controls with no significant difference. Conclusion: In spite of cardiac morphological changes in athletes, TDE shows that cardiac diastolic function won-t be adversely affected.Keywords: Tissue Doppler Echocardiography, Diastolic function, Athlete's heart syndrome, Static exercise, Dynamic exercise
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16151902 Innovation Ecosystems in the Construction Industry
Authors: Cansu Gülser, Tuğce Ercan
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The construction sector is a key driver of the global economy, contributing significantly to growth and employment through a diverse array of sub-sectors. However, it faces challenges due to its project-based nature, which often hampers long-term collaboration and broader incentives beyond individual projects. These limitations are frequently discussed in scientific literature as obstacles to innovation and industry-wide change. Traditional practices and unwritten rules further hinder the adoption of new processes within the construction industry. The disadvantages of the construction industry’s project-based structure in fostering innovation and long-term relationships include limited continuity, fragmented collaborations, and a focus on short-term goals, which collectively hinder the development of sustained partnerships, inhibit the sharing of knowledge and best practices, and reduce incentives for investing in innovative processes and technologies. This structure typically emphasizes specific projects, which restricts broader collaborations and incentives that extend beyond individual projects, thus impeding innovation and change. The temporal complexities inherent in project-based sectors like construction make it difficult to address societal challenges through collaborative efforts. Traditional management approaches are inadequate for scaling up innovations and adapting to significant changes. For systemic transformation in the construction sector, there is a need for more collaborative relationships and activities beyond traditional supply chains. This study delves into the concept of an innovation ecosystem within the construction sector, highlighting various research findings. It aims to explore key questions about the components that enhance innovation capacity, the relationship between a robust innovation ecosystem and this capacity, and the reasons why innovation is less prevalent and implemented in this sector compared to others. Additionally, it examines the main factors hindering innovation within companies and identifies strategies to improve these efforts, particularly in developing countries. The innovation ecosystem in the construction sector generates various outputs through interactions between business resources and external components. These outputs include innovative value creation, sustainable practices, robust collaborations, knowledge sharing, competitiveness, and advanced project management, all of which contribute significantly to company market performance and competitive advantage. This article offers insights and strategic recommendations for industry professionals, policymakers, and researchers interested in developing and sustaining innovation ecosystems in the construction sector. Future research should focus on broader samples for generalization, comparative sector analysis, and application-focused studies addressing real industry challenges. Additionally, studying the long-term impacts of innovation ecosystems, integrating advanced technologies like AI and machine learning into project management, and developing future application strategies and policies are also important.
Keywords: Construction industry, innovation ecosystem, innovation ecosystem components, project management.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 901901 Intuition Operator: Providing Genomes with Reason
Authors: Grigorios N. Beligiannis, Georgios A. Tsirogiannis, Panayotis E. Pintelas
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In this contribution, the use of a new genetic operator is proposed. The main advantage of using this operator is that it is able to assist the evolution procedure to converge faster towards the optimal solution of a problem. This new genetic operator is called ''intuition'' operator. Generally speaking, one can claim that this operator is a way to include any heuristic or any other local knowledge, concerning the problem, that cannot be embedded in the fitness function. Simulation results show that the use of this operator increases significantly the performance of the classic Genetic Algorithm by increasing the convergence speed of its population.
Keywords: Genetic algorithms, intuition operator, reasonable genomes, complex search space, nonlinear fitness functions
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15741900 Comparison and Characterization of Dyneema™ HB-210 and HB-212 for Accelerated UV Aging
Authors: Jonmichael A. Weaver, David A. Miller
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Ultra High Molecular Weight Polyethylene (UHMWPE) presents several distinct advantages as a material with a high strength to weight ratio, durability, and neutron stability. Understanding the change in the mechanical performance of UHMWPE due to environmental exposure is key to safety for future applications. Dyneema® HB-210, a 15 µm diameter UHMWPE multi-filament fiber laid up in a polyurethane matrix in [0/ 90]2, with a thickness of 0.17 mm is compared to the same fiber and orientation system, HB-212, with a rubber-based matrix under UV aging conditions. UV aging tests according to ASTM-G154 were performed on both HB-210 and HB-212 to interrogate the change in mechanical properties, as measured through dynamic mechanical analysis and imaged using a scanning electron microscope. These results showed a decrease in both the storage modulus and loss modulus of the aged material compared to the unaged, even though the tan δ slightly increased. Material degradation occurred at a higher rate in Dyneema® HB-212 compared to HB-210. The HB-210 was characterized for the effects of 100 hours of UV aging via dynamic mechanical analysis. Scanning electron microscope images were taken of the HB-210 and HB-212 to identify the primary damage mechanisms in the matrix. Embrittlement and matrix spall were the products of prolonged UV exposure and erosion, resulting in decreased mechanical properties.
