Search results for: Aseel Mahmood Abdullah
Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 250

Search results for: Aseel Mahmood Abdullah

220 Capacitor Placement in Distribution Systems Using Simulating Annealing (SA)

Authors: Esmail Limouzade, Mahmood.Joorabian, Najaf Hedayat

Abstract:

This paper undertakes the problem of optimal capacitor placement in a distribution system. The problem is how to optimally determine the locations to install capacitors, the types and sizes of capacitors to he installed and, during each load level,the control settings of these capacitors in order that a desired objective function is minimized while the load constraints,network constraints and operational constraints (e.g. voltage profile) at different load levels are satisfied. The problem is formulated as a combinatorial optimization problem with a nondifferentiable objective function. Four solution mythologies based on algorithms (GA),tabu search (TS), and hybrid GA-SA algorithms are presented.The solution methodologies are preceded by a sensitivity analysis to select the candidate capacitor installation locations.

Keywords: Genetic Algorithm (GA) , capacitor placement, voltage profile, network losses, Simulated Annealing, distribution network.

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219 Hierarchical Clustering Algorithms in Data Mining

Authors: Z. Abdullah, A. R. Hamdan

Abstract:

Clustering is a process of grouping objects and data into groups of clusters to ensure that data objects from the same cluster are identical to each other. Clustering algorithms in one of the area in data mining and it can be classified into partition, hierarchical, density based and grid based. Therefore, in this paper we do survey and review four major hierarchical clustering algorithms called CURE, ROCK, CHAMELEON and BIRCH. The obtained state of the art of these algorithms will help in eliminating the current problems as well as deriving more robust and scalable algorithms for clustering.

Keywords: Clustering, method, algorithm, hierarchical, survey.

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218 Fibers Presence Effects on Air Flow of Attenuator of Spun-Bond Production System

Authors: Nasser Ghassembaglou, Abdullah Bolek, Oktay Yilmaz, Ertan Oznergiz, Hikmet Kocabas, Safak Yilmaz

Abstract:

Different designs of attenuator systems have been studied in this research; new analysis have been done on existed designs considering fibers effect on air flow; it was comprehended that, at fibers presence, there is an air flow which agglomerates fibers as a negative effect. So some new representations have been designed and CFD analysis has been done on them. Afterwards, one of these representations selected as the most optimum and effective design which is brought in this paper.

Keywords: Attenuator, CFD, nanofiber, spun-bond.

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217 Use of Detectors Technology for Gamma Ray Issued from Radioactive Isotopes and its Impact on Knowledge of Behavior of the Stationary Case of Solid Phase Holdup

Authors: Abbas Ali Mahmood Karwi

Abstract:

For gamma radiation detection, assemblies having scintillation crystals and a photomultiplier tube, also there is a preamplifier connected to the detector because the signals from photomultiplier tube are of small amplitude. After pre-amplification the signals are sent to the amplifier and then to the multichannel analyser. The multichannel analyser sorts all incoming electrical signals according to their amplitudes and sorts the detected photons in channels covering small energy intervals. The energy range of each channel depends on the gain settings of the multichannel analyser and the high voltage across the photomultiplier tube. The exit spectrum data of the two main isotopes studied ,putting data in biomass program ,process it by Matlab program to get the solid holdup image (solid spherical nuclear fuel)

Keywords: Multichannel analyzer, Spectrum, Energies, Fluids holdup, Image

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216 Maintenance Management System for Upstream Operations in Oil and Gas Industry: Case Study

Authors: Wan Hasrulnizzam Wan Mahmood, Mohd Nizam Ab Rahman, Husiah Mazli, Baba Md Deros

Abstract:

This paper explores the plant maintenance management system that has been used by giant oil and gas company in Malaysia. The system also called as PMMS used to manage the upstream operations for more than 100 plants of the case study company. Moreover, from the observations, focus group discussion with PMMS personnel and application through simulation (SAP R/3), the paper reviews the step-by-step approach and the elements that required for the PMMS. The findings show that the PMMS integrates the overall business strategy in upstream operations that consist of asset management, work management and performance management. In addition, PMMS roles are to help operations personnel organize and plan their daily activities, to improve productivity and reduce equipment downtime and to help operations management analyze the facilities and create performance, and to provide and maintain the operational effectiveness of the facilities.

