Search results for: recycled material
1237 In-Situ EBSD Observations of Bending for Single-Crystalline Pure Copper
Authors: Takashi Sakai, Saori Yoshikawa, Hideo Morimoto
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To understand the material characteristics of singleand poly-crystals of pure copper, the respective relationships between crystallographic orientations and microstructures, and the bending and mechanical properties were examined. And texture distribution is also analyzed. A bending test is performed in a SEM apparatus and while its behaviors are observed in situ. Furthermore, some analytical results related to crystal direction maps, inverse pole figures, and textures were obtained from EBSD analyses.
Keywords: Pure Copper, Bending, Single Crystal, SEM-EBSD Analysis, Texture, Microstructure
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18461236 Haematological Characterization of Reproductive Status at Laying Hens by Age
Authors: P. C. Boisteanu, M. G. Usturoi, Roxana Lazar, B. V. Avarvarei
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Physiological activity of the pineal gland with specific responses in the reproductive territory may be interpreted by monitoring the process parameters used in poultry practice in different age batches of laying hens. As biological material were used 105 laying hens, clinically healthy, belonging to ALBO SL- 2000 hybrid, raised on ground, from which blood samples were taken at the age of 12 and 28 weeks. The haematological examinations were concerned to obtain the total number of erythrocytes and leukocytes and the main erythrocyte constant (RBC, PCV, MCV, MCH, MCHC and WBC). The results allow the interpretation of the reproductive status through the dynamics of the presented values.Keywords: laying hens, haematology, reproductive status,
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14061235 Issues on Optimizing the Structural Parameters of the Induction Converter
Authors: Marinka K. Baghdasaryan, Siranush M. Muradyan, Avgen A. Gasparyan
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Analytical expressions of the current and angular errors, as well as the frequency characteristics of an induction converter describing the relation with its structural parameters, the core and winding characteristics are obtained. Based on estimation of the dependences obtained, a mathematical problem of parametric optimization is formulated which can successfully be used for investigating and diagnosing an induction converter.
Keywords: Induction converters, magnetic circuit material, current and angular errors, frequency response, mathematical formulation, structural parameters.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15541234 Use of Semantic Networks as Learning Material and Evaluation of the Approach by Students
Authors: Philippe A. Martin
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This article first summarizes reasons why current approaches supporting Open Learning and Distance Education need to be complemented by tools permitting lecturers, researchers and students to cooperatively organize the semantic content of Learning related materials (courses, discussions, etc.) into a fine-grained shared semantic network. This first part of the article also quickly describes the approach adopted to permit such a collaborative work. Then, examples of such semantic networks are presented. Finally, an evaluation of the approach by students is provided and analyzed.
Keywords: knowledge sharing, knowledge evaluation, e-learning
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15081233 Case on Manufacturing Cell Formation Using Production Flow Analysis
Authors: Vladimír Modrák
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This paper offers a case study, in which methodological aspects of cell design for transformation the production process are applied. The cell redesign in this work is tightly focused to reach optimization of material flows under real manufacturing conditions. Accordingly, more individual techniques were aggregated into compact methodical procedure with aim to built one-piece flow production. Case study was concentrated on relatively typical situation of transformation from batch production to cellular manufacturing.Keywords: Product/Quantity analysis, layout, design, manufacturing process.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 33411232 Machining of FRP Composites by Abrasive Jet Machining Optimization Using Taguchi
Authors: D. V. Srikanth, M. Sreenivasa Rao
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Abrasive Jet Machining is an Unconventional machining process in which the metal is removed from brittle and hard material in the form of micro-chips. With increase in need of materials like ceramics, composites, in manufacturing of various Mechanical & Electronic components, AJM has become a useful technique for micro machining. The present study highlights the influence of different parameters like Pressure, SOD, Time, Abrasive grain size, nozzle diameter on the Metal removal of FRP (Fiber Reinforced Polymer) composite by Abrasive jet machining. The results of the Experiments conducted were analyzed and optimized with TAGUCHI method of Optimization and ANOVA for Optimal Value.
