Search results for: gene regulatory networks (GRNs)
Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 2147

Search results for: gene regulatory networks (GRNs)

1967 A New Robust Stability Criterion for Dynamical Neural Networks with Mixed Time Delays

Authors: Guang Zhou, Shouming Zhong

Abstract:

In this paper, we investigate the problem of the existence, uniqueness and global asymptotic stability of the equilibrium point for a class of neural networks, the neutral system has mixed time delays and parameter uncertainties. Under the assumption that the activation functions are globally Lipschitz continuous, we drive a new criterion for the robust stability of a class of neural networks with time delays by utilizing the Lyapunov stability theorems and the Homomorphic mapping theorem. Numerical examples are given to illustrate the effectiveness and the advantage of the proposed main results.

Keywords: Neural networks, Delayed systems, Lyapunov function, Stability analysis.

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1966 Safety of Industrial Networks

Authors: P. Vazan, P. Tanuska, M. Kebisek, S. Duchovicova

Abstract:

The paper deals with communication standards for control and production system. The authors formulate the requirements for communication security protection. The paper is focused on application protocols of the industrial networks and their basic classification. The typical attacks are analysed and the safety protection, based on requirements for specific industrial network is suggested and defined in this paper.

Keywords: Application protocols, communication standards, industrial networks.

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1965 A Simple Affymetrix Ratio-transformation Method Yields Comparable Expression Level Quantifications with cDNA Data

Authors: Chintanu K. Sarmah, Sandhya Samarasinghe, Don Kulasiri, Daniel Catchpoole

Abstract:

Gene expression profiling is rapidly evolving into a powerful technique for investigating tumor malignancies. The researchers are overwhelmed with the microarray-based platforms and methods that confer them the freedom to conduct large-scale gene expression profiling measurements. Simultaneously, investigations into cross-platform integration methods have started gaining momentum due to their underlying potential to help comprehend a myriad of broad biological issues in tumor diagnosis, prognosis, and therapy. However, comparing results from different platforms remains to be a challenging task as various inherent technical differences exist between the microarray platforms. In this paper, we explain a simple ratio-transformation method, which can provide some common ground for cDNA and Affymetrix platform towards cross-platform integration. The method is based on the characteristic data attributes of Affymetrix- and cDNA- platform. In the work, we considered seven childhood leukemia patients and their gene expression levels in either platform. With a dataset of 822 differentially expressed genes from both these platforms, we carried out a specific ratio-treatment to Affymetrix data, which subsequently showed an improvement in the relationship with the cDNA data.

Keywords: Gene expression profiling, microarray, cDNA, Affymetrix, childhood leukaemia.

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1964 Fast Forecasting of Stock Market Prices by using New High Speed Time Delay Neural Networks

Authors: Hazem M. El-Bakry, Nikos Mastorakis

Abstract:

Fast forecasting of stock market prices is very important for strategic planning. In this paper, a new approach for fast forecasting of stock market prices is presented. Such algorithm uses new high speed time delay neural networks (HSTDNNs). The operation of these networks relies on performing cross correlation in the frequency domain between the input data and the input weights of neural networks. It is proved mathematically and practically that the number of computation steps required for the presented HSTDNNs is less than that needed by traditional time delay neural networks (TTDNNs). Simulation results using MATLAB confirm the theoretical computations.

Keywords: Fast Forecasting, Stock Market Prices, Time Delay NeuralNetworks, Cross Correlation, Frequency Domain.

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1963 Ensuring Uniform Energy Consumption in Non-Deterministic Wireless Sensor Network to Protract Networks Lifetime

Authors: Vrince Vimal, Madhav J. Nigam

Abstract:

Wireless sensor networks have enticed much of the spotlight from researchers all around the world, owing to its extensive applicability in agricultural, industrial and military fields. Energy conservation node deployment stratagems play a notable role for active implementation of Wireless Sensor Networks. Clustering is the approach in wireless sensor networks which improves energy efficiency in the network. The clustering algorithm needs to have an optimum size and number of clusters, as clustering, if not implemented properly, cannot effectively increase the life of the network. In this paper, an algorithm has been proposed to address connectivity issues with the aim of ensuring the uniform energy consumption of nodes in every part of the network. The results obtained after simulation showed that the proposed algorithm has an edge over existing algorithms in terms of throughput and networks lifetime.

