Search results for: Case-based reasoning; Breast cancer diagnosis; Genetic algorithm; Wrapper feature selection

Authors: N. Khatiashvili, Ch. Pirumova, V. Akhobadze

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In the paper the mathematical model of tumor growth is considered. New capillary network formation, which supply cancer cells with the nutrients, is taken into the account. A formula estimating a tumor growth in connection with the number of capillaries is obtained.

Keywords: Differential Equations, Mathematical Models, Vascular Endothelial, Tumor

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Authors: Ion-Cosmin Dita, Vasile Gui, Franz Quint, Marius Otesteanu

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In automatic manufacturing and assembling of mechanical, electrical and electronic parts one needs to reliably identify the position of components and to extract the information of these components. Data Matrix Codes (DMC) are established by these days in many areas of industrial manufacturing thanks to their concentration of information on small spaces. In today’s usually order-related industry, where increased tracing requirements prevail, they offer further advantages over other identification systems. This underlines in an impressive way the necessity of a robust code reading system for detecting DMC on the components in factories. This paper compares two methods for estimating the angle of orientation of Data Matrix Codes: one method based on the Hough Transform and the other based on the Mean Shift Algorithm. We concentrate on Data Matrix Codes in industrial environment, punched, milled, lasered or etched on different materials in arbitrary orientation.

Keywords: Industrial data matrix code, Hough transform, mean shift.

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Authors: Xiaofei Hu, Zhiyu Cai, Weian Yao

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V-notch problem under dynamic loading condition is considered in this paper. In the time domain, the precise time domain expanding algorithm is employed, in which a self-adaptive technique is carried out to improve computing accuracy. By expanding variables in each time interval, the recursive finite element formulas are derived. In the space domain, a Symplectic Analytical Singular Element (SASE) for V-notch problem is constructed addressing the stress singularity of the notch tip. Combining with the conventional finite elements, the proposed SASE can be used to solve the dynamic stress intensity factors (DSIFs) in a simple way. Numerical results show that the proposed SASE for V-notch problem subjected to dynamic loading condition is effective and efficient.

Keywords: V-notch, dynamic stress intensity factor, finite element method, precise time domain expanding algorithm.

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Authors: Kasim Terzic, Bernd Neumann

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Scene interpretation systems need to match (often ambiguous) low-level input data to concepts from a high-level ontology. In many domains, these decisions are uncertain and benefit greatly from proper context. This paper demonstrates the use of decision trees for estimating class probabilities for regions described by feature vectors, and shows how context can be introduced in order to improve the matching performance.

Keywords: Classification, Decision Trees, Interpretation, Vision

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Authors: Ying-jie Zhang, Li-ling Ge

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This paper presents an improved image segmentation model with edge preserving regularization based on the piecewise-smooth Mumford-Shah functional. A level set formulation is considered for the Mumford-Shah functional minimization in segmentation, and the corresponding partial difference equations are solved by the backward Euler discretization. Aiming at encouraging edge preserving regularization, a new edge indicator function is introduced at level set frame. In which all the grid points which is used to locate the level set curve are considered to avoid blurring the edges and a nonlinear smooth constraint function as regularization term is applied to smooth the image in the isophote direction instead of the gradient direction. In implementation, some strategies such as a new scheme for extension of u+ and u- computation of the grid points and speedup of the convergence are studied to improve the efficacy of the algorithm. The resulting algorithm has been implemented and compared with the previous methods, and has been proved efficiently by several cases.

Keywords: Energy minimization, image segmentation, level sets, edge regularization.

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Authors: S. Loumi, H. Merrad, F. Alilat, B. Sansal

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In this article, we propose a methodology for the characterization of the suspended matter along Algiers-s bay. An approach by multi layers perceptron (MLP) with training by back propagation of the gradient optimized by the algorithm of Levenberg Marquardt (LM) is used. The accent was put on the choice of the components of the base of training where a comparative study made for four methods: Random and three alternatives of classification by K-Means. The samples are taken from suspended matter image, obtained by analytical model based on polynomial regression by taking account of in situ measurements. The mask which selects the zone of interest (water in our case) was carried out by using a multi spectral classification by ISODATA algorithm. To improve the result of classification, a cleaning of this mask was carried out using the tools of mathematical morphology. The results of this study presented in the forms of curves, tables and of images show the founded good of our methodology.