Keywords: ANOVA, FRP Composite, AJC.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 26921231 Laser Forming of Titanium and Its Alloys – An Overview
Authors: Esther T. Akinlabi, Mukul Shukla, Stephen A. Akinlabi
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Laser beam forming is a novel technique developed for the joining of metallic components. In this study, an overview of the laser beam forming process, areas of application, the basic mechanisms of the laser beam forming process, some recent research studies and the need to focus more research effort on improving the laser-material interaction of laser beam forming of titanium and its alloys are presented.Keywords: Aerospace, Deformation, Laser forming, Mechanisms, Titanium, Titanium alloy.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 31811230 Pilot Scale Production and Compatibility Criteria of New Self-Cleaning Materials
Authors: J. Ranogajec, O. Rudic, S. Pasalic, S. Vucetic, D. Cjepa
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The paper involves a chain of activities from synthesis, establishment of the methodology for characterization and testing of novel protective materials through the pilot production and application on model supports. It summarizes the results regarding the development of the pilot production protocol for newly developed self-cleaning materials. The optimization of the production parameters was completed in order to improve the most important functional properties (mineralogy characteristics, particle size, self-cleaning properties and photocatalytic activity) of the newly designed nanocomposite material.
Keywords: Cultural heritage. Materials compatibility. Pilot production. Self-cleaning.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 23181229 Property of Polyurethane: from Soy-derived Phosphate Ester
Authors: Flora Elvistia Firdaus
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Polyurethane foams (PUF) were formed by a chemical reaction of polyol and isocyanate. The polyol was manufactured by ring-opening hydrolysis of epoxidized soybean oil in the presence of phosphoric acid under varying experimental conditions. Other factors in the foam formulation such as water content and surfactant were kept constant. The effect of the amount of solvents, phosphoric acid, and their derivates in the foam formulation on the properties of polyurethane foams were studied. The properties of the material were measured via a number of parameters, which are water content of prepared polyol, polymer density and cellular structures.Keywords: soy, polyurethane, phosporic acid
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17961228 Study on Characterization of Tuncbilek Fly Ash
Authors: A.S. Kipcak, N. Baran Acarali, S. Kolemen, N. Tugrul, E. Moroydor Derun, S. Piskin
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Fly ash is one of the residues generated in combustion, and comprises the fine particles that rise with the flue gases. Ash which does not rise is termed bottom ash [1]. In our country, it is expected that will be occurred 50 million tons of waste ash per year until 2020. Released waste from the thermal power plants is caused very significant problems as known. The fly ashes can be evaluated by using as adsorbent material. The purpose of this study is to investigate the possibility of use of Tuncbilek fly ash like low-cost adsorbents for heavy metal adsorption. First of all, Tuncbilek fly ash was characterized. For this purpose; analysis such as sieve analysis, XRD, XRF, SEM and FT-IR were performed.Keywords: Fly ash, heavy metal, sieve, adsorbent
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18531227 Flexible Manufacturing System
Authors: Peter Kostal, Karol Velisek
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Flexible manufacturing system is a system that is able to respond to changed conditions. In general, this flexibility is divided into two key categories and several subcategories. The first category is the so called machine flexibility which enables to make various products by the given machinery. The second category is routing flexibility enabling to execute the same operation by various machines. Flexible manufacturing systems usually consist of three main parts: CNC machine tools, transport system and control system. A higher level of flexible manufacturing systems is represented by the so called intelligent manufacturing systems.
Keywords: drawing-free manufacturing, flexible manufacturing system, industrial robot, material flow.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 49591226 Intensity of Singular Stress Field at the Corner of Adhesive Layer in Bonded Plate
Authors: Nao-Aki Noda, Yu Zhang, Ken-Tarou Takaishi, Hiroyuki Shibahara
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In this paper the strength of adhesive joint under tension and bending is discussed on the basis of intensity of singular stress by the application of FEM. A useful method is presented with focusing on the stress at the edge of interface between the adhesive and adherent obtained by FEM. After analyzing the adhesive joint strength with all material combinations, it is found that to improve the interface strength, thin adhesive layers are desirable because the intensity of singular stress decreases with decreasing the thickness.Keywords: Adhesive, Adherent, Intensity of singular stress, Bonded strip
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15041225 A Survey on Hyperbolic Cooling Towers
Authors: E. Asadzadeh, M. Alam
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This study offers a comprehensive review of the research papers published in the field of cooling towers and gives an insight into the latest developments of the natural draught cooling towers. Different modeling, analysis and design techniques are summarized and the challenges are discussed. The 118 references included in this paper are mostly concentrated on the review of the published papers after 2005. The present paper represents a complete collection of the studies done for cooling towers and would give an updated material for the researchers and design engineers in the field of hyperbolic cooling towers.
