Search results for: Single and Multi-objective function.
2709 Impact of Music on Brain Function during Mental Task using Electroencephalography
Authors: B. Geethanjali, K. Adalarasu, R. Rajsekaran
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Music has a great effect on human body and mind; it can have a positive effect on hormone system. Objective of this study is to analysis the effect of music (carnatic, hard rock and jazz) on brain activity during mental work load using electroencephalography (EEG). Eight healthy subjects without special musical education participated in the study. EEG signals were acquired at frontal (Fz), parietal (Pz) and central (Cz) lobes of brain while listening to music at three experimental condition (rest, music without mental task and music with mental task). Spectral powers features were extracted at alpha, theta and beta brain rhythms. While listening to jazz music, the alpha and theta powers were significantly (p < 0.05) high for rest as compared to music with and without mental task in Cz. While listening to Carnatic music, the beta power was significantly (p < 0.05) high for with mental task as compared to rest and music without mental task at Cz and Fz location. This finding corroborates that attention based activities are enhanced while listening to jazz and carnatic as compare to Hard rock during mental task.Keywords: Music, Brain Function, Electroencephalography (EEG), Mental Task, Features extraction parameters
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 45152708 Hybrid Gravity Gradient Inversion-Ant Colony Optimization Algorithm for Motion Planning of Mobile Robots
Authors: Meng Wu
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Motion planning is a common task required to be fulfilled by robots. A strategy combining Ant Colony Optimization (ACO) and gravity gradient inversion algorithm is proposed for motion planning of mobile robots. In this paper, in order to realize optimal motion planning strategy, the cost function in ACO is designed based on gravity gradient inversion algorithm. The obstacles around mobile robot can cause gravity gradient anomalies; the gradiometer is installed on the mobile robot to detect the gravity gradient anomalies. After obtaining the anomalies, gravity gradient inversion algorithm is employed to calculate relative distance and orientation between mobile robot and obstacles. The relative distance and orientation deduced from gravity gradient inversion algorithm is employed as cost function in ACO algorithm to realize motion planning. The proposed strategy is validated by the simulation and experiment results.
Keywords: Motion planning, gravity gradient inversion algorithm, ant colony optimization.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 11812707 Development of a Complete Single Jet Common Rail Injection System Gas Dynamic Model for Hydrogen Fueled Engine with Port Injection Feeding System
Authors: Mohammed Kamil, M. M. Rahman, Rosli A. Bakar
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Modeling of hydrogen fueled engine (H2ICE) injection system is a very important tool that can be used for explaining or predicting the effect of advanced injection strategies on combustion and emissions. In this paper, a common rail injection system (CRIS) is proposed for 4-strokes 4-cylinders hydrogen fueled engine with port injection feeding system (PIH2ICE). For this system, a numerical one-dimensional gas dynamic model is developed considering single injection event for each injector per a cycle. One-dimensional flow equations in conservation form are used to simulate wave propagation phenomenon throughout the CR (accumulator). Using this model, the effect of common rail on the injection system characteristics is clarified. These characteristics include: rail pressure, sound velocity, rail mass flow rate, injected mass flow rate and pressure drop across injectors. The interaction effects of operational conditions (engine speed and rail pressure) and geometrical features (injector hole diameter) are illustrated; and the required compromised solutions are highlighted. The CRIS is shown to be a promising enhancement for PIH2ICE.Keywords: Common rail, hydrogen engine, port injection, wave propagation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15972706 Multiscale Syntheses of Knee Collateral Ligament Stresses: Aggregate Mechanics as a Function of Molecular Properties
Authors: Raouf Mbarki, Fadi Al Khatib, Malek Adouni
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Knee collateral ligaments play a significant role in restraining excessive frontal motion (varus/valgus rotations). In this investigation, a multiscale frame was developed based on structural hierarchies of the collateral ligaments starting from the bottom (tropocollagen molecule) to up where the fibred reinforced structure established. Experimental data of failure tensile test were considered as the principal driver of the developed model. This model was calibrated statistically using Bayesian calibration due to the high number of unknown parameters. Then the model is scaled up to fit the real structure of the collateral ligaments and simulated under realistic boundary conditions. Predications have been successful in describing the observed transient response of the collateral ligaments during tensile test under pre- and post-damage loading conditions. Collateral ligaments maximum stresses and strengths were observed near to the femoral insertions, a results that is in good agreement with experimental investigations. Also for the first time, damage initiation and propagation were documented with this model as a function of the cross-link density between tropocollagen molecules.
