Search results for: massive weight loss
Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 7422

Search results for: massive weight loss

2922 Reliability and Validity of Determining Ventilatory Threshold and Respiratory Compensation Point by Near-Infrared Spectroscopy

Authors: Tso-Yen Mao, De-Yen Liu, Chun-Feng Huang

Abstract:

Purpose: This research intends to investigate the reliability and validity of ventilatory threshold (VT) and respiratory compensation point (RCP) determined by skeletal muscle hemodynamic status. Methods: One hundred healthy male (age: 22±3 yrs; height: 173.1±6.0 cm; weight: 67.1±10.5 kg) performed graded cycling exercise test which ventilatory and skeletal muscle hemodynamic data were collected simultaneously. VT and RCP were determined by combined V-slope (VE vs. VCO2) and ventilatory efficiency (VE/VO2 vs. VE/VCO2) methods. Pearson correlation, paired t-test, and Bland-Altman plots were used to analyze reliability, validity, and similarities. Statistical significance was set at α =. 05. Results: There are high test-retest correlations of VT and RCP in ventilatory or near-infrared spectroscopy (NIRS) methods (VT vs. VTNIRS: 0.95 vs. 0.94; RCP vs. RCPNIRS: 0.93 vs. 0.93, p<. 05). There are high coefficient of determination at the first timing point of O2Hb decreased (R2 = 0.88, p<. 05) with VT, and high coefficient of determination at the second timing point of O2Hb declined (R2 = 0.89, p< .05) with RCP. VO2 of VT and RCP are not significantly different between ventilatory and NIRS methods (p>. 05). Conclusion: Using NIRS method to determine VT and RCP is reliable and valid in male individuals during graded exercise. Non-invasive skeletal muscle hemodynamics monitor also can be used for controlling training intensity in the future.

Keywords: anaerobic threshold, exercise intensity, hemodynamic, NIRS

Procedia PDF Downloads 318
2921 Facile Hydrothermal Synthesis of Hierarchical NiO/ZnCo₂O₄ Nanocomposite for High-Energy Supercapacitor Applications

Authors: Fayssal Ynineb, Toufik Hadjersi, Fatsah Moulai, Wafa Achour

Abstract:

Currently, tremendous attention has been paid to the rational design and synthesis of core/shell heterostructures for high-performance supercapacitors. In this study, the hierarchical NiO/ZnCo₂O₄ Core-Shell Nanorods Arrays were successfully deposited onto ITO substrate via a two-step hydrothermal and electrodeposition methods. The effect of the thin carbon layer between NiO and ZnCo₂O₄ in this multi-scale hierarchical structure was investigated. The selection of this structure was based on: (i) a high specific area of pseudo-capacitive NiO to maximize specific capacitance; (ii) an effective NiO-electrolyte interface to facilitate fast charging/discharging; and (iii) conducting carbon layer between ZnCo₂O₄ and NiO enhance the electric conductivity which reduces energy loss, and the corrosion protection of ZnCo₂O₄ in alkaline electrolyte. The obtained results indicate that hierarchical NiO/ZnCo₂O₄ present a high specific capacitance of 63 mF.cm⁻² at a current density of 0.05 mA.cm⁻² higher than that of pristine NiO and ZnCo₂O₄ of 6 and 3 mF.cm⁻², respectively. The carbon layer improves the electrical conductivity among NiO and ZnCo₂O₄ in the hierarchical NiO/C/ZnCo₂O₄ electrode. As well, the specific capacitance drastically increased to reach 125 mF.cm⁻². Moreover, this multi-scale hierarchical structure exhibits superior cycling stability with ~ 95.7 % capacitance retention after 65k cycles. These results indicate that the NiO/C/ZnCo₂O₄ nanocomposite material is an outstanding electrode material for supercapacitors.

Keywords: NiO/C/ZnCo₂O₄, specific capacitance, hydrothermal, supercapacitors

Procedia PDF Downloads 102
2920 Perfect Prey: Coercive Control and Subjugation, A Foundation for Dismissing the Truth

Authors: Christine Marie Cocchiola

Abstract:

This study assesses the relationship between coercive control and subjugation. Coercive control is the foundation of most domestic violence and a serious public health problem, having significant legal and social justice ramifications. Beyond the physical, it oftentimes is preceded by or motivated by a need for control. Subjugation, as a personality trait and a maladaptive schema, leads individuals to minimize their own needs or wants and, thereby, often to a loss of autonomy, a dismissal of what one might know to be true. This includes a dismissal of the trademarks of an abusive relationship. Subjugation may contribute to a person engaging in or remaining in a coercively controlling relationship. One hundred fifty-four female survivors of domestic violence participated in this study, assessing their own level of subjugation. Participants were limited to individuals who experienced non-physical abuse in their relationships. Subjugation was attributed as a “concern” or greater in 137 of the 154 participants. 11 participants were interviewed to determine their personal experiences in this abusive relationship. Common themes emerged from interviews, including that the participants worked diligently to fix these abusive relationships by regulating their own behaviors and attempting to please the offender. The results indicate a continued need for advocacy and support of this vulnerable population. Further education is indicated for mental health professionals and for individuals in or having left an abusive relationship on how to identify signs of subjugation, thereby empowering individuals to avoid future experiences of abuse.

Keywords: coercive control, intimate partner violence, subjugation, schemas, gender oppression, autonomy, gaslighting

Procedia PDF Downloads 88
2919 Chongqing's Urban Regeneration for Maintaining the Historic Urban Landscape: Success and Failure of Achieving Sustainable Development

Authors: Hanyu Wei

Abstract:

The last two decades have witnessed a significant number of regeneration practices in historical Chinese cities with the context of rapid urbanisation and economic development. As a response to the possible loss of place identity in the redevelopment process, city makers recognise the potentials of places with cultural significance for maintaining the original landscape. In Chongqing, the prosperities of human settlement history together with the anti-war and post-industrial culture bring this riverside city with its unique urban landscape. Great amounts of historical sites are identified and subjected to conservation planning approaches for urban revitalisation while also maintaining the historic urban landscape. This paper reviews three practices of cultural-led regeneration projects (Hongyadong, Ciqikou, Danzishi) in Chongqing, detailing the urban design and planning principals for the case sites. The paper also presents the conflicting opinions from groups with different interests. By carrying a systematical sustainability evaluation assessment on those projects, the paper critically analyzes the influence of these projects on the broad socio-economic aspects. Although these regeneration cases are thought to achieve the general success in abstaining economic benefits, they are criticised for the over-tourism issues and damages on the authenticity, which further fails to achieve sustainable development.

