Search results for: Boundary layer profile
496 Parameters Optimization of the Laminated Composite Plate for Sound Transmission Problem
Authors: Yu T. Tsai, Jin H. Huang
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In this paper, the specific sound Transmission Loss (TL) of the Laminated Composite Plate (LCP) with different material properties in each layer is investigated. The numerical method to obtain the TL of the LCP is proposed by using elastic plate theory. The transfer matrix approach is novelty presented for computational efficiency in solving the numerous layers of dynamic stiffness matrix (D-matrix) of the LCP. Besides the numerical simulations for calculating the TL of the LCP, the material properties inverse method is presented for the design of a laminated composite plate analogous to a metallic plate with a specified TL. As a result, it demonstrates that the proposed computational algorithm exhibits high efficiency with a small number of iterations for achieving the goal. This method can be effectively employed to design and develop tailor-made materials for various applications.Keywords: Sound transmission loss, laminated composite plate, transfer matrix approach, inverse problem, elastic plate theory, material properties.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1973495 Effect of Polyvinyl Pyrrolidone and Ethyl Cellulose Concentration on Release Profile and Kinetics of Glibenclamide Extended Release Dosage Form System
Authors: Amit Kumar, Peeyush Sharma, Anil Bhandari
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The aim of present work was to optimize the effect of Ethyl Cellulose (EC) and Polyvinyl Pyrrolidone (PVP) concentration in extended release solid dispersion of Glibenclamide using combination of hydrophilic and hydrophobic polymers such as Polyvinyl Pyrrolidone and Ethyl cellulose. The advantage of solid dispersion technique provides a unique approach to particle size reduction and increased rates of dissolution. The compatibility studies of the drug and polymers were studied by TLC and results suggested no interaction between drug and polymers. Solid dispersions of Glibenclamide were prepared by common solvent evaporation method using Polyvinyl Pyrrolidone and Ethyl cellulose. The results indicated that homogeneous or heterogeneous conditions during the preparation methods employed governed the internal structures of the polymer matrices while retaining the drug in an amorphous form. F2 formulation prepared by solid dispersion method, displayed extended drug release followed by Higuchi matrix model indicating diffusion release of GLB from polymer matrices.
Keywords: Ethyl Cellulose, Glibenclamide, Polyvinyl Pyrrolidone, Solid Dispersion.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2526494 Computer Modeling of Drug Distribution after Intravitreal Administration
Authors: N. Haghjou, M. J. Abdekhodaie, Y. L. Cheng, M. Saadatmand
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Intravitreal injection (IVI) is the most common treatment for eye posterior segment diseases such as endopthalmitis, retinitis, age-related macular degeneration, diabetic retinopathy, uveitis, and retinal detachment. Most of the drugs used to treat vitreoretinal diseases, have a narrow concentration range in which they are effective, and may be toxic at higher concentrations. Therefore, it is critical to know the drug distribution within the eye following intravitreal injection. Having knowledge of drug distribution, ophthalmologists can decide on drug injection frequency while minimizing damage to tissues. The goal of this study was to develop a computer model to predict intraocular concentrations and pharmacokinetics of intravitreally injected drugs. A finite volume model was created to predict distribution of two drugs with different physiochemical properties in the rabbit eye. The model parameters were obtained from literature review. To validate this numeric model, the in vivo data of spatial concentration profile from the lens to the retina were compared with the numeric data. The difference was less than 5% between the numerical and experimental data. This validation provides strong support for the numerical methodology and associated assumptions of the current study.
Keywords: Posterior segment, Intravitreal injection (IVI), Pharmacokinetic, Modelling, Finite volume method.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2447493 Soil Compaction in Tropical Organic Farming Systems and Its Impact on Natural Soil-Borne Disease Suppression: Challenges for Management
Authors: Ishak, L., McHenry, M. T., Brown, P. H.
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Organic farming systems still depend on intensive, mechanical soil tillage. Frequent passes by machinery traffic cause substantial soil compaction that threatens soil health. Adopting practices as reduced tillage and organic matter retention on the soil surface are considered effective ways to control soil compaction. In tropical regions, however, the acceleration of soil organic matter decomposition and soil carbon turnover on the topsoil layer is influenced more rapidly by the oscillation process of drying and wetting. It is hypothesized therefore, that rapid reduction in soil organic matter hastens the potential for compaction to occur in organic farming systems. Compaction changes soil physical properties and as a consequence it has been implicated as a causal agent in the inhibition of natural disease suppression in soils. Here we describe relationships between soil management in organic vegetable systems, soil compaction, and declining soil capacity to suppress pathogenic microorganisms.
