Search results for: time complexity.
3458 Curvature Ductility Factor of Rectangular Sections Reinforced Concrete Beams
Authors: Y. Si Youcef, M. Chemrouk
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The present work presents a method of calculating the ductility of rectangular sections of beams considering nonlinear behavior of concrete and steel. This calculation procedure allows us to trace the curvature of the section according to the bending moment, and consequently deduce ductility. It also allowed us to study the various parameters that affect the value of the ductility. A comparison of the effect of maximum rates of tension steel, adopted by the codes, ACI [1], EC8 [2] and RPA [3] on the value of the ductility was made. It was concluded that the maximum rate of steels permitted by the ACI [1] codes and RPA [3] are almost similar in their effect on the ductility and too high. Therefore, the ductility mobilized in case of an earthquake is low, the inverse of code EC8 [2]. Recommendations have been made in this direction.Keywords: Ductility, beam, reinforced concrete, seismic code, relationship, time bending, resistance, non-linear behavior.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 61943457 Three-Dimensional Generalized Thermoelasticity with Variable Thermal Conductivity
Authors: Hamdy M. Youssef, Mowffaq Oreijah, Hunaydi S. Alsharif
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In this paper, a three-dimensional model of the generalized thermoelasticity with one relaxation time and variable thermal conductivity has been constructed. The resulting non-dimensional governing equations together with the Laplace and double Fourier transforms techniques have been applied to a three-dimensional half-space subjected to thermal loading with rectangular pulse and traction free in the directions of the principle co-ordinates. The inverses of double Fourier transforms, and Laplace transforms have been obtained numerically. Numerical results for the temperature increment, the invariant stress, the invariant strain, and the displacement are represented graphically. The variability of the thermal conductivity has significant effects on the thermal and the mechanical waves.
Keywords: Thermoelasticity, three-dimensional, Laplace transforms, Fourier transforms, thermal conductivity.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 7493456 Kinetic Parameters for Bioethanol Production from Oil Palm Trunk Juice
Authors: A. H. Norhazimah, C. K. M. Faizal
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Abundant and cheap agricultural waste of oil palm trunk (OPT) juice was used to produce bioethanol. Two strains of Saccharomyces cerevisiae and a strain of Pichia stipitis were used to produce bioethanol from the OPT juice. Fermentation was conducted at previously optimized condition at 30oC and without shaking. The kinetic parameters were estimated and calculated. Monod equation and Hinshelwood model is used to relate the specific growth to the concentration of the limiting substrate and also to simulate bioethanol production rate. Among the three strains, single S. cerevisiae Kyokai no. 7 produce the highest ethanol yield of 0.477 g/l.h within the shortest time (12 h). This yeast also produces more than 20 g/l ethanol concentration within 10 h of fermentation.
Keywords: Oil palm trunk, Pichia stipitis, Saccharomyces cerevisiae.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 20373455 Symbolic Analysis of Large Circuits Using Discrete Wavelet Transform
Authors: Ali Al-Ataby , Fawzi Al-Naima
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Symbolic Circuit Analysis (SCA) is a technique used to generate the symbolic expression of a network. It has become a well-established technique in circuit analysis and design. The symbolic expression of networks offers excellent way to perform frequency response analysis, sensitivity computation, stability measurements, performance optimization, and fault diagnosis. Many approaches have been proposed in the area of SCA offering different features and capabilities. Numerical Interpolation methods are very common in this context, especially by using the Fast Fourier Transform (FFT). The aim of this paper is to present a method for SCA that depends on the use of Wavelet Transform (WT) as a mathematical tool to generate the symbolic expression for large circuits with minimizing the analysis time by reducing the number of computations.Keywords: Numerical Interpolation, Sparse Matrices, SymbolicAnalysis, Wavelet Transform.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15513454 Balancing of Quad Tree using Point Pattern Analysis
Authors: Amitava Chakraborty, Sudip Kumar De, Ranjan Dasgupta
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Point quad tree is considered as one of the most common data organizations to deal with spatial data & can be used to increase the efficiency for searching the point features. As the efficiency of the searching technique depends on the height of the tree, arbitrary insertion of the point features may make the tree unbalanced and lead to higher time of searching. This paper attempts to design an algorithm to make a nearly balanced quad tree. Point pattern analysis technique has been applied for this purpose which shows a significant enhancement of the performance and the results are also included in the paper for the sake of completeness.Keywords: Algorithm, Height balanced tree, Point patternanalysis, Point quad tree.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 27003453 Realization of a Temperature Based Automatic Controlled Domestic Electric Boiling System