Keywords: Composite materials, material characterization, UV aging, UHMWPE.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 6751899 Long-Term Follow-up of Dynamic Balance, Pain and Functional Performance in Cruciate Retaining and Posterior Stabilized Total Knee Arthroplasty
Authors: Ahmed R. Z. Baghdadi, Mona H. Gamal Eldein
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Background: With the perceived pain and poor function experienced following knee arthroplasty, patients usually feel un-satisfied. Yet, a controversy still persists on the appropriate operative technique that doesn’t affect proprioception much. Purpose: This study compared the effects of Cruciate Retaining (CR) and Posterior Stabilized (PS) total knee arthroplasty (TKA on dynamic balance, pain and functional performance following rehabilitation. Methods: Thirty patients with CRTKA (group I), thirty with PSTKA (group II) and fifteen indicated for arthroplasty but weren’t operated on yet (group III) participated in the study. The mean age was 54.53±3.44, 55.13±3.48 and 55.33±2.32 years and BMI 35.7±3.03, 35.7±1.99 and 35.73±1.03 kg/m2 for groups I, II and III respectively. The Berg Balance Scale (BBS), WOMAC pain subscale and Timed Up-and-Go (TUG) and Stair-Climbing (SC) tests were used for assessment. Assessments were conducted four weeks preand post-operatively, three, six and twelve months post-operatively with the control group being assessed at the same time intervals. The post-operative rehabilitation involved hospitalization (1st week), home-based (2nd-4th weeks), and outpatient clinic (5th-12th weeks) programs, follow-up to all groups for twelve months. Results: The Mixed design MANOVA revealed that group I had significantly lower pain scores and SC time compared with group II three, six and twelve months post-operatively. Moreover, the BBS scores increased significantly and the pain scores and TUG and SC time decreased significantly six months post-operatively compared with four weeks pre- and post-operatively and three months postoperatively in groups I and II with the opposite being true four weeks post-operatively. But no significant differences in BBS scores, pain scores and TUG and SC time between six and twelve months postoperatively in groups I and II. Interpretation/Conclusion: CRTKA is preferable to PSTKA, possibly due to the preserved human proprioceptors in the un-excised PCL.
Keywords: Dynamic Balance, Functional Performance, Knee Arthroplasty, Long-Term.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 20611898 Parallel Block Backward Differentiation Formulas For Solving Large Systems of Ordinary Differential Equations
Authors: Zarina Bibi, I., Khairil Iskandar, O.
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In this paper, parallelism in the solution of Ordinary Differential Equations (ODEs) to increase the computational speed is studied. The focus is the development of parallel algorithm of the two point Block Backward Differentiation Formulas (PBBDF) that can take advantage of the parallel architecture in computer technology. Parallelism is obtained by using Message Passing Interface (MPI). Numerical results are given to validate the efficiency of the PBBDF implementation as compared to the sequential implementation.Keywords: Ordinary differential equations, parallel.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16661897 Practical Application of Simulation of Business Processes
Authors: Markéta Gregušová, Vladimíra Schindlerová, Ivana Šajdlerová, Petr Mohyla, Jan Kedroň
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Company managers are always looking for more and more opportunities to succeed in today's fiercely competitive market. To maintain your place among the successful companies on the market today or to come up with a revolutionary business idea is much more difficult than before. Each new or improved method, tool, or approach that can improve the functioning of business processes or even of the entire system is worth checking and verification. The use of simulation in the design of manufacturing systems and their management in practice is one of the ways without increased risk, which makes it possible to find the optimal parameters of manufacturing processes and systems. The paper presents an example of use of simulation for solution of the bottleneck problem in the concrete company.