Keywords: WSN, random deployment, clustering, isolated nodes, network lifetime.

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1962 Effects of Intrauterine and Extrauterine Exposure to 1800 MHz GSM-Like Radiofrequency Radiation on Liver Regulatory Enzymes Activities in Infant Female Rabbits

Authors: A. Tomruk, G. Guler, B. Tandogan, E. Ozgur, N.N. Ulusu, N. Seyhan

Abstract:

In the present study, we aimed to design the intrauterine and extrauterine exposure to 1800 MHz GSM-like RF radiation and investigate its possible bio-effects on infant female rabbits. Totally thirty-six New Zealand White female rabbits, onemonth old, were randomly divided into four groups which are composed of 9 rabbits; i. Group I [Intrauterine (IU) exposure(-); Extrauterine (EU) exposure (-)], Group II [IU exposure (-); EU exposure (+)], Group III [IU exposure(+);EU exposure(-)], Group IV [IU exposure (+);EU exposure(+)]. The master regulatory enzymes activities of pentose phosphate pathway (glucose-6-phosphate dehydrogenase, G-6PD; 6-phosphogluconate dehydrogenase, 6- PGDH) and glutathione-dependent metabolism (glutathione peroxidase, GSH-Px; glutathione reductase, GR; glutathione Stransferase, GST, thioredoxin reductase, TRx) were analyzed in liver tissues of young female rabbits. Decreased G-6PD, 6-PGD, GSH-Px, GR activities were found in Group III compared to Group I (p<0.05, Mann Whitney). Increased GSH-px and TRx activities were found in Group IV compared to Group I (p<0.05, Mann Whitney). It can be concluded that the intrauterine and extrauterine exposure to GSMlike RF radiation may influence the liver regulatory enzymes activities.

Keywords: Radiofrequency (RF), intrauterine (IU) andextrauterine (EU) exposure, infant female rabbits.

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1961 A Novel Approach to Positive Almost Periodic Solution of BAM Neural Networks with Time-Varying Delays

Authors: Lili Wang, Meng Hu

Abstract:

In this paper, based on almost periodic functional hull theory and M-matrix theory, some sufficient conditions are established for the existence and uniqueness of positive almost periodic solution for a class of BAM neural networks with time-varying delays. An example is given to illustrate the main results.

Keywords: Delayed BAM neural networks, Hull theorem, Mmatrix, Almost periodic solution, Global exponential stability.

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1960 Passivity Analysis of Stochastic Neural Networks With Multiple Time Delays

Authors: Biao Qin, Jin Huang, Jiaojiao Ren, Wei Kang

Abstract:

This paper deals with the problem of passivity analysis for stochastic neural networks with leakage, discrete and distributed delays. By using delay partitioning technique, free weighting matrix method and stochastic analysis technique, several sufficient conditions for the passivity of the addressed neural networks are established in terms of linear matrix inequalities (LMIs), in which both the time-delay and its time derivative can be fully considered. A numerical example is given to show the usefulness and effectiveness of the obtained results.

Keywords: Passivity, Stochastic neural networks, Multiple time delays, Linear matrix inequalities (LMIs).

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1959 Neural Networks Approaches for Computing the Forward Kinematics of a Redundant Parallel Manipulator

Authors: H. Sadjadian , H.D. Taghirad Member, A. Fatehi

Abstract:

In this paper, different approaches to solve the forward kinematics of a three DOF actuator redundant hydraulic parallel manipulator are presented. On the contrary to series manipulators, the forward kinematic map of parallel manipulators involves highly coupled nonlinear equations, which are almost impossible to solve analytically. The proposed methods are using neural networks identification with different structures to solve the problem. The accuracy of the results of each method is analyzed in detail and the advantages and the disadvantages of them in computing the forward kinematic map of the given mechanism is discussed in detail. It is concluded that ANFIS presents the best performance compared to MLP, RBF and PNN networks in this particular application.

Keywords: Forward Kinematics, Neural Networks, Numerical Solution, Parallel Manipulators.

