Search results for: California red scale
946 Talent Management and its Use in the Field of Human Resources Management in the Organization of the Czech Republic
Authors: Petra Horváthová, Irena Durdová
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The article is aimed at bringing information on the scope and the level of use of talent management by organizations in one of the Czech Republic regions, in the Moravian-Silesian Region. On the basis of data acquired by a questionnaire survey it has been found out that organizations in the above-mentioned region are implementing the system of talent management on a small scale: this approach is used by 3.8 % of organizations only that is 9 from 237 (100 %) of the approached respondents. The main reasons why this approach is not used is either that organizations have no knowledge of it or there is lack of financial and personnel resources. In the article recommendations suggested by the author can be found for a wider application of talent management in the Czech practice.
Keywords: Talent, talent management, use, mind map of talent management.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2154945 Seismic Vulnerability Assessment of Buildings in Algiers Area
Authors: F. Lazzali, M. Farsi
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Several models of vulnerability assessment have been proposed. The selection of one of these models depends on the objectives of the study. The classical methodologies for seismic vulnerability analysis, as a part of seismic risk analysis, have been formulated with statistical criteria based on a rapid observation. The information relating to the buildings performance is statistically elaborated. In this paper, we use the European Macroseismic Scale EMS-98 to define the relationship between damage and macroseismic intensity to assess the seismic vulnerability. Applying to Algiers area, the first step is to identify building typologies and to assign vulnerability classes. In the second step, damages are investigated according to EMS-98.
Keywords: Damage, EMS-98, inventory building, vulnerability classes
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1804944 Response of a Bridge Crane during an Earthquake
Authors: F. Fekak, A. Gravouil, M. Brun, B. Depale
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During an earthquake, a bridge crane may be subjected to multiple impacts between crane wheels and rail. In order to model such phenomena, a time-history dynamic analysis with a multi-scale approach is performed. The high frequency aspect of the impacts between wheels and rails is taken into account by a Lagrange explicit event-capturing algorithm based on a velocity-impulse formulation to resolve contacts and impacts. An implicit temporal scheme is used for the rest of the structure. The numerical coupling between the implicit and the explicit schemes is achieved with a heterogeneous asynchronous time-integrator.Keywords: Earthquake, bridge crane, heterogeneous asynchronous time-integrator, impacts.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1420943 Payment for Pain: Differences between Hypothetical and Real Preferences
Authors: J. Trarbach, S. Schosser, B. Vogt
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Decision-makers tend to prefer the first alternative over subsequent alternatives which is called the primacy effect. To reliably measure this effect, we conducted an experiment with real consequences for preference statements. Therefore, we elicit preferences of subjects using a rating scale, i.e. hypothetical preferences, and willingness to pay, i.e. real preferences, for two sequences of pain. Within these sequences, both overall intensity and duration of pain are identical. Hence, a rational decision-maker should be indifferent, whereas the primacy effect predicts a stronger preference for the first sequence. What we see is a primacy effect only for hypothetical preferences. This effect vanishes for real preferences.
Keywords: Decision making, primacy effect, real incentives, willingness to pay.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 866942 The Viscosity of Xanthan Gum Grout with Different pH and Ionic Strength
Authors: H. Ahmad Raji, R. Ziaie Moayed, M. A. Nozari
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Xanthan gum (XG) an eco-friendly biopolymer has been recently explicitly investigated for ground improvement approaches. Rheological behavior of this additive strongly depends on electrochemical condition such as pH, ionic strength and also its content in aqueous solution. So, the effects of these factors have been studied in this paper considering various XG contents as 0.25, 0.5, 1, and 2% of water. Moreover, adjusting pH values such as 3, 5, 7 and 9 in addition to increasing ionic strength to 0.1 and 0.2 in the molar scale has covered a practical range of electrochemical condition. The viscosity of grouts shows an apparent upward trend with an increase in ionic strength and XG content. Also, pH affects the polymerization as much as other parameters. As a result, XG behavior is severely influenced by electrochemical settingsKeywords: Electrochemical condition, ionic strength, viscosity, xanthan gum.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 642941 Analysis of Long-Term File System Activities on Cluster Systems
