Search results for: binding site
169 Experimental Investigation to Find Transition Temperature of VG-30 Binder
Authors: D. Latha, V. Sunitha, Samson Mathew
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In India, most of the pavement is laid by bituminous road and the consumption of binder is high for pavement construction and also modified binders are used to satisfy any specific pavement requirement. Since the binders are visco-elastic material which is having the mechanical properties of binder transition from viscoelastic solid to visco-elastic fluid. In this paper, two different protocols were used to measure the viscosity property of binder using a Brookfield Viscometer and there is a need to find the appropriate mixing and compaction temperatures of various types of binders which can result in complete aggregate coating and adequate field density of HMA mixtures. The aim of this work is to find the transition temperature from Non-Newtonian behavior to Newtonian behavior of the binder by adopting a steady shear protocol and the shear rate ramp protocol. The transition from non-Newtonian to Newtonian can occur through an increase of temperature and shear of the material. The test has been conducted for unmodified binder VG 30. The transition temperature was found in the unmodified binder VG is 120oC. Therefore, the application of both modified binder and unmodified binder in the pavement construction needs to be studied properly by considering temperature and traffic loading factors of the respective project site.Keywords: Unmodified and modified binders, Brookfield Viscometer, transition temperature, steady shear, shear rate protocol.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1877168 Non-Linear Numerical Modeling of the Interaction of Twin Tunnels-Structure
Authors: A. Bayoumi, M. Abdallah, F. Hage Chehade
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Structures on the ground surface bear impact from the tunneling-induced settlement, especially when twin tunnels are constructed. The tunneling influence on the structure is considered as a critical issue based on the construction procedure and relative position of tunnels. Lebanon is suffering from a traffic phenomenon caused by the lack of transportation systems. After several traffic counts and geotechnical investigations in Beirut city, efforts aim for the construction of tunneling systems. In this paper, we present a non-linear numerical modeling of the effect of the twin tunnels constructions on the structures located at soil surface for a particular site in Beirut. A parametric study, which concerns the geometric configuration of tunnels, the distance between their centers, the construction order, and the position of the structure, is performed. The tunnel-soil-structure interaction is analyzed by using the non-linear finite element modeling software PLAXIS 2D. The results of the surface settlement and the bending moment of the structure reveal significant influence when the structure is moved away, especially in vertical aligned tunnels.Keywords: Bending moment, construction procedure, elastic modulus, relative position, soil, structure location, surface settlement, twin tunnels.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1467167 A New Suburb Renovation Concept
Authors: A. Soikkeli, L. Sorri
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Finnish national research project, User- and Business-oriented Suburb Renovation Concept (KLIKK), was started in January 2012 and will end in June 2014. The perspective of energy efficiency is emphasised in the project, but also it addresses what improving the energy efficiency of suburban apartment buildings means from the standpoint of architecturally valuable buildings representing different periods. The project will also test the impacts of stricter energy efficiency requirements on renovation projects.
The primary goal of the project is to develop a user-oriented, industrial, economic renovation concept for suburban apartment building renovation, extension and construction of additional storeys. The concept will make it possible to change from performance- and cost-based operation to novel service- and user-oriented, site-specifically tailored renovation methods utilizing integrated order and delivery chains.
The present project is collaborating with Ministry of the Environment and participating cities in developing a new type of lighter town planning model for suburban renovations and in-fill construction. To support this, the project will simultaneously develop practices for environmental impact assessment tools in renovation and suburban supplementary and in-fill construction.
Keywords: Energy efficiency, Prefabrication, Renovation concept, Suburbs, Sustainability, User-Orientated.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2039166 Simulation of PM10 Source Apportionment at An Urban Site in Southern Taiwan by a Gaussian Trajectory Model
Authors: Chien-Lung Chen, Jeng-Lin Tsai, Feng-Chao Chung, Su-Ching Kuo, Kuo-Hsin Tseng, Pei-Hsuan Kuo, Li-Ying Hsieh, Ying I. Tsai
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This study applied the Gaussian trajectory transfer-coefficient model (GTx) to simulate the particulate matter concentrations and the source apportionments at Nanzih Air Quality Monitoring Station in southern Taiwan from November 2007 to February 2008. The correlation coefficient between the observed and the calculated daily PM10 concentrations is 0.5 and the absolute bias of the PM10 concentrations is 24%. The simulated PM10 concentrations matched well with the observed data. Although the emission rate of PM10 was dominated by area sources (58%), the results of source apportionments indicated that the primary sources for PM10 at Nanzih Station were point sources (42%), area sources (20%) and then upwind boundary concentration (14%). The obvious difference of PM10 source apportionment between episode and non-episode days was upwind boundary concentrations which contributed to 20% and 11% PM10 sources, respectively. The gas-particle conversion of secondary aerosol and long range transport played crucial roles on the PM10 contribution to a receptor.Keywords: back trajectory model, particulate matter, sourceapportionment
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1600165 Design of an Innovative Accelerant Detector
Authors: Esther T. Akinlabi, Milan Isvarial, Stephen A. Akinlabi
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Today, canines are still used effectively in acceleration detection situation. However, this method is becoming impractical in modern age and a new automated replacement to the canine is required. This paper reports the design of an innovative accelerant detector. Designing an accelerant detector is a long process as is any design process; therefore, a solution to the need for a mobile, effective accelerant detector is hereby presented. The device is simple and efficient to ensure that any accelerant detection can be conducted quickly and easily. The design utilizes Ultra Violet (UV) light to detect the accelerant. When the UV light shines on an accelerant, the hydrocarbons in the accelerant emit florescence. The advantages of using the UV light to detect accelerant are also outlined in this paper. The mobility of the device is achieved by using a Direct Current (DC) motor to run tank tracks. Tank tracks were chosen as to ensure that the device will be mobile in the rough terrain of a fire site. The materials selected for the various parts are also presented. A Solid Works Simulation was also conducted on the stresses in the shafts and the results are presented. This design is an innovative solution which offers a user friendly interface. The design is also environmentally friendly, ecologically sound and safe to use.