Keywords: Multiscale model, tropocollagen, fibrils, ligaments.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 6042705 Vibration Control of Building Using Multiple Tuned Mass Dampers Considering Real Earthquake Time History
Authors: Rama Debbarma, Debanjan Das
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The performance of multiple tuned mass dampers to mitigate the seismic vibration of structures considering real time history data is investigated in this paper. Three different real earthquake time history data like Kobe, Imperial Valley and Mammoth Lake are taken in the present study. The multiple tuned mass dampers (MTMD) are distributed at each storey. For comparative study, single tuned mass damper (STMD) is installed at top of the similar structure. This study is conducted for a fixed mass ratio (5%) and fixed damping ratio (5%) of structures. Numerical study is performed to evaluate the effectiveness of MTMDs and overall system performance. The displacement, acceleration, base shear and storey drift are obtained for both combined system (structure with MTMD and structure with STMD) for all earthquakes. The same responses are also obtained for structure without damper system. From obtained results, it is investigated that the MTMD configuration is more effective for controlling the seismic response of the primary system with compare to STMD configuration.Keywords: Earthquake, multiple tuned mass dampers, single tuned mass damper, time history.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 20042704 Effect of Hydrogen-Diesel Dual Fuel Combustion on the Performance and Emission Characteristics of a Four Stroke-Single Cylinder Diesel Engine
Authors: Madhujit Deb, G. R. K. Sastry, R. S. Panua, Rahul Banerjee, P. K. Bose
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The present work attempts to investigate the combustion, performance and emission characteristics of an existing single-cylinder four-stroke compression-ignition engine operated in dual-fuel mode with hydrogen as an alternative fuel. Environmental concerns and limited amount of petroleum fuels have caused interests in the development of alternative fuels like hydrogen for internal combustion (IC) engines. In this experimental investigation, a diesel engine is made to run using hydrogen in dual fuel mode with diesel, where hydrogen is introduced into the intake manifold using an LPGCNG injector and pilot diesel is injected using diesel injectors. A Timed Manifold Injection (TMI) system has been developed to vary the injection strategies. The optimized timing for the injection of hydrogen was 10^0 CA after top dead center (ATDC). From the study it was observed that with increasing hydrogen rate, enhancement in brake thermal efficiency (BTHE) of the engine has been observed with reduction in brake specific energy consumption (BSEC). Furthermore, Soot contents decrease with an increase in indicated specific NOx emissions with the enhancement of hydrogen flow rate.
Keywords: Diesel engine, Hydrogen, BTHE, BSEC, Soot, NOx.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 44842703 Effect of Installation of Long Cylindrical External Store on Performance, Stability, Control and Handling Qualities of Light Transport Aircraft
Authors: Ambuj Srivastava, Narender Singh
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This paper presents the effect of installation of cylindrical external store on the performance, stability, control and handling qualities of light transport category aircraft. A pair of long cylindrical store was installed symmetrically on either side of the fuselage (port and starboard) ahead of the wing and below the fuselage bottom surface running below pilot and co-pilot window. The cylindrical store was installed as hanging from aircraft surface through specially designed brackets. The adjoining structure was sufficiently reinforced for bearing aerodynamic loads. The length to diameter ratio of long cylindrical store was ~20. Based on academic studies and flow simulation analysis, a considerable detrimental effect on single engine second segment climb performance was found which was later validated through extensive flight testing exercise. The methodology of progressive flight envelope opening was adopted. The certification was sought from Regional airworthiness authorities and for according approval.Keywords: Second segment climb, maximum operating speed, cruise performance, single engine and twin engine, minimum control speed, and additional trim required.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 12442702 On the Exact Solution of Non-Uniform Torsion for Beams with Axial Symmetric Cross-Section
Authors: A.Campanile, M. Mandarino, V. Piscopo, A. Pranzitelli
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In the traditional theory of non-uniform torsion the axial displacement field is expressed as the product of the unit twist angle and the warping function. The first one, variable along the beam axis, is obtained by a global congruence condition; the second one, instead, defined over the cross-section, is determined by solving a Neumann problem associated to the Laplace equation, as well as for the uniform torsion problem. So, as in the classical theory the warping function doesn-t punctually satisfy the first indefinite equilibrium equation, the principal aim of this work is to develop a new theory for non-uniform torsion of beams with axial symmetric cross-section, fully restrained on both ends and loaded by a constant torque, that permits to punctually satisfy the previous equation, by means of a trigonometric expansion of the axial displacement and unit twist angle functions. Furthermore, as the classical theory is generally applied with good results to the global and local analysis of ship structures, two beams having the first one an open profile, the second one a closed section, have been analyzed, in order to compare the two theories.Keywords: Non-uniform torsion, Axial symmetric cross-section, Fourier series, Helmholtz equation, FE method.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 23742701 Cereals' Products with Red Grape and Walnut Extracts as Functional Foods for Prevention of Kidney Dysfunction
Authors: Sahar Y. Al-Okbi, Doha A. Mohamed, Thanaa E. Hamed, Ahmed Ms Hussein
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In the present research, two nutraceuticals made from red grape and walnut that showed previously to improve kidney dysfunction were incorporated separately into functional foods' bread made from barley and rice bran. The functional foods were evaluated in rats in which chronic renal failure was induced through feeding diet rich in adenine and phosphate (APD). The evaluation based on assessing kidney function, oxidative stress, inflammatory biomarkers and body weight gain. Results showed induction of chronic kidney failure reflected in significant increase in plasma urea, creatinine, malondialdehyde, tumor necrosis factor- α and low density lipoprotein cholesterol along with significant reduction of plasma albumin, and total antioxidant and creatinine clearance and body weight gain on feeding APD compared to control healthy group. Feeding the functional foods produced amelioration in the different biochemical parameters and body weight gain indicating improvement in kidney function.
