Search results for: Rahmani sheep

Authors: A. R. Rahmani, H. R. Ghaffari, M. T. Samadi

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The present work was conducted for Arsenic (III) removal, which one of the most poisonous groundwater pollutants, by synthetic nano size zerovalent iron (nZVI). Batch experiments were performed to investigate the influence of As (III), nZVI concentration, pH of solution and contact time on the efficiency of As (III) removal. nZVI was synthesized by reduction of ferric chloride by sodium borohydrid. SEM and XRD were used to determine particle size and characterization of produced nanoparticles. Up to 99.9% removal efficiency for arsenic (III) was obtained by nZVI dosage of 1 g/L at time equal to 10 min. and pH=7. It could be concluded that the removal efficiency were enhanced with increasing of ZVI dosage and reaction time, but decreased with increasing of arsenic concentration and pH for nano sized ZVI. nZVI presented an outstanding ability to remove As (III) due to not only a high surface area and low particle size but also to high inherent activity.

Keywords: Arsenic removal, aqueous solution, zero valent iron.

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Authors: S. Dehghan, A.M. Rahmani

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The group mutual exclusion (GME) problem is an interesting generalization of the mutual exclusion problem. In the group mutual exclusion, multiple processes can enter a critical section simultaneously if they belong to the same group. In the extended group mutual exclusion, each process is a member of multiple groups at the same time. As a result, after the process by selecting a group enter critical section, other processes can select the same group with its belonging group and can enter critical section at the moment, so that it avoids their unnecessary blocking. This paper presents a quorum-based distributed algorithm for the extended group mutual exclusion problem. The message complexity of our algorithm is O(4Q ) in the best case and O(5Q) in the worst case, where Q is a quorum size.

Keywords: Group Mutual Exclusion (GME), Extended GME, Distributed systems.

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Authors: Simon Brown, Noorzaid Muhamad, David C Simcock

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The kinetic properties of enzymes are often reported using the apparent KM and Vmax appropriate to the standard Michaelis-Menten enzyme. However, this model is inappropriate to enzymes that have more than one substrate or where the rate expression does not apply for other reasons. Consequently, it is desirable to have a means of estimating the appropriate kinetic parameters from the apparent values of KM and Vmax reported for each substrate. We provide a means of estimating the range within which the parameters should lie and apply the method to data for glutamate dehydrogenase from the nematode parasite of sheep Teladorsagia circumcincta.

Keywords: enzyme kinetics, glutamate dehydrogenase, intervalanalysis, parameter estimation.

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Authors: A. E. O. Malau-Aduli, B. W. B. Holman, P. A. Lane

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Our objectives were to evaluate the effects of sire breed, type of protein supplement, level of supplementation and sex on wool spinning fineness (SF), its correlations with other wool characteristics and prediction accuracy in F1 Merino crossbred lambs. Texel, Coopworth, White Suffolk, East Friesian and Dorset rams were mated with 500 purebred Merino dams at a ratio of 1:100 in separate paddocks within a single management system. The F1 progeny were raised on ryegrass pasture until weaning, before forty lambs were randomly allocated to treatments in a 5 x 2 x 2 x 2 factorial experimental design representing 5 sire breeds, 2 supplementary feeds (canola or lupins), 2 levels of supplementation (1% or 2% of liveweight) and sex (wethers or ewes). Lambs were supplemented for six weeks after an initial three weeks of adjustment, wool sampled at the commencement and conclusion of the feeding trial and analyzed for SF, mean fibre diameter (FD), coefficient of variation (CV), standard deviation, comfort factor (CF), fibre curvature (CURV), and clean fleece yield. Data were analyzed using mixed linear model procedures with sire fitted as a random effect, and sire breed, sex, supplementary feed type, level of supplementation and their second-order interactions as fixed effects. Sire breed (P<0.001), sex (P<0.004), sire breed x level of supplementation (P<0.004), and sire breed x sex (P<0.019) interactions significantly influenced SF. SF ranged from 22.7 ± 0.2μm in White Suffolk-sired lambs to 25.1 ± 0.2μm in East Friesian crossbred lambs. Ewes had higher SF than wethers. There were significant (P<0.001) correlations between SF and FD (0.93), CV (0.40), CF (-0.94) and CURV (-0.12). Its strong relationship with other wool quality traits enabled accurate predictions explaining up to about 93% of the observed variation. The interactions between sire breed genetics and nutrition will have an impact on the choices that dual-purpose sheep producers make when selecting sire breeds and protein supplementary feed levels to achieve optimal wool spinning fineness at the farmgate level. This will facilitate selective breeding programs being able to better account for SF and its interactions with other wool characteristics.