Keywords: Accelerant detector, Canines, Gas Chromatography- Mass Spectrometry (GC-MS), Ultra Violet light.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2366164 Ambient Vibration Testing of Existing Buildings in Madinah
Authors: Tarek M. Alguhane, Ayman H. Khalil, M. N. Fayed, Ayman M. Ismail
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The elastic period has a primary role in the seismic assessment of buildings. Reliable calculations and/or estimates of the fundamental frequency of a building and its site are essential during analysis and design process. Various code formulas based on empirical data are generally used to estimate the fundamental frequency of a structure. For existing structures, in addition to code formulas and available analytical tools such as modal analyses, various methods of testing including ambient and forced vibration testing procedures may be used to determine dynamic characteristics. In this study, the dynamic properties of the 32 buildings located in the Madinah of Saudi Arabia were identified using ambient motions recorded at several, spatially-distributed locations within each building. Ambient vibration measurements of buildings have been analyzed and the fundamental longitudinal and transverse periods for all tested buildings are presented. The fundamental mode of vibration has been compared in plots with codes formulae (Saudi Building Code, EC8, and UBC1997). The results indicate that measured periods of existing buildings are shorter than that given by most empirical code formulas. Recommendations are given based on the common design and construction practice in Madinah city.
Keywords: Ambient vibration, Fundamental period, RC buildings, Infill walls.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2339163 Regionalization of IDF Curves with L-Moments for Storm Events
Authors: Noratiqah Mohd Ariff, Abdul Aziz Jemain, Mohd Aftar Abu Bakar
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The construction of Intensity-Duration-Frequency (IDF) curves is one of the most common and useful tools in order to design hydraulic structures and to provide a mathematical relationship between rainfall characteristics. IDF curves, especially those in Peninsular Malaysia, are often built using moving windows of rainfalls. However, these windows do not represent the actual rainfall events since the duration of rainfalls is usually prefixed. Hence, instead of using moving windows, this study aims to find regionalized distributions for IDF curves of extreme rainfalls based on storm events. Homogeneity test is performed on annual maximum of storm intensities to identify homogeneous regions of storms in Peninsular Malaysia. The L-moment method is then used to regionalized Generalized Extreme Value (GEV) distribution of these annual maximums and subsequently. IDF curves are constructed using the regional distributions. The differences between the IDF curves obtained and IDF curves found using at-site GEV distributions are observed through the computation of the coefficient of variation of root mean square error, mean percentage difference and the coefficient of determination. The small differences implied that the construction of IDF curves could be simplified by finding a general probability distribution of each region. This will also help in constructing IDF curves for sites with no rainfall station.
Keywords: IDF curves, L-moments, regionalization, storm events.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1718162 Effect of Zinc Chloride Activation on Physicochemical Characteristics of Cassava Peel and Waste Bamboo Activated Carbon
Authors: Olayinka Omotosho, Anthony Amori
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Cassava peels and bamboo waste materials discarded from construction are two sources of waste that could constitute serious menace where they exist in large quantities and inadequately handled. The study examined the physicochemical characteristics of activated carbon materials derived from cassava peels and bamboo waste materials discarded from construction site. Both materials were subjected to carbonization and chemical activation using zinc chloride. Results show that the chemical activation of the materials had a more effect on pore formation in cassava peels than in bamboo materials. Bamboo material exhibited a reverse trend for zinc and sulphate ion decontamination efficiencies as the value of zinc chloride impregnation varied unlike cassava peel carbon biomass which exhibited a more consistent result of decontamination efficiency for the seven contaminants tested. Although waste bamboo biomass exhibited higher adsorption intensity as indicated by values of decontamination for most of the contaminants tested, the cassava peel carbon biomass showed a more balanced adsorption level.