Keywords: Chongqing, historic urban landscape, sustainable development, urban regeneration

Procedia PDF Downloads 240
2918 Head and Neck Extranodal Rosai-Dorfman Disease- Utility of immunohistochemistry

Authors: Beverly Wang

Abstract:

Background: Rosai-Dorfman disease (RDD), aka sinus histiocytosis with massive lymphadenopathy, is a rare, idiopathic histiocytic proliferative disorder. Although RDD can be seen involving the head and neck lymph nodes, rarely it can affect other extranodal sites. It present 3 unique cases of RDD affecting the nasal cavity, paranasal sinuses, and ear canal. The initial clinical presentation on two cases mimicked a malignant neoplasm. The 3rd case of RDD co-existed with a cholesteatoma of the ear canal. The clinical presentation, histology and immunohistochemical stains, and radiographic findings are discussed. Design: An overview of 3 cases of RDD affected sinonasal cavity and ear canal from UCI Medical Center was conducted. Case 1: A 61 year old male complaining of breathing difficulty presented with bilateral polypoid sinonasal masses and severe nasal obstruction. The masses elevated the nasal floor, and involved the anterior nasal septum to lateral wall. It was endoscopically excised. At intraoperative consultation, frozen section reported a pleomorphic spindle cell neoplasm with scattered large atypical spindle cells, resembling a high grade sarcoma. Case 2: A 46 year old male presented with recurrent bilateral maxillary chronic sinusitis with mass formation, clinically suspicious for malignant lymphoma. Excisional tissue sample showed large irregular spindled histiocytes with abundant granular and vacuolated cytoplasm. Case 3: A 36 year old female with a history of asthma initially presented with left-sided chronic otalgia, occasional nausea, vertigo, and fluctuating pain exacerbated by head movement and temperature changes. CT scan revealed an external auditory canal mass extending to the middle ear, coexisting with a small cholesteatoma. Results: The morphology of all cases revealed large atypical spindled histiocytes resembling fibrohistiocytic or myofibroblastic proliferative neoplasms. Scattered emperipolesis was seen. All 3 cases were confirmed as extranodal sinus RDD, confirmed by immunohistochemistry. The large atypical cells were positive for S100, CD68, and CD163. No evidence for malignancy was identified. Case 3 showed concurrent RDD co-existing with a cholesteatoma. Conclusion: Due to its rarity and variable clinical presentations, the diagnosis of RDD is seldom clinically considered. Extranodal sinus RDD morphologically can be pitfall as mimicker of spindly neoplasm, especially at intraoperative consultation. It can create diagnostic and therapeutic challenges. Correlation of radiological findings with histologic features will help to reach the diagnosis.

Keywords: head and neck, extranodal, rosai-dorfman disease, mimicker, immunohistochemistry

Procedia PDF Downloads 85
2917 Reinforcement Learning Optimization: Unraveling Trends and Advancements in Metaheuristic Algorithms

Authors: Rahul Paul, Kedar Nath Das

Abstract:

The field of machine learning (ML) is experiencing rapid development, resulting in a multitude of theoretical advancements and extensive practical implementations across various disciplines. The objective of ML is to facilitate the ability of machines to perform cognitive tasks by leveraging knowledge gained from prior experiences and effectively addressing complex problems, even in situations that deviate from previously encountered instances. Reinforcement Learning (RL) has emerged as a prominent subfield within ML and has gained considerable attention in recent times from researchers. This surge in interest can be attributed to the practical applications of RL, the increasing availability of data, and the rapid advancements in computing power. At the same time, optimization algorithms play a pivotal role in the field of ML and have attracted considerable interest from researchers. A multitude of proposals have been put forth to address optimization problems or improve optimization techniques within the domain of ML. The necessity of a thorough examination and implementation of optimization algorithms within the context of ML is of utmost importance in order to provide guidance for the advancement of research in both optimization and ML. This article provides a comprehensive overview of the application of metaheuristic evolutionary optimization algorithms in conjunction with RL to address a diverse range of scientific challenges. Furthermore, this article delves into the various challenges and unresolved issues pertaining to the optimization of RL models.

Keywords: machine learning, reinforcement learning, loss function, evolutionary optimization techniques

Procedia PDF Downloads 83
2916 Using Passive Cooling Strategies to Reduce Thermal Cooling Load for Coastal High-Rise Buildings of Jeddah, Saudi Arabia

Authors: Ahmad Zamzam

Abstract:

With the development of the economy in recent years, Saudi Arabia has been maintaining high economic growth. Therefore, its energy consumption has increased dramatically. This economic growth reflected on the expansion of high-rise tower's construction. Jeddah coastal strip (cornice) has many high-rise buildings planned to start next few years. These projects required a massive amount of electricity that was not planned to be supplied by the old infrastructure. This research studies the effect of the building envelope on its thermal performance. It follows a parametric simulation methodology using Ecotect software to analyze the effect of the building envelope design on its cooling energy load for an office high-rise building in Jeddah, Saudi Arabia, which includes building geometrical form, massing treatments, orientation and glazing type effect. The research describes an integrated passive design approach to reduce the cooling requirement for high-rise building through an improved building envelope design. The research used Ecotect to make four simulation studies; the first simulation compares the thermal performance of five high-rise buildings, presenting the basic shape of the plan. All the buildings have the same plan area and same floor height. The goal of this simulation is to find out the best shape for the thermal performance. The second simulation studies the effect of orientation on the thermal performance by rotating the same building model to find out the best and the worst angle for the building thermal performance. The third simulation studies the effect of the massing treatment on the total cooling load. It compared five models with different massing treatment, but with the same total built up area. The last simulation studied the effect of the glazing type by comparing the total cooling load of the same building using five different glass type and also studies the feasibility of using these glass types by studying the glass cost effect. The results indicate that using the circle shape as building plan could reduce the thermal cooling load by 40%. Also, using shading devices could reduce the cooling loads by 5%. The study states that using any of the massing grooving, recess or any treatment that could increase the outer exposed surface is not preferred and will decrease the building thermal performance. Also, the result shows that the best direction for glazing and openings from thermal performance viewpoint in Jeddah is the North direction while the worst direction is the East one. The best direction angle for openings - regarding the thermal performance in Jeddah- is 15 deg West and the worst is 250 deg West (110 deg East). Regarding the glass type effect, comparing to the double glass with air fill type as a reference case, the double glass with Air-Low-E will save 14% from the required amount of the thermal cooling load annually. Argon fill and triple glass will save 16% and 17% from the total thermal cooling load respectively, but for the glass cost purpose, using the Argon fill and triple glass is not feasible.

Keywords: passive cooling, reduce thermal load, Jeddah, building shape, energy

Procedia PDF Downloads 132
2915 Improving the Run Times of Existing and Historical Demand Models Using Simple Python Scripting

Authors: Abhijeet Ostawal, Parmjit Lall

Abstract:

The run times for a large strategic model that we were managing had become too long leading to delays in project delivery, increased costs and loss in productivity. Software developers are continuously working towards developing more efficient tools by changing their algorithms and processes. The issue faced by our team was how do you apply the latest technologies on validated existing models which are based on much older versions of software that do not have the latest software capabilities. The multi-model transport model that we had could only be run in sequential assignment order. Recent upgrades to the software now allowed the assignment to be run in parallel, a concept called parallelization. Parallelization is a Python script working only within the latest version of the software. A full model transfer to the latest version was not possible due to time, budget and the potential changes in trip assignment. This article is to show the method to adapt and update the Python script in such a way that it can be used in older software versions by calling the latest version and then recalling the old version for assignment model without affecting the results. Through a process of trial-and-error run time savings of up to 30-40% have been achieved. Assignment results were maintained within the older version and through this learning process we’ve applied this methodology to other even older versions of the software resulting in huge time savings, more productivity and efficiency for both client and consultant.

Keywords: model run time, demand model, parallelisation, python scripting

Procedia PDF Downloads 124
2914 Effect of Shrinkage on Heat and Mass Transfer Parameters of Solar Dried Potato Samples of Variable Diameter

Authors: Kshanaprava Dhalsamant, Punyadarshini P. Tripathy, Shanker L. Shrivastava

Abstract:

Potato is chosen as the food product for carrying out the natural convection mixed-mode solar drying experiments since they are easily available and globally consumed. The convective heat and mass transfer coefficients along with effective diffusivity were calculated considering both shrinkage and without shrinkage for the potato cylinders of different geometry (8, 10 and 13 mm diameters and a constant length of 50 mm). The convective heat transfer coefficient (hc) without considering shrinkage effect were 24.28, 18.69, 15.89 W/m2˚C and hc considering shrinkage effect were 37.81, 29.21, 25.72 W/m2˚C for 8, 10 and 13 mm diameter samples respectively. Similarly, the effective diffusivity (Deff) without considering shrinkage effect were 3.20×10-9, 4.82×10-9, 2.48×10-8 m2/s and Deff considering shrinkage effect were 1.68×10-9, 2.56×10-9, 1.34×10-8 m2/s for 8, 10 and 13 mm diameter samples respectively and the mass transfer coefficient (hm) without considering the shrinkage effect were 5.16×10-7, 2.93×10-7, 2.59×10-7 m/s and hm considering shrinkage effect were 3.71×10-7, 2.04×10-7, 1.80×10-7 m/s for 8, 10 and 13 mm diameter samples respectively. Increased values of hc were obtained by considering shrinkage effect in all diameter samples because shrinkage results in decreasing diameter with time achieving in enhanced rate of water loss. The average values of Deff determined without considering the shrinkage effect were found to be almost double that with shrinkage effect. The reduction in hm values is due to the fact that with increasing sample diameter, the exposed surface area per unit mass decreases, resulting in a slower moisture removal. It is worth noting that considering shrinkage effect led to overestimation of hc values in the range of 55.72-61.86% and neglecting the shrinkage effect in the mass transfer analysis, the values of Deff and hm are overestimated in the range of 85.02-90.27% and 39.11-45.11%, respectively, for the range of sample diameter investigated in the present study.

Keywords: shrinkage, convective heat transfer coefficient, effectivive diffusivity, convective mass transfer coefficient

Procedia PDF Downloads 261
2913 Determination of Verapamil Hydrochloride in Tablets and Injection Solutions With the Verapamil-Selective Electrode and Possibilities of Application in Pharmaceutical Analysis

Authors: Faisal A. Salih

Abstract:

Verapamil hydrochloride (Ver) is a drug used in medicine for arrythmia, angina and hypertension as a calcium channel blocker. For the quantitative determination of Ver in dosage forms, the HPLC method is most often used. A convenient alternative to the chromatographic method is potentiometry using a Verselective electrode, which does not require expensive equipment, can be used without separation from the matrix components, which significantly reduces the analysis time, and does not use toxic organic solvents, being a "green", "environmentally friendly" technique. It has been established in this study that the rational choice of the membrane plasticizer and the preconditioning and measurement algorithms, which prevent nonexchangeable extraction of Ver into the membrane phase, makes it possible to achieve excellent analytical characteristics of Ver-selective electrodes based on commercially available components. In particular, an electrode with the following membrane composition: PVC (32.8 wt %), ortho-nitrophenyloctyl ether (66.6 wt %), and tetrakis-4-chlorophenylborate (0.6 wt % or 0.01 M) have the lower detection limit 4 × 10−8 M and potential reproducibility 0.15–0.22 mV. Both direct potentiometry (DP) and potentiometric titration (PT) methods can be used for the determination of Ver in tablets and injection solutions. Masses of Ver per average tablet weight determined by the methods of DP and PT for the same set of 10 tablets were (80.4±0.2 and80.7±0.2) mg, respectively. The masses of Ver in solutions for injection, determined by DP for two ampoules from one set, were (5.00±0.015 and 5.004±0.006) mg. In all cases, good reproducibility and excellent correspondence with the declared quantities were observed.