Keywords: Classification K-means, mathematical morphology, neural network MLP, remote sensing, suspended particulate matter

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Authors: V. Nikkhah Rashidabad, M. Manteghian, M. Masoumi, S. Mousavian, D. Ashouri

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In this research, the capability of neural networks in  modeling and learning complicated and nonlinear relations has been  used to develop a model for the prediction of changes in the diameter  of bubbles in pool boiling distilled water. The input parameters used  in the development of this network include element temperature, heat  flux, and retention time of bubbles. The test data obtained from the  experiment of the pool boiling of distilled water, and the  measurement of the bubbles form on the cylindrical element. The  model was developed based on training algorithm, which is  typologically of back-propagation type. Considering the correlation  coefficient obtained from this model is 0.9633. This shows that this  model can be trusted for the simulation and modeling of the size of  bubble and thermal transfer of boiling.

Keywords: Bubble Diameter, Heat Flux, Neural Network, Training Algorithm.

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Authors: Kyaw Myo Lin, Pyone Lai Swe, Khine Zin Oo

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In this paper, an approach combining analytical method for the distributed generator (DG) sizing and meta-heuristic search for the optimal location of DG has been presented. The optimal size of DG on each bus is estimated by the loss sensitivity factor method while the optimal sites are determined by Particle Swarm Optimization (PSO) based optimal reactive power dispatch for minimizing active power loss. To confirm the proposed approach, it has been tested on IEEE-30 bus test system. The adjustments of operating constraints and voltage profile improvements have also been observed. The obtained results show that the allocation of DGs results in a significant loss reduction with good voltage profiles and the combined approach is competent in keeping the system voltages within the acceptable limits.

Keywords: Analytical approach, distributed generations, optimal size, optimal location, optimal reactive power dispatch, particle swarm optimization algorithm.

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Authors: Naveen Chauhan, L.K. Awasthi, Narottam chand, Vivek Katiyar, Ankit Chug

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Mobile ad-hoc networks (MANETs) are a form of wireless networks which do not require a base station for providing network connectivity. Mobile ad-hoc networks have many characteristics which distinguish them from other wireless networks which make routing in such networks a challenging task. Cluster based routing is one of the routing schemes for MANETs in which various clusters of mobile nodes are formed with each cluster having its own clusterhead which is responsible for routing among clusters. In this paper we have proposed and implemented a distributed weighted clustering algorithm for MANETs. This approach is based on combined weight metric that takes into account several system parameters like the node degree, transmission range, energy and mobility of the nodes. We have evaluated the performance of proposed scheme through simulation in various network situations. Simulation results show that proposed scheme outperforms the original distributed weighted clustering algorithm (DWCA).

Keywords: MANETs, Clustering, Routing, WirelessCommunication, Distributed Clustering

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Authors: T. Damak, O. Kriaa, A. Baccar, M. A. Ben Ayed, N. Masmoudi

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In the last few years, Automatic Number Plate Recognition (ANPR) systems have become widely used in the safety, the security, and the commercial aspects. Forethought, several methods and techniques are computing to achieve the better levels in terms of accuracy and real time execution. This paper proposed a computer vision algorithm of Number Plate Localization (NPL) and Characters Segmentation (CS). In addition, it proposed an improved method in Optical Character Recognition (OCR) based on Deep Learning (DL) techniques. In order to identify the number of detected plate after NPL and CS steps, the Convolutional Neural Network (CNN) algorithm is proposed. A DL model is developed using four convolution layers, two layers of Maxpooling, and six layers of fully connected. The model was trained by number image database on the Jetson TX2 NVIDIA target. The accuracy result has achieved 95.84%.