Keywords: Practical applications, business processes, systems, simulation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 30321896 Representing Shared Join Points with State Charts: A High Level Design Approach
Authors: Muhammad Naveed, Muhammad Khalid Abdullah, Khalid Rashid, Hafiz Farooq Ahmad
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Aspect Oriented Programming promises many advantages at programming level by incorporating the cross cutting concerns into separate units, called aspects. Join Points are distinguishing features of Aspect Oriented Programming as they define the points where core requirements and crosscutting concerns are (inter)connected. Currently, there is a problem of multiple aspects- composition at the same join point, which introduces the issues like ordering and controlling of these superimposed aspects. Dynamic strategies are required to handle these issues as early as possible. State chart is an effective modeling tool to capture dynamic behavior at high level design. This paper provides methodology to formulate the strategies for multiple aspect composition at high level, which helps to better implement these strategies at coding level. It also highlights the need of designing shared join point at high level, by providing the solutions of these issues using state chart diagrams in UML 2.0. High level design representation of shared join points also helps to implement the designed strategy in systematic way.Keywords: Aspect Oriented Software Development, Shared Join Points.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17151895 Combination Scheme of Affine Projection Algorithm Filters with Complementary Order
Authors: Young-Seok Choi
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This paper proposes a complementary combination scheme of affine projection algorithm (APA) filters with different order of input regressors. A convex combination provides an interesting way to keep the advantage of APA having different order of input regressors. Consequently, a novel APA which has the rapid convergence and the reduced steady-state error is derived. Experimental results show the good properties of the proposed algorithm.
Keywords: Adaptive filter, affine projection algorithm, convex combination, input order.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16631894 Criteria of Selecting 3pl Provider: A Literature Review
Authors: Rajesh Gupta, Anish Sachdeva, Arvind Bhardwaj
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Shippers are concentrating on the core competency to stay competitive and outsourcing the logistic activities to the third party who is expert in this field. This third party logistics (3PL) is drawing the due attention at government, industrial, academicians and practitioner-s levels. If the logistics cost in India can be brought down from the current level of 13% of GDP to 9% (level in the U.S.), the savings would be around Rs 3 lakh crore approximately per annum. But the problem with the shippers is to select the suitable 3PL provider. Various criteria for selection of 3PL have been listed in the literature which are discussed in the present literature review. Every shipper will select the criteria suitable to its own requirement which have to be dynamically reviewed time to time so as to fit in the ever changing environment.Keywords: 3PL, criteria, shipper, outsourcing
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 50661893 Effect of Ionic Strength on Mercury Adsorption on Contaminated Soil
Authors: G. Petruzzelli, F. Pedron, I. Rosellini, E. Tassi, F. Gorini, B. Pezzarossa, M. Barbafieri
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Mercury adsorption on soil was investigated at different ionic strengths using Ca(NO3)2 as a background electrolyte. Results fitted the Langmuir equation and the adsorption isotherms reached a plateau at higher equilibrium concentrations. Increasing ionic strength decreased the sorption of mercury, due to the competition of Ca ions for the sorption sites in the soils. The influence of ionic strength was related to the mechanisms of heavy metal sorption by the soil. These results can be of practical importance both in the agriculture and contaminated soils since the solubility of mercury in soils are strictly dependent on the adsorption and release process.Keywords: Heavy metals, bioavailability, remediation, competitive sorption.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 24481892 Mixed Traffic Speed–Flow Behavior under Influence of Road Side Friction and Non-Motorized Vehicles: A Comparative Study of Arterial Roads in India
Authors: Chetan R. Patel, G. J. Joshi
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Present study is carried out on six lane divided urban arterial road in Patna and Pune city of India. Both the road having distinct differences in terms of the vehicle composition and the road side parking. Arterial road in Patan city has 33% of non-motorized mode, whereas Pune arterial road dominated by 65% of Two wheeler. Also road side parking is observed in Patna city. The field studies using videography techniques are carried out for traffic data collection. Data are extracted for one minute duration for vehicle composition, speed variation and flow rate on selected arterial road of the two cities. Speed flow relationship is developed and capacity is determine. Equivalency factor in terms of dynamic car unit is determine to represent the vehicle is single unit. The variation in the capacity due to side friction, presence of non motorized traffic and effective utilization of lane width is compared at concluding remarks.Keywords: Arterial Road, Capacity, Dynamic Equivalency Factor, Effect of Non motorized mode, Side friction.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 32091891 Development of a Complete Single Jet Common Rail Injection System Gas Dynamic Model for Hydrogen Fueled Engine with Port Injection Feeding System
