Search results for: Marvin Hartmann

Authors: Abdul Halim Bhuiyan, M. A. Alim, Md. Nasir Uddin

Abstract:

This paper is concerned with the effect of Hartmann number on the free convective flow in a square cavity with different positions of heated square block. The two-dimensional Physical and mathematical model have been developed, and mathematical model includes the system of governing mass, momentum and energy equations are solved by the finite element method. The calculations have been computed for Prandtl number Pr = 0.71, the Rayleigh number Ra = 1000 and the different values of Hartmann number. The results are illustrated with the streamlines, isotherms, velocity and temperature fields as well as local Nusselt number.

Keywords: Finite element method, free convection, Hartmann number, square cavity.

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Authors: Dagmar Monett, Sven-Erik Kujat, Marvin Hartmann

Abstract:

This paper discusses the use of a template-based approach for documenting high-quality requirements as part of course projects in an undergraduate Software Engineering course. In order to ease some of the Requirements Engineering activities that are performed when defining requirements by using the template, a new CASE tool, RED:WIRE, was first developed and later tested by students attending the course. Two questionnaires were conceived around a study that aims to analyze the new tool’s learnability as well as other obtained results concerning its usability in particular and the Requirements Engineering skills developed by the students in general.

Keywords: CASE tool, collaborative learning, requirements engineering, undergraduate teaching.

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Authors: Bouchmel Mliki, Chaouki Ali, Mohamed Ammar Abbassi

Abstract:

In this numerical study, natural convection of Cu–water nanofluid in a cavity submitted to different heating modes on its vertical walls is analyzed. Maxwell-Garnetts (MG) and Brinkman models have been utilized for calculating the effective thermal conductivity and dynamic viscosity of nanofluid, respectively. Influences of Rayleigh number (Ra = 10³−10⁶), nanoparticle volume concentration (f = 0-0.04) and Hartmann number (Ha = 0-90) on the flow and heat transfer characteristics have been examined. The results indicate that the Hartmann number influences the heat transfer at Ra = 10⁶ more than other Raleigh numbers, as the least effect is observed at Ra = 10³. Moreover, the results show that the solid volume fraction has a significant influence on heat transfer, depending on the value of Hartmann, heat generation or absorption coefficient and Rayleigh numbers.

Keywords: Heat transfer, linearly/sinusoidally heated, Lattice Boltzmann Method, natural convection, nanofluid.

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Authors: Virupakshaiah DBM, Madiha Ahmed, Smita T. Patil, Chandrakanth Kelmani

Abstract:

Tuberculosis (TB) is a bacterial infectious disease caused by the obligate human pathogen, Mycobacterium tuberculosis. Multidrug-resistant tuberculosis (MDR-TB) is a global reality that threatens tuberculosis control. Resistance to antibiotic Rifampicin, occurs in 95% of cases through nucleotide substitutions in an 81-bp core region of the rpoB i.e; beta subunit of DNA dependant RNA polymerase. In this paper, we studied the Rifampicin-rpoB receptor interactions In silico. First, homology modeling was performed to obtain the three dimensional structure of Mycobacterium rpoB. Sixty analogs of Rifampicin were prepared using Marvin sketch software. Both original Rifampicin and the analogs were docked with rpoB and energy values were obtained. Out of sixty analogs, 43 analogs had lesser energy values than conventional Rifampicin and hence are predicted to have greater binding affinity to rpoB. Thus, this study offers a route for the development of Rifampicin analogs against multi drug resistant Mycobacterium rpoB.

Keywords: Marvin Sketch, Mycobacterium tuberculosis, Rifampicin, rpoB.

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Authors: Imen Mejri, Ahmed Mahmoudi, Mohamed A. Abbassi, Ahmed Omri

Abstract:

This paper examines the natural convection in a square enclosure filled with a water-Al₂O₃ nanofluid and is subjected to a magnetic field. The side walls of the cavity have spatially varying sinusoidal temperature distributions. The horizontal walls are adiabatic. Lattice Boltzmann method (LBM) is applied to solve the coupled equations of flow and temperature fields. This study has been carried out for the pertinent parameters in the following ranges: Rayleigh number of the base fluid, Ra=10³ to 10⁶, Hartmann number varied from Ha=0 to 90, phase deviation (γ=0, π/4, π/2, 3π/4 and π) and the solid volume fraction of the nanoparticles between Ø = 0 and 6%. The results show that the heat transfer rate increases with an increase of the Rayleigh number but it decreases with an increase of the Hartmann number. For γ=π/2 and Ra=10⁵ the magnetic field augments the effect of nanoparticles. At Ha=0, the greatest effects of nanoparticles are obtained at γ = 0 and π/4 for Ra=10⁴ and 10⁵ respectively.

 

Keywords: Lattice Boltzmann Method, magnetic field, Natural convection, nanofluid, Sinusoidal temperature distribution.