Authors: Hyeyoung Cho, Sungho Kim, Sik Lee
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I/O workload is a critical and important factor to analyze I/O pattern and to maximize file system performance. However to measure I/O workload on running distributed parallel file system is non-trivial due to collection overhead and large volume of data. In this paper, we measured and analyzed file system activities on two large-scale cluster systems which had TFlops level high performance computation resources. By comparing file system activities of 2009 with those of 2006, we analyzed the change of I/O workloads by the development of system performance and high-speed network technology.Keywords: I/O workload, Lustre, GPFS, Cluster File System
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1451940 Numerical Investigation on Damage Evolution of Piles inside Liquefied Soil Foundation - Dynamic-Loading Experiments -
Authors: Ahmed Mohammed Youssef Mohammed, Mohammad Reza Okhovat, Koichi Maekawa
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The large and small-scale shaking table tests, which was conducted for investigating damage evolution of piles inside liquefied soil, are numerically simulated and experimental verified by the3D nonlinear finite element analysis. Damage evolution of elasto-plastic circular steel piles and reinforced concrete (RC) one with cracking and yield of reinforcement are focused on, and the failure patterns and residual damages are captured by the proposed constitutive models. The superstructure excitation behind quay wall is reproduced as well.Keywords: Soil-Structure Interaction, Piles, Soil Liquefaction.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1985939 Undecimated Wavelet Transform Based Contrast Enhancement
Authors: Numan Unaldi, Samil Temel, Süleyman Demirci
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A novel undecimated wavelet transform based contrast enhancement algorithmis proposed to for both gray scale andcolor images. Contrast enhancement is realized by tuning the magnitude of approximation coefficients at each level with respect to the approximation coefficients of one higher level during the inverse transform phase in a center/surround enhancement sense.The performance of the proposed algorithm is evaluated using a statistical visual contrast measure (VCM). Experimental results on the proposed algorithm show improvement in terms of the VCM.
Keywords: Image enhancement, local contrast enhancement, visual contrast measure.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2739938 Efficient Use of Energy through Incorporation of a Gas Turbine in Methanol Plant
Authors: M. Azadi, N. Tahouni, M. H. Panjeshahi
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A techno-economic evaluation for efficient use of energy in a large scale industrial plant of methanol is carried out. This assessment is based on integration of a gas turbine with an existing plant of methanol in which the outlet gas products of exothermic reactor is expanded to power generation. Also, it is decided that methanol production rate is constant through addition of power generation system to the existing methanol plant. Having incorporated a gas turbine with the existing plant, the economic results showed total investment of MUSD 16.9, energy saving of 3.6 MUSD/yr with payback period of approximately 4.7 years.
Keywords: Energy saving, Gas turbine, Methanol, Power generation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2129937 Feedback Stabilization Based on Observer and Guaranteed Cost Control for Lipschitz Nonlinear Systems
Authors: A. Thabet, G. B. H. Frej, M. Boutayeb
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This paper presents a design of dynamic feedback control based on observer for a class of large scale Lipschitz nonlinear systems. The use of Differential Mean Value Theorem (DMVT) is to introduce a general condition on the nonlinear functions. To ensure asymptotic stability, sufficient conditions are expressed in terms of linear matrix inequalities (LMIs). High performances are shown through real time implementation with ARDUINO Duemilanove board to the one-link flexible joint robot.Keywords: Feedback stabilization, DMVT, Lipschitz nonlinear systems, nonlinear observer, real time implementation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1350936 Development of a Mathematical Theoretical Model and Simulation of the Electromechanical System for Wave Energy Harvesting
Authors: P. Valdez, M. Pelissero, A. Haim, F. Muiño, F. Galia, R. Tula
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As a result of the studies performed on the wave energy resource worldwide, a research project was set up to harvest wave energy for its conversion into electrical energy. Within this framework, a theoretical model of the electromechanical energy harvesting system, developed with MATLAB’s Simulink software, will be provided. This tool recreates the site conditions where the device will be installed and offers valuable information about the amount of energy that can be harnessed. This research provides a deeper understanding of the utilization of wave energy in order to improve the efficiency of a 1:1 scale prototype of the device.