Keywords: Functional food, kidney dysfunction, rats.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 23182700 The Study on the Stationarity of Housing Price-to-Rent and Housing Price-to-Income Ratios in China
Authors: Wen-Chi Liu
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This paper aims to examine whether a bubble is present in the housing market of China. Thus, we use the housing price-to-income ratios and housing price-to-rent ratios of 35 cities from 1998 to 2010. The methods of the panel KSS unit root test with a Fourier function and the SPSM process are likewise used. The panel KSS unit root test with a Fourier function considers the problem of non-linearity and structural changes, and the SPSM process can avoid the stationary time series from dominating the result-generated bias. Through a rigorous empirical study, we determine that the housing price-to-income ratios are stationary in 34 of the 35 cities in China. Only Xining is non-stationary. The housing price-to-rent ratios are stationary in 32 of the 35 cities in China. Chengdu, Fuzhou, and Zhengzhou are non-stationary. Overall, the housing bubbles are not a serious problem in China at the time.
Keywords: Housing Price-to-Income Ratio, Housing Price-to-Rent Ratio, Housing Bubbles, Panel Unit-Root Test.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 23922699 Robust Design and Optimization of Production Wastes: An Application for Industries
Authors: Christopher C. Ihueze, Charles C. Okpala, Christian E. Okafor, Peter O. Ogbobe
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This paper focuses on robust design and optimization of industrial production wastes. Past literatures were reviewed to case study Clamason Industries Limited (CIL) - a leading ladder-tops manufacturer. A painstaking study of the firm-s practices at the shop floor revealed that Over-production, Waiting time, Excess inventory, and Defects are the major wastes that are impeding their progress and profitability. Design expert8 software was used to apply Taguchi robust design and response surface methodology in order to model, analyse and optimise the wastes cost in CIL. Waiting time and overproduction rank first and second in contributing to the costs of wastes in CIL. For minimal wastes cost the control factors of overproduction, waiting-time, defects and excess-inventory must be set at 0.30, 390.70, 4 and 55.70 respectively for CIL. The optimal value of cost of wastes for the months studied was 22.3679. Finally, a recommendation was made that for the company to enhance their profitability and customer satisfaction, they must adopt the Shingeo Shingo-s Single Minute Exchange of Dies (SMED), which will immediately tackle the waste of waiting by drastically reducing their setup time.Keywords: Excess-inventory, setup time, single minute exchange of dies, optimal value, over-production, robust design.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17212698 Environmentally Adaptive Acoustic Echo Suppression for Barge-in Speech Recognition
Authors: Jong Han Joo, Jeong Hun Lee, Young Sun Kim, Jae Young Kang, Seung Ho Choi
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In this study, we propose a novel technique for acoustic echo suppression (AES) during speech recognition under barge-in conditions. Conventional AES methods based on spectral subtraction apply fixed weights to the estimated echo path transfer function (EPTF) at the current signal segment and to the EPTF estimated until the previous time interval. However, the effects of echo path changes should be considered for eliminating the undesired echoes. We describe a new approach that adaptively updates weight parameters in response to abrupt changes in the acoustic environment due to background noises or double-talk. Furthermore, we devised a voice activity detector and an initial time-delay estimator for barge-in speech recognition in communication networks. The initial time delay is estimated using log-spectral distance measure, as well as cross-correlation coefficients. The experimental results show that the developed techniques can be successfully applied in barge-in speech recognition systems.
