Search results for: Bar Code Medication Administration (BCMA)
Commenced in January 2007
Frequency: Monthly
Edition: International
Paper Count: 983

Search results for: Bar Code Medication Administration (BCMA)

563 Impact of Harmonic Resonance and V-THD in Sohar Industrial Port–C Substation

Authors: R. S. Al Abri, M. H. Albadi, M. H. Al Abri, U. K. Al Rasbi, M. H. Al Hasni, S. M. Al Shidi

Abstract:

This paper presents an analysis study on the impacts of the changes of the capacitor banks, the loss of a transformer, and the installation of distributed generation on the voltage total harmonic distortion and harmonic resonance. The study is applied in a real system in Oman, Sohar Industrial Port–C Substation Network. Frequency scan method and Fourier series analysis method are used with the help of EDSA software. Moreover, the results are compared with limits specified by national Oman distribution code.

Keywords: Power quality, capacitor bank, voltage total harmonics distortion, harmonic resonance, frequency scan.

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562 RP-ADAS: Relative Position-Advanced Drive Assistant System based on VANET (GNSS)

Authors: Hun-Jung Lim, Tai-Myoung Chung

Abstract:

Few decades ago, electronic and sensor technologies are merged into vehicles as the Advanced Driver Assistance System(ADAS). However, sensor-based ADASs have limitations about weather interference and a line-of-sight nature problem. In our project, we investigate a Relative Position based ADAS(RP-ADAS). We divide the RP-ADAS into four main research areas: GNSS, VANET, Security/Privacy, and Application. In this paper, we research the GNSS technologies and determine the most appropriate one. With the performance evaluation, we figure out that the C/A code based GPS technologies are inappropriate for 'which lane-level' application. However, they can be used as a 'which road-level' application.

Keywords: Relative Positioning, VANET, GNSS, ADAS

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561 The Bodybuilding Passage to the Act of the Adolescent

Authors: L. Chikhani, H. Issa

Abstract:

Objective: this work focuses on bodybuilding as narcissistic inscription of the relational dynamic of the ego and the body, in this sense we think that this symptomatic adolescent act highlights a defective image of the body, leading, by a sadistic passage exercized on the split body, to an Ego/body-ideal. Method: Semi structured interviews with 16 adolescents between 15 and 18 years old allowed us to highlight a lexical field related to the body and the excessiveness in sports;also, the administration of TAT to a bodybuilder (17 years old) for more than 2 years. Results: - Defectiveness in the structuration of the body image; the future bodybuilder will be fixated to the image of the narcissistic misrecognition. - Unsatisfying object relation, implicating incompleteness in the process of subjectivation. - Narcissistic and corporealizedego ideal leading the adolescent to a sadistic pathology directed toward one-s own body as a compensatory defense.

Keywords: Bodybuilding, body image, narcissism, object relation.

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560 Identifying Autism Spectrum Disorder Using Optimization-Based Clustering

Authors: Sharifah Mousli, Sona Taheri, Jiayuan He

Abstract:

Autism spectrum disorder (ASD) is a complex developmental condition involving persistent difficulties with social communication, restricted interests, and repetitive behavior. The challenges associated with ASD can interfere with an affected individual’s ability to function in social, academic, and employment settings. Although there is no effective medication known to treat ASD, to our best knowledge, early intervention can significantly improve an affected individual’s overall development. Hence, an accurate diagnosis of ASD at an early phase is essential. The use of machine learning approaches improves and speeds up the diagnosis of ASD. In this paper, we focus on the application of unsupervised clustering methods in ASD, as a large volume of ASD data generated through hospitals, therapy centers, and mobile applications has no pre-existing labels. We conduct a comparative analysis using seven clustering approaches, such as K-means, agglomerative hierarchical, model-based, fuzzy-C-means, affinity propagation, self organizing maps, linear vector quantisation – as well as the recently developed optimization-based clustering (COMSEP-Clust) approach. We evaluate the performances of the clustering methods extensively on real-world ASD datasets encompassing different age groups: toddlers, children, adolescents, and adults. Our experimental results suggest that the COMSEP-Clust approach outperforms the other seven methods in recognizing ASD with well-separated clusters.

Keywords: Autism spectrum disorder, clustering, optimization, unsupervised machine learning.