Keywords: Organic farming systems, soil compaction, soil disease suppression, tropical regions.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2167492 A Comparison of Artificial Neural Networks for Prediction of Suspended Sediment Discharge in River- A Case Study in Malaysia
Authors: M.R. Mustafa, M.H. Isa, R.B. Rezaur
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Prediction of highly non linear behavior of suspended sediment flow in rivers has prime importance in the field of water resources engineering. In this study the predictive performance of two Artificial Neural Networks (ANNs) namely, the Radial Basis Function (RBF) Network and the Multi Layer Feed Forward (MLFF) Network have been compared. Time series data of daily suspended sediment discharge and water discharge at Pari River was used for training and testing the networks. A number of statistical parameters i.e. root mean square error (RMSE), mean absolute error (MAE), coefficient of efficiency (CE) and coefficient of determination (R2) were used for performance evaluation of the models. Both the models produced satisfactory results and showed a good agreement between the predicted and observed data. The RBF network model provided slightly better results than the MLFF network model in predicting suspended sediment discharge.Keywords: ANN, discharge, modeling, prediction, suspendedsediment,
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1725491 Experimental Investigation of Proton Exchange Membrane Fuel Cells Operated with Nanofiber and Nanofiber/Nanoparticle
Authors: Kevser Dincer, Basma Waisi, M. Ozan Ozdemir, Ugur Pasaogullari, Jeffrey McCutcheon
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Nanofibers are defined as fibers with diameters less than 100 nanometers. In this study, behaviours of activated carbon nanofiber (ACNF), carbon nanofiber (CNF), polyacrylonitrile/ carbon nanotube (PAN/CNT), polyvinyl alcohol/nanosilver (PVA/Ag) in proton exchange membrane (PEM) fuel cells are investigated experimentally. This material was used as gas diffusion layer (GDL) in PEM fuel cells. In this study, the electrical conductivities of nanofiber and nanofiber/nanoparticles have been studied to understand their effects on PEM fuel cell performance. According to the experimental results, the maximum electrical conductivity performance of the fuel cell with nanofiber was found to be at PVA/Ag (at UConn condition). The electrical conductivities of CNF, ACNF, PAN/CNT are lower for PEM. The resistance of cell with PVA/Ag is lower than the resistance of cell with PAN/CNT, ACNF, CNF.Keywords: Proton exchange membrane fuel cells, electrospinning, carbon nanofiber, activate carbon nanofiber, PVA fiber, pan fiber, carbon nanotube, nanoparticle, nanocomposites.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2510490 Hiding Data in Images Using PCP
Authors: Souvik Bhattacharyya, Gautam Sanyal
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In recent years, everything is trending toward digitalization and with the rapid development of the Internet technologies, digital media needs to be transmitted conveniently over the network. Attacks, misuse or unauthorized access of information is of great concern today which makes the protection of documents through digital media a priority problem. This urges us to devise new data hiding techniques to protect and secure the data of vital significance. In this respect, steganography often comes to the fore as a tool for hiding information. Steganography is a process that involves hiding a message in an appropriate carrier like image or audio. It is of Greek origin and means "covered or hidden writing". The goal of steganography is covert communication. Here the carrier can be sent to a receiver without any one except the authenticated receiver only knows existence of the information. Considerable amount of work has been carried out by different researchers on steganography. In this work the authors propose a novel Steganographic method for hiding information within the spatial domain of the gray scale image. The proposed approach works by selecting the embedding pixels using some mathematical function and then finds the 8 neighborhood of the each selected pixel and map each bit of the secret message in each of the neighbor pixel coordinate position in a specified manner. Before embedding a checking has been done to find out whether the selected pixel or its neighbor lies at the boundary of the image or not. This solution is independent of the nature of the data to be hidden and produces a stego image with minimum degradation.Keywords: Cover Image, LSB, Pixel Coordinate Position (PCP), Stego Image.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1821489 Revea Ling Casein Micelle Dispersion under Various Ranges of Nacl: Evolution of Particles Size and Structure
Authors: Raza Hussain, Claire Gaiani, Joël Scher