Keywords: verapamil, potentiometry, ion-selective electrode, pharmaceutical analysis

Procedia PDF Downloads 92
2912 Fraud Detection in Credit Cards with Machine Learning

Authors: Anjali Chouksey, Riya Nimje, Jahanvi Saraf

Abstract:

Online transactions have increased dramatically in this new ‘social-distancing’ era. With online transactions, Fraud in online payments has also increased significantly. Frauds are a significant problem in various industries like insurance companies, baking, etc. These frauds include leaking sensitive information related to the credit card, which can be easily misused. Due to the government also pushing online transactions, E-commerce is on a boom. But due to increasing frauds in online payments, these E-commerce industries are suffering a great loss of trust from their customers. These companies are finding credit card fraud to be a big problem. People have started using online payment options and thus are becoming easy targets of credit card fraud. In this research paper, we will be discussing machine learning algorithms. We have used a decision tree, XGBOOST, k-nearest neighbour, logistic-regression, random forest, and SVM on a dataset in which there are transactions done online mode using credit cards. We will test all these algorithms for detecting fraud cases using the confusion matrix, F1 score, and calculating the accuracy score for each model to identify which algorithm can be used in detecting frauds.

Keywords: machine learning, fraud detection, artificial intelligence, decision tree, k nearest neighbour, random forest, XGBOOST, logistic regression, support vector machine

Procedia PDF Downloads 153
2911 Managing Subretinal Bleeds with Intravitreal Aflibercept

Authors: Prachi Abhishek Dave, Abhishek Dave

Abstract:

Purpose: The purpose of this study is to elucidate the role of intravitreal injection Aflibercept in managing complex cases of Wet Age Related Macular Degeneration (ARMD) and the gratifying visual recovery experienced with a minimally invasive procedure. Methods: A 73-year-old gentleman presented with a drop in vision in the left eye for 25 days. On examination, his best corrected visual acuity (BCVA) in the Right eye (OD) was 6/60, and finger counting close to face in the Left eye (OS). On multimodal imaging, he was diagnosed to have a scarred Wet ARMD in OD and an active Wet ARMD with a large subretinal bleed secondary to Wet ARMD in OS. Treatment management options included monotherapy with an Injection Aflibercept or an intravitreal gas injection with tPA followed by Injection Aflibercept. Considering his one-eyed status, the patient decided to go for Aflibercept monotherapy. Results: After 3 monthly injections of injection Aflibercept, the subretinal bleed reduced, the subretinal fluid resolved, and his vision in OS improved to 6/9. He is on a regular follow-up and has not needed any further injections in OS and he maintains 6/9 vision. Conclusions: Conventional treatment guidelines for a large subretinal bleed dictate the use of gas followed by intravitreal Injection Aflibercept. However, gas has its own limitations of causing a rise in intraocular pressure and a transient loss of vision, which is particularly troublesome in one-eyed patients. Injection Aflibercept offers a much safer, less invasive, and elegant treatment option for such patients with equally good or even better visual outcomes.

Keywords: wet ARMD, subretinal bleed, intravitreal injections, aflibercept, EYELEA, intravitreal gas

Procedia PDF Downloads 47
2910 Fault Tolerant Control System Using a Multiple Time Scale SMC Technique and a Geometric Approach

Authors: Ghodbane Azeddine, Saad Maarouf, Boland Jean-Francois, Thibeault Claude

Abstract:

This paper proposes a new design of an active fault-tolerant flight control system against abrupt actuator faults. This overall system combines a multiple time scale sliding mode controller for fault compensation and a geometric approach for fault detection and diagnosis. The proposed control system is able to accommodate several kinds of partial and total actuator failures, by using available healthy redundancy actuators. The overall system first estimates the correct fault information using the geometric approach. Then, and based on that, a new reconfigurable control law is designed based on the multiple time scale sliding mode technique for on-line compensating the effect of such faults. This approach takes advantages of the fact that there are significant difference between the time scales of aircraft states that have a slow dynamics and those that have a fast dynamics. The closed-loop stability of the overall system is proved using Lyapunov technique. A case study of the non-linear model of the F16 fighter, subject to the rudder total loss of control confirms the effectiveness of the proposed approach.

Keywords: actuator faults, fault detection and diagnosis, fault tolerant flight control, sliding mode control, multiple time scale approximation, geometric approach for fault reconstruction, lyapunov stability

Procedia PDF Downloads 375
2909 Influence of Processing Parameters on the Reliability of Sieving as a Particle Size Distribution Measurements

Authors: Eseldin Keleb

Abstract:

In the pharmaceutical industry particle size distribution is an important parameter for the characterization of pharmaceutical powders. The powder flowability, reactivity and compatibility, which have a decisive impact on the final product, are determined by particle size and size distribution. Therefore, the aim of this study was to evaluate the influence of processing parameters on the particle size distribution measurements. Different Size fractions of α-lactose monohydrate and 5% polyvinylpyrrolidone were prepared by wet granulation and were used for the preparation of samples. The influence of sieve load (50, 100, 150, 200, 250, 300, and 350 g), processing time (5, 10, and 15 min), sample size ratios (high percentage of small and large particles), type of disturbances (vibration and shaking) and process reproducibility have been investigated. Results obtained showed that a sieve load of 50 g produce the best separation, a further increase in sample weight resulted in incomplete separation even after the extension of the processing time for 15 min. Performing sieving using vibration was rapider and more efficient than shaking. Meanwhile between day reproducibility showed that particle size distribution measurements are reproducible. However, for samples containing 70% fines or 70% large particles, which processed at optimized parameters, the incomplete separation was always observed. These results indicated that sieving reliability is highly influenced by the particle size distribution of the sample and care must be taken for samples with particle size distribution skewness.