Keywords: Zinc chloride, cassava peels, activated carbon, bamboo waste, SEM.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1521161 Production of H5N1 Hemagglutinin inTrichoplusia ni Larvae by a Novel Bi-cistronic Baculovirus Expression Vector
Authors: Tzyy Rong Jinn, Nguyen Tiep Khac, Tzong Yuan Wu
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Highly pathogenic avian influenza (HPAI) H5N1 viruses have created demand for a cost-effective vaccine to prevent a pandemic of the disease. Here, we report that Trichoplusia ni (T. ni) larvae can act as a cost-effective bioreactor to produce recombinant HA5 (rH5HA) proteins as an potential effective vaccine for chickens. To facilitate the recombinant virus identification, virus titer determination and access the infected larvae, we employed the internal ribosome entry site (IRES) derived from Perina nuda virus (PnV, belongs to insect picorna like Iflavirus genus) to construct a bi-cistronic baculovirus expression vector that can express the rH5HA protein and enhanced green fluorescent protein (EGFP) simultaneously. Western blot analysis revealed that the 70 kDa rH5HA protein and partially cleaved products (40 kDa H5HA1) were generated in T. ni larvae infected with recombinant baculovirus carrying the H5HA gene. These data suggest that the baculovirus-larvae recombinant protein expression system could be a cost-effective platform for H5N1 vaccine production.
Keywords: Avian Influenza, baculovirus, hemagglutinin, Trichoplusia ni larvae
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1819160 Role-play Gaming Simulation for Flood Management on Cultural Heritage: A Case Study of Ayutthaya Historic City
Authors: Pongpisit Huyakorn, Chaweewan Denpaiboon, Hidehiko Kanegae
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The main aim of this research is to develop a methodology to encourage people's awareness, knowledge and understanding on the participation of flood management for cultural heritage, as the cooperation and interaction among government section, private section, and public section through role-play gaming simulation theory. The format of this research is to develop Role-play gaming simulation from existing documents, game or role-playing from several sources and existing data of the research site. We found that role-play gaming simulation can be implemented to help improving the understanding of the existing problem and the impact of the flood on cultural heritage, and the role-play game can be developed into the tool to improve people's knowledge, understanding and awareness about people's participation for flood management on cultural heritage, moreover the cooperation among the government, private section and public section will be improved through the theory of role-play gaming simulation.
Keywords: Climate change, Role-play gaming simulation, Sustainable development, Public participation, Cultural heritage
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2753159 Prediction of Metals Available to Maize Seedlings in Crude Oil Contaminated Soil
Authors: Stella O. Olubodun, George E. Eriyamremu
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The study assessed the effect of crude oil applied at rates, 0, 2, 5, and 10% on the fractional chemical forms and availability of some metals in soils from Usen, Edo State, with no known crude oil contamination and soil from a crude oil spill site in Ubeji, Delta State, Nigeria. Three methods were used to determine the bioavailability of metals in the soils: maize (Zea mays) plant, EDTA and BCR sequential extraction. The sequential extract acid soluble fraction of the BCR extraction (most labile fraction of the soils, normally associated with bioavailability) were compared with total metal concentration in maize seedlings as a means to compare the chemical and biological measures of bioavailability. Total Fe was higher in comparison to other metals for the crude oil contaminated soils. The metal concentrations were below the limits of 4.7% Fe, 190mg/kg Cu and 720mg/kg Zn intervention values and 36mg/kg Cu and 140mg/kg Zn target values for soils provided by the Department of Petroleum Resources (DPR) guidelines. The concentration of the metals in maize seedlings increased with increasing rates of crude oil contamination. Comparison of the metal concentrations in maize seedlings with EDTA extractable concentrations showed that EDTA extracted more metals than maize plant.Keywords: Availability, crude oil contamination, EDTA, maize, metals.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1383158 Efficient Web-Learning Collision Detection Tool on Five-Axis Machine
Authors: Chia-Jung Chen, Rong-Shine Lin, Rong-Guey Chang
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As networking has become popular, Web-learning tends to be a trend while designing a tool. Moreover, five-axis machining has been widely used in industry recently; however, it has potential axial table colliding problems. Thus this paper aims at proposing an efficient web-learning collision detection tool on five-axis machining. However, collision detection consumes heavy resource that few devices can support, thus this research uses a systematic approach based on web knowledge to detect collision. The methodologies include the kinematics analyses for five-axis motions, separating axis method for collision detection, and computer simulation for verification. The machine structure is modeled as STL format in CAD software. The input to the detection system is the g-code part program, which describes the tool motions to produce the part surface. This research produced a simulation program with C programming language and demonstrated a five-axis machining example with collision detection on web site. The system simulates the five-axis CNC motion for tool trajectory and detects for any collisions according to the input g-codes and also supports high-performance web service benefiting from C. The result shows that our method improves 4.5 time of computational efficiency, comparing to the conventional detection method.