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Dispersions of casein micelles (CM) were studied at a constant protein concentration of 5 wt % in high NaCl environment ranging from 0% to 12% by Dynamic light scattering (DLS) and Fourier Transform Infrared (FTIR). The rehydration profiles obtained were interpreted in term of wetting, swelling and dispersion stages by using a turbidity method. Two behaviours were observed depending on the salt concentration. The first behaviour (low salt concentration) presents a typical rehydration profile with a significant change between 3 and 6% NaCl indicating quick wetting, swelling and long dispersion stage. On the opposite, the dispersion stage of the second behaviour (high salt concentration) was significantly shortened indicating a strong modification of the protein backbone. A salt increase result to a destabilization of the micelle and the formation of mini-micelles more or less aggregated indicating an average micelles size ranging from 100 to 200 nm. For the first time, the estimations of secondary structural elements (irregular, ß-sheet, α-helix and turn) by the Amide III assignments were correlated with results from Amide I.Keywords: Casein, DLS, FTIR, Ionic environment.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1877488 A Cognitive Robot Collaborative Reinforcement Learning Algorithm
Authors: Amit Gil, Helman Stern, Yael Edan
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A cognitive collaborative reinforcement learning algorithm (CCRL) that incorporates an advisor into the learning process is developed to improve supervised learning. An autonomous learner is enabled with a self awareness cognitive skill to decide when to solicit instructions from the advisor. The learner can also assess the value of advice, and accept or reject it. The method is evaluated for robotic motion planning using simulation. Tests are conducted for advisors with skill levels from expert to novice. The CCRL algorithm and a combined method integrating its logic with Clouse-s Introspection Approach, outperformed a base-line fully autonomous learner, and demonstrated robust performance when dealing with various advisor skill levels, learning to accept advice received from an expert, while rejecting that of less skilled collaborators. Although the CCRL algorithm is based on RL, it fits other machine learning methods, since advisor-s actions are only added to the outer layer.Keywords: Robot learning, human-robot collaboration, motion planning, reinforcement learning.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1724487 Dry Sliding Wear Behavior of Epoxy-Rubber Dust Composites
Authors: Antaryami Mishra
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Composite pins of rubber dust collected from tyre retreading centres of trucks, cars and buses etc.and epoxy with weight percentages of 10. 15, and 20 % of rubber (weight fractions of 9, 13 and 17 % respectively) have been prepared in house with the help of a split wooden mould. The pins were tested in a pin-on-disc wear monitor to determine the co-efficient of friction and weight losses with varying speeds, loads and time. The wear volume and wear rates have also been found out for all these three specimens.. It is observed that all the specimens have exhibited very low coefficient of friction and low wear rates under dry sliding condition. Out of the above three samples tested, the specimen with 10 % rubber dust by weight has shown lowest wear rates. However a peculiar result i.e decreasing trend has been obtained with 20% reinforcement of rubber in epoxy while rubbed against steel at varying speeds. This might have occurred due to high surface finish of the disc and formation of a thin transfer layer from the compositeKeywords: epoxy, rubber dust, composites, weight fractions, pin-on-disc wear tests, wear volume and wear rate calculations.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2148486 Simulation of Laser Structuring by Three Dimensional Heat Transfer Model
Authors: Bassim Bachy, Joerg Franke
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In this study, a three dimensional numerical heat transfer model has been used to simulate the laser structuring of polymer substrate material in the Three-Dimensional Molded Interconnect Device (3D MID) which is used in the advanced multifunctional applications. A finite element method (FEM) transient thermal analysis is performed using APDL (ANSYS Parametric Design Language) provided by ANSYS. In this model, the effect of surface heat source was modeled with Gaussian distribution, also the effect of the mixed boundary conditions which consist of convection and radiation heat transfers have been considered in this analysis. The model provides a full description of the temperature distribution, as well as calculates the depth and the width of the groove upon material removal at different set of laser parameters such as laser power and laser speed. This study also includes the experimental procedure to study the effect of laser parameters on the depth and width of the removal groove metal as verification to the modeled results. Good agreement between the experimental and the model results is achieved for a wide range of laser powers. It is found that the quality of the laser structure process is affected by the laser scan speed and laser power. For a high laser structured quality, it is suggested to use laser with high speed and moderate to high laser power.