Keywords: Acoustic echo suppression, barge-in, speech recognition, echo path transfer function, initial delay estimator, voice activity detector.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 23262697 Implementation the Average Input Current Mode Control of Two-Phase Interleaved Boost Converter Using Low-Cost Microcontroller
Authors: Yin Yin Phyo, Tun Lin Naing
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In this paper, the average input current mode control is proposed for two-phase interleaved boost converter with two separate input inductors operating in continuous conduction mode (CCM). The required mathematical model is obtained from the equivalent circuits of its different four modes of operation. The small ripple approximation is derived to find the transfer functions from dynamic model using switching function. In average input current mode control, the inner current loop and outer voltage loop are designed with PI controller using bode analysis. Anti-windup structure is applied for PI controllers in control system. Moreover, the simulation work is carried out by MATLAB/Simulink. And, the hardware prototype is implemented by using low-cost microcontroller Arduino Nano. Finally, the laboratory prototype, available from the local market, is constructed to validate the mathematical model. The results show that the output voltage response is the faster rise time and settling time with acceptable overshoot.
Keywords: Average input current mode control, interleaved boost converter, low-cost microcontroller, PI controller, switching function.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 13662696 Numerical Simulations of Cross-Flow around Four Square Cylinders in an In-Line Rectangular Configuration
Authors: Shams Ul Islam, Chao Ying Zhou, Farooq Ahmad
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A two-dimensional numerical simulation of crossflow around four cylinders in an in-line rectangular configuration is studied by using the lattice Boltzmann method (LBM). Special attention is paid to the effect of the spacing between the cylinders. The Reynolds number ( Re ) is chosen to be e 100 R = and the spacing ratio L / D is set at 0.5, 1.5, 2.5, 4.0, 5.0, 6.0, 7.0, 8.0, 9.0 and 10.0. Results show that, as in the case of four cylinders in an inline rectangular configuration , flow fields show four different features depending on the spacing (single square cylinder, stable shielding flow, wiggling shielding flow and a vortex shedding flow) are observed in this study. The effects of spacing ratio on physical quantities such as mean drag coefficient, Strouhal number and rootmean- square value of the drag and lift coefficients are also presented. There is more than one shedding frequency at small spacing ratios. The mean drag coefficients for downstream cylinders are less than that of the single cylinder for all spacing ratios. The present results using the LBM are compared with some existing experimental data and numerical studies. The comparison shows that the LBM can capture the characteristics of the bluff body flow reasonably well and is a good tool for bluff body flow studies.Keywords: Four square cylinders, Lattice Boltzmann method, rectangular configuration, spacing ratios, vortex shedding.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 27062695 Effects of Blast Load on Historic Stone Masonry Buildings in Canada: A Review and Analytical Study
Authors: Abass Braimah, Maha Hussein Abdallah
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The global ascendancy of terrorist attacks on building infrastructure with economic and heritage significance has increased awareness of the possibility of terrorism in Canada. Many structures in Canada that are at risk of terrorist attacks include government buildings, built many years ago of historic stone masonry construction. Although many researchers are investigating ways to retrofit masonry stone buildings to mitigate the effect of blast loadings, lack of knowledge on the dynamic behavior of historic stone masonry structures under blast loads makes it difficult to ascertain the effectiveness of the retrofitting techniques. This paper presents a review of open-source literature for the experimental and numerical stone masonry structures under blast loads. This review yielded very little information of the response of the historic stone masonry structures under blast loads. Thus, a comprehensive study is needed to understand the blast load effects on historic stone masonry buildings. The out-of-plane response of historic masonry structures to blast loads is investigated by using single-degree-of-freedom analysis. This approach presents equations that can be used effectively in the analysis of historic masonry walls to out-of-plane blast loading.