Keywords: Collision detection, Five-axis machining, Separating axis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2181157 Effect of Self-Compacting Concrete and Aggregate Size on Anchorage Performance at Highly Congested Reinforcement Regions
Authors: Umair Baig, Kohei Nagai
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At highly congested reinforcement regions, which is common at beam-column joint area, clear spacing between parallel bars becomes less than maximum normal aggregate size (20mm) which has not been addressed in any design code and specifications. Limited clear spacing between parallel bars (herein after thin cover) is one of the causes which affect anchorage performance. In this study, an experimental investigation was carried out to understand anchorage performance of reinforcement in Self-Compacting Concrete (SCC) and Normal Concrete (NC) at highly congested regions under uni-axial tensile loading. Column bar was pullout whereas; beam bars were offset from column reinforcement creating thin cover as per site condition. Two different sizes of coarse aggregate were used for NC (20mm and 10mm). Strain gauges were also installed along the bar in some specimens to understand the internal stress mechanism. Test results reveal that anchorage performance is affected at highly congested reinforcement region in NC with maximum aggregate size 20mm whereas; SCC and Small Aggregate (10mm) gives better structural performance.
Keywords: Anchorage capacity, bond, Normal Concrete, self-compacting concrete.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3434156 Reinvestment of the Urban Context in Historic Cities: The Case Study of El Sheikh Kandil Street, Rosetta, Egypt
Authors: Riham A. Ragheb, Ingy M. Naguib
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Conservation and urban investment are a prerequisite to improve the quality of life. Since the historic street is a part of the economic system, it should be able to play an important role in the city development by upgrading all services, public open spaces and reuse of historical buildings and sites. Furthermore, historical conservation enriches the political, economic, social, cultural and functional aspects of the site. Rosetta has been selected as an area of study because it has a unique character due to its possession of a variety of monuments and historical buildings. The aim of this research is to analyze the existing situation of an historic street named El Sheikh Kandil, to be able to identify the potentials and problems. The paper gives a proposal for the redesign and reinvestment of the street and the reuse for the historical buildings to serve the community, users and visitors. Then, it concludes with recommendations to improve quality of life through the rehabilitation of the historical buildings and strengthening of the cultural and historical identity of the street. Rosetta city can benefit from these development proposals by preserving and revitalizing its unique character which leads to tourism development and benefits from the new investments.
Keywords: Adaptive reuse, heritage street, historic investment, restoration, urban design.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1057155 Sedimentological Study of Bivalve Fossils Site Locality in Hong Hoi Formation, Lampang, Thailand
Authors: Kritsada Moonpa, Kannipa Motanated, Weerapan Srichan
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Hong Hoi Formation is a Middle Triassic deep marine succession presented in outcrops throughout the Lampang Basin of northern Thailand. The primary goal of this research is to diagnose the paleoenvironment, petrographic compositions, and sedimentary sources of the Hong Hoi Formation in Ban Huat, Ngao District. The Triassic Hong Hoi Formation is chosen because the outcrops are continuous and fossils are greatly exposed and abundant. Depositional environment is reconstructed through sedimentological studies along with facies analysis. The Hong Hoi Formation is petrographically divided into two major facies, they are: sandstones with mudstone interbeds, and mudstones or shale with sandstone interbeds. Sandstone beds are lithic arenite and lithic greywacke, volcanic lithic fragments are dominated. Sedimentary structures, paleocurrent data and lithofacies arrangement indicate that the formation deposited in a part of deep marine abyssal plain environment. The sedimentological and petrographic features suggest that during the deposition the Hong Hoi Formation received sediment supply from nearby volcanic arc. This suggested that the intensive volcanic activity within the Sukhothai Arc during the Middle Triassic is the main sediment source.
Keywords: Sukhothai Zone, petrography, Hong Hoi Formation, Lampang, Triassic.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 734154 Application of GIS-Based Construction Engineering: An Electronic Document Management System
Authors: Mansour N. Jadid
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This paper describes the implementation of a GIS to provide decision support for successfully monitoring the movements and storage of materials, hence ensuring that finished products travel from the point of origin to the destination construction site through the supply-chain management (SCM) system. This system ensures the efficient operation of suppliers, manufacturers, and distributors by determining the shortest path from the point of origin to the final destination to reduce construction costs, minimize time, and enhance productivity. These systems are essential to the construction industry because they reduce costs and save time, thereby improve productivity and effectiveness. This study describes a typical supply-chain model and a geographical information system (GIS)-based SCM that focuses on implementing an electronic document management system, which maps the application framework to integrate geodetic support with the supply-chain system. This process provides guidance for locating the nearest suppliers to fill the information needs of project members in different locations. Moreover, this study illustrates the use of a GIS-based SCM as a collaborative tool in innovative methods for implementing Web mapping services, as well as aspects of their integration by generating an interactive GIS for the construction industry platform.