Authors: Shengqi Yu, Jinwei Zhao
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This paper presents a kind of analog circuit based temperature control system, which is mainly composed by threshold control signal circuit, synchronization signal circuit and trigger pulse circuit. Firstly, the temperature feedback signal function is realized by temperature sensor TS503F3950E. Secondly, the main control circuit forms the cycle controlled pulse signal to control the thyristor switching model. Finally two reverse paralleled thyristors regulate the output power by their switching state. In the consequence, this is a modernized and energy-saving domestic electric heating system.Keywords: Time base circuit, automatic control, zero-crossing trigger, temperature control.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 10023452 SPH Method used for Flow Predictions at a Turgo Impulse Turbine: Comparison with Fluent
Authors: Phoevos K. Koukouvinis, John S. Anagnostopoulos, Dimitris E. Papantonis
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This work is an attempt to use the standard Smoothed Particle Hydrodynamics methodology for the simulation of the complex unsteady, free-surface flow in a rotating Turgo impulse water turbine. A comparison of two different geometries was conducted. The SPH method due to its mesh-less nature is capable of capturing the flow features appearing in the turbine, without diffusion at the water/air interface. Furthermore results are compared with a commercial CFD package (Fluent®) and the SPH algorithm proves to be capable of providing similar results, in much less time than the mesh based CFD program. A parametric study was also performed regarding the turbine inlet angle.Keywords: Smoothed Particle Hydrodynamics, Mesh-lessmethods, Impulse turbines, Turgo turbine.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 26413451 The Cultural and Anthropological Bases of Culture Ecology of the Turkic Peoples in Central Asia
Authors: S.Kaupenbayeva, A. Tashagil, A.Kanagatova, Zh. Suleimenova
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this scientific article considers the peculiarities of ecology of culture and ecological outlook from cultural and anthropological aspect of Turkic languages speaking peoples in the Central Asia. The ecology of culture of Turkic languages speaking peoples in the Central Asia, formed under the influence of climatic, geographical, economic, religious, ethno cultural and political factors and defining the originality of traditions which have laid down in its basis and functioned, as its components, causes an interest and urgency simultaneously, representing the sample of life of the Person in the World by which it is necessary to be guided today.Keywords: ecology of culture, civilization, the Eurasian civilization, Turkic languages speaking peoples, space-time characteristics, the Central Asia
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 21713450 Presenting a Combinatorial Feature to Estimate Depth of Anesthesia
Authors: Toktam Zoughi, Reza Boostani
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Determining depth of anesthesia is a challenging problem in the context of biomedical signal processing. Various methods have been suggested to determine a quantitative index as depth of anesthesia, but most of these methods suffer from high sensitivity during the surgery. A novel method based on energy scattering of samples in the wavelet domain is suggested to represent the basic content of electroencephalogram (EEG) signal. In this method, first EEG signal is decomposed into different sub-bands, then samples are squared and energy of samples sequence is constructed through each scale and time, which is normalized and finally entropy of the resulted sequences is suggested as a reliable index. Empirical Results showed that applying the proposed method to the EEG signals can classify the awake, moderate and deep anesthesia states similar to BIS.Keywords: Depth of anesthesia, EEG, BIS, Wavelet transforms.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18543449 Plants as Alternative Covers at Contaminated Sites
Authors: M. Grifoni, G. Petruzzelli, M. Barbafieri, I. Rosellini, B. Pezzarossa, F. Pedron
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Evapotranspiration (ET) covers are an alternative cover system that utilizes water balance approach to maximize the ET process to reduce the contaminants leaching through the soil profile. Microcosm tests allow to identify in a short time the most suitable plant species to be used as alternative covers, their survival capacity, and simultaneously the transpiration and evaporation rate of the cover in a specific contaminated soil. This work shows the soil characterization and ET results of microcosm tests carried out on two contaminated soils by using Triticum durum and Helianthus annuus species. The data indicated that transpiration was higher than evaporation, supporting the use of plants as alternative cover at this contaminated site.