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1958 Hubs as Catalysts for Geospatial Communication in Kinship Networks

Authors: Sameer Kumar, Jariah Mohd. Jan

Abstract:

Earlier studies in kinship networks have primarily focused on observing the social relationships existing between family relatives. In this study, we pre-identified hubs in the network to investigate if they could play a catalyst role in the transfer of physical information. We conducted a case study of a ceremony performed in one of the families of a small Hindu community – the Uttar Rarhi Kayasthas. Individuals (n = 168) who resided in 11 geographically dispersed regions were contacted through our hub-based representation. We found that using this representation, over 98% of the individuals were successfully contacted within the stipulated period. The network also demonstrated a small-world property, with an average geodesic distance of 3.56.

Keywords: Social Networks, Kinship Networks, Social Network Analysis, Geospatial Communication, Hubs

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1957 Authentication in Multi-Hop Wireless Mesh Networks

Authors: Kaleemullah Khan, Muhammmad Akbar

Abstract:

Wireless Mesh Networks (WMNs) are an emerging technology for last-mile broadband access. In WMNs, similar to ad hoc networks, each user node operates not only as a host but also as a router. User packets are forwarded to and from an Internet-connected gateway in multi-hop fashion. The WMNs can be integrated with other networking technologies i.e. ad hoc networks, to implement a smooth network extension. The meshed topology provides good reliability and scalability, as well as low upfront investments. Despite the recent start-up surge in WMNs, much research remains to be done in standardizing the functional parameters of WMNs to fully exploit their full potential. An edifice of the security concerns of these networks is authentication of a new client joining an integrated ad hoc network and such a scenario will require execution of a multihop authentication technique. Our endeavor in this paper is to introduce a secure authentication technique, with light over-heads that can be conveniently implemented for the ad-hoc nodes forming clients of an integrated WMN, thus facilitating their inter-operability.

Keywords: Multi-Hop WMNs, PANA, EAP-TTLS, Authentication, RADIUS.

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1956 Sub-Image Detection Using Fast Neural Processors and Image Decomposition

Authors: Hazem M. El-Bakry, Qiangfu Zhao

Abstract:

In this paper, an approach to reduce the computation steps required by fast neural networksfor the searching process is presented. The principle ofdivide and conquer strategy is applied through imagedecomposition. Each image is divided into small in sizesub-images and then each one is tested separately usinga fast neural network. The operation of fast neuralnetworks based on applying cross correlation in thefrequency domain between the input image and theweights of the hidden neurons. Compared toconventional and fast neural networks, experimentalresults show that a speed up ratio is achieved whenapplying this technique to locate human facesautomatically in cluttered scenes. Furthermore, fasterface detection is obtained by using parallel processingtechniques to test the resulting sub-images at the sametime using the same number of fast neural networks. Incontrast to using only fast neural networks, the speed upratio is increased with the size of the input image whenusing fast neural networks and image decomposition.

Keywords: Fast Neural Networks, 2D-FFT, CrossCorrelation, Image decomposition, Parallel Processing.

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1955 Gene Expressions Associated with Ultrastructural Changes in Vascular Endothelium of Atherosclerotic Lesion

Authors: M. Maimunah, G.A. Froemming, H. Nawawi, M.I. Nafeeza, O. Effat, M.R. Rohayu Izanwati, M.S. Mohamed Saifulaman

Abstract:

Attachment of the circulating monocytes to the endothelium is the earliest detectable events during formation of atherosclerosis. The adhesion molecules, chemokines and matrix proteases genes were identified to be expressed in atherogenesis. Expressions of these genes may influence structural integrity of the luminal endothelium. The aim of this study is to relate changes in the ultrastructural morphology of the aortic luminal surface and gene expressions of the endothelial surface, chemokine and MMP-12 in normal and hypercholesterolemic rabbits. Luminal endothelial surface from rabbit aortic tissue was examined by scanning electron microscopy (SEM) using low vacuum mode to ascertain ultrastructural changes in development of atherosclerotic lesion. Gene expression of adhesion molecules, MCP-1 and MMP-12 were studied by Real-time PCR. Ultrastructural observations of the aortic luminal surface exhibited changes from normal regular smooth intact endothelium to irregular luminal surface including marked globular appearance and ruptures of the membrane layer. Real-time PCR demonstrated differentially expressed of studied genes in atherosclerotic tissues. The appearance of ultrastructural changes in aortic tissue of hypercholesterolemic rabbits is suggested to have relation with underlying changes of endothelial surface molecules, chemokine and MMP-12 gene expressions.