Keywords: Electromechanical device, modeling, renewable energy, sea wave energy, simulation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1162935 A Contribution to the Application of the Structural Analysis Method in Entrepreneurial Practice
Authors: Kamila Janovská, Šárka Vilamová, Petr Besta, Iveta Vozňáková, Roman Kozel
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Quantitative methods of economic decision-making as the methodological base of the so called operational research represent an important set of tools for managing complex economic systems,both at the microeconomic level and on the macroeconomic scale. Mathematical models of controlled and controlling processes allow, by means of artificial experiments, obtaining information foroptimalor optimum approaching managerial decision-making.The quantitative methods of economic decision-making usually include a methodology known as structural analysis -an analysisof interdisciplinary production-consumption relations.Keywords: economic decision-making, mathematical methods, structuralanalysis, technical coefficient
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1425934 The Effect of Slow Variation of Base Flow Profile on the Stability of Slightly Curved Mixing Layers
Authors: Irina Eglite, Andrei A. Kolyshkin
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The effect of small non-parallelism of the base flow on the stability of slightly curved mixing layers is analyzed in the present paper. Assuming that the instability wavelength is much smaller than the length scale of the variation of the base flow we derive an amplitude evolution equation using the method of multiple scales. The proposed asymptotic model provides connection between parallel flow approximations and takes into account slow longitudinal variation of the base flow.Keywords: shallow water, parallel flow assumption, weaklynonlinear analysis, method of multiple scales
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1466933 Evaluating Content Based Image Retrieval Techniques with the One Million Images CLIC Test Bed
Authors: Pierre-Alain Moëllic, Patrick Hède, Gr egory Grefenstette, Christophe Millet
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Pattern recognition and image recognition methods are commonly developed and tested using testbeds, which contain known responses to a query set. Until now, testbeds available for image analysis and content-based image retrieval (CBIR) have been scarce and small-scale. Here we present the one million images CEA-List Image Collection (CLIC) testbed that we have produced, and report on our use of this testbed to evaluate image analysis merging techniques. This testbed will soon be made publicly available through the EU MUSCLE Network of Excellence.
Keywords: CBIR, CLIC, evaluation, image indexing and retrieval, testbed.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1378932 On Unburned Carbon in Coal Ash from Various Combustion Units
Authors: L. Bartonová, D. Juchelková, Z. Klika, B. Cech
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Work is focused to the study of unburned carbon in ash from coal (and wastes) combustion in 8 combustion tests at 3 fluidised-bed power station, at co-combustion of coal and wastes (also at fluidized bed) and at bench-scale unit simulating coal combustion in small domestic furnaces. The attention is paid to unburned carbon contents in bottom ashes and fly ashes at these 8 combustion tests and to morphology of unburned carbons. Specific surface area of coals, unburned carbons and ashes and the relation of specific surface area of unburned carbon and the content of volatile combustibles in coal were studied as well.Keywords: Coal combustion, emissions, toxic elements, unburned carbon.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3735931 Slugging Frequency Correlation for Inclined Gas-liquid Flow
Authors: V. Hernandez-Perez, M. Abdulkadir, B. J. Azzopardi
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In this work, new experimental data for slugging frequency in inclined gas-liquid flow are reported, and a new correlation is proposed. Scale experiments were carried out using a mixture of air and water in a 6 m long pipe. Two different pipe diameters were used, namely, 38 and 67 mm. The data were taken with capacitance type sensors at a data acquisition frequency of 200 Hz over an interval of 60 seconds. For the range of flow conditions studied, the liquid superficial velocity is observed to influence the frequency strongly. A comparison of the present data with correlations available in the literature reveals a lack of agreement. A new correlation for slug frequency has been proposed for the inclined flow, which represents the main contribution of this work.Keywords: slug frequency, inclined flow
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 3148930 Comparing Measurements of UV Radiation in Winter and Summer in Finland
Authors: R. Pääkkönen, L. Korpinen, F. Gobba
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The objective of our study is to investigate UV exposure in Finland through sample measurements as a typical case study in summer and winter. We measured UV-BC weighted radiation and calculated a daily dose, which is about 100–150 times the Finnish exposure limit value in summer and 1–6 times in winter. The measured ultraviolet indices varied from 0 to 7 (scale 0–18), which is less than the values obtained in countries that are located farther south from Tampere latitude of 61 degrees. In wintertime, the UV exposure was modest compared to summertime, 50–150 mW/m2 and about 1–5 mW/m2 in summer and winter, respectively. However, technical means to manage UV exposure in Scandinavia are also needed in summer- and springtime.
Keywords: Ultraviolet radiation, measurement, winter, summer.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1469929 System Detecting Border Gateway Protocol Anomalies Using Local and Remote Data
Authors: A. Starczewska, A. Nawrat, K. Daniec, J. Homa, K. Hołda
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Border Gateway Protocol (BGP) is the main routing protocol that enables routing establishment between all autonomous systems, which are the basic administrative units of the internet. Due to the poor protection of BGP, it is important to use additional BGP security systems. Many solutions to this problem have been proposed over the years, but none of them have been implemented on a global scale. This article describes a system capable of building images of real-time BGP network topology in order to detect BGP anomalies. Our proposal performs a detailed analysis of BGP messages that come into local network cards supplemented by information collected by remote collectors in different localizations.