Keywords: Automatic number plate recognition, character segmentation, convolutional neural network, CNN, deep learning, number plate localization.

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Authors: Kazuki Abe, Myungryun Yoo, Takanori Yokoyama

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Tasks of an application program of an embedded system are managed by the scheduler of a real-time operating system (RTOS). Most RTOSs adopt just fixed priority scheduling, which is not optimal in all cases. Some applications require earliest deadline first (EDF) scheduling, which is an optimal scheduling algorithm. In order to develop an efficient real-time embedded system, the scheduling algorithm of the RTOS should be selectable. The paper presents a method to customize the scheduler using aspectoriented programming. We define aspects to replace the fixed priority scheduling mechanism of an OSEK OS with an EDF scheduling mechanism. By using the aspects, we can customize the scheduler without modifying the original source code. We have applied the aspects to an OSEK OS and get a customized operating system with EDF scheduling. The evaluation results show that the overhead of aspect-oriented programming is small enough.

Keywords: aspect-oriented programming, embedded system, operating system, real-time system

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Authors: T. N. Janakiraman, P. V. S. S. R. Chandra Mouli

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A color image edge detection algorithm is proposed in this paper using Pseudo-complement and matrix rotation operations. First, pseudo-complement method is applied on the image for each channel. Then, matrix operations are applied on the output image of the first stage. Dominant pixels are obtained by image differencing between the pseudo-complement image and the matrix operated image. Median filtering is carried out to smoothen the image thereby removing the isolated pixels. Finally, the dominant or core pixels occurring in at least two channels are selected. On plotting the selected edge pixels, the final edge map of the given color image is obtained. The algorithm is also tested in HSV and YCbCr color spaces. Experimental results on both synthetic and real world images show that the accuracy of the proposed method is comparable to other color edge detectors. All the proposed procedures can be applied to any image domain and runs in polynomial time.

Keywords: Color edge detection, dominant pixels, matrixrotation/shift operations, pseudo-complement.

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Authors: Jinghao Sun, Guozhen Tan, Guangjian Hou

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The Chinese Postman Problem (CPP) is one of the classical problems in graph theory and is applicable in a wide range of fields. With the rapid development of hybrid systems and model based testing, Chinese Postman Problem with Time Dependent Travel Times (CPPTDT) becomes more realistic than the classical problems. In the literature, we have proposed the first integer programming formulation for the CPPTDT problem, namely, circuit formulation, based on which some polyhedral results are investigated and a cutting plane algorithm is also designed. However, there exists a main drawback: the circuit formulation is only available for solving the special instances with all circuits passing through the origin. Therefore, this paper proposes a new integer programming formulation for solving all the general instances of CPPTDT. Moreover, the size of the circuit formulation is too large, which is reduced dramatically here. Thus, it is possible to design more efficient algorithm for solving the CPPTDT in the future research.

Keywords: Chinese Postman Problem, Time Dependent, Integer Programming, Upper Bound Analysis.

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Authors: A. Pedram, M. R. Jamali, T. Pedram, S. M. Fakhraie, C. Lucas

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Local Linear Neuro-Fuzzy Models (LLNFM) like other neuro- fuzzy systems are adaptive networks and provide robust learning capabilities and are widely utilized in various applications such as pattern recognition, system identification, image processing and prediction. Local linear model tree (LOLIMOT) is a type of Takagi-Sugeno-Kang neuro fuzzy algorithm which has proven its efficiency compared with other neuro fuzzy networks in learning the nonlinear systems and pattern recognition. In this paper, a dedicated reconfigurable and parallel processing hardware for LOLIMOT algorithm and its applications are presented. This hardware realizes on-chip learning which gives it the capability to work as a standalone device in a system. The synthesis results on FPGA platforms show its potential to improve the speed at least 250 of times faster than software implemented algorithms.

Keywords: LOLIMOT, hardware, neurofuzzy systems, reconfigurable, parallel.