Keywords: Merino crossbred sheep, protein supplementation, sire breed, wool quality, wool spinning fineness

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Authors: Saeed Rahmani Bagha, Mohammad Mirzahosseinian, Sonatkhatoon Kashanimotlagh

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Nowadays, under developed countries for progress in science and technology and decreasing the technologic gap with developed countries, increasing the capacities and technology transfer from developed countries. To remain competitive, industry is continually searching for new methods to evolve their products. Business model is one of the latest buzzwords in the Internet and electronic business world. To be successful, organizations must look into the needs and wants of their customers. This research attempts to identify a specific feature of the company with a strong competitive advantage by analyzing the cause of Customer satisfaction. Due to the rapid development of knowledge and information technology, business environments have become much more complicated. Information technology can help a firm aiming to gain a competitive advantage. This study explores the role and effect of Information Communication Technology in Business Models and Customer satisfaction on firms and also relationships between ICTs and Outsourcing strategic.

Keywords: Information Communication Technology, Outsourcing, Customer Satisfaction, Business Plan

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Authors: A. G. Silva Sobrinho, G. M. Manzi, N. L. L. Lima, F. A. Almeida, V. Endo, N. M. B. L. Zeola

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The purpose of this study was to evaluate the tissue composition and carcass muscularity of 32 legs of Ile de France lambs fed with diets containing sunflower seeds and vitamin E, with mean body weight of 15 kg, lodged in individual pens at 15 kg and slaughtered at 32 kg of body weight. The treatments influenced (P<0,05) leg weight, femur length and muscle:bone ratio, being the highest values (2,13 kg, 16,19 cm and 7,38, respectively) in lambs that received diet without sunflower seeds and vitamin E. The other variables were not affected (P>0,05) by the treatments. The interaction of the sunflower and vitamin E was positive for bone total weights and intermuscular fat.

Keywords: sheep, conformation, feedlot, nutrition, sugar-cane

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Authors: A.R. Rahmani, M.T. Samadi, R. Noroozi

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The present work was conducted for the synthesis of nano size zerovalent iron (nZVI) and hexavalent chromium (Cr(VI)) removal as a highly toxic pollutant by using this nanoparticles. Batch experiments were performed to investigate the effects of Cr(VI), nZVI concentration, pH of solution and contact time variation on the removal efficiency of Cr(VI). nZVI was synthesized by reduction of ferric chloride using sodium borohydrid. SEM and XRD examinations applied for determination of particle size and characterization of produced nanoparticles. The results showed that the removal efficiency decreased with Cr(VI) concentration and pH of solution and increased with adsorbent dosage and contact time. The Langmuir and Freundlich isotherm models were used for the adsorption equilibrium data and the Langmuir isotherm model was well fitted. Nanoparticle ZVI presented an outstanding ability to remove Cr(VI) due to high surface area, low particle size and high inherent activity.

Keywords: Adsorption, aqueous solution, Chromium, nZVI, removal.

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Authors: O. Miraliyari, M.M. Najafizadeh, A.R. Rahmani, A. Momeni Hezaveh

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This paper presents the buckling analysis of short and long functionally graded cylindrical shells under thermal and mechanical loads. The shell properties are assumed to vary continuously from the inner surface to the outer surface of the shell. The equilibrium and stability equations are derived using the total potential energy equations, Euler equations and first order shear deformation theory assumptions. The resulting equations are solved for simply supported boundary conditions. The critical temperature and pressure loads are calculated for both short and long cylindrical shells. Comparison studies show the effects of functionally graded index, loading type and shell geometry on critical buckling loads of short and long functionally graded cylindrical shells.

Keywords: Buckling, Functionally graded materials, Short and long cylindrical shell, Thermal and mechanical loads.

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Authors: Ali Reza Rahmani, Mohamad Taghi Samadi, Maryam Khodadadi

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A laboratory set-up was designed to survey the effectiveness of UV/O3 advanced oxidation process (AOP) for the removal of Carbaryl from polluted water in batch reactor. The study was carried out by UV/O3 process for water samples containing 1 to 20 mg/L of Carbaryl in distilled water. Also the range of drinking water resources adjusted in synthetic water and effects of contact time, pH and Carbaryl concentration were studied. The residual pesticide concentration was determined by applying high performance liquid chromatography (HPLC). The results indicated that increasing of retention time and pH, enhances pesticide removal efficiency. The removal efficiency has been affected by pesticide initial concentration. Samples with low pesticide concentration showed a remarkable removal efficiency compared to the samples with high pesticide concentration. AOP method showed the removal efficiencies of 80% to 100%. Although process showed high performance for removal of pesticide from water samples, this process has different disadvantages including complication, intolerability, difficulty of maintenance and equipmental and structural requirements.