Keywords: sieving, reliability, particle size distribution, processing parameters

Procedia PDF Downloads 617
2908 Effect of Dietary Supplementation of Allium Hookeri Root and Processed Sulfur on the Growth Performance of Guinea Pigs

Authors: Nayeon, Lee, Won-Young, Cho, Hyun Joo, Jang, Chi-Ho, Lee

Abstract:

This study investigated the effects of the dietary supplementation of the Allium hookeri root, and processed sulfur, on the growth performance of guinea pigs. The guinea pigs were fed a control diet (CON), as well as the control diet including 1% freeze-dried Allium hookeri root (AH), or 0.1% processed sulfur (S), or including both the freeze-dried Allium hookeri root and the processed sulfur (AHS). The weight of perirenal adipose tissue (PAT) and the epididymal adipose tissue (EAT) in the AH were significantly lower than CON (p < 0.05). The serum cholesterols levels of the AH and the AHS were significantly lower than the S (p < 0.05). While the total saturated fatty acid content in the serum of the AH and AHS groups showed a tendency to decrease, the total monounsaturated fatty acid increased. The results of this study suggested that dietary consumption of Allium hookeri root may help to decrease fat accumulation, lower serum cholesterol levels, and control serum free fatty acid contents in the guinea pigs.

Keywords: Allium hookeri, dietary supplementation, growth performance, processed sulfur, Guinea pig

Procedia PDF Downloads 271
2907 Serum Levels of Plasminogen Activator Inhibitor-1 (PAI-1) Are Increased in Alzheimer’s Disease and MCI Patients and Correlate With Cognitive Deficits

Authors: Francesco Angelucci, Katerina Veverova, Alžbeta Katonová, Lydia Piendel, Martin Vyhnalek, Jakub Hort

Abstract:

Alzheimer's disease (AD) is a central nervous system (CNS) disease characterized by loss of memory, cognitive functions and neurodegeneration. Plasmin is an enzyme degrading many plasma proteins. In the CNS, plasmin may reduce the accumulation of A, and have other actions relevant to AD pathophysiology. Brain plasmin synthesis is regulated by two enzymes: one activating, the tissue plasminogen activator (tPA), and the other inhibiting, the plasminogen activator inhibitor-1 (PAI-1). We investigated whether tPA and PAI-1 serum levels in AD and amnestic mild cognitive impairment (aMCI) patients are altered compared to cognitively healthy controls. Moreover, we examined the PAI-1/tPA ratio in these patient groups. 40 AD, 40 aMCI and 10 healthy controls were recruited. Venous blood was collected and PAI-1 and tPA serum concentrations were quantified by sandwich ELISAs. The results showed that PAI-1 levels increased in AD and aMCI patients. This increase negatively correlated with cognitive deficit measured by MMSE. Similarly, the ratio between tPA and PAI-1 gradually increases in aMCI and AD patients. This study demonstrates that AD and aMCI patients have altered PAI-1 serum levels and PAI-1/tPA ratio. Since these enzymes are CNS regulators of plasmin, PAI-1 serum levels could be a marker reflecting a cognitive decline in AD.

Keywords: Alzheimer disease, amnestic mild cognitive impairment, plasmin, tissue-type plasminogen activator

Procedia PDF Downloads 85
2906 Speed Control of DC Motor Using Optimization Techniques Based PID Controller

Authors: Santosh Kumar Suman, Vinod Kumar Giri

Abstract:

The goal of this paper is to outline a speed controller of a DC motor by choice of a PID parameters utilizing genetic algorithms (GAs), the DC motor is extensively utilized as a part of numerous applications such as steel plants, electric trains, cranes and a great deal more. DC motor could be represented by a nonlinear model when nonlinearities such as attractive dissemination are considered. To provide effective control, nonlinearities and uncertainties in the model must be taken into account in the control design. The DC motor is considered as third order system. Objective of this paper three type of tuning techniques for PID parameter. In this paper, an independently energized DC motor utilizing MATLAB displaying, has been outlined whose velocity might be examined utilizing the Proportional, Integral, Derivative (KP, KI , KD) addition of the PID controller. Since, established controllers PID are neglecting to control the drive when weight parameters be likewise changed. The principle point of this paper is to dissect the execution of optimization techniques viz. The Genetic Algorithm (GA) for improve PID controllers parameters for velocity control of DC motor and list their points of interest over the traditional tuning strategies. The outcomes got from GA calculations were contrasted and that got from traditional technique. It was found that the optimization techniques beat customary tuning practices of ordinary PID controllers.

Keywords: DC motor, PID controller, optimization techniques, genetic algorithm (GA), objective function, IAE

Procedia PDF Downloads 426
2905 Comparative Analysis of Three Types of Recycled Aggregates and its Use in Masonry Mortar Fabrication

Authors: Mariano Gonzalez Cortina, Pablo Saiz Martinez, Francisco Fernandez Martinez, Antonio Rodriguez Sanchez

Abstract:

Construction sector incessant activity of the last years preceding the crisis has originated a high waste generation and an increased use of raw materials. The main aim of this research is to compare three types of recycled aggregates and the feasibility to incorporate them into masonry mortar fabrication. The tests were developed using two types of binders: CEM II/B-L 32.5 N and CEM IV/B (V) 32.5 N. 50%, 75% and 100% of natural sand were replaced with three types of recycled aggregates. Cement-to-aggregate by dry weight proportions were 1:3 and 1:4. Physical and chemical characterization of recycled aggregates showed continues particle size distribution curve, lower density and higher absorption, which was the reason to use additive to obtain required mortar consistency. Main crystalline phases determined in the X-Ray diffraction test were calcite, quartz, and gypsum. Performed tests show that cement-based mortars fabricated with CEM IV/B (V) 32. 5 N can incorporate recycled aggregates coming from ceramic, concrete and mixed recycling processes, using 1:3 and 1:4 cement-to-aggregate proportions, complying with the limits established by the Spanish standards. It was concluded that recycled mortar coming from concrete recycling process is the one which presents better characteristics.