Keywords: Border Gateway Protocol, BGP, BGP hijacking, cybersecurity, detection.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 55928 A Review of Enterprise Risk Management Practices among Malaysian Public Listed Companies
Authors: Fong-Woon Lai
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The risk sphere in business is fast changing and expanding. Almost anything has become a risk factor that will have potent, direct, and far reaching impacts on business. This paper examines the intensity of enterprise risk management (ERM) practices among the Malaysian public listed companies. The paper espouses a ERM framework comprising fourteen important implementation elements and processes. Results of the analysis indicate that the intensity of ERM implementation among the respondents is in the ‘good’ category of the semantic scale, which is deemed encouraging vis-à-vis the country’s regulatory regime.
Keywords: Enterprise risk management, implementation framework, ERM practices.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2984927 Morphological Parameters and Selection of Turkish Edible Seed Pumpkins (Cucurbita pepo L.) Germplasm
Authors: Onder Turkmen, Musa Seymen, Sali Fidan, Mustafa Paksoy
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There is a requirement for registered edible seed pumpkin suitable for eating in Turkey. A total of 81 genotypes collected from the researchers in 2005 originated from Eskisehir, Konya, Nevsehir, Tekirdag, Sakarya, Kayseri and Kirsehir provinces were utilized. The used genetic materials were brought to S5 generation by the research groups among 2006 and 2010 years. In this research, S5 stage reached in the genotype given some of the morphological features, and selection of promising genotypes generated scale were made. Results showed that the A-1 (420), A-7 (410), A-8 (420), A-32 (420), B-17 (410), B-24 (410), B-25 (420), B-33 (400), C-24 (420), C-25 (410), C-26 (410) and C-30 (420) genotypes are expected to be promising varieties.
Keywords: Candidate cultivar, edible seed pumpkin, morphologic parameters, selection.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1200926 FACTS Impact on Grid Stability and Power Markets
Authors: Abdulrahman Alsuhaibani, Martin Macken
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FACTS devices have great influence on the grid stability and power markets price. Recently, there is intent to integrate a large scale of renewable energy sources to the power system which in turn pushes the power system to operate closer to the security limits. This paper discusses the power system stability and reliability improvement that could be achieved by using FACTS. There is a comparison between FACTS devices to evaluate their performance for different functions. A case study has also been made about its effect on reducing generation cost and minimizing transmission losses which have good impact on efficient and economic operation of electricity markets.
Keywords: FACTS, grid stability, spot price, Optimal Power Flow.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 350925 Optimal ECG Sampling Frequency for Multiscale Entropy-Based HRV
Authors: Manjit Singh
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Multiscale entropy (MSE) is an extensively used index to provide a general understanding of multiple complexity of physiologic mechanism of heart rate variability (HRV) that operates on a wide range of time scales. Accurate selection of electrocardiogram (ECG) sampling frequency is an essential concern for clinically significant HRV quantification; high ECG sampling rate increase memory requirements and processing time, whereas low sampling rate degrade signal quality and results in clinically misinterpreted HRV. In this work, the impact of ECG sampling frequency on MSE based HRV have been quantified. MSE measures are found to be sensitive to ECG sampling frequency and effect of sampling frequency will be a function of time scale.Keywords: ECG, heart rate variability, HRV, multiscale entropy, sampling frequency.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1344924 Transmission Lines Loading Enhancement Using ADPSO Approach
Authors: M. Mahdavi, H. Monsef, A. Bagheri
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Discrete particle swarm optimization (DPSO) is a powerful stochastic evolutionary algorithm that is used to solve the large-scale, discrete and nonlinear optimization problems. However, it has been observed that standard DPSO algorithm has premature convergence when solving a complex optimization problem like transmission expansion planning (TEP). To resolve this problem an advanced discrete particle swarm optimization (ADPSO) is proposed in this paper. The simulation result shows that optimization of lines loading in transmission expansion planning with ADPSO is better than DPSO from precision view point.Keywords: ADPSO, TEP problem, Lines loading optimization.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1608923 Probabilistic Robustness Assessment of Structures under Sudden Column-Loss Scenario
Authors: Ali Y Al-Attraqchi, P. Rajeev, M. Javad Hashemi, Riadh Al-Mahaidi
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This paper presents a probabilistic incremental dynamic analysis (IDA) of a full reinforced concrete building subjected to column loss scenario for the assessment of progressive collapse. The IDA is chosen to explicitly account for uncertainties in loads and system capacity. Fragility curves are developed to predict the probability of progressive collapse given the loss of one or more columns. At a broader scale, it will also provide critical information needed to support the development of a new generation of design codes that attempt to explicitly quantify structural robustness.