Keywords: AOP, Carbaryl, Pesticides, Water treatment.

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Authors: Hamed Rahmani, Wim Groot

Abstract:

The term "youth not in employment, education or training (NEET)" refers to a combination of youth unemployment and school dropout. This study investigates the variables that increase the risk of becoming NEET in Iran. A selection bias-adjusted Probit model was employed using machine learning to identify these risk factors. We used cross-sectional data obtained from the Statistical Center of Iran and the Ministry of Cooperatives Labor and Social Welfare that are taken from the labor force survey conducted in the spring of 2021. We look at years of education, work experience, housework, the number of children under the age of 6 years in the home, family education, birthplace, and the amount of land owned by households. Results show that hours spent performing domestic chores enhance the likelihood of youth becoming NEET, and years of education, years of potential work experience decrease the chance of being NEET. The findings also show that female youth born in cities were less likely than those born in rural regions to become NEET.

Keywords: NEET youth, probit, CART, machine learning, unemployment.

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Authors: J. Zach, J. Hroudova, J. Brozovsky

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Thermal insulation materials based on natural fibers represent a very promising area of materials based on natural easy renewable row sources. These materials may be in terms of the properties of most competing synthetic insulations, but show somewhat higher moisture sensitivity and thermal insulation properties are strongly influenced by the density and orientation of fibers. The paper described the problem of hygrothermal behavior of thermal insulation materials based on natural plant and animal fibers. This is especially the dependence of the thermal properties of these materials on the type of fiber, bulk density, temperature, moisture and the fiber orientation.

Keywords: Thermal insulating materials, hemp fibers, sheep wool fibers, thermal conductivity, moisture.

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Authors: H. Rezzouk, M. Hatti, H. Rahmani, S. Atoui

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This paper discusses the design and analysis of a hybrid PV-Fuel cell energy system destined to power a DC load. The system is composed of a photovoltaic array, a fuel cell, an electrolyzer and a hydrogen tank. HOMER software is used in this study to calculate the optimum capacities of the power system components that their combination allows an efficient use of solar resource to cover the hourly load needs. The optimal system sizing allows establishing the right balance between the daily electrical energy produced by the power system and the daily electrical energy consumed by the DC load using a 28 KW PV array, a 7.5 KW fuel cell, a 40KW electrolyzer and a 270 Kg hydrogen tank. The variation of powers involved into the DC bus of the hybrid PV-fuel cell system has been computed and analyzed for each hour over one year: the output powers of the PV array and the fuel cell, the input power of the elctrolyzer system and the DC primary load. Equally, the annual variation of stored hydrogen produced by the electrolyzer has been assessed. The PV array contributes in the power system with 82% whereas the fuel cell produces 18%. 38% of the total energy consumption belongs to the DC primary load while the rest goes to the electrolyzer.

Keywords: Electrolyzer, Hydrogen, Hydrogen Fueled Cell, Photovoltaic.

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Authors: S. A. Naeini, H. R. Rahmani, M. Hossein Zade

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Many classical bearing capacity theories assume that the natural soil's layers are homogenous for determining the bearing capacity of the soil. But, in many practical projects, we encounter multi-layer soils. Geosynthetic as reinforcement materials have been extensively used in the construction of various structures. In this paper, numerical analysis of the Plate Load Test (PLT) using of ABAQUS software in double-layered soils with different thicknesses of sandy and gravelly layers reinforced with geogrid was considered. The PLT is one of the common filed methods to calculate parameters such as soil bearing capacity, the evaluation of the compressibility and the determination of the Subgrade Reaction module. In fact, the influence of the geogrid layers on the bearing capacity of the layered soils is investigated. Finally, the most appropriate mode for the distance and number of reinforcement layers is determined. Results show that using three layers of geogrid with a distance of 0.3 times the width of the loading plate has the highest efficiency in bearing capacity of double-layer (sand and gravel) soils. Also, the significant increase in bearing capacity between unreinforced and reinforced soil with three layers of geogrid is caused by the condition that the upper layer (gravel) thickness is equal to the loading plate width.