Keywords: Maintenance, Oil and Gas Industry, Upstream Operations

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215 Wireless Backhauling for 5G Small Cell Networks

Authors: Abdullah A. Al Orainy

Abstract:

Small cell backhaul solutions need to be cost-effective, scalable, and easy to install. This paper presents an overview of small cell backhaul technologies. Wireless solutions including TV white space, satellite, sub-6 GHz radio wave, microwave and mmWave with their backhaul characteristics are discussed. Recent research on issues like beamforming, backhaul architecture, precoding and large antenna arrays, and energy efficiency for dense small cell backhaul with mmWave communications is reviewed. Recent trials of 5G technologies are summarized.

Keywords: Backhaul, Small Cells, Wireless, 5G.

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214 E-Books in Malaysian Primary Schools: The Terengganu Chapter

Authors: Azelin Mohamed Noor, Abd Mutalib Embong, Muhamad Ridhuan Tony Lim Abdullah

Abstract:

After the Terengganu state government decided to give a boost in teaching and learning through the allocation of free ebooks to all Primary five and six students; it was time to examine the presence of e-books in the classrooms. A survey was conducted on 101 students to determine how they felt about using the e-book and their experiences. It was discovered that a majority of these students liked using the e-book. However, although they had little problems using the e-book and the e-book helped to lighten the schoolbags, these new-age textbooks were not fully utilized. It is implied that perhaps the school administrators, teachers and students may not be able to overcome the unfamiliar characteristics of the e-book and its limitations.

Keywords: E-books, students, classroom, limitations

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213 The Influence of Gravity on The Temporal Instability of Viscoelastic Liquid Curved Jets

Authors: Abdullah Madhi Alsharif, Jamal Uddin

Abstract:

A liquid curved jet has many applications in different industrial and engineering processes, such as the prilling process for generating small spherical pellets (fertilizer or magnesium). The liquids used are usually molten and contain small quantities of polymers and therefore can be modelled as non-Newtonian liquids. In this paper, we model the viscoelastic liquid jet by using the Oldroyd- B model. An asymptotic analysis has been used to simplify the governing equations. Furthermore, the trajectory and a linear temporal stability in the presence of gravity and rotation have been determined.

Keywords: gravity, prilling, rotation, viscoelastic jets.

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212 A Genetic-Algorithm-Based Approach for Audio Steganography

Authors: Mazdak Zamani , Azizah A. Manaf , Rabiah B. Ahmad , Akram M. Zeki , Shahidan Abdullah

Abstract:

In this paper, we present a novel, principled approach to resolve the remained problems of substitution technique of audio steganography. Using the proposed genetic algorithm, message bits are embedded into multiple, vague and higher LSB layers, resulting in increased robustness. The robustness specially would be increased against those intentional attacks which try to reveal the hidden message and also some unintentional attacks like noise addition as well.

Keywords: Artificial Intelligence, Audio Steganography, DataHiding, Genetic Algorithm, Substitution Techniques.

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211 Hybrid Approach for Memory Analysis in Windows System

Authors: Khairul Akram Zainol Ariffin, Ahmad Kamil Mahmood, Jafreezal Jaafar, Solahuddin Shamsuddin

Abstract:

Random Access Memory (RAM) is an important device in computer system. It can represent the snapshot on how the computer has been used by the user. With the growth of its importance, the computer memory has been an issue that has been discussed in digital forensics. A number of tools have been developed to retrieve the information from the memory. However, most of the tools have their limitation in the ability of retrieving the important information from the computer memory. Hence, this paper is aimed to discuss the limitation and the setback for two main techniques such as process signature search and process enumeration. Then, a new hybrid approach will be presented to minimize the setback in both individual techniques. This new approach combines both techniques with the purpose to retrieve the information from the process block and other objects in the computer memory. Nevertheless, the basic theory in address translation for x86 platforms will be demonstrated in this paper.

Keywords: Algorithms, Digital Forensics, Memory Analysis, Signature Search.

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210 Performance Analysis of the Time-Based and Periodogram-Based Energy Detector for Spectrum Sensing

Authors: Sadaf Nawaz, Adnan Ahmed Khan, Asad Mahmood, Chaudhary Farrukh Javed

Abstract:

Classically, an energy detector is implemented in time domain (TD). However, frequency domain (FD) based energy detector has demonstrated an improved performance. This paper presents a comparison between the two approaches as to analyze their pros and cons. A detailed performance analysis of the classical TD energy-detector and the periodogram based detector is performed. Exact and approximate mathematical expressions for probability of false alarm (Pf) and probability of detection (Pd) are derived for both approaches. The derived expressions naturally lead to an analytical as well as intuitive reasoning for the improved performance of (Pf) and (Pd) in different scenarios. Our analysis suggests the dependence improvement on buffer sizes. Pf is improved in FD, whereas Pd is enhanced in TD based energy detectors. Finally, Monte Carlo simulations results demonstrate the analysis reached by the derived expressions.