Keywords: Contaminated sites, ET cover, evapotranspiration, microcosm experiments.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 12533448 The Taste of Native Land in Everyday Practices of Repatriates – Variations by the Countries of Origin (by Field Materials)
Authors: Amanzhol Kalysh, Didar Kassymova, Aliya Isaeva
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Practices of food sharing as part of the brotherhood and hospitality interpretation have been essential part of the Kazakh ethnic culture since early times. Dialogue in time and space between Kazakhs through differences in food interpretation among the ethnic repatriates may become a link connecting them and platform for stable relations with the host society or serious barrier on the way of their integration in the Kazakhstani society. The article elucidates by the field materials how some aspects of food culture differences among ethnic Kazakhs living abroad (XUAR of China) and ethnic repatriates in Kazakhstan may influence their integration path.
Keywords: Ethnic repatriation, food canon, Kazakh identity, oralman.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16133447 Categorical Missing Data Imputation Using Fuzzy Neural Networks with Numerical and Categorical Inputs
Authors: Pilar Rey-del-Castillo, Jesús Cardeñosa
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There are many situations where input feature vectors are incomplete and methods to tackle the problem have been studied for a long time. A commonly used procedure is to replace each missing value with an imputation. This paper presents a method to perform categorical missing data imputation from numerical and categorical variables. The imputations are based on Simpson-s fuzzy min-max neural networks where the input variables for learning and classification are just numerical. The proposed method extends the input to categorical variables by introducing new fuzzy sets, a new operation and a new architecture. The procedure is tested and compared with others using opinion poll data.
Keywords: Classifier, imputation techniques, fuzzy systems, fuzzy min-max neural networks.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17793446 Generating Frequent Patterns through Intersection between Transactions
Authors: M. Jamali, F. Taghiyareh
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The problem of frequent itemset mining is considered in this paper. One new technique proposed to generate frequent patterns in large databases without time-consuming candidate generation. This technique is based on focusing on transaction instead of concentrating on itemset. This algorithm based on take intersection between one transaction and others transaction and the maximum shared items between transactions computed instead of creating itemset and computing their frequency. With applying real life transactions and some consumption is taken from real life data, the significant efficiency acquire from databases in generation association rules mining.Keywords: Association rules, data mining, frequent patterns, shared itemset.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14043445 Adaptive Notch Filter for Harmonic Current Mitigation
Authors: T. Messikh, S. Mekhilef, N. A. Rahim
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This paper presents an effective technique for harmonic current mitigation using an adaptive notch filter (ANF) to estimate current harmonics. The proposed filter consists of multiple units of ANF connected in parallel structure; each unit is governed by two ordinary differential equations. The frequency estimation is carried out based on the output of these units. The simulation and experimental results show the ability of the proposed tracking scheme to accurately estimate harmonics. The proposed filter was implemented digitally in TMS320F2808 and used in the control of hybrid active power filter (HAPF). The theoretical expectations are verified and demonstrated experimentally.
Keywords: Adaptive notch filter, Active power filter, harmonic filtering, Time varying frequency.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 30533444 Towards a Measurement-Based E-Government Portals Maturity Model
Authors: Abdoullah Fath-Allah, Laila Cheikhi, Rafa E. Al-Qutaish, Ali Idri
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The e-government emerging concept transforms the way in which the citizens are dealing with their governments. Thus, the citizens can execute the intended services online anytime and anywhere. This results in great benefits for both the governments (reduces the number of officers) and the citizens (more flexibility and time saving). Therefore, building a maturity model to assess the egovernment portals becomes desired to help in the improvement process of such portals. This paper aims at proposing an egovernment maturity model based on the measurement of the best practices’ presence. The main benefit of such maturity model is to provide a way to rank an e-government portal based on the used best practices, and also giving a set of recommendations to go to the higher stage in the maturity model.