Keywords: Bearing capacity, reinforcement, geogrid, plate load test, layered soils.

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Authors: A. G. Silva Sobrinho, L. G. A. Cirne, V. T. Santana

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The aim of this trial was to evaluate fatty acid profile of meat from lambs fed on diets containing 0, 12.5 and 25.0% mulberry hay as a substitute for the concentrate. Twenty-four feedlot Ile de France lambs (average weight of 15kg and average age of 60 days) were randomized to receive the different diets and slaughtered at 32kg body weight. Increases were observed in the concentrations of the saturated pentadecanoic, heptadecanoic and arachidic fatty acids; of the monounsaturated nervonic fatty acid and of the polyunsaturated α-linolenic, ɣ-linolenic and eicosapentaenoic fatty acids. Increased conjugated linoleic acid (CLA) was also found in the meat of lambs fed on 12.5% mulberry hay. In addition, the omega-3 composition was augmented, while the omega-3/omega-6 ratio was decreased in mulberry hay-fed animals. In conclusion, a more desirable fatty acid profile was observed in lamb meat following the substitution of mulberry hay in the concentrate of fed, resulting in improved nutritional characteristics of the meat.

Keywords: Alternative food, fatty acids, feedlot, sheep meat.

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Authors: M. E. Silva, I. Brás

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The aim of this work was to study the viability of recycling the residual yeast and diatomaceous earth (RYDE) slurry generated by the beer brewing industry by composting with animal manures, as well as to evaluate the quality of the composts obtained. Two pilot composting trials were carried out with different mixes: cow manure/RYDE slurry (Pile CM) and sheep manure/RYDE slurry (Pile SM). For all piles, wood chips were applied as bulking agent. The process was monitored by evaluating standard physical and chemical parameters. The compost quality was assessed by the heavy metals content and phytotoxicity. Both piles reached a thermophilic phase in the first day, however having different trends. The pH showed a slight alkaline character. The C/N reached values lower than 19 at the end of composting process. Generally, all the piles exhibited absence of heavy metals. However, the pile SM exhibited phytotoxicity. This study showed that RYDE slurry can be valorized by composting with cow manure.

Keywords: Beer brewing wastes, compost; quality, valorization.

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Authors: Ali Rahmani, Abbas Maleki, Mohammad Mirzaeiheydari, Rahim Naseri

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Most parts of the world such as Iran are facing the excessive consumption of fertilizers, that are used to achieve high yield, but increase the cost of production of fertilizer and degradation of soil and water resources. This experiment was carried out to study the effect of PGPR and planting pattern on yield and yield components of rice (Oryza sativa L.) using split plot based on randomized complete block design with three replications in Ilam province, Iran. Bio-fertilizer including Azotobacter, Nitroxin and control treatment (without consumption) were designed as a main plot and planting pattern including 15 × 10, 15 × 15 and 15 × 20 and the number of plant in hill including 3, 4 and 5 plants in hill were considered as a sub-plots. The results showed that the effect of bio-fertilizers, planting pattern and the number of plants in hill were significant affect on yield and yield components. Interaction effect between bio-fertilizer and planting pattern had important difference on the number spikelet of panicle and harvest index. Interaction effect between bio-fertilizer and the number of plants in hill were significant affect on the number of spikelet per panicle. The maximum grain yield was obtained by inoculation with Nitroxin, planting pattern of 15 × 15 and 4 plants in hill with mean of 1110.6 g.m^-2, 959.9 g.m^-2 and 928.4 g.m^-2, respectively.

Keywords: Bio-fertilizer, Grain yield, Planting pattern, Rice.

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Authors: M. Omer Faruk, A. M. A. M. Zonaed Siddiki, M. Fazal Karim, Md. Masuduzzaman, S. Chowdhury, Md. Shafiqul Islam, M. Alamgir Hossain

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The dog tapeworms Echinococcus granulosus develop hydatid cysts in various organs in human and domestic animals worldwide including Bangladesh. The aim of this study was to identify and characterize the genotype of E. granulosus isolated from cattle using 12S rRNA and Cytochrome oxidase 1 (COX 1) genes. A total of 43 hydatid cyst samples were collected from 390 examined cattle samples derived from slaughterhouses. Among them, three cysts were fertile. Genomic DNA was extracted from germinal membrane and/or protoscoleces followed by PCR amplification of mitochondrial 12S rRNA and Cytochrome oxidase 1 gene fragments. The sequence data revealed existence of G1 (64.28%) and possible G3 (21.43%) genotypes for the first time in Bangladesh. The study indicates that common sheep strain G1 is the dominant subtype of E. granulosus in Chittagong region of Bangladesh. This will increase our understanding of the epidemiology of hydatidosis in the southern part of the country and will be useful to plan suitable control measures in the long run.