Keywords: Incremental dynamic analysis, progressive collapse, structural engineering, pushdown analysis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1043922 Disinfection of Water by Adsorption with Electrochemical Regeneration
Authors: S. N. Hussain, H. M. A. Asghar, E. P. L. Roberts, N. W. Brown
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Arvia®, a spin-out company of University of Manchester, UK is commercialising a water treatment technology for the removal of low concentrations of organics from water. This technology is based on the adsorption of organics onto graphite based adsorbents coupled with their electrochemical regeneration in a simple electrochemical cell. In this paper, the potential of the process to adsorb microorganisms and electrochemically disinfect them present in water has been demonstrated. Bench scale experiments have indicated that the process of adsorption using graphite adsorbents with electrochemical regeneration can be used for water disinfection effectively. The most likely mechanisms of disinfection of water through this process include direct electrochemical oxidation and electrochemical chlorination.Keywords: Arvia, Adsorption, Electrochemical Regeneration, Nyex
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2140921 A Novel Dual-Purpose Image Watermarking Technique
Authors: Maha Sharkas, Dahlia R. ElShafie, Nadder Hamdy
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Image watermarking has proven to be quite an efficient tool for the purpose of copyright protection and authentication over the last few years. In this paper, a novel image watermarking technique in the wavelet domain is suggested and tested. To achieve more security and robustness, the proposed techniques relies on using two nested watermarks that are embedded into the image to be watermarked. A primary watermark in form of a PN sequence is first embedded into an image (the secondary watermark) before being embedded into the host image. The technique is implemented using Daubechies mother wavelets where an arbitrary embedding factor α is introduced to improve the invisibility and robustness. The proposed technique has been applied on several gray scale images where a PSNR of about 60 dB was achieved.Keywords: Image watermarking, Multimedia Security, Wavelets, Image Processing.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1688920 Transmission Expansion Planning with Economic Dispatch and N-1Constraints
Authors: A. Charlangsut, M. Boonthienthong, N. Rugthaicharoencheep
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This paper proposes a mathematical model for transmission expansion employing optimization method with scenario analysis approach. Economic transmission planning, on the other hand, seeks investment opportunities so that network expansions can generate more economic benefits than the costs. This approach can be used as a decision model for building new transmission lines added to the existing transmission system minimizing costs of the entire system subject to various system’s constraints and consider of loss value of transmission system and N-1 checking. The results show that the proposed model is efficient to be applied for the larger scale of power system topology.
Keywords: Transmission Expansion Planning, Economic Dispatch, Scenario Analysis, Contingency.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2090919 Minimizing Examinee Collusion with a Latin- Square Treatment Structure
Authors: M. H. Omar
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Cheating on standardized tests has been a major concern as it potentially minimizes measurement precision. One major way to reduce cheating by collusion is to administer multiple forms of a test. Even with this approach, potential collusion is still quite large. A Latin-square treatment structure for distributing multiple forms is proposed to further reduce the colluding potential. An index to measure the extent of colluding potential is also proposed. Finally, with a simple algorithm, the various Latin-squares were explored to find the best structure to keep the colluding potential to a minimum.Keywords: Colluding pairs, Scale for Colluding Potential, Latin-Square Structure, Minimization of Cheating.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1157918 Decentralised Edge Authentication in the Industrial Enterprise IoT Space
Authors: C. P. Autry, A.W. Roscoe
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Authentication protocols based on public key infrastructure (PKI) and trusted third party (TTP) are no longer adequate for industrial scale IoT networks thanks to issues such as low compute and power availability, the use of widely distributed and commercial off-the-shelf (COTS) systems, and the increasingly sophisticated attackers and attacks we now have to counter. For example, there is increasing concern about nation-state-based interference and future quantum computing capability. We have examined this space from first principles and have developed several approaches to group and point-to-point authentication for IoT that do not depend on the use of a centralised client-server model. We emphasise the use of quantum resistant primitives such as strong cryptographic hashing and the use multi-factor authentication.
Keywords: Authentication, enterprise IoT cybersecurity, public key infrastructure, trusted third party.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 457917 Integration of Microarray Data into a Genome-Scale Metabolic Model to Study Flux Distribution after Gene Knockout
Authors: Mona Heydari, Ehsan Motamedian, Seyed Abbas Shojaosadati
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Prediction of perturbations after genetic manipulation (especially gene knockout) is one of the important challenges in systems biology. In this paper, a new algorithm is introduced that integrates microarray data into the metabolic model. The algorithm was used to study the change in the cell phenotype after knockout of Gss gene in Escherichia coli BW25113. Algorithm implementation indicated that gene deletion resulted in more activation of the metabolic network. Growth yield was more and less regulating gene were identified for mutant in comparison with the wild-type strain.Keywords: Metabolic network, gene knockout, flux balance analysis, microarray data, integration.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 987