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559 Effect of Mean Stress on Fatigue Crack Growth Behavior of Stainless Steel 304L

Authors: M. Benachour, N. Benachour

Abstract:

Stainless steel has been employed in many engineering applications ranging from pharmaceutical equipment to piping in the nuclear reactors and storage to chemical products. In this attempt, simulation of fatigue crack growth based on experimental results of austenitic stainless steel 304L was presented using AFGROW code when NASGRO mode laws adopted. Double through crack at hole specimen is used in this investigation under constant amplitude loading. Effect of mean stress is highlighted. Results show that fatigue crack growth rate (FCGR) and fatigue life were affected by maximum applied load and dimension of hole. An equivalent of Paris law for this material was estimated.

Keywords: Fatigue crack, stainless steel, mean stress, amplitudeloading.

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558 Transverse Vibration of Non-Homogeneous Rectangular Plates of Variable Thickness Using GDQ

Authors: R. Saini, R. Lal

Abstract:

The effect of non-homogeneity on the free transverse vibration of thin rectangular plates of bilinearly varying thickness has been analyzed using generalized differential quadrature (GDQ) method. The non-homogeneity of the plate material is assumed to arise due to linear variations in Young’s modulus and density of the plate material with the in-plane coordinates x and y. Numerical results have been computed for fully clamped and fully simply supported boundary conditions. The solution procedure by means of GDQ method has been implemented in a MATLAB code. The effect of various plate parameters has been investigated for the first three modes of vibration. A comparison of results with those available in literature has been presented.

Keywords: Bilinear thickness, generalized differential quadrature (GDQ), non-homogeneous, Rectangular.

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557 Security of Mobile Agent in Ad hoc Network using Threshold Cryptography

Authors: S.M. Sarwarul Islam Rizvi, Zinat Sultana, Bo Sun, Md. Washiqul Islam

Abstract:

In a very simple form a Mobile Agent is an independent piece of code that has mobility and autonomy behavior. One of the main advantages of using Mobile Agent in a network is - it reduces network traffic load. In an, ad hoc network Mobile Agent can be used to protect the network by using agent based IDS or IPS. Besides, to deploy dynamic software in the network or to retrieve information from network nodes Mobile Agent can be useful. But in an ad hoc network the Mobile Agent itself needs some security. Security services should be guaranteed both for Mobile Agent and for Agent Server. In this paper to protect the Mobile Agent and Agent Server in an ad hoc network we have proposed a solution which is based on Threshold Cryptography, a new vibe in the cryptographic world where trust is distributed among multiple nodes in the network.

Keywords: Ad hoc network, Mobile Agent, Security, Threats, Threshold Cryptography.

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556 A Cooperative Transmission Scheme Using Two Sources Based On OFDM System

Authors: Bit-Na Kwon, Dong-Hyun Ha, Hyoung-Kyu Song

Abstract:

In wireless communication, space-time block code (STBC), cyclic delay diversity (CDD) and space-time cyclic delay diversity (STCDD)are used as the spatial diversity schemes and have been widely studied for the reliablecommunication. If these schemes are used, the communication system can obtain the improved performance. However,the quality of the system is degraded when the distance between a source and a destination is distant in wireless communication system. In this paper, the cooperative transmission scheme using two sources is proposed and improves the performance of the wireless communication system.

Keywords: OFDM, Cooperative communication, CDD, STBC, STCDD.

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555 Aspect based Reusable Synchronization Schemes

Authors: Nathar Shah

Abstract:

Concurrency and synchronization are becoming big issues as every new PC comes with multi-core processors. A major reason for Object-Oriented Programming originally was to enable easier reuse: encode your algorithm into a class and thoroughly debug it, then you can reuse the class again and again. However, when we get to concurrency and synchronization, this is often not possible. Thread-safety issues means that synchronization constructs need to be entangled into every class involved. We contributed a detailed literature review of issues and challenges in concurrent programming and present a methodology that uses the Aspect- Oriented paradigm to address this problem. Aspects will allow us to extract the synchronization concerns as schemes to be “weaved in" later into the main code. This allows the aspects to be separately tested and verified. Hence, the functional components can be weaved with reusable synchronization schemes that are robust and scalable.

Keywords: Aspect-orientation, development methodologysoftware concurrency, synchronization.