Keywords: Echinococcus granulosus, molecular characterization, cattle, Bangladesh.

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Authors: Omaymah AlAzhari

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Nomadic tribes have always had the need to relocate and build shelters, moving from one site to another in search of food, water, and natural resources. They are affected by weather and seasonal changes and consequently started innovating textiles to build better shelters. Their solutions came from the observation of their natural environment, material, and surroundings. ‘AlRahala’ Nomadic Bedouin tribes from the Middle East and North African region have used textiles as a fundamental architectural element in their tent structure, ‘Bayt AlShar’ (House of Hair). The nomadic tribe has innovated their textile to create a fabric that is more suited to change in climatic and weather conditions. They used sheep, goat, or camel hair to weave the textiles to make their shelters. The research is based on existing literature on the weaving technicalities used by these tribes, based on their available materials encountered during travel. To conclude how they create the traditional textiles and use in the tents are a rich source of information for designers to create innovative solutions of modern-day textiles and environmentally responsive products.

Keywords: AlRahala Nomadic Tribes, Bayt AlShar, tent structure, textile innovation.

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Authors: L. Moussaoui, L. Rahmani

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This paper deals with the direct torque control (DTC) of the induction motor. This type of control allows decoupling control between the flux and the torque without the need for a transformation of coordinates. However, as with other hysteresis-based systems, the classical DTC scheme represents a high ripple, in both the electromagnetic torque and the stator flux and a distortion in the stator current. As well, it suffers from variable switching frequency. To solve these problems various modifications, in conventional DTC scheme, have been made during the last decade. Indeed the DTC based on space vector modulation (SVM) has proved to generate very low ripples in torque and flux with constant switching frequency. It also shows almost the same dynamic performances as the classical DTC system. On the other hand, fuzzy logic is considered as an interesting alternative approach for its advantages: Analysis close to the exigencies of user, ability of nonlinear systems control, best dynamic performances and inherent quality of robustness.

Therefore, two fuzzy direct torque control approaches, for the induction motor fed by SVM-voltage source inverter, are proposed in this paper. By using these two approaches of DTC, the advantages of fuzzy logic control, space vector modulation, and direct torque control method are combined. The performances of these DTC schemes are evaluated through digital simulation using Matlab/Simulink platform and fuzzy logic tools. Simulation results illustrate the effectiveness and the superiority of the proposed Fuzzy DTC-SVM schemes in comparison to the classical DTC.

Keywords: Direct torque control, Fuzzy logic control, Induction motor, Switching frequency, Space vector modulation, Torque and flux ripples.

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Authors: H. Rasouli Pirouzian, J. Hesari, S. Farajnia, M. Moghaddam, S. Ghiassifar, M. Manafi

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Lighvan cheese is basically made from sheep milk in the area of Sahand mountainside which is located in the North West of Iran. The main objective of this study was to investigate the effect of enterococci isolated from traditional Lighvan cheese on the quality of Iranian UF white during ripening. The experimental design was split plot based on randomized complete blocks, main plots were four types of starters and subplots were different ripening durations. Addition of Enterococcus spp. did not significantly (P<0.01) affect the pH and gross composition of cheeses. In the cheeses produced with Ent. faecalis and Ent. faecium strains, lipolysis rates were higher and flavor were improved. Moreover, proteolysis assay by measuring percentage of soluble nitrogen at pH 4.6 and urea polyacrylamide gel electrophoresis indicated the increase in proteolysis rate in the cheese containing Ent. faecalis and Ent. faecium strains compared to the control cheeses. Furthermore, the highest percentage of non- protein nitrogen was observed in the cheese containing Ent. faecium. In conclusion, the results showed the positive effect of the Ent. faecalis and Ent. faecium on secondary proteolysis, lipolysis and sensorial characteristics development of UF white cheeses.