Keywords: Ultrastructure of luminal endothelial surface, Macrophage metalloelastase (MMP-12), Real-time PCR.

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1954 Using Artificial Neural Networks for Optical Imaging of Fluorescent Biomarkers

Authors: K. A. Laptinskiy, S. A. Burikov, A. M. Vervald, S. A. Dolenko, T. A. Dolenko

Abstract:

The article presents the results of the application of artificial neural networks to separate the fluorescent contribution of nanodiamonds used as biomarkers, adsorbents and carriers of drugs in biomedicine, from a fluorescent background of own biological fluorophores. The principal possibility of solving this problem is shown. Use of neural network architecture let to detect fluorescence of nanodiamonds against the background autofluorescence of egg white with high accuracy - better than 3 ug/ml.

Keywords: Artificial neural networks, fluorescence, data aggregation.

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1953 New Stability Analysis for Neural Networks with Time-Varying Delays

Authors: Miaomiao Yang, Shouming Zhong

Abstract:

This paper studies the problem of asymptotically stability for neural networks with time-varying delays.By establishing a suitable Lyapunov-Krasovskii function and several novel sufficient conditions are obtained to guarantee the asymptotically stability of the considered system. Finally,two numerical examples are given to illustrate the effectiveness of the proposed main results.

Keywords: Neural networks, Lyapunov-Krasovskii, Time-varying delays, Linear matrix inequality.

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1952 Neural Networks: From Black Box towards Transparent Box Application to Evapotranspiration Modeling

Authors: A. Johannet, B. Vayssade, D. Bertin

Abstract:

Neural networks are well known for their ability to model non linear functions, but as statistical methods usually does, they use a no parametric approach thus, a priori knowledge is not obvious to be taken into account no more than the a posteriori knowledge. In order to deal with these problematics, an original way to encode the knowledge inside the architecture is proposed. This method is applied to the problem of the evapotranspiration inside karstic aquifer which is a problem of huge utility in order to deal with water resource.

Keywords: Neural-Networks, Hydrology, Evapotranpiration, Hidden Function Modeling.

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1951 A Sub-mW Low Noise Amplifier for Wireless Sensor Networks

Authors: Gianluca Cornetta, David J. Santos, Balwant Godara

Abstract:

A 1.2 V, 0.61 mA bias current, low noise amplifier (LNA) suitable for low-power applications in the 2.4 GHz band is presented. Circuit has been implemented, laid out and simulated using a UMC 130 nm RF-CMOS process. The amplifier provides a 13.3 dB power gain a noise figure NF< 2.28 dB and a 1-dB compression point of -15.69 dBm, while dissipating 0.74 mW. Such performance make this design suitable for wireless sensor networks applications such as ZigBee.

Keywords: Current Reuse, IEEE 802.15.4 (ZigBee), Low NoiseAmplifiers, Wireless Sensor Networks.

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1950 A Hypercube Social Feature Extraction and Multipath Routing in Delay Tolerant Networks

Authors: S. Balaji, M. Rajaram, Y. Harold Robinson, E. Golden Julie

Abstract:

Delay Tolerant Networks (DTN) which have sufficient state information include trajectory and contact information, to protect routing efficiency. However, state information is dynamic and hard to obtain without a global and/or long-term collection process. To deal with these problems, the internal social features of each node are introduced in the network to perform the routing process. This type of application is motivated from several human contact networks where people contact each other more frequently if they have more social features in common. Two unique processes were developed for this process; social feature extraction and multipath routing. The routing method then becomes a hypercube–based feature matching process. Furthermore, the effectiveness of multipath routing is evaluated and compared to that of single-path routing.

Keywords: Delay tolerant networks, entropy, human contact networks, hyper cubes, multipath Routing, social features.

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1949 Robust Artificial Neural Network Architectures

Authors: A. Schuster

Abstract:

Many artificial intelligence (AI) techniques are inspired by problem-solving strategies found in nature. Robustness is a key feature in many natural systems. This paper studies robustness in artificial neural networks (ANNs) and proposes several novel, nature inspired ANN architectures. The paper includes encouraging results from experimental studies on these networks showing increased robustness.

Keywords: robustness, robust artificial neural networks architectures.