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Authors: Virupakshaiah DBM, Chandrakanth Kelmani, Rachanagouda Patil, Prasad Hegade

Abstract:

Severe acute respiratory syndrome (SARS) is a respiratory disease in humans which is caused by the SARS coronavirus. The treatment of coronavirus-associated SARS has been evolving and so far there is no consensus on an optimal regimen. The mainstream therapeutic interventions for SARS involve broad-spectrum antibiotics and supportive care, as well as antiviral agents and immunomodulatory therapy. The Protein- Ligand interaction plays a significant role in structural based drug designing. In the present work we have taken the receptor Angiotensin converting enzyme 2 and identified the drugs that are commonly used against SARS. They are Lopinavir, Ritonavir, Ribavirin, and Oseltamivir. The receptor Angiotensin converting enzyme 2 (ACE-2) was docked with above said drugs and the energy value obtained are as follows, Lopinavir (-292.3), Ritonavir (-325.6), Oseltamivir (- 229.1), Ribavirin (-208.8). Depending on the least energy value we have chosen the best two drugs out of the four conventional drugs. We tried to improve the binding efficiency and steric compatibility of the two drugs namely Ritonavir and Lopinavir. Several modifications were made to the probable functional groups (phenylic, ketonic groups in case of Ritonavir and carboxylic groups in case of Lopinavir respectively) which were interacting with the receptor molecule. Analogs were prepared by Marvin Sketch software and were docked using HEX docking software. Lopinavir analog 8 and Ritonavir analog 11 were detected with significant energy values and are probable lead molecule. It infers that some of the modified drugs are better than the original drugs. Further work can be carried out to improve the steric compatibility of the drug based upon the work done above for a more energy efficient binding of the drugs to the receptor.

Keywords: Protein data bank, Rasmol, Marvin sketch, Hexdocking.

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Authors: Julian Becker, Wiebke Hartmann, Sebastian Bertsch, Johannes Nywlt, Matthias Schmidt

Abstract:

In order to ensure a high service level industrial enterprises have to maintain safety-stock that directly influences the economic efficiency at the same time. This paper analyses established mathematical methods to calculate safety-stock. Therefore, the performance measured in stock and service level is appraised and the limits of several methods are depicted. Afterwards, a new dynamic approach is presented to gain an extensive method to calculate safety-stock that also takes the knowledge of future volatility into account.

Keywords: Inventory dimensioning, material requirement planning, safety-stock calculation.

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Authors: R.YadollahiFarsani, B. Ghasemi

Abstract:

A magnetohydrodynamic mixed convective flow in a cavity was studied in this paper. The lower surface of cavity was heated from below whereas other walls of the cavity were thermally isolated. The governing two-dimensional flow equations have been solved by using finite volume code. The effects of magnetic field were studied on flow and temperature field and heat transfer performance at a wide range of parameters, Such as Hartmann (0≤Ha≤100) and Reynolds (1≤Re≤100) numbers. The results showed that as Hartman number increases the Nusselt number, representing heat transfer from the cavity decreases.

Keywords: Cavity, Magnetic Field, Mixed Convection, Magnetohydrodynamic

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Authors: M. Aghajani Haghighi, H. Emdad, K. Jafarpur, A. N. Ziaei

Abstract:

The effect of a uniform magnetic field on the formation of drops of specific size has been investigated numerically in a T-shaped microchannel. Previous researches indicated that the drop sizes of secondary stream decreases, with increasing main stream flow rate and decreasing interfacial tension. In the present study the effect of a uniform magnetic field on the main stream is considered, and it is proposed that by increasing the Hartmann number, the size of the drops of the secondary stream will be decreased.

Keywords: Drop formation, Magnetohydrodynamics, Microchannel, Volume-of-Fluid

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Authors: B. Fersadou, H. Kahalerras

Abstract:

This work deals with the problem of MHD mixed convection in a completely porous and differentially heated vertical channel. The model of Darcy-Brinkman-Forchheimer with the Boussinesq approximation is adopted and the governing equations are solved by the finite volume method. The effects of magnetic field and buoyancy force intensities are given by the Hartmann and Richardson numbers respectively, as well as the Joule heating represented by Eckert number on the velocity and temperature fields, are examined. The main results show an augmentation of heat transfer rate with the decrease of Darcy number and the increase of Ri and Ha when Joule heating is neglected.

Keywords: Heat sources, magnetic field, mixed convection, porous channel.