Authors: Mohammed Kamil, M. M. Rahman, Rosli A. Bakar
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Modeling of hydrogen fueled engine (H2ICE) injection system is a very important tool that can be used for explaining or predicting the effect of advanced injection strategies on combustion and emissions. In this paper, a common rail injection system (CRIS) is proposed for 4-strokes 4-cylinders hydrogen fueled engine with port injection feeding system (PIH2ICE). For this system, a numerical one-dimensional gas dynamic model is developed considering single injection event for each injector per a cycle. One-dimensional flow equations in conservation form are used to simulate wave propagation phenomenon throughout the CR (accumulator). Using this model, the effect of common rail on the injection system characteristics is clarified. These characteristics include: rail pressure, sound velocity, rail mass flow rate, injected mass flow rate and pressure drop across injectors. The interaction effects of operational conditions (engine speed and rail pressure) and geometrical features (injector hole diameter) are illustrated; and the required compromised solutions are highlighted. The CRIS is shown to be a promising enhancement for PIH2ICE.Keywords: Common rail, hydrogen engine, port injection, wave propagation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15891890 A Holistic Workflow Modeling Method for Business Process Redesign
Authors: Heejung Lee
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In a highly competitive environment, it becomes more important to shorten the whole business process while delivering or even enhancing the business value to the customers and suppliers. Although the workflow management systems receive much attention for its capacity to practically support the business process enactment, the effective workflow modeling method remain still challenging and the high degree of process complexity makes it more difficult to gain the short lead time. This paper presents a workflow structuring method in a holistic way that can reduce the process complexity using activity-needs and formal concept analysis, which eventually enhances the key performance such as quality, delivery, and cost in business process.
Keywords: Workflow management, reengineering, formal concept analysis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 19491889 Shock Induced Damage onto Free-Standing Objects in an Earthquake
Authors: Haider AlAbadi, Joe Petrolito, Nelson Lam, Emad Gad
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In areas of low to moderate seismicity many building contents and equipment are not positively fixed to the floor or tied to adjacent walls. Under seismic induced horizontal vibration, such contents and equipment can suffer from damage by either overturning or impact associated with rocking. This paper focuses on the estimation of shock on typical contents and equipment due to rocking. A simplified analytical model is outlined that can be used to estimate the maximum acceleration on a rocking object given its basic geometric and mechanical properties. The developed model was validated against experimental results. The experimental results revealed that the maximum shock acceleration can be underestimated if the static stiffness of the materials at the interface between the rocking object and floor is used rather than the dynamic stiffness. Excellent agreement between the model and experimental results was found when the dynamic stiffness for the interface material was used, which was found to be generally much higher than corresponding static stiffness under different investigated boundary conditions of the cushion. The proposed model can be a beneficial tool in performing a rapid assessment of shock sensitive components considered for possible seismic rectification.
Keywords: Impact, shock, earthquakes, rocking, building contents, overturning.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18181888 The Effect of Acrylic Gel Grouting on Groundwater in Porous Media
Authors: S. Wagner, C. Boley, Y. Forouzandeh
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When digging excavations, groundwater bearing layers are often encountered. In order to allow anhydrous excavation, soil groutings are carried out, which form a water-impermeable layer. As it is injected into groundwater areas, the effects of the materials used on the environment must be known. Developing an eco-friendly, economical and low viscous acrylic gel which has a sealing effect on groundwater is therefore a significant task. At this point the study begins. Basic investigations with the rheometer and a reverse column experiment have been performed with different mixing ratios of an acrylic gel. A dynamic rheology study was conducted to determine the time at which the gel still can be processed and the maximum gel strength is reached. To examine the effect of acrylic gel grouting on determine the parameters pH value, turbidity, electric conductivity, and total organic carbon on groundwater, an acrylic gel was injected in saturated sand filled the column. The structure was rinsed with a constant flow and the eluate was subsequently examined. The results show small changes in pH values and turbidity but there is a dependency between electric conductivity and total organic carbon. The curves of the two parameters react at the same time, which means that the electrical conductivity in the eluate can be measured constantly until the maximum is reached and only then must total organic carbon (TOC) samples be taken.