Keywords: Construction, coordinate, engineering, GIS, management, map.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1453153 Design and Fabrication of a Parabolic Trough Collector and Experimental Investigation of Wind Impact on Direct Steam Production in Tehran
Authors: H. Akhbari, M. Bidi, A. Bakhtiari, S. Eslami
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The present paper aims to the techno-economic feasibility of enhancing low-cost parabolic trough collectors in the light of developing the use of solar energy in under-developed regions where expensive high-tech solar devices cannot be afforded. Moreover, the collector is aimed to produce steam so that its performance is based on heat which can be discovered. In this regard, the manufacturing process and the detailed design models in Solidworks software are elaborated. Furthermore, the colletor’s material is chosen in a way to minimize the costs. Finally, to assess the performance of the built collector, it is installed in the site of Shahid Beheshti University, Tehran, and the values of the effective peripheral parameters, such as temperature, wind speed, and most importantly, solar irradiance, are recorded simultaneously in June. According to the results obtained, the manufactured collector with the aperture area of 2 m2 (1×2 m) is capable of producing 350 ml.h-1 steam. Also, the wind influence is comprehensively investigated in this paper. As a case in point, it was measured that as the wind speed maximized to 9.77 km/h, the amount of steam outlet is minimized to 580 ml.
Keywords: Direct steam production, design and fabrication parabolic trough collector, solar water heater, wind impact, experimental investigation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 996152 Characterisation of Hydrocarbons in Atmospheric Aerosols from Different European Sites
Authors: C. A. Alves, A. Vicente, M. Evtyugina, C. A. Pio, A. Hoffer, G. Kiss, S. Decesari, R. Hillamo, E.Swietlicki
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The concentrations of aliphatic and polycyclic aromatic hydrocarbons (PAH) were determined in atmospheric aerosol samples collected at a rural site in Hungary (K-puszta, summer 2008), a boreal forest (Hyytiälä, April 2007) and a polluted rural area in Italy (San Pietro Capofiume, Po Valley, April 2008). A clear distinction between “clean" and “polluted" periods was observed. Concentrations obtained for Hyytiälä are significantly lower than those for the other two sites. Source reconciliation was performed using diagnostic parameters, such as the carbon preference index and ratios between PAH. The presence of an unresolved complex mixture of hydrocarbons, especially for the Finnish and Italian samples, is indicative of petrogenic inputs. In K-puszta, the aliphatic hydrocarbons are dominated by leaf wax n-alkanes. The long range transport of anthropogenic pollution contributed to the Finnish aerosol. Industrial activities and vehicular emissions represent major sources in San Pietro Capofiume. PAH in K-puszta consist of both pyrogenic and petrogenic compounds.
Keywords: Particulate matter, n-alkanes, PAH, BaPE, ruralsites, source reconciliation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1949151 Computer Aided Drug Design and Studies of Antiviral Drug against H3N2 Influenza Virus
Authors: Aditi Shukla, Ambarish S. Vidyarthi, Subir Samanta
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The worldwide prevalence of H3N2 influenza virus and its increasing resistance to the existing drugs necessitates for the development of an improved/better targeting anti-influenza drug. H3N2 influenza neuraminidase is one of the two membrane-bound proteins belonging to group-2 neuraminidases. It acts as key player involved in viral pathogenicity and hence, is an important target of anti-influenza drugs. Oseltamivir is one of the potent drugs targeting this neuraminidase. In the present work, we have taken subtype N2 neuraminidase as the receptor and probable analogs of oseltamivir as drug molecules to study the protein-drug interaction in anticipation of finding efficient modified candidate compound. Oseltamivir analogs were made by modifying the functional groups using Marvin Sketch software and were docked using Schrodinger-s Glide. Oseltamivir analog 10 was detected to have significant energy value (16% less compared to Oseltamivir) and could be the probable lead molecule. It infers that some of the modified compounds can interact in a novel manner with increased hydrogen bonding at the active site of neuraminidase and it might be better than the original drug. Further work can be carried out such as enzymatic inhibition studies; synthesis and crystallizing the drug-target complex to analyze the interactions biologically.Keywords: H3N2 Influenza, Neuraminidase, Oseltamiviranalogs, structure based drug designing
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2542150 Displaying of GnRH Peptides on Bacteriophage T7 and Its Immunogenicity in Mice Model
Authors: Hai Xu, Yiwei Wang, Xi Bao, Bihua Deng, Pengcheng Li, Yu Lu
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T7 phage could be used as a perfect vector for peptides expression and haptens presentation. T7-3GnRH recombinant phage was constructed by inserting three copies of Gonadotrophin Releasing Hormone (GnRH) gene into the multiple cloning site of T7 Select 415-1b phage genome. The positive T7-3GnRH phage was selected by using polymerase chain reaction amplification, and the p10B-3GnRH fusion protein was verified by SDS-PAGE and Western-blotting assay. T7-3GnRH vaccine was made and immunized with 1010 pfu in 0.2 ml per dose in mice. Blood samples were collected at an interval in weeks, and anti-GnRH antibody and testosterone concentrations were detected by ELISA and radioimmunoassay, respectively. The results show that T7-3GnRH phage particles confer a high immunogenicity to the GnRH-derived epitope. Moreover, the T7-3GnRH vaccine induced higher level of anti-GnRH antibody than ImproVac®. However, the testosterone concentrations in both immunized groups were at a similar level, and the testis developments were significantly inhibited compared to controls. These findings demonstrated that the anti-GnRH antibody could neutralize the endogenous GnRH to down regulate testosterone level and limit testis development, highlighting the potential value of T7-3GnRH in the immunocastration vaccine research.