Keywords: Cognitive radio, energy detector, periodogram, spectrum sensing.

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209 Modeling “Web of Trust“ with Web 2.0

Authors: Omer Mahmood, Selvakennedy Selvadurai

Abstract:

“Web of Trust" is one of the recognized goals for Web 2.0. It aims to make it possible for the people to take responsibility for what they publish on the web, including organizations, businesses and individual users. These objectives, among others, drive most of the technologies and protocols recently standardized by the governing bodies. One of the great advantages of Web infrastructure is decentralization of publication. The primary motivation behind Web 2.0 is to assist the people to add contents for Collective Intelligence (CI) while providing mechanisms to link content with people for evaluations and accountability of information. Such structure of contents will interconnect users and contents so that users can use contents to find participants and vice versa. This paper proposes conceptual information storage and linking model, based on decentralized information structure, that links contents and people together. The model uses FOAF, Atom, RDF and RDFS and can be used as a blueprint to develop Web 2.0 applications for any e-domain. However, primary target for this paper is online trust evaluation domain. The proposed model targets to assist the individuals to establish “Web of Trust" in online trust domain.

Keywords: Web of Trust, Semantic Web, Electronic SocialNetworks, Information Management

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208 EEG Spikes Detection, Sorting, and Localization

Authors: Mazin Z. Othman, Maan M. Shaker, Mohammed F. Abdullah

Abstract:

This study introduces a new method for detecting, sorting, and localizing spikes from multiunit EEG recordings. The method combines the wavelet transform, which localizes distinctive spike features, with Super-Paramagnetic Clustering (SPC) algorithm, which allows automatic classification of the data without assumptions such as low variance or Gaussian distributions. Moreover, the method is capable of setting amplitude thresholds for spike detection. The method makes use of several real EEG data sets, and accordingly the spikes are detected, clustered and their times were detected.

Keywords: EEG time localizations, EEG spike detection, superparamagnetic algorithm, wavelet transform.

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207 Adaptive Skin Segmentation Using Color Distance Map

Authors: Mohammad Shoyaib, M. Abdullah-Al-Wadud, Oksam Chae

Abstract:

In this paper an effective approach for segmenting human skin regions in images taken at different environment is proposed. The proposed method uses a color distance map that is flexible enough to reliably detect the skin regions even if the illumination conditions of the image vary. Local image conditions is also focused, which help the technique to adaptively detect differently illuminated skin regions of an image. Moreover, usage of local information also helps the skin detection process to get rid of picking up much noisy pixels.

Keywords: Color Distance map, Reference skin color, Regiongrowing, Skin segmentation.

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206 Coherent and Incoherent Scattering Cross Sections for Elements with 13

Authors: Panakkada Latha, K. K. Abdullah, M. P. Unnikrishnan, K. M. Varier, B. R. S. Babu

Abstract:

Coherent and incoherent scattering cross section measurements have been carried out using a HPGe detector on elements in the range of Z = 13 - 50 using 241Am gamma rays. The cross sections have been derived by comparing the net count rate obtained from the Compton peak of aluminium with the corresponding peak of the target. The measured cross sections for the coherent and incoherent processes are compared with theoretical values and earlier reported values. Our results are in agreement with the theoretical values.

Keywords: Cross section, coherent scattering, incoherent scattering, 241Am.

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205 Some Considerations on UML Class Diagram Formalisation Approaches

Authors: Abdullah A. H. Alzahrani, Majd Zohri Yafi, Fawaz K. Alarfaj

Abstract:

Unified Modelling Language (UML) is a software modelling language that is widely used and accepted. One significant drawback, of which, is that the language lacks formality. This makes carrying out any type of rigorous analysis difficult process. Many researchers attempt to introduce their approaches to formalise UML diagrams. However, it is always hard to decide what language and/or approach to use. Therefore, in this paper, we highlight some of the advantages and disadvantages of number of those approaches. We also try to compare different counterpart approaches. In addition, we draw some guidelines to help in choosing the suitable approach. Special concern is given to the formalisation of the static aspects of UML shown is class diagrams.