Keywords: construction and demolition waste, masonry mortar, mechanical properties, recycled aggregate, waste treatment

Procedia PDF Downloads 428
2904 Carbon Fibre Reinforced Polymers Modified with PET-G/MWCNTs Nonwovens

Authors: Kamil Dydek, Szymon Demski, Kamil Majchrowicz, Paulina Kozera, Bogna Sztorch, Dariusz Brząkalski, Zuzanna Krawczyk, Robert Przekop, Anna Boczkowska

Abstract:

Carbon fibre reinforced polymers (CFRPs) are characterized by very high strength and stiffness in relation to their weight. In addition, properties such as corrosion resistance and low thermal expansion allow them to replace traditional materials, i.e., wood or metals, in many industries such as aerospace, automotive, marine, and sports goods. However, CFRPs, have some disadvantages -they have relatively low electrical conductivity and break brittle, which significantly limits their application possibilities. Moreover, conventional CFRPs are usually manufactured based on thermosets, which makes them difficult to recycle. The solution to these drawbacks is the use of the innovative thermoplastic resin (ELIUM from ARKEMA) as a matrix of composites and the modification by introducing into their structure thermoplastic nonwovens based on PET-G with the addition of multi-wall carbon nanotubes (MWCNTs). The acrylic-carbon composites, which were produced by the infusion technique, were tested for mechanical, thermo-mechanical, and electrical properties, and the effect of modifications on their microstructure was studied. Acknowledgment: This study was carried out with funding from grant no. LIDER/46/0185/L-11/19/NCBR/2020, financed by The National Centre for Research and Development.

Keywords: CFRP, MWCNT, ELIUM, electrical properties, infusion

Procedia PDF Downloads 143
2903 Mechanical Properties and Chloride Diffusion of Ceramic Waste Aggregate Mortar Containing Ground Granulated Blast-Furnace Slag

Authors: H. Higashiyama, M. Sappakittipakorn, M. Mizukoshi, O. Takahashi

Abstract:

Ceramic waste aggregates (CWAs) were made from electric porcelain insulator wastes supplied from an electric power company, which were crushed and ground to fine aggregate sizes. In this study, to develop the CWA mortar as an eco–efficient, ground granulated blast–furnace slag (GGBS) as a supplementary cementitious material (SCM) was incorporated. The water–to–binder ratio (W/B) of the CWA mortars was varied at 0.4, 0.5, and 0.6. The cement of the CWA mortar was replaced by GGBS at 20 and 40% by volume (at about 18 and 37% by weight). Mechanical properties of compressive and splitting tensile strengths, and elastic modulus were evaluated at the age of 7, 28, and 91 days. Moreover, the chloride ingress test was carried out on the CWA mortars in a 5.0% NaCl solution for 48 weeks. The chloride diffusion was assessed by using an electron probe microanalysis (EPMA). To consider the relation of the apparent chloride diffusion coefficient and the pore size, the pore size distribution test was also performed using a mercury intrusion porosimetry at the same time with the EPMA. The compressive strength of the CWA mortars with the GGBS was higher than that without the GGBS at the age of 28 and 91 days. The resistance to the chloride ingress of the CWA mortar was effective in proportion to the GGBS replacement level.

Keywords: ceramic waste aggregate, chloride diffusion, GGBS, pore size distribution

Procedia PDF Downloads 347
2902 Exploring the Impact of Tillage and Manure on Soil Water Retention and Van Genuchten

Authors: Azadeh Safadoust, Ali Akbar Mahboubi

Abstract:

A study was conducted to evaluate hydraulic properties of a sandy loam soil and corn (Zea mays L.) crop production under a short-term tillage and manure combinations field experiment carried out in west of Iran. Treatments included composted cattle manure application rates [0, 30, and 60 Mg (dry weight) ha-1] and tillage systems [no-tillage (NT), chisel plowing (CP), and moldboard plowing (MP)] arranged in a split-plot design. Soil water characteristic curve (SWCC) and saturated hydraulic conductivity (Ks) were significantly affected by manure and tillage treatments. At any matric suction, the soil water content was in the order of MP>CP>NT. At all matric suctions, the amount of water retained by the soil increased as manure application rate increased (i.e. 60>30>0 Mg ha-1). Similar to the tillage effects, at high suctions the differences of water retained due to manure addition were less than that at low suctions. The change of SWCC from tillage methods and manure applications may attribute to the change of pore size and aggregate size distributions. Soil Ks was in the order of CP>MP>NT for the first two layers and in the order of MP>CP and NT for the deeper soil layer. The Ks also increased with increasing rates of manure application (i.e. 60>30>0 Mg ha-1). This was due to the increase in the total pore size and continuity.

Keywords: corn, manure, saturated hydraulic conductivity, soil water characteristic curve, tillage

Procedia PDF Downloads 83
2901 Experimental Lead Toxicity in Lohi Sheep: Risks and Impact on Edible Tissues

Authors: Muhammad Younus, Muhammad Sajid, Muti-ur-Rehman Khan, Aftab Ahmad Anjum, Muhammad Asif Idrees, Iahtasham Khan, Aman Ullah Khan, Sajid Umar, Raheela Akhtar

Abstract:

The present study was conducted to investigate the hazardous effects of lead on health and edible organs of Lohi sheep. The adult Lohi sheep (n=48) were randomly divided into two equal groups. The first group was administered lead acetate at dose of 70 mg/kg live body weight daily as 10% solution by oral route for a period of 90 days and the second group served as a negative control. Blood and tissue samples were collected at day 0, 30, 60 and 90 and analyzed for lead concentration by atomic absorption spectrophotometry. The kidney showed the highest lead concentration (p < 0.05) followed by liver and then muscle. Lead acetate treated sheep showed structural and behavioral changes during the last month of trial. Liver showed necrosis, hemorrhages and hyperactivation of macrophages. Kidney showed degenerative and necrotic changes in glomeruli and tubules and the characteristic intranuclear inclusion bodies in tubular epithelial cells on H and E staining. It was concluded that Lohi sheep is affected by lead intoxication at low dose for longer period and hence exhibits lead accumulation in edible tissues.