Keywords: Laser Structuring, Simulation, Finite element analysis, Thermal modeling.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 4346485 Evaluation for Punching Shear Strength of Slab-Column Connections with Ultra High Performance Fiber-Reinforced Concrete Overlay
Authors: H. S. Youm, S. G. Hong
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This paper presents the test results on 5 slab-column connection specimens with Ultra High Performance Fiber-Reinforced Concrete (UHPFRC) overlay including 1 control specimen to investigate retrofitting effect of UHPFRC overlay on the punching shear capacity. The test parameters were the thickness of the UHPFRC overlay and the amount of steel re-bars in it. All specimens failed in punching shear mode with abrupt failure aspect. The test results showed that by adding a thin layer of UHPFRC over the Reinforced Concrete (RC) substrates, considerable increases in global punching shear resistance up to 82% and structural rigidity were achieved. Furthermore, based on the cracking patterns the composite systems appeared to be governed by two failure modes: 1) diagonal shear failure in RC section and 2) debonding failure at the interface.
Keywords: Punching shear strength, retrofit, slab-column connection, UHPFRC, UHPFRC overlay.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1026484 The Implementation of the Javanese Lettered-Manuscript Image Preprocessing Stage Model on the Batak Lettered-Manuscript Image
Authors: Anastasia Rita Widiarti, Agus Harjoko, Marsono, Sri Hartati
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This paper presents the results of a study to test whether the Javanese character manuscript image preprocessing model that have been more widely applied, can also be applied to segment of the Batak characters manuscripts. The treatment process begins by converting the input image into a binary image. After the binary image is cleaned of noise, then the segmentation lines using projection profile is conducted. If unclear histogram projection is found, then the smoothing process before production indexes line segments is conducted. For each line image which has been produced, then the segmentation scripts in the line is applied, with regard of the connectivity between pixels which making up the letters that there is no characters are truncated. From the results of manuscript preprocessing system prototype testing, it is obtained the information about the system truth percentage value on pieces of Pustaka Batak Podani Ma AjiMamisinon manuscript ranged from 65% to 87.68% with a confidence level of 95%. The value indicates the truth percentage shown the initial processing model in Javanese characters manuscript image can be applied also to the image of the Batak characters manuscript.Keywords: Connected component, preprocessing manuscript image, projection profiles.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 923483 Method and Experiment of Fabricating and Cutting the Burr for Y Shape Nanochannel
Authors: Zone-Ching Lin, Hao-Yuan Jheng, Shih-Hung Ma
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The present paper proposes using atomic force microscopy (AFM) and the concept of specific down force energy (SDFE) to establish a method for fabricating and cutting the burr for Y shape nanochannel on silicon (Si) substrate. For fabricating Y shape nanochannel, it first makes the experimental cutting path planning for fabricating Y shape nanochannel until the fifth cutting layer. Using the constant down force by AFM and SDFE theory and following the experimental cutting path planning, the cutting depth and width of each pass of Y shape nanochannel can be predicted by simulation. The paper plans the path for cutting the burr at the edge of Y shape nanochannel. Then, it carries out cutting the burr along the Y nanochannel edge by using a smaller down force. The height of standing burr at the edge is required to be below the set value of 0.54 nm. The results of simulation and experiment of fabricating and cutting the burr for Y shape nanochannel is further compared.Keywords: Atomic force microscopy, nanochannel, specific down force energy, Y shape, burr, silicon.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1082482 Unsteady Flow of an Incompressible Elastico-Viscous Fluid of Second order Type in Tube of Ellipsoidal Cross Section on a Porous Boundary
Authors: Sanjay Baburao Kulkarni
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Exact solution of an unsteady flow of elastico-viscous fluid through a porous media in a tube of ellipsoidal cross section under the influence of constant pressure gradient has been obtained in this paper. Initially, the flow is generated by a constant pressure gradient. After attaining the steady state, the pressure gradient is suddenly withdrawn and the resulting fluid motion in a tube of ellipsoidal cross section by taking into account of the porosity factor of the bounding surface is investigated. The problem is solved in twostages the first stage is a steady motion in tube under the influence of a constant pressure gradient, the second stage concern with an unsteady motion. The problem is solved employing separation of variables technique. The results are expressed in terms of a nondimensional porosity parameter (K) and elastico-viscosity parameter (β), which depends on the Non-Newtonian coefficient. The flow parameters are found to be identical with that of Newtonian case as elastic-viscosity parameter tends to zero and porosity tends to infinity. It is seen that the effect of elastico-viscosity parameter and the porosity parameter of the bounding surface has significant effect on the velocity parameter.
