%0 Journal Article
	%A Christian A. Romero and  Tanja Grkovic and  John. R. J. French and  D. İpek. Kurtböke and  Ronald J. Quinn
	%D 2024
	%J International Journal of Biotechnology and Bioengineering
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 205, 2024
	%T Identification of Arglecins B and C and Actinofuranosin A from a Termite Gut-Associated Streptomyces Species
	%U https://publications.waset.org/pdf/10013464
	%V 205
	%X A high-throughput and automated 1H NMR metabolic fingerprinting dereplication approach was used to accelerate the discovery of unknown bioactive secondary metabolites. The applied dereplication strategy accelerated the discovery of new natural products, provided rapid and competent identification and quantification of the known secondary metabolites and avoided time-consuming isolation procedures. The effectiveness of the technique was demonstrated by the isolation and elucidation of arglecins B (1), C (2) and actinofuranosin A (3) from a termite-gut associated Streptomyces sp. (USC 597) grown under solid state fermentation. The structures of these compounds were elucidated by extensive interpretation of 1H, 13C and 2D NMR spectroscopic data. These represent the first report of arglecin analogues isolated from a termite gut-associated Streptomyces species.
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