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1948 A Novel Multiplex Real-Time PCR Assay Using TaqMan MGB Probes for Rapid Detection of Trisomy 21

Authors: Mehrdad Hashemi, Mitra Behrooz Aghdam, Reza Mahdian, Ahmad Reza Kamyab

Abstract:

Cytogenetic analysis still remains the gold standard method for prenatal diagnosis of trisomy 21 (Down syndrome, DS). Nevertheless, the conventional cytogenetic analysis needs live cultured cells and is too time-consuming for clinical application. In contrast, molecular methods such as FISH, QF-PCR, MLPA and quantitative Real-time PCR are rapid assays with results available in 24h. In the present study, we have successfully used a novel MGB TaqMan probe-based real time PCR assay for rapid diagnosis of trisomy 21 status in Down syndrome samples. We have also compared the results of this molecular method with corresponding results obtained by the cytogenetic analysis. Blood samples obtained from DS patients (n=25) and normal controls (n=20) were tested by quantitative Real-time PCR in parallel to standard G-banding analysis. Genomic DNA was extracted from peripheral blood lymphocytes. A high precision TaqMan probe quantitative Real-time PCR assay was developed to determine the gene dosage of DSCAM (target gene on 21q22.2) relative to PMP22 (reference gene on 17p11.2). The DSCAM/PMP22 ratio was calculated according to the formula; ratio=2 -ΔΔCT. The quantitative Real-time PCR was able to distinguish between trisomy 21 samples and normal controls with the gene ratios of 1.49±0.13 and 1.03±0.04 respectively (p value <0.001). These results represent the presence of 3 copies of target gene in DS samples Vs 2 copies in normal controls. The results of quantitative Real-time PCR were in complete agreement with results of cytogenetic analysis. This study confirms previous reports regarding successful implementation of quantitative Real-time PCR for detection of trisomy 21. However, the assay has been improved by using MGB probes and more accurate data analysis. This assay, in particular, when performed in combination with another molecular assay such as QF-PCR or MLPA, can be used as a reliable technique for rapid prenatal diagnosis of trisomy 21.

Keywords: Trisomy 21, Real-time PCR, MGB-TaqMan Probes, Gene Dosage.

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1947 Tariff as a Determining Factor in Choosing Mobile Operators: A Case Study from Higher Learning Institution in Dodoma Municipality in Tanzania

Authors: Justinian Anatory, Ekael Stephen Manase

Abstract:

In recent years, the adoption of mobile phones has been exceptionally rapid in many parts of the world, and Tanzania is not exceptional. We are witnessing a number of new mobile network operators being licensed from time to time by Tanzania Communications Regulatory Authority (TCRA). This makes competition in the telecommunications market very stiff. All mobile phone companies are struggling to earn more new customers into their networks. This trend courses a stiff competition. The various measures are being taken by different companies including, lowering tariff, and introducing free short messages within and out of their networks, and free calls during off-peak periods. This paper is aimed at investigating the influence of tariffs on students’ mobile customers in selecting their mobile network operators. About seventy seven students from high learning institutions in Dodoma Municipality, Tanzania, participated in responding to the prepared questionnaires. The sought information was aimed at determining if tariffs influenced students into selection of their current mobile operators. The results indicate that tariffs were the major driving factor in selection of mobile operators. However, female mobile customers were found to be more easily attracted into subscribing to a mobile operator due to low tariffs, a bigger number of free short messages or discounted call charges than their fellow male customers.

Keywords: Consumer Buying, mobile operators, tariff.

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1946 Performance Evaluation of Routing Protocols for High Density Ad Hoc Networks Based on Energy Consumption by GlomoSim Simulator

Authors: E. Ahvar, M. Fathy

Abstract:

Ad hoc networks are characterized by multihop wireless connectivity, frequently changing network topology and the need for efficient dynamic routing protocols. We compare the performance of three routing protocols for mobile ad hoc networks: Dynamic Source Routing (DSR), Ad Hoc On-Demand Distance Vector Routing (AODV), location-aided routing (LAR1).Our evaluation is based on energy consumption in mobile ad hoc networks. The performance differentials are analyzed using varying network load, mobility, and network size. We simulate protocols with GLOMOSIM simulator. Based on the observations, we make recommendations about when the performance of either protocol can be best.

Keywords: Ad hoc Network, energy consumption, Glomosim, routing protocols.