Keywords: Hyperbolic cooling towers, earthquakes, wind, nonlinear behavior, buckling, collapse, interference.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 39891224 Automatic Vehicle Location Systems
Authors: S.A. Mahdavifar, G.R. Sotudeh., K. Heydari
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In this article, a single application is suggested to determine the position of vehicles using Geographical Information Systems (GIS) and Geographical Position Systems (GPS). The part of the article material included mapping three dimensional coordinates to two dimensional coordinates using UTM or LAMBERT geographical methods, and the algorithm of conversion of GPS information into GIS maps is studied. Also, suggestions are given in order to implement this system based on web (called web based systems). To apply this system in IRAN, related official in this case are introduced and their duties are explained. Finally, economy analyzed is assisted according to IRAN communicational system.
Keywords: GIS-GPS-UTM-LAMBERT.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14081223 Using Fly Ash as a Reinforcement to Increase Wear Resistance of Pure Magnesium
Authors: E. Karakulak, R. Yamanoğlu, M. Zeren
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In the current study, fly ash obtained from a thermal power plant was used as reinforcement in pure magnesium. The composite materials with different fly ash contents were produced with powder metallurgical methods. Powder mixtures were sintered at 540oC under 30 MPa pressure for 15 minutes in a vacuum assisted hot press. Results showed that increasing ash content continuously increases hardness of the composite. On the other hand, minimum wear damage was obtained at 2 wt. % ash content. Addition of higher level of fly ash results with formation of cracks in the matrix and increases wear damage of the material.Keywords: Mg composite, fly ash, wear, powder metallurgy.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 13981222 Dynamic Safety-Stock Calculation
Authors: Julian Becker, Wiebke Hartmann, Sebastian Bertsch, Johannes Nywlt, Matthias Schmidt
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In order to ensure a high service level industrial enterprises have to maintain safety-stock that directly influences the economic efficiency at the same time. This paper analyses established mathematical methods to calculate safety-stock. Therefore, the performance measured in stock and service level is appraised and the limits of several methods are depicted. Afterwards, a new dynamic approach is presented to gain an extensive method to calculate safety-stock that also takes the knowledge of future volatility into account.
Keywords: Inventory dimensioning, material requirement planning, safety-stock calculation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 68771221 Sintering of Composite Ceramic based on Corundum with Additive in the Al2O3-TiO2-MnO System
Authors: Aung Kyaw Moe, Lukin Evgeny Stepanovich, Popova Nelya Alexandrovna
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In this paper, the effect of the additive content in the Al2O3-TiO2-MnO system on the sintering of composite ceramics based on corundum was studied. The samples were pressed by uniaxial semi-dry pressing under 100 MPa and sintered at 1500 °С and 1550 °С. The properties of composite ceramics for porosity and flexural strength were studied. When the amount of additives increases, the properties of composite ceramic samples are better than samples without additives.Keywords: Ceramic, composite material, sintering, corundum.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 8711220 Determination of Optical Constants of Semiconductor Thin Films by Ellipsometry
Authors: Aïssa Manallah, Mohamed Bouafia
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Ellipsometry is an optical method based on the study of the behavior of polarized light. The light reflected on a surface induces a change in the polarization state which depends on the characteristics of the material (complex refractive index and thickness of the different layers constituting the device). The purpose of this work is to determine the optical properties of semiconductor thin films by ellipsometry. This paper describes the experimental aspects concerning the semiconductor samples, the SE400 ellipsometer principle, and the results obtained by direct measurements of ellipsometric parameters and modelling using appropriate software.Keywords: Ellipsometry, optical constants, semiconductors, thin films.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 13371219 Eu+3 Ion as a Luminescent Probe in ZrO2: Gd+3 Co-Doped Nanophosphor
Authors: S. Manjunatha, M. S. Dharmaprakash
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Well-defined 2D Eu+3 co-doped ZrO2: Gd+3 nanoparticles were successfully synthesized by microwave assisted solution combustion technique for luminescent applications. The present investigation reports the rapid and effective method for the synthesis of the Eu+3 co-doped ZrO2:Gd+3 nanoparticles and study of the luminescence behavior of Eu+3 ion in ZrO2:Gd+3 nanostructures. The optical properties of the prepared nanostructures were investigated by using UV-visible spectroscopy and photoluminescence spectra. The phase formation and the morphology of the nanoplatelets were studied by XRD, FESEM and HRTEM. The average grain size was found to be 45-50 nm. The presence of Gd3+ ion increases the crystallinity of the material and hence acts as a good nucleating agent. The ZrO2:Gd3+ co-doped with Eu+3 nanoplatelets gives an emission at 607 nm, a strong red emission under the excitation wavelength of 255 nm.Keywords: Nanoparticles, XRD, TEM, photoluminescence.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 13691218 Photocatalytic Active Surface of LWSCC Architectural Concretes
Authors: P. Novosad, L. Osuska, M. Tazky, T. Tazky