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Authors: Grouz Faten, Sbita Lassaâd

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In this paper, Speed Sensorless Indirect Field Oriented Control (IFOC) of a Permanent Magnet Synchronous machine (PMSM) is studied. The closed loop scheme of the drive system utilizes fuzzy speed and current controllers. Due to the well known drawbacks of the speed sensor, an algorithm is proposed in this paper to eliminate it. In fact, based on the model of the PMSM, the stator currents and rotor speed are estimated simultaneously using adaptive Luenberger observer for currents and MRAS (Model Reference Adaptive System) observer for rotor speed. To overcome the sensivity of this algorithm against parameter variation, adaptive for on line stator resistance tuning is proposed. The validity of the proposed method is verified by an extensive simulation work.

Keywords: PMSM, Indirect Field Oriented Control, fuzzy speed and currents controllers, Adaptive Luenberger observer, MRAS.

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Authors: Debajyoti Mishra, Urmila Bhanja

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In this paper, a novel fuzzy approach is developed while solving the Dynamic Routing and Wavelength Assignment (DRWA) problem in optical networks with Wavelength Division Multiplexing (WDM). In this work, the effect of nonlinear and linear impairments such as Four Wave Mixing (FWM) and amplifier spontaneous emission (ASE) noise are incorporated respectively. The novel algorithm incorporates fuzzy logic controller (FLC) to reduce the effect of FWM noise and ASE noise on a requested lightpath referred in this work as FWM aware fuzzy dynamic routing and wavelength assignment algorithm. The FWM crosstalk products and the static FWM noise power per link are pre computed in order to reduce the set up time of a requested lightpath, and stored in an offline database. These are retrieved during the setting up of a lightpath and evaluated online taking the dynamic parameters like cost of the links into consideration.

Keywords: Amplifier spontaneous emission (ASE), Dynamic routing and wavelength assignment, Four wave mixing (FWM), Fuzzy rule based system (FRBS).

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Authors: Linnea Stenliden

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The aim of this paper is to understand emerging learning conditions, when a visual analytics is implemented and used in K 12 (education). To date, little attention has been paid to the role visual analytics (digital media and technology that highlight visual data communication in order to support analytical tasks) can play in education, and to the extent to which these tools can process actionable data for young students. This study was conducted in three public K 12 schools, in four social science classes with students aged 10 to 13 years, over a period of two to four weeks at each school. Empirical data were generated using video observations and analyzed with help of metaphors within Actor-network theory (ANT). The learning conditions are found to be distinguished by broad complexity, characterized by four dimensions. These emerge from the actors’ deeply intertwined relations in the activities. The paper argues in relation to the found dimensions that novel approaches to teaching and learning could benefit students’ knowledge building as they work with visual analytics, analyzing visualized data.

Keywords: Analytical reasoning, complexity, data use, problem space, visual analytics, visual storytelling, translation.

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Authors: R. Kara, M. Can

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In this paper we study a food chain model with three trophic levels and Michaelis-Menten type ratio-dependent functional response. Distinctive feature of this model is the sensitive dependence of the dynamical behavior on the initial populations and parameters of the real world. The stability of the equilibrium points are also investigated.

Keywords: Food chain, Ratio dependent models, Three level models.

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Authors: Alexandre Boum, Salomon Madinatou

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This paper aims at bringing a scientific contribution to the cardiac arrhythmia biomedical diagnosis systems; more precisely to the study of the amelioration of cardiac arrhythmia classification performance using artificial neural network, adaptive neuro-fuzzy and fuzzy inference systems classifiers. The purpose of this amelioration is to enable cardiologists to make reliable diagnosis through automatic cardiac arrhythmia analyzes and classifications based on high confidence classifiers. In this study, six classes of the most commonly encountered arrhythmias are considered: the Right Bundle Branch Block, the Left Bundle Branch Block, the Ventricular Extrasystole, the Auricular Extrasystole, the Atrial Fibrillation and the Normal Cardiac rate beat. From the electrocardiogram (ECG) extracted parameters, we constructed a matrix (360x360) serving as an input data sample for the classifiers based on neural networks and a matrix (1x6) for the classifier based on fuzzy logic. By varying three parameters (the quality of the neural network learning, the data size and the quality of the input parameters) the automatic classification permitted us to obtain the following performances: in terms of correct classification rate, 83.6% was obtained using the fuzzy logic based classifier, 99.7% using the neural network based classifier and 99.8% for the adaptive neuro-fuzzy based classifier. These results are based on signals containing at least 360 cardiac cycles. Based on the comparative analysis of the aforementioned three arrhythmia classifiers, the classifiers based on neural networks exhibit a better performance.