Keywords: Best practices, e-government portal, maturity model, quality model.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 21133443 A Hidden Markov Model for Modeling Pavement Deterioration under Incomplete Monitoring Data
Authors: Nam Lethanh, Bryan T. Adey
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In this paper, the potential use of an exponential hidden Markov model to model a hidden pavement deterioration process, i.e. one that is not directly measurable, is investigated. It is assumed that the evolution of the physical condition, which is the hidden process, and the evolution of the values of pavement distress indicators, can be adequately described using discrete condition states and modeled as a Markov processes. It is also assumed that condition data can be collected by visual inspections over time and represented continuously using an exponential distribution. The advantage of using such a model in decision making process is illustrated through an empirical study using real world data.Keywords: Deterioration modeling, Exponential distribution, Hidden Markov model, Pavement management
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 23053442 Using Data Mining Techniques for Estimating Minimum, Maximum and Average Daily Temperature Values
Authors: S. Kotsiantis, A. Kostoulas, S. Lykoudis, A. Argiriou, K. Menagias
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Estimates of temperature values at a specific time of day, from daytime and daily profiles, are needed for a number of environmental, ecological, agricultural and technical applications, ranging from natural hazards assessments, crop growth forecasting to design of solar energy systems. The scope of this research is to investigate the efficiency of data mining techniques in estimating minimum, maximum and mean temperature values. For this reason, a number of experiments have been conducted with well-known regression algorithms using temperature data from the city of Patras in Greece. The performance of these algorithms has been evaluated using standard statistical indicators, such as Correlation Coefficient, Root Mean Squared Error, etc.
Keywords: regression algorithms, supervised machine learning.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 34183441 The Relationship between the Energy of Gravitational Field and the Representative Pseudotensor
Authors: R. I. Khrapko
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As is known, the role of the energy-momentum pseudotensors of the gravitational field is to extend the conservation law to the gravitational interaction by taking into account the energy and momentum of the gravitational field. We calculated the contribution of the Einstein pseudotensor to the total mass of a stationary material body and its gravitational field. It turned out that this contribution is positive, despite the fact that the mass-energy of a stationary gravitational field is negative. We concluded that the pseudotensor incorrectly describes the energy of the gravitational field. Nevertheless, this pseudotensor has been used in a large number of scientific works for 100 years. We explain this by the fact that the covariant component of the pseudotensor was regarded as the mass-energy. Besides, we prove the advantage of the covariant energy-momentum conservation law for matter in the Minkowski space-time.
Keywords: Conservation law, covariant integration, gravitation field, isolated system.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 7483440 A Classical Method of Optimizing Manufacturing Systems Using a Number of Industrial Engineering Techniques
Authors: John M. Ikome, Martha E. Ikome, Therese Van Wyk
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Productivity optimization of a company can significantly increase the company’s output and productivity which can be in the form of corrective actions of ineffective activities, process simplification, and reduction of variations, responsiveness, and reduction of set-up-time which are all under the classification of waste within the manufacturing environment. Deriving a means to eliminate a number of these issues has a key importance for manufacturing organization. This paper focused on a number of industrial engineering techniques which include a cause and effect diagram, to identify and optimize the method or systems being used. Based on our results, it shows that there are a number of variations within the production processes that can significantly disrupt the expected output.
Keywords: Optimization, fishbone diagram, productivity.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 10003439 A Study of Classification Models to Predict Drill-Bit Breakage Using Degradation Signals
Authors: Bharatendra Rai
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Cutting tools are widely used in manufacturing processes and drilling is the most commonly used machining process. Although drill-bits used in drilling may not be expensive, their breakage can cause damage to expensive work piece being drilled and at the same time has major impact on productivity. Predicting drill-bit breakage, therefore, is important in reducing cost and improving productivity. This study uses twenty features extracted from two degradation signals viz., thrust force and torque. The methodology used involves developing and comparing decision tree, random forest, and multinomial logistic regression models for classifying and predicting drill-bit breakage using degradation signals.