Keywords: UML formalisation, Object Constraints Language (OCL), Description Logic (DL), Z language.

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204 A New Approach for Network Reconfiguration Problem in Order to Deviation Bus Voltage Minimization with Regard to Probabilistic Load Model and DGs

Authors: Mahmood Reza Shakarami, Reza Sedaghati

Abstract:

Recently, distributed generation technologies have received much attention for the potential energy savings and reliability assurances that might be achieved as a result of their widespread adoption. The distribution feeder reconfiguration (DFR) is one of the most important control schemes in the distribution networks, which can be affected by DGs. This paper presents a new approach to DFR at the distribution networks considering wind turbines. The main objective of the DFR is to minimize the deviation of the bus voltage. Since the DFR is a nonlinear optimization problem, we apply the Adaptive Modified Firefly Optimization (AMFO) approach to solve it. As a result of the conflicting behavior of the single- objective function, a fuzzy based clustering technique is employed to reach the set of optimal solutions called Pareto solutions. The approach is tested on the IEEE 32-bus standard test system.

Keywords: Adaptive Modified Firefly Optimization (AMFO), Pareto solutions, feeder reconfiguration, wind turbines, bus voltage.

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203 A Novel Steganographic Method for Gray-Level Images

Authors: Ahmad T. Al-Taani, Abdullah M. AL-Issa

Abstract:

In this work we propose a novel Steganographic method for hiding information within the spatial domain of the gray scale image. The proposed approach works by dividing the cover into blocks of equal sizes and then embeds the message in the edge of the block depending on the number of ones in left four bits of the pixel. The proposed approach is tested on a database consists of 100 different images. Experimental results, compared with other methods, showed that the proposed approach hide more large information and gave a good visual quality stego-image that can be seen by human eyes.

Keywords: Data Embedding, Cryptography, Watermarking, Steganography, Least Significant Bit, Information Hiding.

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202 Some Physical Properties of Musk Lime (Citrus Microcarpa)

Authors: M.H.R.O. Abdullah, P.E. Ch'ng, N.A. Yunus

Abstract:

Some physical properties of musk lime (Citrus microcarpa) were determined in this study. The average moisture content (wet basis) of the fruit was found to be 85.10 (±0.72) %. The mean of length, width and thickness of the fruit was 26.36 (±0.97), 26.40 (±1.04) and 25.26 (±0.94) mm respectively. The average value for geometric mean diameter, sphericity, aspect ratio, mass, surface area, volume, true density, bulk density and porosity was 26.00 (±0.82) mm, 98.67 (±2.04) %, 100.23 (±3.28) %, 10.007 (±0.878) g, 2125.07 (±133.93) mm2, 8800.00 (±731.82) mm3, 1002.87 (±39.16) kgm-3, 501.70 (±22.58) kgm-3 and 49.89 (±3.15) % respectively. The coefficient of static friction on four types of structural surface was found to be varying from 0.238 (±0.025) for glass to 0.247 (±0.024) for steel surface.

Keywords: Musk lime, Citrus microcarpa, physical properties.

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201 Digital Social Networks: Examining the Knowledge Characteristics

Authors: Nurul Aini M. Nordan, Ahmad I. Z. Abidin, Ahmad K. Mahmood, Noreen I. Arshad

Abstract:

In today-s information age, numbers of organizations are still arguing on capitalizing the values of Information Technology (IT) and Knowledge Management (KM) to which individuals can benefit from and effective communication among the individuals can be established. IT exists in enabling positive improvement for communication among knowledge workers (k-workers) with a number of social network technology domains at workplace. The acceptance of digital discourse in sharing of knowledge and facilitating the knowledge and information flows at most of the organizations indeed impose the culture of knowledge sharing in Digital Social Networks (DSN). Therefore, this study examines whether the k-workers with IT background would confer an effect on the three knowledge characteristics -- conceptual, contextual, and operational. Derived from these three knowledge characteristics, five potential factors will be examined on the effects of knowledge exchange via e-mail domain as the chosen query. It is expected, that the results could provide such a parameter in exploring how DSN contributes in supporting the k-workers- virtues, performance and qualities as well as revealing the mutual point between IT and KM.

Keywords: Digital social networks, e-mail, knowledge management, knowledge worker.