Keywords: Lohi sheep, lead acetate, edible tissue, histopathology

Procedia PDF Downloads 458
2900 Effect of Pulverised Burnt Clay Waste Fineness on the Compressive Strength of Concrete

Authors: Emmanuel Onaivi Ajayi, Adewumi John Babafemi

Abstract:

The use of supplementary cementitious materials as partial replacement for cement is steadily increasing in the construction industry. Concrete produced with these materials has shown significant improvement in durability compared to conventional concrete. However, blended cement concretes produced using these supplementary materials typically gain compressive strength at later ages beyond the 28-day, and this does not favour its use when early age strength is required. Improving the fineness of the supplementary materials could be a way to improving the strength performance of its blended cement concrete. In this paper, the effect of pulverised burnt clay waste fineness on the compressive strength of concrete has been investigated. Two different fineness of pulverised burnt clay waste classified as coarse and fine portions were obtained by sieving the original pulverised burnt clay waste portion through sieve sizes No. 100 (150 µm) and No. 200 (75 µm), respectively. Pulverised burnt clay waste dosages of 0% (control), 10% and 20% by weight of binder were used in producing the concrete mixtures. It is found that the compressive strength of the concrete depends on the fineness and proportion of pulverised burnt clay waste. The result shows improvement in compressive strength at all curing ages with the fine portion pulverised burnt clay waste having the highest strength and improved early age compressive strength.

Keywords: pulverized burnt clay waste, supplementary cementitious materials, compressive strength, pozzolans, fineness

Procedia PDF Downloads 366
2899 Financial Intermediation: A Transaction Two-Sided Market Model Approach

Authors: Carlo Gozzelino

Abstract:

Since the early 2000s, the phenomenon of the two-sided markets has been of growing interest in academic literature as such kind of markets differs by having cross-side network effects and same-side network effects characterizing the transactions, which make the analysis different when compared to traditional seller-buyer concept. Due to such externalities, pricing strategies can be based on subsidizing the participation of one side (i.e. considered key for the platform to attract the other side) while recovering the loss on the other side. In recent years, several players of the Italian financial intermediation industry moved from an integrated landscape (i.e. selling their own products) to an open one (i.e. intermediating third party products). According to academic literature such behavior can be interpreted as a merchant move towards a platform, operating in a two-sided market environment. While several application of two-sided market framework are available in academic literature, purpose of this paper is to use a two-sided market concept to suggest a new framework applied to financial intermediation. To this extent, a model is developed to show how competitors behave when vertically integrated and how the peculiarities of a two-sided market act as an incentive to disintegrate. Additionally, we show that when all players act as a platform, the dynamics of a two-sided markets can allow at least a Nash equilibrium to exist, in which platform of different sizes enjoy positive profit. Finally, empirical evidences from Italian market are given to sustain – and to challenge – this interpretation.

Keywords: financial intermediation, network externalities, two-sided markets, vertical differentiation

Procedia PDF Downloads 162
2898 Evaluation of Green Logistics Performance: An Application of Analytic Hierarchy Process Method for Ranking Environmental Indicators

Authors: Eduarda Dutra De Souza, Gabriela Hammes, Marina Bouzon, Carlos M. Taboada Rodriguez

Abstract:

The search for minimizing harmful impacts on the environment has become the focus of global society, affecting mainly how to manage organizations. Thus, companies have sought to transform their activities into environmentally friendly initiatives by applying green practices throughout their supply chains. In the logistics domain, the implementation of environmentally sound practices is still in its infancy in emerging countries such as Brazil. Given the need to reduce these environmental damages, this study aims to evaluate the performance of green logistics (GL) in the plastics industry sector in order to help to improve environmental performance within organizations and reduce the impact caused by their activities. The performance tool was based on theoretical research and the use of experts in the field. The Analytic Hierarchy Process (AHP) was used to prioritize green practices and assign weight to the indicators contained in the proposed tool. The tool also allows the co-production of a single indicator. The developed tool was applied in an industry of the plastic packaging sector. However, this tool may be applied in different industry sectors, and it is adaptable to different sizes of companies. Besides the contributions to the literature, this work also presents future paths of research in the field of green logistics.

Keywords: AHP, green logistics, green supply chain, performance evaluation

Procedia PDF Downloads 165
2897 The Elastic Field of a Nano-Pore, and the Effective Modulus of Composites with Nano-Pores

Authors: Xin Chen, Moxiao Li, Xuechao Sun, Fei Ti, Shaobao Liu, Feng Xu, Tian Jian Lu

Abstract:

The composite materials with pores have the characteristics of light weight, sound insulation, and heat insulation, and have broad prospects in many fields, including aerospace. In general, the stiffness of such composite is less than the stiffness of the matrix material, limiting their applications. In this paper, we establish a theoretical model to analyze the deformation mechanism of a nano-pore. The interface between the pores and matrix material is described by the Gurtin-Murdoch model. By considering scale effect related with current deformation, we estimate the effective mechanical properties (e.g., effective shear modulus and bulk modulus) of a composite with nano-pores. Due to the scale effect, the elastic field in the composite was changed and local hardening was observed around the nano-pore, and the effective shear modulus and effective bulk modulus were found to be a function of the surface energy. The effective shear modulus increase with the surface energy and decrease with the size of the nano-pores, and the effective bulk modulus decrease with the surface energy and increase with the size of the nano-pores. These results have potential applications in the nanocomposite mechanics and aerospace field.