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1945 Deregulation of Turkish State Railways Based on Public-Private Partnership Approaches

Authors: S. Shakibaei, P. Alpkokin

Abstract:

The railway network is one of the major components of a transportation system in a country which may be an indicator of the country’s level of economic improvement. Since 2000s on, revival of national railways and development of High Speed Rail (HSR) lines are one of the most remarkable policies of Turkish government in railway sector. Within this trend, the railway age is to be revived and coming decades will be a golden opportunity. Indubitably, major infrastructures such as road and railway networks require sizeable investment capital, precise maintenance and reparation. Traditionally, governments are held responsible for funding, operating and maintaining these infrastructures. However, lack or shortage of financial resources, risk responsibilities (particularly cost and time overrun), and in some cases inefficacy in constructional, operational and management phases persuade governments to find alternative options. Financial power, efficient experiences and background of private sector are the factors convincing the governments to make a collaboration with private parties to develop infrastructures. Public-Private Partnerships (PPP or 3P or P3) and related regulatory issues are born considering these collaborations. In Turkey, PPP approaches have attracted attention particularly during last decade and these types of investments have been accelerated by government to overcome budget limitations and cope with inefficacy of public sector in improving transportation network and its operation. This study mainly tends to present a comprehensive overview of PPP concept, evaluate the regulatory procedure in Europe and propose a general framework for Turkish State Railways (TCDD) as an outlook on privatization, liberalization and deregulation of railway network.

Keywords: Deregulation, high-speed rail, liberalization, privatization, public-private partnership.

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1944 Cloning and Over Expression of an Aspergillus niger XP Phytase Gene (phyA) in Pichia pastoris

Authors: Ngo Thanh Xuan, Mai Thi Hang, Vu Nguyen Thanh

Abstract:

A. niger XP isolated from Vietnam produces very low amount of acidic phytase with optimal pH at 2.5 and 5.5. The phytase production of this strain was successfully improved through gene cloning and expression. A 1.4 - kb DNA fragment containing the coding region of the phyA gene was amplified by PCR and inserted into the expression vector pPICZαA with a signal peptide α- factor, under the control of AOX1 promoter. The recombined plasmid was transformed into the host strain P. pastoris KM71H and X33 by electroporation. Both host strains could efficiently express and secret phytase. The multicopy strains were screened for over expression of phytase. All the selected multicopy strains of P. pastoris X33 were examined for phytase activity, the maximum phytase yield of 1329 IU/ml was obtained after 4 days of incubation in medium BMM. The recombinant protein with MW of 97.4 KW showed to be the only one protein secreted in the culture broth. Multicopy transformant P. pastoris X33 supposed to be potential candidate for producing the commercial preparation of phytase.

Keywords: Aspergillus niger XP, cloning, over expression, Pichia pastoris, phyA , phytase.

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1943 An Efficient Data Collection Approach for Wireless Sensor Networks

Authors: Hanieh Alipour, Alireza Nemaney Pour

Abstract:

One of the most important applications of wireless sensor networks is data collection. This paper proposes as efficient approach for data collection in wireless sensor networks by introducing Member Forward List. This list includes the nodes with highest priority for forwarding the data. When a node fails or dies, this list is used to select the next node with higher priority. The benefit of this node is that it prevents the algorithm from repeating when a node fails or dies. The results show that Member Forward List decreases power consumption and latency in wireless sensor networks.

Keywords: Data Collection, Wireless Sensor Network, SensorNode, Tree-Based

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1942 Exponential Passivity Criteria for BAM Neural Networks with Time-Varying Delays

Authors: Qingqing Wang, Baocheng Chen, Shouming Zhong

Abstract:

In this paper,the exponential passivity criteria for BAM neural networks with time-varying delays is studied.By constructing new Lyapunov-Krasovskii functional and dividing the delay interval into multiple segments,a novel sufficient condition is established to guarantee the exponential stability of the considered system.Finally,a numerical example is provided to illustrate the usefulness of the proposed main results

Keywords: BAM neural networks, Exponential passivity, LMI approach, Time-varying delays.