Keywords: Blast loads, historical buildings, masonry structure, single-degree-of-freedom analysis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 4622694 Virulent-GO: Prediction of Virulent Proteins in Bacterial Pathogens Utilizing Gene Ontology Terms
Authors: Chia-Ta Tsai, Wen-Lin Huang, Shinn-Jang Ho, Li-Sun Shu, Shinn-Ying Ho
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Prediction of bacterial virulent protein sequences can give assistance to identification and characterization of novel virulence-associated factors and discover drug/vaccine targets against proteins indispensable to pathogenicity. Gene Ontology (GO) annotation which describes functions of genes and gene products as a controlled vocabulary of terms has been shown effectively for a variety of tasks such as gene expression study, GO annotation prediction, protein subcellular localization, etc. In this study, we propose a sequence-based method Virulent-GO by mining informative GO terms as features for predicting bacterial virulent proteins. Each protein in the datasets used by the existing method VirulentPred is annotated by using BLAST to obtain its homologies with known accession numbers for retrieving GO terms. After investigating various popular classifiers using the same five-fold cross-validation scheme, Virulent-GO using the single kind of GO term features with an accuracy of 82.5% is slightly better than VirulentPred with 81.8% using five kinds of sequence-based features. For the evaluation of independent test, Virulent-GO also yields better results (82.0%) than VirulentPred (80.7%). When evaluating single kind of feature with SVM, the GO term feature performs much well, compared with each of the five kinds of features.Keywords: Bacterial virulence factors, GO terms, prediction, protein sequence.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 21952693 Optimal Tuning of Linear Quadratic Regulator Controller Using a Particle Swarm Optimization for Two-Rotor Aerodynamical System
Authors: Ayad Al-Mahturi, Herman Wahid
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This paper presents an optimal state feedback controller based on Linear Quadratic Regulator (LQR) for a two-rotor aero-dynamical system (TRAS). TRAS is a highly nonlinear multi-input multi-output (MIMO) system with two degrees of freedom and cross coupling. There are two parameters that define the behavior of LQR controller: state weighting matrix and control weighting matrix. The two parameters influence the performance of LQR. Particle Swarm Optimization (PSO) is proposed to optimally tune weighting matrices of LQR. The major concern of using LQR controller is to stabilize the TRAS by making the beam move quickly and accurately for tracking a trajectory or to reach a desired altitude. The simulation results were carried out in MATLAB/Simulink. The system is decoupled into two single-input single-output (SISO) systems. Comparing the performance of the optimized proportional, integral and derivative (PID) controller provided by INTECO, results depict that LQR controller gives a better performance in terms of both transient and steady state responses when PSO is performed.Keywords: Linear quadratic regulator, LQR controller, optimal control, particle swarm optimization, PSO, two-rotor aero-dynamical system, TRAS.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 21492692 Effect of Infills in Influencing the Dynamic Responses of Multistoried Structures
Authors: E. Rahmathulla Noufal
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Investigating the dynamic responses of high rise structures under the effect of siesmic ground motion is extremely important for the proper analysis and design of multitoried structures. Since the presence of infilled walls strongly influences the behaviour of frame systems in multistoried buildings, there is an increased need for developing guidelines for the analysis and design of infilled frames under the effect of dynamic loads for safe and proper design of buildings. In this manuscript, we evaluate the natural frequencies and natural periods of single bay single storey frames considering the effect of infill walls by using the Eigen value analysis and validating with SAP 2000 (free vibration analysis). Various parameters obtained from the diagonal strut model followed for the free vibration analysis is then compared with the Finite Element model, where infill is modeled as shell elements (four noded). We also evaluated the effect of various parameters on the natural periods of vibration obtained by free vibration analysis in SAP 2000 comparing them with those obtained by the empirical expressions presented in I.S. 1893(Part I)- 2002.Keywords: Infilled frame, eigen value analysis, free vibration analysis, diagonal strut model, finite element model, SAP 2000, natural period.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17252691 Reliability of Chute-Feeders in Automatic Machines of High Production Capacity
Authors: R. Usubamatov, A. Usubamatova, S. Hussain
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Modern highly automated production systems faces problems of reliability. Machine function reliability results in changes of productivity rate and efficiency use of expensive industrial facilities. Predicting of reliability has become an important research and involves complex mathematical methods and calculation. The reliability of high productivity technological automatic machines that consists of complex mechanical, electrical and electronic components is important. The failure of these units results in major economic losses of production systems. The reliability of transport and feeding systems for automatic technological machines is also important, because failure of transport leads to stops of technological machines. This paper presents reliability engineering on the feeding system and its components for transporting a complex shape parts to automatic machines. It also discusses about the calculation of the reliability parameters of the feeding unit by applying the probability theory. Equations produced for calculating the limits of the geometrical sizes of feeders and the probability of sticking the transported parts into the chute represents the reliability of feeders as a function of its geometrical parameters.Keywords: Chute-feeder, parts, reliability.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14632690 Systematic Identification and Quantification of Substrate Specificity Determinants in Human Protein Kinases
Authors: Manuel A. Alonso-Tarajano, Roberto Mosca, Patrick Aloy
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Protein kinases participate in a myriad of cellular processes of major biomedical interest. The in vivo substrate specificity of these enzymes is a process determined by several factors, and despite several years of research on the topic, is still far from being totally understood. In the present work, we have quantified the contributions to the kinase substrate specificity of i) the phosphorylation sites and their surrounding residues in the sequence and of ii) the association of kinases to adaptor or scaffold proteins. We have used position-specific scoring matrices (PSSMs), to represent the stretches of sequences phosphorylated by 93 families of kinases. We have found negative correlations between the number of sequences from which a PSSM is generated and the statistical significance and the performance of that PSSM. Using a subset of 22 statistically significant PSSMs, we have identified specificity determinant residues (SDRs) for 86% of the corresponding kinase families. Our results suggest that different SDRs can function as positive or negative elements of substrate recognition by the different families of kinases. Additionally, we have found that human proteins with known function as adaptors or scaffolds (kAS) tend to interact with a significantly large fraction of the substrates of the kinases to which they associate. Based on this characteristic we have identified a set of 279 potential adaptors/scaffolds (pAS) for human kinases, which is enriched in Pfam domains and functional terms tightly related to the proposed function. Moreover, our results show that for 74.6% of the kinase–pAS association found, the pAS colocalize with the substrates of the kinases they are associated to. Finally, we have found evidence suggesting that the association of kinases to adaptors and scaffolds, may contribute significantly to diminish the in vivo substrate crossed-specificity of protein kinases. In general, our results indicate the relevance of several SDRs for both the positive and negative selection of phosphorylation sites by kinase families and also suggest that the association of kinases to pAS proteins may be an important factor for the localization of the enzymes with their set of substrates.