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Current trends in the building industry are oriented towards the reduction of maintenance costs and the ecological benefits of buildings or building materials. Surface treatment of building materials with photocatalytic active titanium dioxide added into concrete can offer a good solution in this context. Architectural concrete has one disadvantage – dust and fouling keep settling on its surface, diminishing its aesthetic value and increasing maintenance e costs. Concrete surface – silicate material with open porosity – fulfils the conditions of effective photocatalysis, in particular, the self-cleaning properties of surfaces. This modern material is advantageous in particular for direct finishing and architectural concrete applications. If photoactive titanium dioxide is part of the top layers of road concrete on busy roads and the facades of the buildings surrounding these roads, exhaust fumes can be degraded with the aid of sunshine; hence, environmental load will decrease. It is clear that options for removing pollutants like nitrogen oxides (NOx) must be found. Not only do these gases present a health risk, they also cause the degradation of the surfaces of concrete structures. The photocatalytic properties of titanium dioxide can in the long term contribute to the enhanced appearance of surface layers and eliminate harmful pollutants dispersed in the air, and facilitate the conversion of pollutants into less toxic forms (e.g., NOx to HNO3). This paper describes verification of the photocatalytic properties of titanium dioxide and presents the results of mechanical and physical tests on samples of architectural lightweight self-compacting concretes (LWSCC). The very essence of the use of LWSCC is their rheological ability to seep into otherwise extremely hard accessible or inaccessible construction areas, or sections thereof where concrete compacting will be a problem, or where vibration is completely excluded. They are also able to create a solid monolithic element with a large variety of shapes; the concrete will at the same meet the requirements of both chemical aggression and the influences of the surrounding environment. Due to their viscosity, LWSCCs are able to imprint the formwork elements into their structure and thus create high quality lightweight architectural concretes.
Keywords: Photocatalytic concretes, titanium dioxide, architectural concretes, LWSCC.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 7671217 Measurement of Systemic Power Efficiency of Microwave Heating Application
Authors: Yi He, Nutdechatorn Puangngernmak, Suramate Chalermwisutkul
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Microwave heating process has been developed about sixty years while measurement system has also progressed. Because of irradiation of high frequency of microwave, researchers have been utilized many costly technical instrument measuring parameters to evaluate the performance of microwave heating system. Therefore, this paper is intended to present an easier and feasible efficiency measurement method. It can help inspecting efficiency of microwave heating system with good accuracy, while the method can also give reference to optimizing procedure for microwave heating system for various load material
Keywords: measurement, microwave heating system, systemic power efficiency
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18471216 Velocity Distribution in Open Channels with Sand: An Experimental Study
Authors: E. Keramaris
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In this study, laboratory experiments in open channel flows over a sand bed were conducted. A porous bed (sand bed) with porosity of ε=0.70 and porous thickness of s΄=3 cm was tested. Vertical distributions of velocity were evaluated by using a two-dimensional (2D) Particle Image Velocimetry (PIV). Velocity profiles are measured above the impermeable bed and above the sand bed for the same different total water heights (h= 6, 8, 10 and 12 cm) and for the same slope S=1.5. Measurements of mean velocity indicate the effects of the bed material used (sand bed) on the flow characteristics (Velocity distribution and Reynolds number) in comparison with those above the impermeable bed.
Keywords: Particle image velocimetry, sand bed, velocity distribution, Reynolds number.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17111215 Thermodynamic Attainable Region for Direct Synthesis of Dimethyl Ether from Synthesis Gas
Authors: Thulane Paepae, Tumisang Seodigeng
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This paper demonstrates the use of a method of synthesizing process flowsheets using a graphical tool called the GH-plot and in particular, to look at how it can be used to compare the reactions of a combined simultaneous process with regard to their thermodynamics. The technique uses fundamental thermodynamic principles to allow the mass, energy and work balances locate the attainable region for chemical processes in a reactor. This provides guidance on what design decisions would be best suited to developing new processes that are more effective and make lower demands on raw material and energy usage.Keywords: Attainable region, dimethyl ether synthesis, mass balance, optimal reaction networks.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14901214 In-situ Observations Using SEM-EBSD for Bending Deformation in Single-Crystal Materials
Authors: Yuko Matayoshi, Takashi Sakai, Ying-jun Jin, Jun-ichi Koyama
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To elucidate the material characteristics of single crystals of pure aluminum and copper, the respective relations between crystallographic orientations and microstructures were examined, along with bending and mechanical properties. The texture distribution was also analysed. Bending tests were performed in a SEM apparatus while its behaviors were observed. Some analytical results related to crystal direction maps, inverse pole figures, and textures were obtained from electron backscatter diffraction (EBSD) analyses.