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554 Energy and Exergy Performance Optimization on a Real Gas Turbine Power Plant

Authors: Farhat Hajer, Khir Tahar, Cherni Rafik, Dakhli Radhouen, Ammar Ben Brahim

Abstract:

This paper presents the energy and exergy optimization of a real gas turbine power plant performance of 100 MW of power, installed in the South East of Tunisia. A simulation code is established using the EES (Engineering Equation Solver) software. The parameters considered are those of the actual operating conditions of the gas turbine thermal power station under study. The results show that thermal and exergetic efficiency decreases with the increase of the ambient temperature. Air excess has an important effect on the thermal efficiency. The emission of NOx rises in the summer and decreases in the winter. The obtained rates of NOx are compared with measurements results.

Keywords: Efficiency, exergy, gas turbine, temperature.

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553 JREM: An Approach for Formalising Models in the Requirements Phase with JSON and NoSQL Databases

Authors: Aitana Alonso-Nogueira, Helia Estévez-Fernández, Isaías García

Abstract:

This paper presents an approach to reduce some of its current flaws in the requirements phase inside the software development process. It takes the software requirements of an application, makes a conceptual modeling about it and formalizes it within JSON documents. This formal model is lodged in a NoSQL database which is document-oriented, that is, MongoDB, because of its advantages in flexibility and efficiency. In addition, this paper underlines the contributions of the detailed approach and shows some applications and benefits for the future work in the field of automatic code generation using model-driven engineering tools.

Keywords: Conceptual modeling, JSON, NoSQL databases, requirements engineering, software development.

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552 High Level Synthesis of Kahn Process Networks(KPN) for Streaming Applications

Authors: Attiya Mahmood, Syed Ali Abbas, Shoab A. Khan

Abstract:

Streaming Applications usually run in parallel or in series that incrementally transform a stream of input data. It poses a design challenge to break such an application into distinguishable blocks and then to map them into independent hardware processing elements. For this, there is required a generic controller that automatically maps such a stream of data into independent processing elements without any dependencies and manual considerations. In this paper, Kahn Process Networks (KPN) for such streaming applications is designed and developed that will be mapped on MPSoC. This is designed in such a way that there is a generic Cbased compiler that will take the mapping specifications as an input from the user and then it will automate these design constraints and automatically generate the synthesized RTL optimized code for specified application.

Keywords: KPN, DFG, FPGA

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551 Finite Difference Method of the Seismic Analysis of Earth Dam

Authors: Alaoua Bouaicha, Fahim Kahlouche, Abdelhamid Benouali

Abstract:

Many embankment dams have suffered failures during earthquakes due to the increase of pore water pressure under seismic loading. After analyzing of the behavior of embankment dams under severe earthquakes, major advances have been attained in the understanding of the seismic action on dams. The present study concerns numerical analysis of the seismic response of earth dams. The procedure uses a nonlinear stress-strain relation incorporated into the code FLAC2D based on the finite difference method. This analysis provides the variation of the pore water pressure and horizontal displacement.

Keywords: Earthquake, numerical analysis, FLAC2D, displacement, Embankment Dam, pore water pressure.

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550 Impact Analysis Based on Change Requirement Traceability in Object Oriented Software Systems

Authors: Sunil Tumkur Dakshinamurthy, Mamootil Zachariah Kurian

Abstract:

Change requirement traceability in object oriented software systems is one of the challenging areas in research. We know that the traces between links of different artifacts are to be automated or semi-automated in the software development life cycle (SDLC). The aim of this paper is discussing and implementing aspects of dynamically linking the artifacts such as requirements, high level design, code and test cases through the Extensible Markup Language (XML) or by dynamically generating Object Oriented (OO) metrics. Also, non-functional requirements (NFR) aspects such as stability, completeness, clarity, validity, feasibility and precision are discussed. We discuss this as a Fifth Taxonomy, which is a system vulnerability concern.

Keywords: Artifacts, NFRs, OO metrics, SDLC, XML.

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549 Safety Practices among Bus Operators during Wee Hour Operations

Authors: M.R. Osman, F. Abas, M.S. Noh, A. Mohamad Suffian, O. Ilhamah, H.Z. Zarir, A.B. Wahida, P. Noor Faradila, M.F. Siti Atiqah

Abstract:

Safety Health and Environment Code of Practice (SHE COP) was developed to help road transportation operators to manage its operation in a systematic and safe manner. A study was conducted to determine the effectiveness of SHE COP implementation during non-OPS period. The objective of the study is to evaluate the implementations of SHE COP among bus operators during wee hour operations. The data was collected by completing a set of checklist after observing the activities during pre departure, during the trip, and upon arrival. The results show that there are seven widely practiced SHE COP elements. 22% of the buses have average speed exceeding the maximum permissible speed on the highways (90 km/h), with 13% of the buses were travelling at the speed of more than 100 km/h. The statistical analysis shows that there is only one significant association which relates speeding with prior presence of enforcement officers.