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200 Using Axiomatic Design for Developing a Framework of Manufacturing Cloud Service Composition in the Equilibrium State

Authors: Ehsan Vaziri Goodarzi, Mahmood Houshmand, Omid Fatahi Valilai, Vahidreza Ghezavati, Shahrooz Bamdad

Abstract:

One important paradigm of industry 4.0 is Cloud Manufacturing (CM). In CM everything is considered as a service, therefore, the CM platform should consider all service provider's capabilities and tries to integrate services in an equilibrium state. This research develops a framework for implementing manufacturing cloud service composition in the equilibrium state. The developed framework using well-known tools called axiomatic design (AD) and game theory. The research has investigated the factors for forming equilibrium for measures of the manufacturing cloud service composition. Functional requirements (FRs) represent the measures of manufacturing cloud service composition in the equilibrium state. These FRs satisfied by related Design Parameters (DPs). The FRs and DPs are defined by considering the game theory, QoS, consumer needs, parallel and cooperative services. Ultimately, four FRs and DPs represent the framework. To insure the validity of the framework, the authors have used the first AD’s independent axiom.

Keywords: Axiomatic design, manufacturing cloud service composition, cloud manufacturing, Industry 4.0.

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199 Simple and Advanced Models for Calculating Single-Phase Diode Rectifier Line-Side Harmonics

Authors: Hussein A. Kazem, Abdulhakeem Abdullah Albaloshi, Ali Said Ali Al-Jabri, Khamis Humaid AlSaidi

Abstract:

This paper proposes different methods for estimation of the harmonic currents of the single-phase diode bridge rectifier. Both simple and advanced methods are compared and the models are put into a context of practical use for calculating the harmonic distortion in a typical application. Finally, the different models are compared to measurements of a real application and convincing results are achieved.

Keywords: Single-phase rectifier, line side Harmonics

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198 Forecasting the Istanbul Stock Exchange National 100 Index Using an Artificial Neural Network

Authors: Birol Yildiz, Abdullah Yalama, Metin Coskun

Abstract:

Many studies have shown that Artificial Neural Networks (ANN) have been widely used for forecasting financial markets, because of many financial and economic variables are nonlinear, and an ANN can model flexible linear or non-linear relationship among variables. The purpose of the study was to employ an ANN models to predict the direction of the Istanbul Stock Exchange National 100 Indices (ISE National-100). As a result of this study, the model forecast the direction of the ISE National-100 to an accuracy of 74, 51%.

Keywords: Artificial Neural Networks, Istanbul StockExchange, Non-linear Modeling.

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197 Cooperative Movements in Malaysia: The Issue of Governance

Authors: Intan Waheedah Othman, Maslinawati Mohamad, Azizah Abdullah

Abstract:

Cooperative organizations in Malaysia are going through a phase of rapid growth. They are seen by the government as another crucial vehicle to drive and boost up the country-s economical development and growth. Hence, the issue of cooperative governance is of great importance. Unlike literatures on corporate governance for public listed companies-, literatures on governance for social enterprises, in particular the cooperative organizations are still at the early stage in Malaysia and very scant in number. This paper will look into current practices as well as issues and challenges related to cooperative governance. The need for a better solution towards forming best practices of cooperative governance framework appears imperative in deterring cases of mismanagement and fraud.

Keywords: Cooperative, Governance, Issues, Malaysia.

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196 Metoprolol Tartrate-Ethylcellulose Tabletted Microparticles: Development of a Validated Invitro In-vivo Correlation

Authors: Fatima Rasool, Mahmood Ahmad, Ghulam Murtaza, Haji M. S. Khan, Shujaat A. Khan, Sonia Khiljee, Muhammad Qamar-Uz-Zaman

Abstract:

This study describes the methodology for the development of a validated in-vitro in-vivo correlation (IVIVC) for metoprolol tartrate modified release dosage forms with distinctive release rate characteristics. Modified release dosage forms were formulated by microencapsulation of metoprolol tartrate into different amounts of ethylcellulose by non-solvent addition technique. Then in-vitro and in-vivo studies were conducted to develop and validate level A IVIVC for metoprolol tartrate. The values of regression co-efficient (R2-values) for IVIVC of T2 and T3 formulations were not significantly (p<0.05) different from 1 while the values of R2 for IVIVC of T1 and Mepressor® were significantly (p<0.05) different from 1. Internal prediction errors of IVIVC, calculated from observed Area under Curve (AUC) and predicted AUC, were less than 10%. This study successfully presents a valid level A IVIVC for metoprolol tartrate modified dosage forms.