Keywords: Adaptive neuro-fuzzy, artificial neural network, cardiac arrythmias, fuzzy inference systems.

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Authors: Nael Y. Zabel, Maged E. Georgy, Moheeb E. Ibrahim

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A knowledge-based expert system with the acronym RASPE is developed as an application tool to help decision makers in construction companies make informed decisions about managing risks in pipeline construction projects. Choosing to use expert systems from all available artificial intelligence techniques is due to the fact that an expert system is more suited to representing a domain’s knowledge and the reasoning behind domain-specific decisions. The knowledge-based expert system can capture the knowledge in the form of conditional rules which represent various project scenarios and potential risk mitigation/response actions. The built knowledge in RASPE is utilized through the underlying inference engine that allows the firing of rules relevant to a project scenario into consideration. Paper provides an overview of the knowledge acquisition process and goes about describing the knowledge structure which is divided up into four major modules. The paper shows one module in full detail for illustration purposes and concludes with insightful remarks.

Keywords: Expert System, Knowledge Management, Pipeline Projects, Risk Mismanagement.

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Authors: Mustafa M. Donma

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Metabolic syndrome (MetS) is characterized by a series of biochemical, physiological and anthropometric indicators and is a life-threatening health problem due to its close association with chronic diseases such as obesity, diabetes mellitus, hypertension, cancer and cardiovascular diseases. The syndrome deserves great interest both in adults and children. Particularly, children with morbid obesity have a great tendency to develop the disease. The diagnostic decision is not so easy and may not be complete particularly in the pediatric population. Therefore, preventive measures should be considered at this stage. The aim of the study was to develop a MetS index capable of predicting MetS, while children are at the morbid obesity stage. This study was performed on morbid obese (MO) children, which were divided into two groups. MO children, who do not possess MetS criteria comprised the first group (n = 44). The second group was composed of children with MetS diagnosis (n = 42). Anthropometric measurements including weight, height, waist circumference (WC), hip C, head C, neck C, biochemical tests including fasting blood glucose (FBG), insulin (INS), triglycerides (TRG), high density lipoprotein cholesterol (HDL-C) and blood pressure measurements (systolic (SBP) and diastolic (DBP)) were performed. Body fat percentage (BFP) values were determined by TANITA’s Bioelectrical Impedance Analysis technology. Body mass index and MetS indices were calculated. Descriptive statistics including median values, t-test, Mann Whitney U test, correlation-regression analysis were performed within the scope of data evaluation using the statistical package program, SPSS. Statistically significant mean differences were determined by a p value smaller than 0.05. Median values for MetSI and ADMI in MO (MetS-) and MO (MetS+) groups were calculated as 25.9 and 36.5 and 74.0 and 106.1, respectively. Corresponding mean ± SD values for BFPs were 35.9 ± 7.1 and 38.2 ± 7.7 in groups. Correlation analysis of these two indices with corresponding general BFP values exhibited significant association with ADMI, close to significance with MetSI in MO group. Any significant correlation was found with neither of the indices in MetS group. In conclusion, important associations observed with MetS indices in MO group were quite meaningful. The presence of these associations in MO group was important for showing the tendency towards the development of MetS in MO (MetS-) participants. The other index, ADMI, was more helpful for predictive purpose.

Keywords: Body fat percentage, child obesity, metabolic syndrome index, morbid obesity.