Keywords: Elastico-viscous fluid, Ellipsoidal cross-section, Porous media, Second order fluids.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1693481 Study of the Oxidation Resistance of Coated AISI 441 Ferritic Stainless Steel for SOFCs
Authors: M. B. Limooei, Hadi Ebrahimifar, Sh. Hosseini
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Protective coatings that resist oxide scale growth and decrease chromium evaporation are necessary to make stainless steel interconnect materials for long-term durable operation of solid oxide fuel cells (SOFCs). In this study a layer of cobalt was electroplated on the surface of AISI 441 ferritic stainless steel which is used in solid oxide fuel cells for interconnect applications. The oxidation behavior of coated substrates was studied as a function of time at operating conditions of SOFCs. Cyclic oxidation has been also tested at 800ºC for 100 cycles. Cobalt coating during isothermal oxidation caused to the oxide growth resistance by limiting the outward diffusion of Cr cation and the inward diffusion of oxygen anion. Results of cyclic oxidation exhibited that coated substrates demonstrate an excellent resistance against the spallation and cracking.
Keywords: Oxidation resistance, full cell, Cobalt coating, ferritic stainless steel.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2032480 Genetic Content-Based MP3 Audio Watermarking in MDCT Domain
Authors: N. Moghadam, H. Sadeghi
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In this paper a novel scheme for watermarking digital audio during its compression to MPEG-1 Layer III format is proposed. For this purpose we slightly modify some of the selected MDCT coefficients, which are used during MPEG audio compression procedure. Due to the possibility of modifying different MDCT coefficients, there will be different choices for embedding the watermark into audio data, considering robustness and transparency factors. Our proposed method uses a genetic algorithm to select the best coefficients to embed the watermark. This genetic selection is done according to the parameters that are extracted from the perceptual content of the audio to optimize the robustness and transparency of the watermark. On the other hand the watermark security is increased due to the random nature of the genetic selection. The information of the selected MDCT coefficients that carry the watermark bits, are saves in a database for future extraction of the watermark. The proposed method is suitable for online MP3 stores to pursue illegal copies of musical artworks. Experimental results show that the detection ratio of the watermarks at the bitrate of 128kbps remains above 90% while the inaudibility of the watermark is preserved.Keywords: Content-Based Audio Watermarking, Genetic AudioWatermarking.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1517479 Optimization of Multi-Zone Unconventional (Shale) Gas Reservoir Using Hydraulic Fracturing Technique
Authors: F.C. Amadi, G. C. Enyi, G. G. Nasr
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Hydraulic fracturing is one of the most important stimulation techniques available to the petroleum engineer to extract hydrocarbons in tight gas sandstones. It allows more oil and gas production in tight reservoirs as compared to conventional means. The main aim of the study is to optimize the hydraulic fracturing as technique and for this purpose three multi-zones layer formation is considered and fractured contemporaneously. The three zones are named as Zone1 (upper zone), Zone2 (middle zone) and Zone3 (lower zone) respectively and they all occur in shale rock. Simulation was performed with Mfrac integrated software which gives a variety of 3D fracture options. This simulation process yielded an average fracture efficiency of 93.8%for the three respective zones and an increase of the average permeability of the rock system. An average fracture length of 909 ft with net height (propped height) of 210 ft (average) was achieved. Optimum fracturing results was also achieved with maximum fracture width of 0.379 inches at an injection rate of 13.01 bpm with 17995 Mscf of gas production.Keywords: Hydraulic fracturing, Mfrac, Optimisation, Tight reservoir.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1959478 Application of Genetic Algorithm for FACTS-based Controller Design
Authors: Sidhartha Panda, N. P. Padhy, R.N.Patel
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In this paper, genetic algorithm (GA) opmization technique is applied to design Flexible AC Transmission System (FACTS)-based damping controllers. Two types of controller structures, namely a proportional-integral (PI) and a lead-lag (LL) are considered. The design problem of the proposed controllers is formulated as an optimization problem and GA is employed to search for optimal controller parameters. By minimizing the time-domain based objective function, in which the deviation in the oscillatory rotor speed of the generator is involved; stability performance of the system is improved. The proposed controllers are tested on a weakly connected power system subjected to different disturbances. The non-linear simulation results are presented to show the effectiveness of the proposed controller and their ability to provide efficient damping of low frequency oscillations. It is also observed that the proposed SSSC-based controllers improve greatly the voltage profile of the system under severe disturbances. Further, the dynamic performances of both the PI and LL structured FACTS-controller are analyzed at different loading conditions and under various disturbance condition as well as under unbalanced fault conditions..