Keywords: Safety practices, speeding, wee hour.

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548 Anisotropic Constitutive Model and its Application in Simulation of Thermal Shock Wave Propagation for Cylinder Shell Composite

Authors: Xia Huang, Wenhui Tang, Banghai Jiang, Xianwen Ran

Abstract:

In this paper, a plane-strain orthotropic elasto-plastic dynamic constitutive model is established, and with this constitutive model, the thermal shock wave induced by intense pulsed X-ray radiation in cylinder shell composite is simulated by the finite element code, then the properties of thermal shock wave propagation are discussed. The results show that the thermal shock wave exhibit different shapes under the radiation of soft and hard X-ray, and while the composite is radiated along different principal axes, great differences exist in some aspects, such as attenuation of the peak stress value, spallation and so on.

Keywords: anisotropic constitutive model, thermal shock wave, X-ray, cylinder shell composite.

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547 The Overload Behaviour of Reinforced Concrete Flexural Members

Authors: Angelo Thurairajah

Abstract:

Sufficient ultimate deformation is necessary to demonstrate the member ductility, which is dependent on the section and the material ductility. The concrete cracking phase of softening prior to the plastic hinge formation is an essential feature as well. The nature of the overload behaviour is studied using the order of the ultimate deflection. The ultimate deflection is primarily dependent on the slenderness (span to depth ratio), the ductility of the reinforcing steel, the degree of moment redistribution, the type of loading, and the support conditions. The ultimate deflection and the degree of moment redistribution from the analytical study are in good agreement with the experimental results and the moment redistribution provisions of the Australian Standards AS3600 Concrete Structures Code.

Keywords: Ductility, softening, ultimate deflection, overload behaviour, moment redistribution.

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546 Effects of Intake Temperature and Intake Pressure on Combustion and Exhaust Emissions of HCCI Engine

Authors: Fridhi Hadia, Soua Wadhah, Hidouri Ammar, Omri Ahmed

Abstract:

In this paper, the effect of the intake temperature (IT) and intake pressure (IP) on ignition timing and pollutants emission of Homogeneous Charge Compression Ignition (HCCI) engine is investigated. Numerical computations are performed using the CHEMKIN computer code. The numerical temperature obtained using different boundary conditions is compared to published data and a good agreement is assigned. Results show that the HCCI combustion engine is significantly improved by increasing the IT. With a value of IT lower than 390 K, combustion cannot occur. However, with an IT greater than 420 K, the cylinder pressure decreases. An optimum crank rotation angle is achieved by using IT of 420 K. So, we can conclude that the variation of the IT and IP influence notably the emission concentration.

Keywords: HCCI engine, CEMKIN, intake temperature, intake pressure.

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545 Quality Assurance and Effectiveness in Kurdistan Higher Education: The Reform Process

Authors: Selar Othman Ali

Abstract:

Implementing quality assurance in higher education establishments is the main focus of the reform process currently undertaken by the Ministry of Higher Education and Scientific Research in the Kurdistan Region of Iraq. The reform agenda has involved attempts to improve academic quality and management processes in universities, technical institutions and colleges. The central challenge for the reform process is to produce change in higher education in a region where administration is described as centralized and bureaucratic. To make these changes, there should be a well-designed plans and follow up processes in order to monitor progress and develop responses to obstacles. Lack of skills, resources, political dilemmas, poor motivation, and readiness to face the consequences of change are factors which will determine the success of the reform process.

Keywords: Higher Education, Kurdistan-Iraq, Quality Assurance

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544 Effectiveness and Equity: New Challenges for Social Recognition in Higher Education

Authors: Correa Arias, César

Abstract:

Today, Higher Education in a global scope is subordinated to the greater institutional controls through the policies of the Quality of Education. These include processes of over evaluation of all the academic activities: students- and professors- performance, educational logistics, managerial standards for the administration of institutions of higher education, as well as the establishment of the imaginaries of excellence and prestige as the foundations on which universities of the XXI century will focus their present and future goals and interests. But at the same time higher education systems worldwide are facing the most profound crisis of sense and meaning and attending enormous mutations in their identity. Based in a qualitative research approach, this paper shows the social configurations that the scholars at the Universities in Mexico build around the discourse of the Quality of Education, and how these policies put in risk the social recognition of these individuals.