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Authors: Hamza A. Al-Sewadi, Akram N. A. Aldakari

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Copyright protection and ownership proof of digital multimedia are achieved nowadays by digital watermarking techniques. A text watermarking algorithm for protecting the property rights and ownership judgment of color images is proposed in this paper. Embedding is achieved by inserting texts elements randomly into the color image as noise. The YIQ image processing model is found to be faster than other image processing methods, and hence, it is adopted for the embedding process. An optional choice of encrypting the text watermark before embedding is also suggested (in case required by some applications), where, the text can is encrypted using any enciphering technique adding more difficulty to hackers. Experiments resulted in embedding speed improvement of more than double the speed of other considered systems (such as least significant bit method, and separate color code methods), and a fairly acceptable level of peak signal to noise ratio (PSNR) with low mean square error values for watermarking purposes.

Keywords: Steganography, watermarking, private keys, time complexity measurements.

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Authors: K. Rajasekaran, Kannan Balasubramanian

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A sensory network consists of multiple detection locations called sensor nodes, each of which is tiny, featherweight and portable. A single path routing protocols in wireless sensor network can lead to holes in the network, since only the nodes present in the single path is used for the data transmission. Apart from the advantages like reduced computation, complexity and resource utilization, there are some drawbacks like throughput, increased traffic load and delay in data delivery. Therefore, multipath routing protocols are preferred for WSN. Distributing the traffic among multiple paths increases the network lifetime. We propose a scheme, for the data to be transmitted through a dominant path to save energy. In order to obtain a high delivery ratio, a basic route reconstruction protocol is utilized to reconstruct the path whenever a failure is detected. A basic reconstruction routing (BRR) algorithm is proposed, in which a node can leap over path failure by using the already existing routing information from its neighbourhood while the composed data is transmitted from the source to the sink. In order to save the energy and attain high data delivery ratio, data is transmitted along a multiple path, which is achieved by BRR algorithm whenever a failure is detected. Further, the analysis of how the proposed protocol overcomes the drawback of the existing protocols is presented. The performance of our protocol is compared to AOMDV and energy efficient node-disjoint multipath routing protocol (EENDMRP). The system is implemented using NS-2.34. The simulation results show that the proposed protocol has high delivery ratio with low energy consumption.

Keywords: Multipath routing, WSN, energy efficient routing, alternate route, assured data delivery.

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Authors: Sangram Keshori Mohapatra, Sidhartha Panda, Prasant Kumar Satpathy

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This paper describes the power-system stability improvement by a static synchronous compensator (STATCOM) based damping controller with Differential evolution (DE) algorithm is used to find out the optimal controller parameters. The present study considered both local and remote signals with associated time delays. The performances of the proposed controllers have been compared with different disturbances for both single-machine infinite bus power system and multi-machine power system. The performance of the proposed controllers with variations in the signal transmission delays has also been investigated. To show the effectiveness and robustness of the proposed controller the Simulation results are presented under different disturbances and loading conditions.

Keywords: Controller Design, Differential Evolution Algorithm Static Synchronous Compensator, Time Delay, Power System Stability, Single Machine Infinite-bus Power System, Multi-Machine Power System.

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Authors: Florin Pop

Abstract:

Simulation is a very powerful method used for highperformance and high-quality design in distributed system, and now maybe the only one, considering the heterogeneity, complexity and cost of distributed systems. In Grid environments, foe example, it is hard and even impossible to perform scheduler performance evaluation in a repeatable and controllable manner as resources and users are distributed across multiple organizations with their own policies. In addition, Grid test-beds are limited and creating an adequately-sized test-bed is expensive and time consuming. Scalability, reliability and fault-tolerance become important requirements for distributed systems in order to support distributed computation. A distributed system with such characteristics is called dependable. Large environments, like Cloud, offer unique advantages, such as low cost, dependability and satisfy QoS for all users. Resource management in large environments address performant scheduling algorithm guided by QoS constrains. This paper presents the performance evaluation of scheduling heuristics guided by different optimization criteria. The algorithms for distributed scheduling are analyzed in order to satisfy users constrains considering in the same time independent capabilities of resources. This analysis acts like a profiling step for algorithm calibration. The performance evaluation is based on simulation. The simulator is MONARC, a powerful tool for large scale distributed systems simulation. The novelty of this paper consists in synthetic analysis results that offer guidelines for scheduler service configuration and sustain the empirical-based decision. The results could be used in decisions regarding optimizations to existing Grid DAG Scheduling and for selecting the proper algorithm for DAG scheduling in various actual situations.