Keywords: Kinase, phosphorylation, substrate specificity, adaptors, scaffolds, cellular colocalization.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15402689 A Partially Accelerated Life Test Planning with Competing Risks and Linear Degradation Path under Tampered Failure Rate Model
Authors: Fariba Azizi, Firoozeh Haghighi, Viliam Makis
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In this paper, we propose a method to model the relationship between failure time and degradation for a simple step stress test where underlying degradation path is linear and different causes of failure are possible. It is assumed that the intensity function depends only on the degradation value. No assumptions are made about the distribution of the failure times. A simple step-stress test is used to shorten failure time of products and a tampered failure rate (TFR) model is proposed to describe the effect of the changing stress on the intensities. We assume that some of the products that fail during the test have a cause of failure that is only known to belong to a certain subset of all possible failures. This case is known as masking. In the presence of masking, the maximum likelihood estimates (MLEs) of the model parameters are obtained through an expectation-maximization (EM) algorithm by treating the causes of failure as missing values. The effect of incomplete information on the estimation of parameters is studied through a Monte-Carlo simulation. Finally, a real example is analyzed to illustrate the application of the proposed methods.Keywords: Expectation-maximization (EM) algorithm, cause of failure, intensity, linear degradation path, masked data, reliability function.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 10802688 Similarity Solutions of Nonlinear Stretched Biomagnetic Flow and Heat Transfer with Signum Function and Temperature Power Law Geometries
Authors: M. G. Murtaza, E. E. Tzirtzilakis, M. Ferdows
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Biomagnetic fluid dynamics is an interdisciplinary field comprising engineering, medicine, and biology. Bio fluid dynamics is directed towards finding and developing the solutions to some of the human body related diseases and disorders. This article describes the flow and heat transfer of two dimensional, steady, laminar, viscous and incompressible biomagnetic fluid over a non-linear stretching sheet in the presence of magnetic dipole. Our model is consistent with blood fluid namely biomagnetic fluid dynamics (BFD). This model based on the principles of ferrohydrodynamic (FHD). The temperature at the stretching surface is assumed to follow a power law variation, and stretching velocity is assumed to have a nonlinear form with signum function or sign function. The governing boundary layer equations with boundary conditions are simplified to couple higher order equations using usual transformations. Numerical solutions for the governing momentum and energy equations are obtained by efficient numerical techniques based on the common finite difference method with central differencing, on a tridiagonal matrix manipulation and on an iterative procedure. Computations are performed for a wide range of the governing parameters such as magnetic field parameter, power law exponent temperature parameter, and other involved parameters and the effect of these parameters on the velocity and temperature field is presented. It is observed that for different values of the magnetic parameter, the velocity distribution decreases while temperature distribution increases. Besides, the finite difference solutions results for skin-friction coefficient and rate of heat transfer are discussed. This study will have an important bearing on a high targeting efficiency, a high magnetic field is required in the targeted body compartment.