Keywords: Acrylic gel grouting, dynamic rheology study, electric conductivity, total organic carbon.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 5421887 Static and Dynamic Characteristics of an Appropriated and Recessed n-GaN/AlGaN/GaN HEMT
Authors: A. Hamdoune, M. Abdelmoumene, A. Hamroun
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The objective of this paper is to simulate static I-V and dynamic characteristics of an appropriated and recessed n-GaN/AlxGa1-xN/GaN high electron mobility (HEMT). Using SILVACO TCAD device simulation, and optimized technological parameters; we calculate the drain-source current (lDS) as a function of the drain-source voltage (VDS) for different values of the gate-source voltage (VGS), and the drain-source current (lDS) depending on the gate-source voltage (VGS) for a drain-source voltage (VDS) of 20 V, for various temperatures. Then, we calculate the cut-off frequency and the maximum oscillation frequency for different temperatures.
We obtain a high drain-current equal to 60 mA, a low knee voltage (Vknee) of 2 V, a high pinch-off voltage (VGS0) of 53.5 V, a transconductance greater than 600 mS/mm, a cut-off frequency (fT) of about 330 GHz, and a maximum oscillation frequency (fmax) of about 1 THz.
Keywords: n-GaN/AlGaN/GaN HEMT, drain-source current (IDS), transconductance (gm), cut-off frequency (fT), maximum oscillation frequency (fmax).
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 23651886 QoS Improvement Using Intelligent Algorithm under Dynamic Tropical Weather for Earth-Space Satellite Applications
Authors: Joseph S. Ojo, Vincent A. Akpan, Oladayo G. Ajileye, Olalekan L, Ojo
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In this paper, the intelligent algorithm (IA) that is capable of adapting to dynamical tropical weather conditions is proposed based on fuzzy logic techniques. The IA effectively interacts with the quality of service (QoS) criteria irrespective of the dynamic tropical weather to achieve improvement in the satellite links. To achieve this, an adaptive network-based fuzzy inference system (ANFIS) has been adopted. The algorithm is capable of interacting with the weather fluctuation to generate appropriate improvement to the satellite QoS for efficient services to the customers. 5-year (2012-2016) rainfall rate of one-minute integration time series data has been used to derive fading based on ITU-R P. 618-12 propagation models. The data are obtained from the measurement undertaken by the Communication Research Group (CRG), Physics Department, Federal University of Technology, Akure, Nigeria. The rain attenuation and signal-to-noise ratio (SNR) were derived for frequency between Ku and V-band and propagation angle with respect to different transmitting power. The simulated results show a substantial reduction in SNR especially for application in the area of digital video broadcast-second generation coding modulation satellite networks.
Keywords: Fuzzy logic, intelligent algorithm, Nigeria, QoS, satellite applications, tropical weather.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 8171885 A New Gateway for Rheumatoid Arthritis: COXIBs with an Improved Cardiovascular Profile
Authors: M. Hoxha, V. Capra, C. Buccellati, A. Sala, C. Cena, R. Fruttero, M. Bertinaria, G. E. Rovati
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Today COXIBs are used in the treatment of arthritis and many other painful conditions in selected patients with high gastrointestinal risk and low cardiovascular (CV) risk. Previously, we have identified an unexpected mechanism of action of a traditional non-steroidal anti-inflammatory drug (NSAID) (diclofenac) and a specific inhibitor of cyclooxygenase-2 (COXIB) (lumiracoxib) demonstrating that they possess weak competitive antagonism at the thromboxane receptor (TP). We hypothesize that modifying the structure of a known COXIB so that it becomes also a more potent TP antagonist will preserve the anti-inflammatory and gastrointestinal safety typical of COXIBs and prevent the CV risk associated with long term therapy.
