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Experiment and Simulation of Laser Effect on Thermal Field of Porcine Liver

Authors: K.Ting, K. T. Chen, Y. L. Su, C. J. Chang


In medical therapy, laser has been widely used to conduct cosmetic, tumor and other treatments. During the process of laser irradiation, there may be thermal damage caused by excessive laser exposure. Thus, the establishment of a complete thermal analysis model is clinically helpful to physicians in reference data. In this study, porcine liver in place of tissue was subjected to laser irradiation to set up the experimental data considering the explored impact on surface thermal field and thermal damage region under different conditions of power, laser irradiation time, and distance between laser and porcine liver. In the experimental process, the surface temperature distribution of the porcine lever was measured by the infrared thermal imager. In the part of simulation, the bio heat transfer Pennes-s equation was solved by software SYSWELD applying in welding process. The double ellipsoid function as a laser source term is firstly considered in the prediction for surface thermal field and internal tissue damage. The simulation results are compared with the experimental data to validate the mathematical model established here in.

Keywords: laser infrared thermal imager, bio-heat transfer, double ellipsoid function

Digital Object Identifier (DOI):

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[1] K. Ivarsson, J. Olstrud, C. Sturesson, et al, Feedback interstitial diode laser (805 nm) thermotherapy system: ex vivo evaluation and mathematical modeling with one and four-fibers, Lasers in Surgery and Medicine 22: 86-96 (1998).
[2] A.M. Minhaj, F. Manns, P.J. Milne, et al, Laser interstitial themotherapy (LITT) monitoring using high-resolution digital mammography: theory and experimental studies, Physics in Medicine and Biology 47: 2987-2999 (2002).
[3] E. Rohde, I. M. V. Rheinbaben, A. Roggan, et al, Interstitial Laser-Induced Thermotherapy (LITT): Comparison of In-Vitro Irradiation Effects of Nd:YAG (1064 nm) and Diode (940 nm) Laser, Medical Laser Application. 16: 81-90 (2001).
[4] A. Roggan, J. P. Ritz, V. Knappe, et al, Radiation Planning for Thermal Laser Treatment, Medical Laser Application 16: 65-72 (2001).
[5] V. Knappei, A. Roggan, M. Glotz, et al, New Flexi ble Applicators for Laser-Induced Thermotherapy, Medical Laser Application 16: 73-80 (2001).
[6] R. A. London, M. E. Glinsky, G. B. Zimmerman, Laser-tissue interaction modeling with LATIS, Applied Optics 36´╝Ü9068-9074 (1997)
[7] R. A Thomas, K. E Donne, M. Clement, et al, Ther- mographic Methods During Laser-Tissue Interaction
[8] A. M. MOLS, V. KNAPPE, H. BUHR, Laser-induced Thermo- therapy (LITT): Dose-Effect Relation on Lung Tissue Medical Laser Application19:160-166 (2004)
[9] H. H. Pennes, Analysis of tissue and arterial blood temperatures in the resting human forearm. Journal of Applied Physiology 1: 93-122 (1948).
[10] B. X. Wang and Y. M. Wang, study on the basic equations of biomedical heat transfer, Transport Phenomena Science and Technology: 273-276 (1992).
[11] S. F Cheng, Bio-heat heat transfer analysis of elective photocoagulation method coordinated with jet cooling effect, Department of Applied Mathematics, National Chung Hsing University, PhD dissertation (2007).
[12] S. Karaa, J. Zhang, F. Yang, A numerical study of a 3D bioheat transfer problem with different spatial heating, Mathematics and Computers in Simulation 68: 375 -388 (2005).
[13] W. Shen, J. Zhang, Modeling and Numerical Simulation of Bioheat Transfer and Biomechanics in Soft Tissue, Mathematical and Computer Modelling 41: 1251- 1265 (2005).
[14] G. Yoon, A. J. Welch, M. Motamedi, et al, Develop- ment and Application of Three- Dimensional Light Distribution Model for Laser Irradiated Tissue, IEEE Journal of Quantum Electronics 23: 1721-1733 (1987).
[15] G. L. LeCarpentier, M. M. Linda, P. McMath, et al, Continuous Wave Laser Ablation of Tissue: Analysis of Thermal and Mechanical Events, IEEE Tran- sactions on Biomedical engineering 40: 188-200 (1993).
[16] F. F. Vélez, O. G. Romanov, J. L. A. Diego, Efficient 3D numerical appro- ach for temperature prediction in laser irradiated biological tissues, Computers in Biology and Medicine 39: 810 - 817 (2009).
[17] R. Dua, S. Chakraborty, A novel modeling and simulation technique of photothermal interactions between lasers and living biological tissues under- going multiple changes in phase, Computers in Biology and Medicine 35: 447-462 (2005).
[18] J. Goldak, A. Chakravarti, M. Bibby, A new finite element model for welding heat sources. Metallurgical Transactions B 15B: 299-305 (1984).
[19] K. Abderrazak, S. Bannour, H. Mhiri, Numerical and experimental study of molten pool formation during continuous laser welding of AZ91 magnesium alloy, Computational Materials Science 44´╝Ü858-866 (2009).
[20] S.A. Tsirkas, P. Papanikos Th. Kermanidis, Numerical simulation of thw laser welding process in butt-joint specimens, Journal of processing Technology 134´╝Ü59-69 (2003).
[21] M. K. Sidhu, A. J. Perkins, W.W. Shaw Dennis, M. A. Bittles,et al, Mhiri, Ultrasound-guided Endovenous Diode Laser in the Treatment of Congenital Venous Malformations: Preliminary Experience, Journal of Vascular and Interventional Radiology 16 : 879-884(2005).
[22] P. Lanzetta, G. Virgili, E. Ferrari, Diode laser photo -coagulation of choroidal hemangioma,International Ophthalmology 19: 239-247(2004)
[23] J. G. Eichler, O. Goncalves, A Review of Different Lasers in Endonasal Surgery :Ar-, KTP-, Dye-, Diode-, Nd-, Ho- and CO2-Laser , Medical Laser Application 17: 190–200 (2002)
[24] H. Watanabe, Y. Kobayashi, T. Hoshi, et al, Integrated System for RFA Therapy with Biomechanical Simulation and Needle Insertion Robot,System Integration, IEEE/SICE International Symposium on :54-59 (2009)
[25] N.Siva Shanmugam , G. Buvanashekaranb, K. Sankaranarayanasamy, etc, A transient finite element simulation of the temperature and bead profiles of T-joint laser welds, International Journal of Modelling and Simulation 30: 5168- 5183(2010)
[26] B. S. Yilbas, Z. Yilbas, M. Sami, Thermal processes taking place in the bone during CO2 laser irradiation, Optics & Laser Technology 28: 513 -519 (1996)
[27] G. L. LeCarpentier, M. M. Linda, P. McMath, et al, Continuous Wave Laser Ablation of Tissue: Analysis of Thermal and Mechanical Events, IEEE Transactions on Biomedical engineering 40: 188- 200 (1993).
[28] D. Rosenthal, Mathematical theory of heat distrib- ution during welding and cutting, Transaction of the ASME 43: 849-866 (1946).
[29] V. Pavelic, R. Tanbakuchi, O. A. Uyehara, et al, Welding Journal Research Supp- lement 48: 295- 305 (1969).