@article{(Open Science Index):https://publications.waset.org/pdf/10000441,
	  title     = {Formulation and ex vivo Evaluation of Solid Lipid Nanoparticles (SLNS) Based Hydrogel for Intranasal Drug Delivery},
	  author    = {Pramod Jagtap and  Kisan Jadhav and  Neha Dand},
	  country	= {},
	  institution	= {},
	  abstract     = {Risperidone (RISP) is an antipsychotic agent and has
low water solubility and nontargeted delivery results in numerous
side effects. Hence, an attempt was made to develop SLNs hydrogel
for intranasal delivery of RISP to achieve maximum bioavailability
and reduction of side effects. RISP loaded SLNs composed of 1.65%
(w/v) lipid mass were produced by high shear homogenization (HSH)
coupled ultrasound (US) method using glycerylmonostearate (GMS)
or Imwitor 900K (solid lipid). The particles were loaded with 0.2%
(w/v) of the RISP & surface-tailored with a 2.02% (w/v) non-ionic
surfactant Tween® 80. Optimization was done using 32 factorial
design using Design Expert® software. The prepared SLNs
dispersion incorporated into Polycarbophil AA1 hydrogel (0.5%
w/v). The final gel formulation was evaluated for entrapment
efficiency, particle size, rheological properties, X ray diffraction, in
vitro diffusion, ex vivo permeation using sheep nasal mucosa and
histopathological studies for nasocilliary toxicity. The entrapment
efficiency of optimized SLNs was found to be 76 ± 2%,
polydispersity index <0.3., particle size 278 ± 5 nm. This optimized
batch was incorporated into hydrogel. The pH was found to be 6.4 ±
0.14. The rheological behaviour of hydrogel formulation revealed no
thixotropic behaviour. In histopathology study, there was no
nasocilliary toxicity observed in nasal mucosa after ex vivo
permeation. X-ray diffraction data shows drug was in amorphous
form. Ex vivo permeation study shows controlled release profile of
drug.
},
	    journal   = {International Journal of Bioengineering and Life Sciences},
	  volume    = {9},
	  number    = {1},
	  year      = {2015},
	  pages     = {43 - 53},
	  ee        = {https://publications.waset.org/pdf/10000441},
	  url   	= {https://publications.waset.org/vol/97},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 97, 2015},
	}