Keywords: Degradation signal, drill-bit breakage, random forest, multinomial logistic regression.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 22433438 Extension of Fish Shelf Life by Ozone Treatment
Authors: Behrouz Mosayebi Dehkordi, Neda Zokaie
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The shelf life of fish was extended using disinfection properties of ozone. For this purpose, Trout specimens were exposed to ozone in the aqueous media for two hours and their microbial growth and biochemical properties were measured over time. Microbial growth of ozone treated fish was significantly slower than control sample, resulting in lower counts of bacteria. According to the biochemical tests; ozone treatment had no negative effects on fat, protein and humidity of fish. Peroxide and TVN (Total Volatile Nitrogen) measurements showed that treatment by ozone increased the trout shelf life from 4 days to 6 days. According to the sensory analysis, no changes were observed in color or flavor of the ozone treated trout.Keywords: Fish, Ozone, Shelf life, Trout.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 22343437 Cantor Interpolating Spline to Design Electronic Mail Boxes
Authors: Adil Al-Rammahi
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Electronic mail is very important in present time. Many researchers work for designing, improving, securing, fasting, goodness and others fields in electronic mail. This paper introduced new algorithm to use Cantor sets and cubic spline interpolating function in the electronic mail design. Cantor sets used as the area (or domain) of the mail, while spline function used for designing formula. The roots of spline function versus Cantor sets used as the controller admin. The roots calculated by the numerical Newton – Raphson's method. The result of this algorithm was promised.
Keywords: Cantor sets, spline, electronic mail design, Newton – Raphson's method.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15973436 Risk Assessment of Acrylamide Intake from Roasted Potatoes in Latvia
Authors: Irisa Murniece, Daina Karklina, Ruta Galoburda
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From food consumption surveys has been found that potato consumption comparing to other European countries is one of the highest. Hence acrylamide (AA) intake coming from fried potatoes in population might be high as well. The aim of the research was to determine acrylamide content and estimate intake of acrylamide from roasted potatoes bred and cultivated in Latvia. Five common Latvian potato varieties were selected: Lenora, Brasla, Imanta, Zile, and Madara. A two-year research was conducted during two periods: just after harvesting and after six months of storage. Time and temperature (210 ± 5°C) was recorded during frying. AA was extracted from potatoes by solid phase extraction and AA content was determined by LC-MS/MS. estimated intake of acrylamide ranges from 0.012 to 0.496μgkg-1 BW per day.
Keywords: potato, roasting, variety, acrylamide, Latvia, risk assessment.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 20623435 A Novel Methodology Proposed for Optimizing the Degree of Hybridization in Parallel HEVs using Genetic Algorithm
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In this paper, a new Genetic Algorithm (GA) based methodology is proposed to optimize the Degree of Hybridization (DOH) in a passenger parallel hybrid car. At first step, target parameters for the vehicle are decided and then using ADvanced VehIcle SimulatOR (ADVISOR) software, the variation pattern of these target parameters, across the different DOHs, is extracted. At the next step, a suitable cost function is defined and is optimized using GA. In this paper, also a new technique has been proposed for deciding the number of battery modules for each DOH, which leads to a great improvement in the vehicle performance. The proposed methodology is so simple, fast and at the same time, so efficient.Keywords: Degree of Hybridization (DOH), Electric Motor, Emissions, Fuel Economy, Genetic Algorithm (GA), Hybrid ElectricVehicle (HEV), Vehicle Performance
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18453434 Fast Segmentation for the Piecewise Smooth Mumford-Shah Functional
Authors: Yingjie Zhang
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This paper is concerned with an improved algorithm based on the piecewise-smooth Mumford and Shah (MS) functional for an efficient and reliable segmentation. In order to speed up convergence, an additional force, at each time step, is introduced further to drive the evolution of the curves instead of only driven by the extensions of the complementary functions u + and u - . In our scheme, furthermore, the piecewise-constant MS functional is integrated to generate the extra force based on a temporary image that is dynamically created by computing the union of u + and u - during segmenting. Therefore, some drawbacks of the original algorithm, such as smaller objects generated by noise and local minimal problem also are eliminated or improved. The resulting algorithm has been implemented in Matlab and Visual Cµ, and demonstrated efficiently by several cases.Keywords: Active contours, energy minimization, image segmentation, level sets.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18603433 Identification of Arglecins B and C and Actinofuranosin A from a Termite Gut-Associated Streptomyces Species
Authors: Christian A. Romero, Tanja Grkovic, John. R. J. French, D. İpek. Kurtböke, Ronald J. Quinn
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A high-throughput and automated 1H NMR metabolic fingerprinting dereplication approach was used to accelerate the discovery of unknown bioactive secondary metabolites. The applied dereplication strategy accelerated the discovery of new natural products, provided rapid and competent identification and quantification of the known secondary metabolites and avoided time-consuming isolation procedures. The effectiveness of the technique was demonstrated by the isolation and elucidation of arglecins B (1), C (2) and actinofuranosin A (3) from a termite-gut associated Streptomyces sp. (USC 597) grown under solid state fermentation. The structures of these compounds were elucidated by extensive interpretation of 1H, 13C and 2D NMR spectroscopic data. These represent the first report of arglecin analogues isolated from a termite gut-associated Streptomyces species.