Keywords: Pure aluminum, Pure copper, Single crystal, Bending, SEM-EBSD analysis, Texture, Microstructure.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 22161213 Micropolar Fluids Effects on the Dynamic Characteristics of Four-lobe Journal Bearing
Authors: B. Chetti
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Dynamic characteristics of a four-lobe journal bearing of micropolar fluids are presented. Lubricating oil containing additives and contaminants is modelled as micropolar fluid. The modified Reynolds equation is obtained using the micropolar lubrication theory and solving it by using finite difference technique. The dynamic characteristics in terms of stiffness, damping coefficients, the critical mass and whirl ratio are determined for various values of size of material characteristic length and the coupling number. The results show compared with Newtonian fluids, that micropolar fluid exhibits better stability.Keywords: Four-lobe bearings, dynamic characteristics, stabilityanalysis, micropolar fluid
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 21231212 A Self-Consistent Scheme for Elastic-Plastic Asperity Contact
Authors: Xu Jianguo
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In this paper, a generalized self-consistent scheme, or “three phase model", is used to set up a micro-mechanics model for rough surface contact with randomly distributed asperities. The dimensionless average real pressure p is obtained as function of the ratio of the real contact area to the apparent contact area, 0 A / A r . Both elastic and plastic materials are considered, and the influence of the plasticity of material on p is discussed. Both two-dimensional and three-dimensional rough surface contact problems are considered.
Keywords: Contact mechanics, plastic deformation, self-consistent scheme.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17561211 Determining the Workability of the New Metallurgical Materials
Authors: Ondrej Dupala, Josef Brychta, Robert Cep, Adam Janasek
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The aim of this paper is to experimentally discover the workability coefficient of the Inconel 718 material by using a slide turning machining. Two different types of cutting inserts, one made of carbide and the other one made of ceramic, are being used. The purpose is to compare measured results and recommend the appropriate materials and cutting parameters for a machining of the Inconel 718. Furthermore, the durability of inserts with the chosen wear criterion is being compared for different cutting speeds. Machinability of these materials is a crucial characteristic as it allows us to shorten the technological cycle time and increase the machining productivity. And this is of great importance from an economic point of view.
Keywords: Workability, Inconel 718, Turning Machining, Durability.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16431210 Static Study of Piezoelectric Bimorph Beams with Delamination Zone
Authors: A. Zemirline, M. Ouali, A. Mahieddine
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The FOSDT (the First Order Shear Deformation Theory) is taking into consideration to study the static behavior of a bimorph beam, with a delamination zone between the upper and the lower layer. The effect of limit conditions and lengths of the delamination zone are presented in this paper, with a PVDF piezoelectric material application. A FEM “Finite Element Method” is used to discretize the beam. In the axial displacement, a displacement field appears in the debonded zone with inverse effect between the upper and the lower layer was observed.
Keywords: Beam, Delamination, Piezoelectricity, Static.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 20111209 Optically Active Material Based on Bi2O3@Yb3+, Nd3+ with High Intensity of Upconversion Luminescence in the Red and Green Region
Authors: D. Artamonov, A. Tsibulnikova, I. Samusev, V. Bryukhanov, A. Kozhevnikov
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The synthesis and luminescent properties of Yb2O3,Nd2O3@Bi2O3 complex with upconversion generation are discussed in this work. The obtained samples were measured in the visible region of the spectrum under excitation with a wavelength of 980 nm. The studies showed that the obtained complexes have a high degree of stability and intense luminescence in the wavelength range of 400-750 nm. Consideration of the time dependence of the intensity of the upconversion luminescence allowed us to conclude that the enhancement of the intensity occurs in the time interval from 5 to 30 min, followed by the appearance of a stationary mode.
Keywords: Lasers, luminescence, upconversion photonics, rare earth metals.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1751208 Synthesis of Analogue to Camptothecine
Authors: Abdulkareem Hamid, Adam Daïch
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Camptothecin (CPT) is a cytotoxic quinoline alkaloid, which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native in China. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecine [1][2][3] and various derivatives to increase the benefits of the chemical, with good results. In our method CPT analogues has be six steps starting from available material DL Malic acid.Keywords: Camptothecine, synthesis, analogue.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1614