Keywords: Gonadotrophin releasing hormone, GnRH, immunocastration, T7 phage, phage vaccine.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1115149 Evaluation of Microleakage of a New Generation Nano-Ionomer in Class II Restoration of Primary Molars
Authors: Ghada Salem, Nihal Kabel
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Objective: This in vitro study was carried out to assess the microleakage properties of nano-filled glass ionomer in comparison to resin-reinforced glass ionomers. Material and Methods: 40 deciduous molar teeth were included in this study. Class-II cavity was prepared in a standard form for all the specimens. The teeth were randomly distributed into two groups (20 per group) according to the restorative material used either nano-glass ionomer or Photac Fill glass ionomer restoration. All specimens were thermocycled for 1000 cycles between 5 and 55 °C. After that, the teeth were immersed in 2% methylene blue dye then sectioned and evaluated under a stereomicroscope. Microleakage was assessed using linear dye penetration and on a scale from zero to five. Results: Two way ANOVA test revealed a statistically significant lower degree of microleakage in both occlusal and gingival restorations (0.4±0.2), (0.9±0.1) for nano-filled glass ionomer group in comparison to resin modified glass ionomer (2.3±0.7), (2.4±0.5). No statistical difference was found between gingival and occlusal leakage regarding the effect of the measured site. Conclusion: Nano-filled glass ionomer shows superior sealing ability which enables this type of restoration to be used in minimum invasive treatment.Keywords: Microleakage, nano-ionomer, resin-reinforced glass ionomer, proximal cavity preparation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1261148 A Case Study of Applying Virtual Prototyping in Construction
Authors: Stephen C. W. Kong
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The use of 3D computer-aided design (CAD) models to support construction project planning has been increasing in the previous year. 3D CAD models reveal more planning ideas by visually showing the construction site environment in different stages of the construction process. Using 3D CAD models together with scheduling software to prepare construction plan can identify errors in process sequence and spatial arrangement, which is vital to the success of a construction project. A number of 4D (3D plus time) CAD tools has been developed and utilized in different construction projects due to the awareness of their importance. Virtual prototyping extends the idea of 4D CAD by integrating more features for simulating real construction process. Virtual prototyping originates from the manufacturing industry where production of products such as cars and airplanes are virtually simulated in computer before they are built in the factory. Virtual prototyping integrates 3D CAD, simulation engine, analysis tools (like structural analysis and collision detection), and knowledgebase to streamline the whole product design and production process. In this paper, we present the application of a virtual prototyping software which has been used in a few construction projects in Hong Kong to support construction project planning. Specifically, the paper presents an implementation of virtual prototyping in a residential building project in Hong Kong. The applicability, difficulties and benefits of construction virtual prototyping are examined based on this project.Keywords: construction project planning, prefabrication, simulation, virtual prototyping.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2832147 The Design of English Materials to Communicate the Identity of Mueang District, Samut Songkram for Ecotourism
Authors: Kitda Praraththajariya
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The main purpose of this research was to study how to communicate the identity of the Mueang district, SamutSongkram province for ecotourism. The qualitative data was collected through studying related materials, exploring the area, in-depth interviews with three groups of people: three directly responsible officers who were key informants of the district, twenty foreign tourists and five Thai tourist guides. A content analysis was used to analyze the qualitative data. The two main findings of the study were as follows: 1. The identity of Amphur (District) Mueang, SamutSongkram province. This establishment was near the Mouth of Maekong River for normal people and tourists, consisting of rest accommodations. There are restaurants where food and drinks are served, rich mangrove forests, Hoy Lod (Razor Clam) and mangrove trees. Don Hoy Lod, is characterized by muddy beaches, is a coastal wetland for Ramsar Site. It is at 1099th ranging where the greatest number of Hoy Lod (Razor Clam) can be seen from March to May each year. 2. The communication of the identity of AmphurMueang, SamutSongkram province which the researcher could find and design to present in English materials can be summed up in 4 items: 1) The history of AmphurMueang, SamutSongkram province 2) WatPhetSamutWorrawihan 3) The Learning source of Ecotourism: Don Hoy Lod and Mangrove forest 4) How to keep AmphurMueang, SamutSongkram province for ecotourism.