Keywords: Scheduling, Simulation, Performance Evaluation, QoS, Distributed Systems, MONARC

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Authors: J. B. V. Subrahmanyam, C. Radhakrishna

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To minimize power losses, it is important to determine the location and size of local generators to be placed in unbalanced power distribution systems. On account of some inherent features of unbalanced distribution systems, such as radial structure, large number of nodes, a wide range of X/R ratios, the conventional techniques developed for the transmission systems generally fail on the determination of optimum size and location of distributed generators (DGs). This paper presents a simple method for investigating the problem of contemporaneously choosing best location and size of DG in three-phase unbalanced radial distribution system (URDS) for power loss minimization and to improve the voltage profile of the system. Best location of the DG is determined by using voltage index analysis and size of DG is computed by variational technique algorithm according to available standard size of DGs. This paper presents the results of simulations for 25-bus and IEEE 37- bus Unbalanced Radial Distribution system.

Keywords: Distributed generator, unbalanced radial distributionsystem, voltage index analysis, variational algorithm.

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Authors: Kheireddine El-Boubbou

Abstract:

Drug delivery to target human acute myeloid leukemia (AML) using a nanoparticulate chemotherapeutic formulation that can deliver drugs selectively to AML cancer is hugely needed. In this work, we report the development of a nanoformulation made of polymeric-stabilized multifunctional magnetic iron oxide nanoparticles (PMNP) loaded with the anticancer drug Doxorubicin (Dox) as a promising drug carrier to treat AML. Dox@PMNP conjugates simultaneously exhibited high drug content, maximized fluorescence, and excellent release properties. Nanoparticulate uptake and cell death following addition of Dox@PMNPs were then evaluated in different types of human AML target cells, as well as on normal human cells. While the unloaded MNPs were not toxic to any of the cells, Dox@PMNPs were found to be highly toxic to the different AML cell lines, albeit at different inhibitory concentrations (IC₅₀ values), but showed very little toxicity towards the normal cells. In comparison, free Dox showed significant potency concurrently to all the cell lines, suggesting huge potentials for the use of Dox@PMNPs as selective AML anticancer cargos. Live confocal imaging, fluorescence and electron microscopy confirmed that Dox is indeed delivered to the nucleus in relatively short periods of time, causing apoptotic cell death. Importantly, this targeted payload may potentially enhance the effectiveness of the drug in AML patients and may further allow physicians to image leukemic cells exposed to Dox@PMNPs using MRI.

Keywords: Magnetic nanoparticles, drug delivery, acute myeloid leukemia, iron oxide, cancer nanotherapy.

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Authors: P. H. Tee, S. M. Zamri, K. M. Kasim, S. K. Tiew