Keywords: Actinomycetes, actinofuranosin, antibiotics, arglecins, NMR spectroscopy.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 2263432 Bearing Fault Feature Extraction by Recurrence Quantification Analysis
Authors: V. G. Rajesh, M. V. Rajesh
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In rotating machinery one of the critical components that is prone to premature failure is the rolling bearing. Consequently, early warning of an imminent bearing failure is much critical to the safety and reliability of any high speed rotating machines. This study is concerned with the application of Recurrence Quantification Analysis (RQA) in fault detection of rolling element bearings in rotating machinery. Based on the results from this study it is reported that the RQA variable, percent determinism, is sensitive to the type of fault investigated and therefore can provide useful information on bearing damage in rolling element bearings.Keywords: Bearing fault detection, machine vibrations, nonlinear time series analysis, recurrence quantification analysis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18573431 Quality Based Approach for Efficient Biologics Manufacturing
Authors: Takashi Kaminagayoshi, Shigeyuki Haruyama
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To improve the manufacturing efficiency of biologics, such as antibody drugs, a quality engineering framework was designed. Within this framework, critical steps and parameters in the manufacturing process were studied. Identification of these critical steps and critical parameters allows a deeper understanding of manufacturing capabilities, and suggests to process development department process control standards based on actual manufacturing capabilities as part of a PDCA (plan-do-check-act) cycle. This cycle can be applied to each manufacturing process so that it can be standardized, reducing the time needed to establish each new process.Keywords: Antibody drugs, biologics, manufacturing efficiency, PDCA cycle, quality engineering.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16533430 Interactive Model Based On an Extended CPN
Authors: Shuzhen Yao, Fengjing Zhao, Jianwei He
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The UML modeling of complex distributed systems often is a great challenge due to the large amount of parallel real-time operating components. In this paper the problems of verification of such systems are discussed. ECPN, an Extended Colored Petri Net is defined to formally describe state transitions of components and interactions among components. The relationship between sequence diagrams and Free Choice Petri Nets is investigated. Free Choice Petri Net theory helps verifying the liveness of sequence diagrams. By converting sequence diagrams to ECPNs and then comparing behaviors of sequence diagram ECPNs and statecharts, the consistency among models is analyzed. Finally, a verification process for an example model is demonstrated.
Keywords: Consistency, liveness, Petri Net, sequence diagram.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16103429 Mathematical Modelling of Different Types of Body Support Surface for Pressure Ulcer Prevention
Authors: Mahbub C. Mishu, Venketesh N. Dubey, Tamas Hickish, Jonathan Cole
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Pressure ulcer is a common problem for today’s healthcare industry. It occurs due to external load applied to the skin. Also when the subject is immobile for a longer period of time and there is continuous load applied to a particular area of human body, blood flow gets reduced and as a result pressure ulcer develops. Body support surface has a significant role in preventing ulceration so it is important to know the characteristics of support surface under loading conditions. In this paper we have presented mathematical models of different types of viscoelastic materials and also we have shown the validation of our simulation results with experiments.
Keywords: Pressure ulcer, viscoelastic material, mathematical model, experimental validation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1919