Keywords: Foreigner tourists, signified, semiotics, ecotourism.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1850146 Automatic Generation Control of Multi-Area Electric Energy Systems Using Modified GA
Authors: Gayadhar Panda, Sidhartha Panda, C. Ardil
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A modified Genetic Algorithm (GA) based optimal selection of parameters for Automatic Generation Control (AGC) of multi-area electric energy systems is proposed in this paper. Simulations on multi-area reheat thermal system with and without consideration of nonlinearity like governor dead band followed by 1% step load perturbation is performed to exemplify the optimum parameter search. In this proposed method, a modified Genetic Algorithm is proposed where one point crossover with modification is employed. Positional dependency in respect of crossing site helps to maintain diversity of search point as well as exploitation of already known optimum value. This makes a trade-off between exploration and exploitation of search space to find global optimum in less number of generations. The proposed GA along with decomposition technique as developed has been used to obtain the optimum megawatt frequency control of multi-area electric energy systems. Time-domain simulations are conducted with trapezoidal integration along with decomposition technique. The superiority of the proposed method over existing one is verified from simulations and comparisons.
Keywords: Automatic Generation Control (AGC), Reheat, Proportional Integral (PI) controller, Dead Band, Genetic Algorithm(GA).
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2660145 The Development of Smart School Condition Assessment Based on Condition Survey Protocol (CSP) 1 Matrix: A Literature Review
Authors: N. Hamzah, M. Mahli, A. I. Che-Ani, M. M Tahir, N. A. G. Abdullah, N. M Tawil
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Building inspection is one of the key components of building maintenance. The primary purpose of performing a building inspection is to evaluate the building-s condition. Without inspection, it is difficult to determine a built asset-s current condition, so failure to inspect can contribute to the asset-s future failure. Traditionally, a longhand survey description has been widely used for property condition reports. Surveys that employ ratings instead of descriptions are gaining wide acceptance in the industry because they cater to the need for numerical analysis output. These kinds of surveys are also in keeping with the new RICS HomeBuyer Report 2009. In this paper, we propose a new assessment method, derived from the current rating systems, for assessing the specifically smart school building-s condition and rating the seriousness of each defect identified. These two assessment criteria are then multiplied to find the building-s score, which we called the Condition Survey Protocol (CSP) 1 Matrix. Instead of a longhand description of a building-s defects, this matrix requires concise explanations about the defects identified, thus saving on-site time during a smart school building inspection. The full score is used to give the building an overall rating: Good, Fair or Dilapidated.
Keywords: Assessment matrix, building condition survey, rating system, smart school and survey protocol.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2465144 Building a Personalized Multidimensional Intelligent Learning System
Authors: Lun-Ping Hung, Nan-Chen Hsieh, Chia-Ling Ho, Chien-Liang Chen
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Currently, most of distance learning courses can only deliver standard material to students. Students receive course content passively which leads to the neglect of the goal of education – “to suit the teaching to the ability of students". Providing appropriate course content according to students- ability is the main goal of this paper. Except offering a series of conventional learning services, abundant information available, and instant message delivery, a complete online learning environment should be able to distinguish between students- ability and provide learning courses that best suit their ability. However, if a distance learning site contains well-designed course content and design but fails to provide adaptive courses, students will gradually loss their interests and confidence in learning and result in ineffective learning or discontinued learning. In this paper, an intelligent tutoring system is proposed and it consists of several modules working cooperatively in order to build an adaptive learning environment for distance education. The operation of the system is based on the result of Self-Organizing Map (SOM) to divide students into different groups according to their learning ability and learning interests and then provide them with suitable course content. Accordingly, the problem of information overload and internet traffic problem can be solved because the amount of traffic accessing the same content is reduced.Keywords: Distance Learning, Intelligent Tutoring System(ITS), Self-Organizing Map (SOM)
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1869143 Earthquake Vulnerability and Repair Cost Estimation of Masonry Buildings in the Old City Center of Annaba, Algeria
Authors: Allaeddine Athmani, Abdelhacine Gouasmia, Tiago Ferreira, Romeu Vicente