Keywords: Cyclooxygenase, inflammation, lumiracoxib, thromboxane A2.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 20421884 Denosing ECG using Translation Invariant Multiwavelet
Authors: Jeong Yup Han, Su Kyung Lee, Hong Bae Park
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In this paper, we propose a method to reduce the various kinds of noise while gathering and recording the electrocardiogram (ECG) signal. Because of the defects of former method in the noise elimination of ECG signal, we use translation invariant (TI) multiwavelet denoising method to the noise elimination. The advantage of the proposed method is that it may not only remain the geometrical characteristics of the original ECG signal and keep the amplitudes of various ECG waveforms efficiently, but also suppress impulsive noise to some extent. The simulation results indicate that the proposed method are better than former removing noise method in aspects of remaining geometrical characteristics of ECG signal and the signal-to-noise ratio (SNR).Keywords: ECG, TI multiwavelet, denoise.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17671883 Measuring Relative Efficiency of Korean Construction Company using DEA/Window
Authors: Jung-Lo Park, Sung-Sik Kim, Sun-Young Choi, Ju-Hyung Kim, Jae-Jun Kim
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Sub-prime mortgage crisis which began in the US is regarded as the most economic crisis since the Great Depression in the early 20th century. Especially, hidden problems on efficient operation of a business were disclosed at a time and many financial institutions went bankrupt and filed for court receivership. The collapses of physical market lead to bankruptcy of manufacturing and construction businesses. This study is to analyze dynamic efficiency of construction businesses during the five years at the turn of the global financial crisis. By discovering the trend and stability of efficiency of a construction business, this study-s objective is to improve management efficiency of a construction business in the ever-changing construction market. Variables were selected by analyzing corporate information on top 20 construction businesses in Korea and analyzed for static efficiency in 2008 and dynamic efficiency between 2006 and 2010. Unlike other studies, this study succeeded in deducing efficiency trend and stability of a construction business for five years by using the DEA/Window model. Using the analysis result, efficient and inefficient companies could be figured out. In addition, relative efficiency among DMU was measured by comparing the relationship between input and output variables of construction businesses. This study can be used as a literature to improve management efficiency for companies with low efficiency based on efficiency analysis of construction businesses.Keywords: Construction Company, DEA, DEA/Window, Efficiency Analysis
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 19831882 Low-MAC FEC Controller for JPEG2000 Image Transmission Over IEEE 802.15.4
Authors: Kyu-Yeul Wang, Sang-Seol Lee, Jea-Yeon Song, Jea-Young Choi, Seong-Seob Shin, Dong-Sun Kim, Duck-Jin Chung
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In this paper, we propose the low-MAC FEC controller for practical implementation of JPEG2000 image transmission using IEEE 802.15.4. The proposed low-MAC FEC controller has very small HW size and spends little computation to estimate channel state. Because of this advantage, it is acceptable to apply IEEE 802.15.4 which has to operate more than 1 year with battery. For the image transmission, we integrate the low-MAC FEC controller and RCPC coder in sensor node of LR-WPAN. The modified sensor node has increase of 3% hardware size than conventional zigbee sensor node.
Keywords: FEC, IEEE 802.15.4, JPEG2000, low-MAC.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 19411881 Modeling the Effects of Type and Intensity of Selective Logging on Forests of the Amazon
Authors: Theodore N.S. Karfakis, Anna Andrade, Carolina Volkmer-Castilho, Dennis R. Valle, Eric Arets, Paul van Gardingen
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The aim of the work presented here was to either use existing forest dynamic simulation models or calibrate a new one both within the SYMFOR framework with the purpose of examining changes in stand level basal area and functional composition in response to selective logging considering trees > 10 cm d.b.h for two areas of undisturbed Amazonian non flooded tropical forest in Brazil and one in Peru. Model biological realism was evaluated for forest in the undisturbed and selectively logged state and it was concluded that forest dynamics were realistically represented. Results of the logging simulation experiments showed that in relation to undisturbed forest simulation subject to no form of harvesting intervention there was a significant amount of change over a 90 year simulation period that was positively proportional to the intensity of logging. Areas which had in the dynamic equilibrium of undisturbed forest a greater proportion of a specific ecological guild of trees known as the light hardwoods (LHW’s) seemed to respond more favorably in terms of less deviation but only within a specific range of baseline forest composition beyond which compositional diversity became more important. These finds are in line partially with practical management experience and partiality basic systematics theory respectively.