Keywords: Genetic algorithm, proportional-integral controller, lead-lag controller, power system stability, FACTS.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2544477 Implementation of the SIP Express Router with Mediaproxy Method on VoIP
Authors: Heru Nurwarsito, R. Arief Setyawan, Rakhmadhany Primananda
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Voice Over IP (VoIP) is a technology that could pass the voice traffic and data packet form over an IP network. Network can be used for intranet or Internet. Phone calls using VoIP has advantages in terms of cheaper cost of PSTN phone to more than half, because the cost is calculated by the cost of the global nature of the Internet. Session Initiation Protocol (SIP) is a signaling protocol at the application layer which serves to establish, modify, and terminate a multimedia session involving one or more users. This SIP signaling has SIP message in text form that is used for session management by the SIP components, such as User Agent, Registrar, Redirect Server, and Proxy Server. To build a SIP communication is required SIP Express Router (SER) to be able to receive SIP messages, for handling the basic functions of SIP messages. Problems occur when the NAT through which affects the voice communication will be blocked starting from the sound that is not sent or one side of the sound are sent (half duplex). How that could be used to penetrate NAT is to use a given mediaproxy random RTP port to penetrate NAT.Keywords: VoIP, SIP, SIP Express Router, NAT, Mediaproxy.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2558476 A Nanosensor System Based On Disuccinimydyl–CYP2E1 for Amperometric Detection of the Anti-Tuberculosis Drug, Pyrazinamide
Authors: R. F. Ajayi, U. Sidwaba, U. Feleni, S. F. Douman, E. Nxusani, L. Wilson, C. Rassie, O. Tovide, P. G. L. Baker, S. L. Vilakazi, R. Tshikhudo, E. I. Iwuoha
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Pyrazinamide (PZA) is among the first-line pro-drugs in the tuberculosis (TB) combination chemotherapy used to treat Mycobacterium tuberculosis. Numerous reports have suggested that hepatotoxicity due to pyrazinamide in patients is due to inappropriate dosing. It is, therefore necessary to develop sensitive and reliable techniques for determining the PZA metabolic profile of diagnosed patients promptly and at point-of-care. This study reports the determination of PZA based on nanobiosensor systems developed from disuccinimidyl octanedioate modified Cytochrome P450-2E1 (CYP2E1) electrodeposited on gold substrates derivatised with (poly(8-anilino-1-napthalene sulphonic acid) PANSA/PVP-AgNPs nanocomposites. The rapid and sensitive amperometric PZA detection gave a dynamic linear range of 2µM to 16µM revealing a limit of detection of 0.044µM and a sensitivity of 1.38µA/µM. The Michaelis-Menten parameters; KM, KM app and IMAX were calculated to be 6.0µM, 1.41µM and 1.51x10-6 A, respectively, indicating a nanobiosensor suitable for use in serum.
Keywords: Cytochrome P450-2E1, Disuccinimidyl octanedioate, Pyrazinamide, Tuberculosis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2224475 Effective Relay Communication for Scalable Video Transmission
Authors: Jung Ah Park, Zhijie Zhao, Doug Young Suh, Joern Ostermann
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In this paper, we propose an effective relay communication for layered video transmission as an alternative to make the most of limited resources in a wireless communication network where loss often occurs. Relaying brings stable multimedia services to end clients, compared to multiple description coding (MDC). Also, retransmission of only parity data about one or more video layer using channel coder to the end client of the relay device is paramount to the robustness of the loss situation. Using these methods in resource-constrained environments, such as real-time user created content (UCC) with layered video transmission, can provide high-quality services even in a poor communication environment. Minimal services are also possible. The mathematical analysis shows that the proposed method reduced the probability of GOP loss rate compared to MDC and raptor code without relay. The GOP loss rate is about zero, while MDC and raptor code without relay have a GOP loss rate of 36% and 70% in case of 10% frame loss rate.Keywords: Relay communication, Multiple Description Coding, Scalable Video Coding
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1437474 Performance of Modified Wedge Anchorage System for Pre-Stressed FRP Bars
Authors: Othman S. Alsheraida, Sherif El-Gamal
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Fiber Reinforced Polymer (FRP) is a composite material with exceptional properties that are capable to replace conventional steel reinforcement in reinforced and pre-stressed concrete structures. However, the main obstacle for their wide use in pre-stressed concrete application is the anchorage system. Due to the weakness of FRP in the transverse direction, the pre-stressing capacity of FRP bars are limited. This paper investigates the modification of the conventional wedge anchorage system to be used for stressing of FRP bars in pre-stressed applications. Epoxy adhesive material with glass FRP (GFRP) bars and conventional steel wedge were used in this paper. The GFRP bars are encased with epoxy at the anchor zone and the wedge system was used in pull-out test. The results showed a loading capacity of 47.6 kN which is 69% of the bar ultimate capacity. Additionally, nylon wedge was made with the same dimensions of the steel wedge and tested for GFRP bars without epoxy layer. The nylon wedge showed a loading capacity of 19.7 kN which is only 28.5% of the ultimate bar capacity.