Keywords: composite mechanics, nano-inhomogeneity, nano-pores, scale effect

Procedia PDF Downloads 139
2896 Machine Learning Algorithms for Rocket Propulsion

Authors: Rômulo Eustáquio Martins de Souza, Paulo Alexandre Rodrigues de Vasconcelos Figueiredo

Abstract:

In recent years, there has been a surge in interest in applying artificial intelligence techniques, particularly machine learning algorithms. Machine learning is a data-analysis technique that automates the creation of analytical models, making it especially useful for designing complex situations. As a result, this technology aids in reducing human intervention while producing accurate results. This methodology is also extensively used in aerospace engineering since this is a field that encompasses several high-complexity operations, such as rocket propulsion. Rocket propulsion is a high-risk operation in which engine failure could result in the loss of life. As a result, it is critical to use computational methods capable of precisely representing the spacecraft's analytical model to guarantee its security and operation. Thus, this paper describes the use of machine learning algorithms for rocket propulsion to aid the realization that this technique is an efficient way to deal with challenging and restrictive aerospace engineering activities. The paper focuses on three machine-learning-aided rocket propulsion applications: set-point control of an expander-bleed rocket engine, supersonic retro-propulsion of a small-scale rocket, and leak detection and isolation on rocket engine data. This paper describes the data-driven methods used for each implementation in depth and presents the obtained results.

Keywords: data analysis, modeling, machine learning, aerospace, rocket propulsion

Procedia PDF Downloads 119
2895 Evaluation of Chromium Fortified-Parboiled Rice Coated with Herbal Extracts: Resistant Starch, and Glycemic Index

Authors: Wisnu Adi Yulianto, Chatarina Lilis Suryani, Mamilisti Susiati, Hendy Indra Permana

Abstract:

Parboiled rice was developed to produce rice that has low glycemic index, especially for diabetics. Yet, parboiled rice is not enough because diabetics also lack of chromium. The sign of chromium (Cr) deficiency in diabetics is impaired glucose tolerance. Cr fortification was done for increasing Cr content in rice. Naturally-occurring compounds that have been proven to improve insulin sensitivity include Cr and polyphenol found in cinnamon, pandan and bay leaf. This research aimed to evaluate content of resistant starch and glycemic index of Cr - fortified - parboiled rice (Cr-PR) coated with herbal extracts. Variety of unhulled rice and forticant used in the experiment were Ciherang and CrCl3, respectively. Three herbal extracts used were cinnamon, pandan and bay leaf. Each concentration of herbal extracts in the amount of 3%, 6%, and 9% were added in the coating substance to coat Cr-PR. Resistant starch (RS) content was determined by enzymatic process through glucooxydase method. Testing of the GI was conducted on 18 non-diabetic volunteers. RS content of Cr-PR coated with herbal extracts ranged between 8.27 – 8.84 % (dry weight). Cr-PR coated with all herbal extracts of 3% concentration had higher RS content than the ones with herbal extracts of 6% and 9% concentration (P <0.05). Value of the rice GI ranged 29 - 40. The lowest GI (29-30) was attained by the rice coated with enrichment of 6-9% cinnamon extract.

Keywords: coating, Cr-fortified-parboiled rice, glycemic index, herbal extracts, resistant starch

Procedia PDF Downloads 364
2894 An Investigation of Raw Material Effects on Nano SiC Based Foam Glass Production

Authors: Aylin Sahin, Yasemin Kilic, Abdulkadir Sari, Burcu Duymaz, Mustafa Kara

Abstract:

Foam glass is an innovative material which composed of glass and carbon/carbonate based minerals; and has incomparable properties like light weight, high thermal insulation and cellular structure with sufficient rigidity. In the present study, the effects of the glass type and mineral addition on the foam glass properties were investigated. Nano sized SiC was fixed as foaming agent at the whole of the samples, mixed glass waste and sheet glass were selectively used as glass sources; finally Al₂O₃ was optionally used as mineral additive. These raw material powders were mixed homogenously, pressed at same pressure and sintered at same schedule. Finally, obtained samples were characterized based on the required properties of foam glass material, and optimum results were determined. At the end of the study, 0.049 W/mK thermal conductivity, 72 % porosity, and 0.21 kg/cm² apparent density with 2.41 MPa compressive strength values were achieved with using nano sized SiC, sheet glass and Al₂O₃ mineral additive. It can be said that the foam glass materials can be preferred as an alternative insulation material rather than polymeric based conventional insulation materials because of supplying high thermal insulation properties without containing unhealthy chemicals and burn risks.

Keywords: foam glass, foaming, silicon carbide, waste glass

Procedia PDF Downloads 375
2893 Synthesis and Performance Adsorbent from Coconut Shells Polyetheretherketone for Natural Gas Storage

Authors: Umar Hayatu Sidik

Abstract:

The natural gas vehicle represents a cost-competitive, lower-emission alternative to the gasoline-fuelled vehicle. The immediate challenge that confronts natural gas is increasing its energy density. This paper addresses the question of energy density by reviewing the storage technologies for natural gas with improved adsorbent. Technical comparisons are made between storage systems containing adsorbent and conventional compressed natural gas based on the associated amount of moles contained with Compressed Natural Gas (CNG) and Adsorbed Natural Gas (ANG). We also compare gas storage in different cylinder types (1, 2, 3 and 4) based on weight factor and storage capacity. For the storage tank system, we discussed the concept of carbon adsorbents, when used in CNG tanks, offer a means of increasing onboard fuel storage and, thereby, increase the driving range of the vehicle. It confirms that the density of the stored gas in ANG is higher than that of compressed natural gas (CNG) operated at the same pressure. The obtained experimental data were correlated using linear regression analysis with common adsorption kinetic (Pseudo-first order and Pseudo-second order) and isotherm models (Sip and Toth). The pseudo-second-order kinetics describe the best fitness with a correlation coefficient of 9945 at 35 bar. For adsorption isotherms, the Sip model shows better fitness with the regression coefficient (R2) of 0.9982 and with the lowest RSMD value of 0.0148. The findings revealed the potential of adsorbent in natural gas storage applications.

Keywords: natural gas, adsorbent, compressed natural gas, adsorption

Procedia PDF Downloads 66