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1941 Investigating Intrusion Detection Systems in MANET and Comparing IDSs for Detecting Misbehaving Nodes

Authors: Marjan Kuchaki Rafsanjani, Ali Movaghar, Faroukh Koroupi

Abstract:

As mobile ad hoc networks (MANET) have different characteristics from wired networks and even from standard wireless networks, there are new challenges related to security issues that need to be addressed. Due to its unique features such as open nature, lack of infrastructure and central management, node mobility and change of dynamic topology, prevention methods from attacks on them are not enough. Therefore intrusion detection is one of the possible ways in recognizing a possible attack before the system could be penetrated. All in all, techniques for intrusion detection in old wireless networks are not suitable for MANET. In this paper, we classify the architecture for Intrusion detection systems that have so far been introduced for MANETs, and then existing intrusion detection techniques in MANET presented and compared. We then indicate important future research directions.

Keywords: Intrusion Detection System(IDS), Misbehavingnodes, Mobile Ad Hoc Network(MANET), Security.

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1940 Improved Technique of Non-viral Gene Delivery into Cancer Cells

Authors: D. Vainauska, S. Kozireva, A. Karpovs, M. Chistyakovs, M. Baryshev

Abstract:

Liposomal magnetofection is a simple, highly efficient technology for cell transfection, demonstrating better outcome than a number of other common gene delivery methods. However, aggregate complexes distribution over the cell surface is non-uniform due to the gradient of the permanent magnetic field. The aim of this study was to estimate the efficiency of liposomal magnetofection for prostate carcinoma PC3 cell line using newly designed device, “DynaFECTOR", ensuring magnetofection in a dynamic gradient magnetic field. Liposomal magnetofection in a dynamic gradient magnetic field demonstrated the highest transfection efficiency for PC3 cells – it increased for 21% in comparison with liposomal magnetofection and for 42% in comparison with lipofection alone. The optimal incubation time under dynamic magnetic field for PC3 cell line was 5 minutes and the optimal rotation frequency of magnets – 5 rpm. The new approach also revealed lower cytotoxic effect to cells than liposomal magnetofection.

Keywords: Dynamic gradient magnetic field, gene delivery, liposomal magnetofection, prostate cancer cell line

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1939 Establishing Pairwise Keys Using Key Predistribution Schemes for Sensor Networks

Authors: Y. Harold Robinson, M. Rajaram

Abstract:

Designing cost-efficient, secure network protocols for Wireless Sensor Networks (WSNs) is a challenging problem because sensors are resource-limited wireless devices. Security services such as authentication and improved pairwise key establishment are critical to high efficient networks with sensor nodes. For sensor nodes to correspond securely with each other efficiently, usage of cryptographic techniques is necessary. In this paper, two key predistribution schemes that enable a mobile sink to establish a secure data-communication link, on the fly, with any sensor nodes. The intermediate nodes along the path to the sink are able to verify the authenticity and integrity of the incoming packets using a predicted value of the key generated by the sender’s essential power. The proposed schemes are based on the pairwise key with the mobile sink, our analytical results clearly show that our schemes perform better in terms of network resilience to node capture than existing schemes if used in wireless sensor networks with mobile sinks.

Keywords: Wireless Sensor Networks, predistribution scheme, cryptographic techniques.

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1938 Normalizing Scientometric Indicators of Individual Publications Using Local Cluster Detection Methods on Citation Networks

Authors: Levente Varga, Dávid Deritei, Mária Ercsey-Ravasz, Răzvan Florian, Zsolt I. Lázár, István Papp, Ferenc Járai-Szabó

Abstract:

One of the major shortcomings of widely used scientometric indicators is that different disciplines cannot be compared with each other. The issue of cross-disciplinary normalization has been long discussed, but even the classification of publications into scientific domains poses problems. Structural properties of citation networks offer new possibilities, however, the large size and constant growth of these networks asks for precaution. Here we present a new tool that in order to perform cross-field normalization of scientometric indicators of individual publications relays on the structural properties of citation networks. Due to the large size of the networks, a systematic procedure for identifying scientific domains based on a local community detection algorithm is proposed. The algorithm is tested with different benchmark and real-world networks. Then, by the use of this algorithm, the mechanism of the scientometric indicator normalization process is shown for a few indicators like the citation number, P-index and a local version of the PageRank indicator. The fat-tail trend of the article indicator distribution enables us to successfully perform the indicator normalization process.

Keywords: Citation networks, scientometric indicator, cross-field normalization, local cluster detection.

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