Keywords: Biomagnetic fluid, FHD, nonlinear stretching sheet, slip parameter.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 8332687 Evolutionary Algorithms for Learning Primitive Fuzzy Behaviors and Behavior Coordination in Multi-Objective Optimization Problems
Authors: Li Shoutao, Gordon Lee
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Evolutionary robotics is concerned with the design of intelligent systems with life-like properties by means of simulated evolution. Approaches in evolutionary robotics can be categorized according to the control structures that represent the behavior and the parameters of the controller that undergo adaptation. The basic idea is to automatically synthesize behaviors that enable the robot to perform useful tasks in complex environments. The evolutionary algorithm searches through the space of parameterized controllers that map sensory perceptions to control actions, thus realizing a specific robotic behavior. Further, the evolutionary algorithm maintains and improves a population of candidate behaviors by means of selection, recombination and mutation. A fitness function evaluates the performance of the resulting behavior according to the robot-s task or mission. In this paper, the focus is in the use of genetic algorithms to solve a multi-objective optimization problem representing robot behaviors; in particular, the A-Compander Law is employed in selecting the weight of each objective during the optimization process. Results using an adaptive fitness function show that this approach can efficiently react to complex tasks under variable environments.Keywords: adaptive fuzzy neural inference, evolutionary tuning
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15202686 Sensory Evaluation of the Selected Coffee Products Using Fuzzy Approach
Authors: M.A. Lazim, M. Suriani
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Knowing consumers' preferences and perceptions of the sensory evaluation of drink products are very significant to manufacturers and retailers alike. With no appropriate sensory analysis, there is a high risk of market disappointment. This paper aims to rank the selected coffee products and also to determine the best of quality attribute through sensory evaluation using fuzzy decision making model. Three products of coffee drinks were used for sensory evaluation. Data were collected from thirty judges at a hypermarket in Kuala Terengganu, Malaysia. The judges were asked to specify their sensory evaluation in linguistic terms of the quality attributes of colour, smell, taste and mouth feel for each product and also the weight of each quality attribute. Five fuzzy linguistic terms represent the quality attributes were introduced prior analysing. The judgment membership function and the weights were compared to rank the products and also to determine the best quality attribute. The product of Indoc was judged as the first in ranking and 'taste' as the best quality attribute. These implicate the importance of sensory evaluation in identifying consumers- preferences and also the competency of fuzzy approach in decision making.Keywords: fuzzy decision making, fuzzy linguistic, membership function, sensory evaluation,
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 27892685 Thermodynamic Modeling of the High Temperature Shift Converter Reactor Using Minimization of Gibbs Free Energy
Authors: H. Zare Aliabadi
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The equilibrium chemical reactions taken place in a converter reactor of the Khorasan Petrochemical Ammonia plant was studied using the minimization of Gibbs free energy method. In the minimization of the Gibbs free energy function the Davidon– Fletcher–Powell (DFP) optimization procedure using the penalty terms in the well-defined objective function was used. It should be noted that in the DFP procedure along with the corresponding penalty terms the Hessian matrices for the composition of constituents in the Converter reactor can be excluded. This, in fact, can be considered as the main advantage of the DFP optimization procedure. Also the effect of temperature and pressure on the equilibrium composition of the constituents was investigated. The results obtained in this work were compared with the data collected from the converter reactor of the Khorasan Petrochemical Ammonia plant. It was concluded that the results obtained from the method used in this work are in good agreement with the industrial data. Notably, the algorithm developed in this work, in spite of its simplicity, takes the advantage of short computation and convergence time.
Keywords: Gibbs free energy, converter reactors, Chemical equilibrium
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 25782684 Fixture Layout Optimization Using Element Strain Energy and Genetic Algorithm
Authors: Zeshan Ahmad, Matteo Zoppi, Rezia Molfino
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The stiffness of the workpiece is very important to reduce the errors in manufacturing process. The high stiffness of the workpiece can be achieved by optimal positioning of fixture elements in the fixture. The minimization of the sum of the nodal deflection normal to the surface is used as objective function in previous research. The deflection in other direction has been neglected. The 3-2-1 fixturing principle is not valid for metal sheets due to its flexible nature. We propose a new fixture layout optimization method N-3-2-1 for metal sheets that uses the strain energy of the finite elements. This method combines the genetic algorithm and finite element analysis. The objective function in this method is to minimize the sum of all the element strain energy. By using the concept of element strain energy, the deformations in all the directions have been considered. Strain energy and stiffness are inversely proportional to each other. So, lower the value of strain energy, higher will be the stiffness. Two different kinds of case studies are presented. The case studies are solved for both objective functions; element strain energy and nodal deflection. The result are compared to verify the propose method.