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This study evaluates the management of osteoporosis in a tertiary care government hospital in Malaysia. As the number of admitted patients having osteoporotic fractures is on the rise, osteoporotic medications are an increasing financial burden to government hospitals because they account for half of the orthopedic budget and expenditure. Comprehensive knowledge among practitioners is important to detect early and avoid this preventable disease and its serious complications. The purpose of this study is to evaluate the awareness, knowledge, and practices in managing osteoporosis among practitioners in Hospital Tengku Ampuan Rahimah (HTAR), Klang. A questionnaire from an overseas study in managing osteoporosis among primary care physicians is adapted to Malaysia’s Clinical Practice Guideline of Osteoporosis 2012 (revised 2015) and international guidelines were distributed to all orthopedic practitioners in HTAR Klang (including surgeons, orthopedic medical officers), endocrinologists, rheumatologists and geriatricians. The participants were evaluated on their expertise in the diagnosis, prevention, treatment decision and medications for osteoporosis. Collected data were analyzed for all descriptive and statistical analyses as appropriate. All 45 participants responded to the questionnaire. Participants scored highest on expertise in prevention, followed by diagnosis, treatment decision and lastly, medication. Most practitioners stated that own-initiated continuing professional education from articles and books was the most effective way to update their knowledge, followed by attendance in conferences on osteoporosis. This study confirms the importance of comprehensive training and education regarding osteoporosis among tertiary care physicians and surgeons, predominantly in pharmacotherapy, to deliver wholesome care for osteoporotic patients.

Keywords: Awareness, knowledge, osteoporosis, practices.

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Authors: Dor Oppenheim, Yael Edan, Guy Shani

Abstract:

This paper presents an image analysis algorithm to detect and count yellow tomato flowers in a greenhouse with uneven illumination conditions, complex growth conditions and different flower sizes. The algorithm is designed to be employed on a drone that flies in greenhouses to accomplish several tasks such as pollination and yield estimation. Detecting the flowers can provide useful information for the farmer, such as the number of flowers in a row, and the number of flowers that were pollinated since the last visit to the row. The developed algorithm is designed to handle the real world difficulties in a greenhouse which include varying lighting conditions, shadowing, and occlusion, while considering the computational limitations of the simple processor in the drone. The algorithm identifies flowers using an adaptive global threshold, segmentation over the HSV color space, and morphological cues. The adaptive threshold divides the images into darker and lighter images. Then, segmentation on the hue, saturation and volume is performed accordingly, and classification is done according to size and location of the flowers. 1069 images of greenhouse tomato flowers were acquired in a commercial greenhouse in Israel, using two different RGB Cameras – an LG G4 smartphone and a Canon PowerShot A590. The images were acquired from multiple angles and distances and were sampled manually at various periods along the day to obtain varying lighting conditions. Ground truth was created by manually tagging approximately 25,000 individual flowers in the images. Sensitivity analyses on the acquisition angle of the images, periods throughout the day, different cameras and thresholding types were performed. Precision, recall and their derived F1 score were calculated. Results indicate better performance for the view angle facing the flowers than any other angle. Acquiring images in the afternoon resulted with the best precision and recall results. Applying a global adaptive threshold improved the median F1 score by 3%. Results showed no difference between the two cameras used. Using hue values of 0.12-0.18 in the segmentation process provided the best results in precision and recall, and the best F1 score. The precision and recall average for all the images when using these values was 74% and 75% respectively with an F1 score of 0.73. Further analysis showed a 5% increase in precision and recall when analyzing images acquired in the afternoon and from the front viewpoint.

Keywords: Agricultural engineering, computer vision, image processing, flower detection.

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Authors: Firas Salih, Luban Hameed, Afaf Kamil, Armin Bolz

Abstract:

Diagnostic and detection of the arterial stiffness is very important; which gives indication of the associated increased risk of cardiovascular diseases. To make a cheap and easy method for general screening technique to avoid the future cardiovascular complexes , due to the rising of the arterial stiffness ; a proposed algorithm depending on photoplethysmogram to be used. The photoplethysmograph signals would be processed in MATLAB. The signal will be filtered, baseline wandering removed, peaks and valleys detected and normalization of the signals should be achieved .The area under the catacrotic phase of the photoplethysmogram pulse curve is calculated using trapezoidal algorithm ; then will used in cooperation with other parameters such as age, height, blood pressure in neural network for arterial stiffness detection. The Neural network were implemented with sensitivity of 80%, accuracy 85% and specificity of 90% were got from the patients data. It is concluded that neural network can detect the arterial STIFFNESS depending on risk factor parameters.

Keywords: Arterial stiffness, area under the catacrotic phase of the photoplethysmograph pulse, neural network

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