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The seismic risk mitigation from the perspective of the old buildings stock is truly essential in Algerian urban areas, particularly those located in seismic prone regions, such as Annaba city, and which the old buildings present high levels of degradation associated with no seismic strengthening and/or rehabilitation concerns. In this sense, the present paper approaches the issue of the seismic vulnerability assessment of old masonry building stocks through the adaptation of a simplified methodology developed for a European context area similar to that of Annaba city, Algeria. Therefore, this method is used for the first level of seismic vulnerability assessment of the masonry buildings stock of the old city center of Annaba. This methodology is based on a vulnerability index that is suitable for the evaluation of damage and for the creation of large-scale loss scenarios. Over 380 buildings were evaluated in accordance with the referred methodology and the results obtained were then integrated into a Geographical Information System (GIS) tool. Such results can be used by the Annaba city council for supporting management decisions, based on a global view of the site under analysis, which led to more accurate and faster decisions for the risk mitigation strategies and rehabilitation plans.Keywords: Damage scenarios, masonry buildings, old city center, seismic vulnerability, vulnerability index.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2098142 Aspects to Motivate users of a Design Engineering Wiki to Share their Knowledge
Authors: Regine W. Vroom, Lysanne E. Vossen, Anoek M. Geers
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Industrial design engineering is an information and knowledge intensive job. Although Wikipedia offers a lot of this information, design engineers are better served with a wiki tailored to their job, offering information in a compact manner and functioning as a design tool. For that reason WikID has been developed. However for the viability of a wiki, an active user community is essential. The main subject of this paper is a study to the influence of the communication and the contents of WikID on the user-s willingness to contribute. At first the theory about a website-s first impression, general usability guidelines and user motivation in an online community is studied. Using this theory, the aspects of the current site are analyzed on their suitability. These results have been verified with a questionnaire amongst 66 industrial design engineers (or students industrial design engineering). The main conclusion is that design engineers are enchanted with the existence of WikID and its knowledge structure (taxonomy) but this structure has not become clear without any guidance. In other words, the knowledge structure is very helpful for inspiring and guiding design engineers through their tailored knowledge domain in WikID but this taxonomy has to be better communicated on the main page. Thereby the main page needs to be fitted more to the target group preferences.Keywords: Industrial Design Engineering Knowledge, SemanticWiki, User Willingness to Contribute Knowledge to a Wiki, Influence of Website Content to User Activation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2129141 The Effectiveness of Banks’ Web Sites: A Study of Turkish Banking Sector
Authors: Raif Parlakkaya, Huseyin Cetin, Duygu Irdiren
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By the development of World Wide Web, the usage rate of Internet has rapidly grown globally; and provided a basis for the emergence of electronic business. As well as other sectors, the banking sector has adopted the use of internet with the developments in information and communication technologies. Due to the public disclosure and transparency principle of Corporate Governance, the importance of information disclosure of banks on their web sites has increased significantly. For the purpose of this study, a Bank Disclosure Attribute Index (BDAI) in Turkey has been constructed through classifying the information disclosure on banks’ web sites into general, financial, investors and corporate governance attributes. All 47 banks in Turkish Banking System have been evaluated according to the index with the aim of providing a comparison between banks. By Chi Square Test, Pearson Correlation, T-Test, and ANOVA statistical tools, it has been concluded that the majority of banks in Turkey have shared information on their web sites adequately with respect to their total index score. Although there is a positive correlation between various types of information on banks’ web sites, there is no uniformity among them. Also, no significant difference between various types of information disclosure and bank types has been observed. Compared with the total index score averages of the five largest banks in Turkey, there are some banks that need to improve the content of their web sites.
Keywords: Banking sector, public disclosure, Turkey, web site evaluation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1428140 The Relations between Seismic Results and Groundwater near the Gokpinar Damp Area, Denizli, Turkey
Authors: Mahmud Gungor, Ali Aydin, Erdal Akyol, Suat Tasdelen
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The understanding of geotechnical characteristics of near-surface material and the effects of the groundwater is very important problem in such as site studies. For showing the relations between seismic data and groundwater, we selected about 25 km2 as the study area. It has been presented which is a detailed work of seismic data and groundwater depths of Gokpinar Damp area. Seismic waves velocity (Vp and Vs) are very important parameters showing the soil properties. The seismic records were used the method of the multichannel analysis of surface waves near area of Gokpinar Damp area. Sixty sites in this area have been investigated with survey lines about 60 m in length. MASW (Multichannel analysis of surface wave) method has been used to generate onedimensional shear wave velocity profile at locations. These shear wave velocities are used to estimate equivalent shear wave velocity in the study area at every 2 and 5 m intervals up to a depth of 45 m. Levels of equivalent shear wave velocity of soil are used the classified of the study area. After the results of the study, it must be considered as components of urban planning and building design of Gokpinar Damp area, Denizli and the application and use of these results should be required and enforced by municipal authorities.
Keywords: Seismic data, Gokpinar Damp, urban planning, Denizli.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2359