Keywords: Anchorage, concrete, epoxy, FRP, pre-stressed.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2515473 Identifying Neighborhoods at Potential Risk of Food Insecurity in Rural British Columbia
Authors: Amirmohsen Behjat, Aleck Ostry, Christina Miewald, Bernie Pauly
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Substantial research has indicated that socioeconomic and demographic characteristics’ of neighborhoods are strong determinants of food security. The aim of this study was to develop a Food Insecurity Neighborhood Index (FINI) based on the associated socioeconomic and demographic variables to identify the areas at potential risk of food insecurity in rural British Columbia (BC). Principle Component Analysis (PCA) technique was used to calculate the FINI for each rural Dissemination Area (DA) using the food security determinant variables from Canadian Census data. Using ArcGIS, the neighborhoods with the top quartile FINI values were classified as food insecure. The results of this study indicated that the most food insecure neighborhood with the highest FINI value of 99.1 was in the Bulkley-Nechako (central BC) area whereas the lowest FINI with the value of 2.97 was for a rural neighborhood in the Cowichan Valley area. In total, 98.049 (19%) of the rural population of British Columbians reside in high food insecure areas. Moreover, the distribution of food insecure neighborhoods was found to be strongly dependent on the degree of rurality in BC. In conclusion, the cluster of food insecure neighbourhoods was more pronounced in Central Coast, Mount Wadington, Peace River, Kootenay Boundary, and the Alberni-Clayoqout Regional Districts.
Keywords: Neighbourhood food insecurity index, socioeconomic and demographic determinants, principal component analysis, Canada Census, ArcGIS.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 898472 Numerical Studies on Flow Field Characteristics of Cavity Based Scramjet Combustors
Authors: Rakesh Arasu, Sasitharan Ambicapathy, Sivaraj Ponnusamy, Mohanraj Murugesan, V. R. Sanal Kumar
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The flow field within the combustor of scramjet engine is very complex and poses a considerable challenge in the design and development of a supersonic combustor with an optimized geometry. In this paper comprehensive numerical studies on flow field characteristics of different cavity based scramjet combustors with transverse injection of hydrogen have been carried out for both non-reacting and reacting flows. The numerical studies have been carried out using a validated 2D unsteady, density based 1st-order implicit k-omega turbulence model with multi-component finite rate reacting species. The results show a wide variety of flow features resulting from the interactions between the injector flows, shock waves, boundary layers, and cavity flows. We conjectured that an optimized cavity is a good choice to stabilize the flame in the hypersonic flow, and it generates a recirculation zone in the scramjet combustor. We comprehended that the cavity based scramjet combustors having a bearing on the source of disturbance for the transverse jet oscillation, fuel/air mixing enhancement, and flameholding improvement. We concluded that cavity shape with backward facing step and 45o forward ramp is a good choice to get higher temperatures at the exit compared to other four models of scramjet combustors considered in this study.
Keywords: Flame holding, Hypersonic flow, Scramjet combustor, Supersonic combustor.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3224471 Effect of Process Parameters on the Proximate Composition, Functional and Sensory Properties
Authors: C. I. Omohimi, O. P. Sobukola, K. O. Sarafadeen, L.O. Sanni
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Flour from Mucuna beans (Mucuna pruriens) were used in producing texturized meat analogue using a single screw extruder to monitor modifications on the proximate composition and the functional properties at high moisture level. Response surface methodology based on Box Behnken design at three levels of barrel temperature (110, 120, 130°C), screw speed (100,120,140rpm) and feed moisture (44, 47, 50%) were used in 17 runs. Regression models describing the effect of variables on the product responses were obtained. Descriptive profile analyses and consumer acceptability test were carried out on optimized flavoured extruded meat analogue. Responses were mostly affected by barrel temperature and moisture level and to a lesser extent by screw speed. Optimization results based on desirability concept indicated that a barrel temperature of 120.15°C, feed moisture of 47% and screw speed of 119.19 rpm would produce meat analogue of preferable proximate composition, functional and sensory properties which reveals consumers` likeness for the product.Keywords: Functional properties, mucuna bean flour, optimization, proximate composition, texturized meat analogue.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3011470 Application of Artificial Neural Network to Forecast Actual Cost of a Project to Improve Earned Value Management System
Authors: Seyed Hossein Iranmanesh, Mansoureh Zarezadeh
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This paper presents an application of Artificial Neural Network (ANN) to forecast actual cost of a project based on the earned value management system (EVMS). For this purpose, some projects randomly selected based on the standard data set , and it is produced necessary progress data such as actual cost ,actual percent complete , baseline cost and percent complete for five periods of project. Then an ANN with five inputs and five outputs and one hidden layer is trained to produce forecasted actual costs. The comparison between real and forecasted data show better performance based on the Mean Absolute Percentage Error (MAPE) criterion. This approach could be applicable to better forecasting the project cost and result in decreasing the risk of project cost overrun, and therefore it is beneficial for planning preventive actions.