Keywords: Higher education, quality of education, social recognition, social configurations.

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543 CScheme in Traditional Concurrency Problems

Authors: Nathar Shah, Visham Cheerkoot

Abstract:

CScheme, a concurrent programming paradigm based on scheme concept enables concurrency schemes to be constructed from smaller synchronization units through a GUI based composer and latter be reused on other concurrency problems of a similar nature. This paradigm is particularly important in the multi-core environment prevalent nowadays. In this paper, we demonstrate techniques to separate concurrency from functional code using the CScheme paradigm. Then we illustrate how the CScheme methodology can be used to solve some of the traditional concurrency problems – critical section problem, and readers-writers problem - using synchronization schemes such as Single Threaded Execution Scheme, and Readers Writers Scheme.

Keywords: Concurrent Programming, Object Oriented Programming, Environments for multiple-processor systems, Programming paradigms.

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542 The Vulnerability Analysis of Java Bytecode Based on Points-to Dataflow

Authors: Tang Hong, Zhang Lufeng, Chen Hua, Zhang Jianbo

Abstract:

Today many developers use the Java components collected from the Internet as external LIBs to design and develop their own software. However, some unknown security bugs may exist in these components, such as SQL injection bug may comes from the components which have no specific check for the input string by users. To check these bugs out is very difficult without source code. So a novel method to check the bugs in Java bytecode based on points-to dataflow analysis is in need, which is different to the common analysis techniques base on the vulnerability pattern check. It can be used as an assistant tool for security analysis of Java bytecode from unknown softwares which will be used as extern LIBs.

Keywords: Java bytecode, points-to dataflow, vulnerability analysis

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541 Into Insights of Contextual Governance Framework for Religious Non-Profit Organizations

Authors: Saunah Zainon, Ruhaya Atan, Nadzira Yahaya, Marshita Hashim

Abstract:

Governance in business firms is a topic that has long been studied in the literature. Traditionally, governance in business firms has focused on the roles of boards of directors in representing and protecting the interests of shareholders. Governance has also been studied in the context of non-profit organizations because good governance is essential to increase the likelihood that they will comply with the regulatory requirements that best serve their multiple stakeholders. This paper provides insights on the need of governance framework for religious non-profit organizations (RNPOs) based on five underlying principles. This paper is important to help regulators to understand RNPOs’ governance framework. The regulators may use the framework suggested for the development of the RNPOs’ code of governance in the future.

Keywords: Framework, governance, religious, RNPOs.

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540 Oblique Wing: Future Generation Transonic Aircraft

Authors: Mushfiqul Alam, Kashyapa Narenathreyas

Abstract:

The demand for efficient transonic transport has been growing every day and may turn out to be the most pressed innovation in coming years. Oblique wing configuration was proposed as an alternative to conventional wing configuration for supersonic and transonic passenger aircraft due to its aerodynamic advantages. This paper re-demonstrates the aerodynamic advantages of oblique wing configuration using open source CFD code. The aerodynamic data were generated using Panel Method. Results show that Oblique Wing concept with elliptical wing planform offers a significant reduction in drag at transonic and supersonic speeds and approximately twice the lift distribution compared to conventional operating aircrafts. The paper also presents a preliminary conceptual aircraft sizing which can be used for further experimental analysis.

Keywords: Aerodynamics, asymmetric sweep, oblique wing, swing wing.

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539 Induction Motor Design with Limited Harmonic Currents Using Particle Swarm Optimization

Authors: C. Thanga Raj, S. P. Srivastava, Pramod Agarwal

Abstract:

This paper presents an optimal design of poly-phase induction motor using Quadratic Interpolation based Particle Swarm Optimization (QI-PSO). The optimization algorithm considers the efficiency, starting torque and temperature rise as objective function (which are considered separately) and ten performance related items including harmonic current as constraints. The QI-PSO algorithm was implemented on a test motor and the results are compared with the Simulated Annealing (SA) technique, Standard Particle Swarm Optimization (SPSO), and normal design. Some benchmark problems are used for validating QI-PSO. From the test results QI-PSO gave better results and more suitable to motor-s design optimization. Cµ code is used for implementing entire algorithms.