Keywords: Amazonbasin, ecological species guild, selective logging, simulation modeling.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16641880 Fragility Assessment for Vertically Irregular Buildings with Soft Storey
Authors: N. Akhavan, Sh. Tavousi Tafreshi, A. Ghasemi
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Seismic behavior of irregular structures through the past decades indicate that the stated buildings do not have appropriate performance. Among these subjects, the current paper has investigated the behavior of special steel moment frame with different configuration of soft storey vertically. The analyzing procedure has been evaluated with respect to incremental dynamic analysis (IDA), and numeric process was carried out by OpenSees finite element analysis package. To this end, nine 2D steel frames, with different numbers of stories and irregularity positions, which were subjected to seven pairs of ground motion records orthogonally with respect to Ibarra-Krawinkler deterioration model, have been investigated. This paper aims at evaluating the response of two-dimensional buildings incorporating soft storey which subjected to bi-directional seismic excitation. The IDAs were implemented for different stages of PGA with various ground motion records, in order to determine maximum inter-storey drift ratio. According to statistical elements and fracture range (standard deviation), the vulnerability or exceedance from above-mentioned cases has been examined. For this reason, fragility curves for different placement of soft storey in the first, middle and the last floor for 4, 8, and 16 storey buildings have been generated and compared properly.
Keywords: Special steel moment frame, soft storey, incremental dynamic analysis, fragility curve.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14781879 Wavelet Based Identification of Second Order Linear System
Authors: Sudipta Majumdar, Harish Parthasarathy
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In this paper, a wavelet based method is proposed to identify the constant coefficients of a second order linear system and is compared with the least squares method. The proposed method shows improved accuracy of parameter estimation as compared to the least squares method. Additionally, it has the advantage of smaller data requirement and storage requirement as compared to the least squares method.Keywords: Least squares method, linear system, system identification, wavelet transform.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15741878 The Effect of a Muscarinic Antagonist on the Lipase Activity
Authors: Zohreh Bayat, Dariush Minai-Tehrani
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Lipases constitute one of the most important groups of industrial enzymes that catalyze the hydrolysis of triacylglycerol to glycerol and fatty acids. Muscarinic antagonist relieves smooth muscle spasm of the gastrointestinal tract and effect on the cardiovascular system. In this research the effect of a muscarinic antagonist on the lipase activity of Pseudomonas aeruginosa was studied. Lineweaver–Burk plot showed that the drug inhibited the enzyme by competitive inhibition. The IC50 value (0.16 mM) and Ki (0.03 mM) of the drug revealed the drug bound to enzyme with high affinity. Determination of enzyme activity in various pH and temperature showed that the maximum activity of lipase was at pH 8 and 60oC both in presence and absence of the drug.
Keywords: Bacteria, inhibition, kinetics, lipase.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 21871877 Indoor Mapping by using Smartphone Device
Authors: Shuib Rambat, Ruzsyahriman Jenal, John Elgy
Abstract:
This paper presented the potential of smart phone to provide support on mapping the indoor asset. The advantage of using the smart phone to generate the indoor map is that it has the ability to capture, store and reproduces still or video images; indeed most of us do have this powerful gadget. The captured images usually used by maintenance team to save a record for future reference. Here, these images are used to generate 3D models of an object precisely and accurately for efficient and effective solution in data gathering. Thus, it could be a resource for an informative database in asset management.Keywords: 3D modeling, Asset Management, Object Extraction, Smart Device
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 27921876 Evaluation of Risks in New Product Innovation
Authors: Emre Alptekin, Damla Yalçınyiğit, Gülfem Alptekin
Abstract:
In highly competitive environments, a growing number of companies must regularly launch new products speedily and successfully. A company-s success is based on the systematic, conscious product designing method which meets the market requirements and takes risks as well as resources into consideration. Research has found that developing and launching new products are inherently risky endeavors. Hence in this research, we aim at introducing a risk evaluation framework for the new product innovation process. Our framework is based on the fuzzy analytical hierarchy process (FAHP) methodology. We have applied all the stages of the framework on the risk evaluation process of a pharmaceuticals company.Keywords: Evaluation, risks, product innovation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1491