Keywords: Earned Value Management System (EVMS), Artificial Neural Network (ANN), Estimate At Completion, Forecasting Methods, Project Performance Measurement.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2768469 Seismic Excitation of Steel Frame Retrofitted by a Multi-Panel PMC Infill Wall
Authors: Bu Seog Ju, Woo Young Jung
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A multi-panel PMC infilled system, using polymer matrix composite (PMC) material, was introduced as new conceptual design for seismic retrofitting. A proposed multi panel PMC infilled system was composed of two basic structural components: inner PMC sandwich infills and outer FRP damping panels. The PMC material had high stiffness-to-weight and strength-to-weight ratios. Therefore, the addition of PMC infill panels into existing structures would not significantly alter the weight of the structure, while providing substantial structural enhancement.
In this study, an equivalent linearized dynamic analysis for a proposed multi-panel PMC infilled frame was performed, in order to assess their effectiveness and their responses under the simulated earthquake loading. Upon comparing undamped (without PMC panel) and damped (with PMC panel) structures, numerical results showed that structural damping with passive interface damping layer could significantly enhance the seismic response.
Keywords: Polymer Matrix Composite (PMC), Panel, Piece-wise linear, Earthquake, FRP.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2333468 Optimal Capacitor Allocation for loss reduction in Distribution System Using Fuzzy and Plant Growth Simulation Algorithm
Authors: R. Srinivasa Rao
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This paper presents a new and efficient approach for capacitor placement in radial distribution systems that determine the optimal locations and size of capacitor with an objective of improving the voltage profile and reduction of power loss. The solution methodology has two parts: in part one the loss sensitivity factors are used to select the candidate locations for the capacitor placement and in part two a new algorithm that employs Plant growth Simulation Algorithm (PGSA) is used to estimate the optimal size of capacitors at the optimal buses determined in part one. The main advantage of the proposed method is that it does not require any external control parameters. The other advantage is that it handles the objective function and the constraints separately, avoiding the trouble to determine the barrier factors. The proposed method is applied to 9 and 34 bus radial distribution systems. The solutions obtained by the proposed method are compared with other methods. The proposed method has outperformed the other methods in terms of the quality of solution.Keywords: Distribution systems, Capacitor allocation, Loss reduction, Fuzzy, PGSA.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2279467 Growth Behaviors, Thermostable Direct Hemolysin Secretion and Fatty Acid Profiles of Acid-adapted and Non-adapted Vibrio parahaemolyticus
Authors: Ming-Lun Chiang, Chieh Wu, Ming-Ju Chen
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Three strains of Vibrio parahaemolyticus (690, BCRC 13023 and BCRC 13025) implicated in food poisoning outbreaks in Taiwan were subjected to acid adaptation at pH 5.5 for 90 min. The growth behaviors of acid-adapted and non-adapted V. parahaemolyticus in the media supplemented with various nitrogen and carbon sources were investigated. The effects of acid adaptation on the thermostable direct hemolysin (TDH) secretion and fatty acid profiles of V. parahaemolyticus were also examined. Results showed that acid-adapted and non-adapted V. parahaemolyticus 690, BCRC 13023 and BCRC 13025 grew similarly in TSB-3% NaCl and basal media supplemented with various carbon and nitrogen sources during incubation period. Higher TDH secretion was noted with V. parahaemolyticus 690 among the three strains. However, acid-adapted strains produced less amounts of TDH than non-adapted strains when they were grown in TSB-3% NaCl. Additionally, acid adaptation increased the ratio of SFA/USFA in cells of V. parahaemolyticus strains.
Keywords: Vibrio parahaemolyticus, acid adaptation, thermostable direct hemolysin, fatty acid profile.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2117