%0 Journal Article %A Abdulkareem Hamid and Adam Daïch %D 2011 %J International Journal of Chemical and Molecular Engineering %B World Academy of Science, Engineering and Technology %I Open Science Index 49, 2011 %T Synthesis of Analogue to Camptothecine %U https://publications.waset.org/pdf/15220 %V 49 %X Camptothecin (CPT) is a cytotoxic quinoline alkaloid, which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native in China. CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecine [1][2][3] and various derivatives to increase the benefits of the chemical, with good results. In our method CPT analogues has be six steps starting from available material DL Malic acid. %P 61 - 64