Keywords: Design, harmonics, induction motor, particle swarm optimization

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538 Block Cipher Based on Randomly Generated Quasigroups

Authors: Deepthi Haridas, S Venkataraman, Geeta Varadan

Abstract:

Quasigroups are algebraic structures closely related to Latin squares which have many different applications. The construction of block cipher is based on quasigroup string transformation. This article describes a block cipher based Quasigroup of order 256, suitable for fast software encryption of messages written down in universal ASCII code. The novelty of this cipher lies on the fact that every time the cipher is invoked a new set of two randomly generated quasigroups are used which in turn is used to create a pair of quasigroup of dual operations. The cryptographic strength of the block cipher is examined by calculation of the xor-distribution tables. In this approach some algebraic operations allows quasigroups of huge order to be used without any requisite to be stored.

Keywords: quasigroups, latin squares, block cipher and quasigroup string transformations.

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537 The Establishment of Probabilistic Risk Assessment Analysis Methodology for Dry Storage Concrete Casks Using SAPHIRE 8

Authors: J. R. Wang, W. Y. Cheng, J. S. Yeh, S. W. Chen, Y. M. Ferng, J. H. Yang, W. S. Hsu, C. Shih

Abstract:

To understand the risk for dry storage concrete casks in the cask loading, transfer, and storage phase, the purpose of this research is to establish the probabilistic risk assessment (PRA) analysis methodology for dry storage concrete casks by using SAPHIRE 8 code. This analysis methodology is used to perform the study of Taiwan nuclear power plants (NPPs) dry storage system. The process of research has three steps. First, the data of the concrete casks and Taiwan NPPs are collected. Second, the PRA analysis methodology is developed by using SAPHIRE 8. Third, the PRA analysis is performed by using this methodology. According to the analysis results, the maximum risk is the multipurpose canister (MPC) drop case.

Keywords: PRA, Dry storage, concrete cask, SAPHIRE.

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536 A Strategy for a Robust Design of Cracked Stiffened Panels

Authors: Francesco Caputo, Giuseppe Lamanna, Alessandro Soprano

Abstract:

This work is focused on the numerical prediction of the fracture resistance of a flat stiffened panel made of the aluminium alloy 2024 T3 under a monotonic traction condition. The performed numerical simulations have been based on the micromechanical Gurson-Tvergaard (GT) model for ductile damage. The applicability of the GT model to this kind of structural problems has been studied and assessed by comparing numerical results, obtained by using the WARP 3D finite element code, with experimental data available in literature. In the sequel a home-made procedure is presented, which aims to increase the residual strength of a cracked stiffened aluminum panel and which is based on the stochastic design improvement (SDI) technique; a whole application example is then given to illustrate the said technique.

Keywords: Residual strength, R-Curve, Gurson model, SDI.

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535 Energy Management Techniques in Mobile Robots

Authors: G. Gurguze, I. Turkoglu

Abstract:

Today, the developing features of technological tools with limited energy resources have made it necessary to use energy efficiently. Energy management techniques have emerged for this purpose. As with every field, energy management is vital for robots that are being used in many areas from industry to daily life and that are thought to take up more spaces in the future. Particularly, effective power management in autonomous and multi robots, which are getting more complicated and increasing day by day, will improve the performance and success. In this study, robot management algorithms, usage of renewable and hybrid energy sources, robot motion patterns, robot designs, sharing strategies of workloads in multiple robots, road and mission planning algorithms are discussed for efficient use of energy resources by mobile robots. These techniques have been evaluated in terms of efficient use of existing energy resources and energy management in robots.

Keywords: Energy management, mobile robot, robot administration, robot management, robot planning.

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534 Proteomic Analysis of Tumor Tissue after Treatment with Ascorbic Acid

Authors: Seyeon Park, Mi Jang

Abstract:

Tumor cells have an invasive and metastatic phenotype that is the main cause of death for cancer patients. Tumor establishment and penetration consists of a series of complex processes involving multiple changes in gene expression. In this study, intraperitoneal administration of a high concentration of ascorbic acid inhibited tumor establishment and decreased tumor mass in BALB/C mice implanted with S-180 sarcoma cancer cells. To identify proteins involved in the ascorbic acid-mediated inhibition of tumor progression, changes in the tumor proteome associated with ascorbic acid treatment of BALB/C mice implanted with S-180 were investigated using two-dimensional gel electrophoresis and mass spectrometry. Twenty protein spots were identified whose expression was different between control and ascorbic acid treatment groups.

Keywords: Ascorbic acid, Proteomic analysis, S-180 implantedBALB/C mouse

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