@article{(Open Science Index):https://publications.waset.org/pdf/13392, title = {Proteomic Analysis of Tumor Tissue after Treatment with Ascorbic Acid}, author = {Seyeon Park and Mi Jang}, country = {}, institution = {}, abstract = {Tumor cells have an invasive and metastatic phenotype that is the main cause of death for cancer patients. Tumor establishment and penetration consists of a series of complex processes involving multiple changes in gene expression. In this study, intraperitoneal administration of a high concentration of ascorbic acid inhibited tumor establishment and decreased tumor mass in BALB/C mice implanted with S-180 sarcoma cancer cells. To identify proteins involved in the ascorbic acid-mediated inhibition of tumor progression, changes in the tumor proteome associated with ascorbic acid treatment of BALB/C mice implanted with S-180 were investigated using two-dimensional gel electrophoresis and mass spectrometry. Twenty protein spots were identified whose expression was different between control and ascorbic acid treatment groups.}, journal = {International Journal of Biomedical and Biological Engineering}, volume = {4}, number = {4}, year = {2010}, pages = {157 - 160}, ee = {https://publications.waset.org/pdf/13392}, url = {https://publications.waset.org/vol/40}, bibsource = {https://publications.waset.org/}, issn = {eISSN: 1307-6892}, publisher = {World Academy of Science, Engineering and Technology}, index = {Open Science Index 40, 2010}, }