Keywords: Enterococcus faecalis, Enterococcus faecium, Lighvan cheese, Lipolysis, Proteolysis, UF cheese

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Authors: Naser Valipour Motlagh, Majid Aliabadi, Elnaz Rahmani, Samira Ghorbanpour

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Strawberry is one of the most favored fruits all along the world. But due to its vulnerability to microbial contamination and short life storage, there are lots of problems in industrial production and transportation of this fruit. Therefore, lots of ideas have tried to increase the storage life of strawberries especially through proper packaging. This paper works on efficient packaging as well. The primary material used is produced through simple mixing of low-density polyethylene (LDPE) and silver nanoparticles in different weight fractions of 0.5 and 1% in presence of dicumyl peroxide as a cross-linking agent. Final packages were made in a twin-screw extruder. Then, their effect on the quality maintenance of strawberry is evaluated. The SEM images of nano-silver packages show the distribution of silver nanoparticles in the packages. Total bacteria count, mold, yeast and E. coli are measured for microbial evaluation of all samples. Texture, color, appearance, odor, taste and total acceptance of various samples are evaluated by trained panelists and based on 9-point hedonic scale method. The results show a decrease in total bacteria count and mold in nano-silver packages compared to the samples packed in polyethylene packages for the same storage time. The optimum concentration of silver nanoparticles for the lowest bacteria count and mold is predicted to be around 0.5% which has attained the most acceptance from the panelist as well. Moreover, organoleptic properties of strawberry are preserved for a longer period in nano-silver packages. It can be concluded that using nano-silver particles in strawberry packages has improved the storage life and quality maintenance of the fruit.

Keywords: Antimicrobial properties, polyethylene, silver nanoparticles, strawberry.

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Authors: Diah Tri Widayati

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Various assisted reproductive techniques have been developed and refined to obtain a large number of offspring from genetically superior animals or obtain offspring from infertile (or subfertile) animals. The embryo transfer is one assisted reproductive technique developed well, aimed at increased productivity of selected females, disease control, importation and exportation of livestock, rapid screening of AI sires for genetically recessive characteristics, treatment or circumvention of certain types of infertility. Embryo transfer also is a useful research tool for evaluating fetal and maternal interactions. This technique has been applied to nearly every species of domestic animal and many species of wildlife and exotic animals, including humans and non-human primates. The successful of embryo transfers have been limited to within-animal, homologous replacement of the embryos. There are several examples of interspecific and intergeneric embryo transfers in which embryos implanted but did not develop to term: sheep and goat, mouse and rat. An immunological rejections and placental incompatibility between the embryo and the surrogate mother appear to restrict interspecific embryo transfer/interspecific pregnancy. Recently, preimplantation embryo manipulation procedures have been applied, such as technique of inner cell mass transfer. This technique will possible to overcome the reproductive barrier interspecific embryo transfer/interspecific pregnancy, if there is a protective mechanism which prevents recognition of the foreign fetus by the mother of the other species

Keywords: Embryo Transfer, Assisted Reproductive Techology, Intraspesific-Interspesific Pregnancy, Inner cell mass.

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Authors: Pramod Jagtap, Kisan Jadhav, Neha Dand

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Risperidone (RISP) is an antipsychotic agent and has low water solubility and nontargeted delivery results in numerous side effects. Hence, an attempt was made to develop SLNs hydrogel for intranasal delivery of RISP to achieve maximum bioavailability and reduction of side effects. RISP loaded SLNs composed of 1.65% (w/v) lipid mass were produced by high shear homogenization (HSH) coupled ultrasound (US) method using glycerylmonostearate (GMS) or Imwitor 900K (solid lipid). The particles were loaded with 0.2% (w/v) of the RISP & surface-tailored with a 2.02% (w/v) non-ionic surfactant Tween® 80. Optimization was done using 32 factorial design using Design Expert® software. The prepared SLNs dispersion incorporated into Polycarbophil AA1 hydrogel (0.5% w/v). The final gel formulation was evaluated for entrapment efficiency, particle size, rheological properties, X ray diffraction, in vitro diffusion, ex vivo permeation using sheep nasal mucosa and histopathological studies for nasocilliary toxicity. The entrapment efficiency of optimized SLNs was found to be 76 ± 2%, polydispersity index <0.3., particle size 278 ± 5 nm. This optimized batch was incorporated into hydrogel. The pH was found to be 6.4 ± 0.14. The rheological behaviour of hydrogel formulation revealed no thixotropic behaviour. In histopathology study, there was no nasocilliary toxicity observed in nasal mucosa after ex vivo permeation. X-ray diffraction data shows drug was in amorphous form. Ex vivo permeation study shows controlled release profile of drug.

Keywords: Ex vivo, particle size, risperidone, solid lipid nanoparticles.

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