Keywords: Fixture layout, optimization, fixturing element, genetic algorithm.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 25712683 Oxygen Transfer by Multiple Inclined Plunging Water Jets
Authors: Surinder Deswal
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There has been a growing interest in the oxygenation by plunging water jets in the last few years due to their inherent advantages, like energy-efficient, low operation cost, etc. Though a lot of work has been reported on the oxygen-transfer by single plunging water jets but very few studies have been carried out using multiple plunging jets. In this paper, volumetric oxygen-transfer coefficient and oxygen-transfer efficiency has been studied experimentally for multiple inclined plunging jets (having jet plunge angle of 60 0 ) in a pool of water for different configurations, in terms of varying number of jets and jet diameters. This research suggests that the volumetric oxygen-transfer coefficient and oxygentransfer efficiency of the multiple inclined plunging jets for air-water system are significantly higher than those of a single vertical as well as inclined plunging jet for same flow area and other similar conditions. The study also reveals that the oxygen-transfer increase with increase in number of multiple jets under similar conditions, which will be most advantageous and energy-efficient in practical situations when large volumes of wastewaters are to be treated. A relationship between volumetric oxygen-transfer coefficient and jet parameters is also proposed. The suggested relationship predicts the volumetric oxygen-transfer coefficient for multiple inclined plunging jet(s) within a scatter of ±15 percent. The relationship will be quite useful in scale-up and in deciding optimum configuration of multiple inclined plunging jet aeration system.Keywords: Multiple inclined plunging jets, jet plunge angle, volumetric oxygen-transfer coefficient, oxygen-transfer efficiency.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17772682 Experiment and Simulation of Laser Effect on Thermal Field of Porcine Liver
Authors: K.Ting, K. T. Chen, Y. L. Su, C. J. Chang
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In medical therapy, laser has been widely used to conduct cosmetic, tumor and other treatments. During the process of laser irradiation, there may be thermal damage caused by excessive laser exposure. Thus, the establishment of a complete thermal analysis model is clinically helpful to physicians in reference data. In this study, porcine liver in place of tissue was subjected to laser irradiation to set up the experimental data considering the explored impact on surface thermal field and thermal damage region under different conditions of power, laser irradiation time, and distance between laser and porcine liver. In the experimental process, the surface temperature distribution of the porcine lever was measured by the infrared thermal imager. In the part of simulation, the bio heat transfer Pennes-s equation was solved by software SYSWELD applying in welding process. The double ellipsoid function as a laser source term is firstly considered in the prediction for surface thermal field and internal tissue damage. The simulation results are compared with the experimental data to validate the mathematical model established here in.
Keywords: laser infrared thermal imager, bio-heat transfer, double ellipsoid function.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 20662681 A Methodology for Automatic Diversification of Document Categories
Authors: Dasom Kim, Chen Liu, Myungsu Lim, Soo-Hyeon Jeon, Byeoung Kug Jeon, Kee-Young Kwahk, Namgyu Kim
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Recently, numerous documents including large volumes of unstructured data and text have been created because of the rapid increase in the use of social media and the Internet. Usually, these documents are categorized for the convenience of users. Because the accuracy of manual categorization is not guaranteed, and such categorization requires a large amount of time and incurs huge costs. Many studies on automatic categorization have been conducted to help mitigate the limitations of manual categorization. Unfortunately, most of these methods cannot be applied to categorize complex documents with multiple topics because they work on the assumption that individual documents can be categorized into single categories only. Therefore, to overcome this limitation, some studies have attempted to categorize each document into multiple categories. However, the learning process employed in these studies involves training using a multi-categorized document set. These methods therefore cannot be applied to the multi-categorization of most documents unless multi-categorized training sets using traditional multi-categorization algorithms are provided. To overcome this limitation, in this study, we review our novel methodology for extending the category of a single-categorized document to multiple categorizes, and then introduce a survey-based verification scenario for estimating the accuracy of our automatic categorization methodology.Keywords: Big Data Analysis, Document Classification, Text Mining, Topic Analysis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17512680 A PIM (Processor-In-Memory) for Computer Graphics : Data Partitioning and Placement Schemes
Authors: Jae Chul Cha, Sandeep K. Gupta
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The demand for higher performance graphics continues to grow because of the incessant desire towards realism. And, rapid advances in fabrication technology have enabled us to build several processor cores on a single die. Hence, it is important to develop single chip parallel architectures for such data-intensive applications. In this paper, we propose an efficient PIM architectures tailored for computer graphics which requires a large number of memory accesses. We then address the two important tasks necessary for maximally exploiting the parallelism provided by the architecture, namely, partitioning and placement of graphic data, which affect respectively load balances and communication costs. Under the constraints of uniform partitioning, we develop approaches for optimal partitioning and placement, which significantly reduce search space. We also present heuristics for identifying near-optimal placement, since the search space for placement is impractically large despite our optimization. We then demonstrate the effectiveness of our partitioning and placement approaches via analysis of example scenes; simulation results show considerable search space reductions, and our heuristics for placement performs close to optimal – the average ratio of communication overheads between our heuristics and the optimal was 1.05. Our uniform partitioning showed average load-balance ratio of 1.47 for geometry processing and 1.44 for rasterization, which is reasonable.Keywords: Data Partitioning and Placement, Graphics, PIM, Search Space Reduction.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1505