Keywords: Metoprolol tartrate, Dissolution, Bioavailability, Validated in-vitro in-vivo correlation.

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195 Effect of Band Contact on the Temperature Distribution for Dry Friction Clutch

Authors: Oday I. Abdullah, J. Schlattmann

Abstract:

In this study, the two dimensional heat conduction problem for the dry friction clutch disc is modeled mathematically analysis and is solved numerically using finite element method, to determine the temperature field when band contacts occurs between the rubbing surfaces during the operation of an automotive clutch. Temperature calculation have been made for contact area of different band width and the results obtained compared with these attained when complete contact occurs. Furthermore, the effects of slipping time and sliding velocity function are investigated as well. Both single and repeated engagements made at regular interval are considered.

Keywords: Band contact, dry friction clutch, frictional heating, temperature field, 2D FEM.

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194 Comparative Study of Universities’ Web Structure Mining

Authors: Z. Abdullah, A. R. Hamdan

Abstract:

This paper is meant to analyze the ranking of University of Malaysia Terengganu, UMT’s website in the World Wide Web. There are only few researches have been done on comparing the ranking of universities’ websites so this research will be able to determine whether the existing UMT’s website is serving its purpose which is to introduce UMT to the world. The ranking is based on hub and authority values which are accordance to the structure of the website. These values are computed using two websearching algorithms, HITS and SALSA. Three other universities’ websites are used as the benchmarks which are UM, Harvard and Stanford. The result is clearly showing that more work has to be done on the existing UMT’s website where important pages according to the benchmarks, do not exist in UMT’s pages. The ranking of UMT’s website will act as a guideline for the web-developer to develop a more efficient website.

Keywords: Algorithm, ranking, website, web structure mining.

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193 Detached-Eddy Simulation of Vortex Generator Jet Using Chimera Grids

Authors: Saqib Mahmood, Rolf Radespiel

Abstract:

This paper aims at numerically analysing the effect of an active flow control (AFC) by a vortex generator jet (VGJ) submerged in a boundary layer via Chimera Grids and Detached- Eddy Simulation (DES). The performance of DES results are judged against Reynolds-Averaged Navier-Stokes (RANS) and compared with the experiments that showed an unsteady vortex motion downstream of VGJ. Experimental results showed that the mechanism of embedding logitudinal vortex structure in the main stream flow is quite effective in increasing the near wall momentum of separated aircraft wing. In order to simulate such a flow configuration together with the VGJ, an efficient numerical approach is required. This requirement is fulfilled by performing the DES simulation over the flat plate using the DLR TAU Code. The DES predictions identify the vortex region via smooth hybrid length scale and predict the unsteady vortex motion observed in the experiments. The DES results also showed that the sufficient grid refinement in the vortex region resolves the turbulent scales downstream of the VGJ, the spatial vortex core postion and nondimensional momentum coefficient RVx .

Keywords: VGJ, Chimera Grid, DES, RANS.

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192 An Optimal Algorithm for HTML Page Building Process

Authors: Maryam Jasim Abdullah, Bassim. H. Graimed, Jalal. S. Hameed

Abstract:

Demand over web services is in growing with increases number of Web users. Web service is applied by Web application. Web application size is affected by its user-s requirements and interests. Differential in requirements and interests lead to growing of Web application size. The efficient way to save store spaces for more data and information is achieved by implementing algorithms to compress the contents of Web application documents. This paper introduces an algorithm to reduce Web application size based on reduction of the contents of HTML files. It removes unimportant contents regardless of the HTML file size. The removing is not ignored any character that is predicted in the HTML building process.

Keywords: HTML code, HTML tag, WEB applications, Document compression, DOM tree.

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191 Application of an in vitro Alveolus Model in Evaluating the Alveolar Response to Pressure- Induced Injury

Authors: Divya D. Nalayanda, William B. Fulton, Tza-Huei Wang, Fizan Abdullah

Abstract:

In an effort to understand the preliminary effects of aerodynamic stress on alveolar epithelial cells, we developed a multifluidic cell culture platform capable of supporting alveolar cultures at an air-liquid interface under constant air flow and exposure to varying pressure stimuli on the apical side while providing nourishment on the basolateral plane. Our current study involved utilizing the platform to study the effect of basement membrane coating and addition of dexamethasone on cellular response to pressure in A549 and H441 alveolar epithelial cells.

Keywords: Aerodynamic stress, Air-liquid interface, Alveolar, Dexamethasone.

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