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Authors: K. Dimitropoulos, N. Grammalidis, I. Gragopoulos, H. Gao, Th. Heuer, M. Weinmann, S. Voit, C. Stockhammer, U. Hartmann, N. Pavlidou

Abstract:

Existing ground movement surveillance technologies at airports are subjected to limitations due to shadowing effects or multiple reflections. Therefore, there is a strong demand for a new sensing technology, which will be cost effective and will provide detection of non-cooperative targets under any weather conditions. This paper aims to present a new intelligent system, developed within the framework of the EC-funded ISMAEL project, which is based on a new magnetic sensing technology and provides detection, tracking and automatic classification of targets moving on the airport surface. The system is currently being installed at two European airports. Initial experimental results under real airport traffic demonstrate the great potential of the proposed system.

Keywords: Air traffic management, magnetic sensors, multitracking, A-SMGCS.

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Authors: H.A. Ashorynejad, M. Farhadi, K.Sedighi, A.Hasanpour

Abstract:

We report the results of an lattice Boltzmann simulation of magnetohydrodynamic damping of sidewall convection in a rectangular enclosure filled with a porous medium. In particular we investigate the suppression of convection when a steady magnetic field is applied in the vertical direction. The left and right vertical walls of the cavity are kept at constant but different temperatures while both the top and bottom horizontal walls are insulated. The effects of the controlling parameters involved in the heat transfer and hydrodynamic characteristics are studied in detail. The heat and mass transfer mechanisms and the flow characteristics inside the enclosure depended strongly on the strength of the magnetic field and Darcy number. The average Nusselt number decreases with rising values of the Hartmann number while this increases with increasing values of the Darcy number.

Keywords: Lattice Boltzmann method , Natural convection , Magnetohydrodynamic , Porous medium

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Authors: M. Battira, R. Bessaih

Abstract:

We numerically study the three-dimensional magnetohydrodynamics (MHD) stability of oscillatory natural convection flow in a rectangular cavity, with free top surface, filled with a liquid metal, having an aspect ratio equal to A=L/H=5, and subjected to a transversal temperature gradient and a uniform magnetic field oriented in x and z directions. The finite volume method was used in order to solve the equations of continuity, momentum, energy, and potential. The stability diagram obtained in this study highlights the dependence of the critical value of the Grashof number Grcrit , with the increase of the Hartmann number Ha for two orientations of the magnetic field. This study confirms the possibility of stabilization of a liquid metal flow in natural convection by application of a magnetic field and shows that the flow stability is more important when the direction of magnetic field is longitudinal than when the direction is transversal.

Keywords: Natural convection, Magnetic field, Oscillatory, Cavity, Liquid metal.

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Authors: Manfred Hartmann, Andreas Graef, Hannes Perko, Christoph Baumgartner, Tilmann Kluge

Abstract:

In this paper we introduce a novel method for the characterization of synchronziation and coupling effects in multivariate time series that can be used for the analysis of EEG or ECoG signals recorded during epileptic seizures. The method allows to visualize the spatio-temporal evolution of synchronization and coupling effects that are characteristic for epileptic seizures. Similar to other methods proposed for this purpose our method is based on a regression analysis. However, a more general definition of the regression together with an effective channel selection procedure allows to use the method even for time series that are highly correlated, which is commonly the case in EEG/ECoG recordings with large numbers of electrodes. The method was experimentally tested on ECoG recordings of epileptic seizures from patients with temporal lobe epilepsies. A comparision with the results from a independent visual inspection by clinical experts showed an excellent agreement with the patterns obtained with the proposed method.

Keywords: EEG, epilepsy, regression analysis, seizurepropagation.

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Authors: Aditi Shukla, Ambarish S. Vidyarthi, Subir Samanta

Abstract:

The worldwide prevalence of H3N2 influenza virus and its increasing resistance to the existing drugs necessitates for the development of an improved/better targeting anti-influenza drug. H3N2 influenza neuraminidase is one of the two membrane-bound proteins belonging to group-2 neuraminidases. It acts as key player involved in viral pathogenicity and hence, is an important target of anti-influenza drugs. Oseltamivir is one of the potent drugs targeting this neuraminidase. In the present work, we have taken subtype N2 neuraminidase as the receptor and probable analogs of oseltamivir as drug molecules to study the protein-drug interaction in anticipation of finding efficient modified candidate compound. Oseltamivir analogs were made by modifying the functional groups using Marvin Sketch software and were docked using Schrodinger-s Glide. Oseltamivir analog 10 was detected to have significant energy value (16% less compared to Oseltamivir) and could be the probable lead molecule. It infers that some of the modified compounds can interact in a novel manner with increased hydrogen bonding at the active site of neuraminidase and it might be better than the original drug. Further work can be carried out such as enzymatic inhibition studies; synthesis and crystallizing the drug-target complex to analyze the interactions biologically.

Keywords: H3N2 Influenza, Neuraminidase, Oseltamiviranalogs, structure based drug designing

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Authors: H.A. Ashorynejad, M. Farhadi, K.Sedighi, A.Hasanpour

Abstract:

We report the results of an lattice Boltzmann simulation of magnetohydrodynamic damping of sidewall convection in a rectangular enclosure filled with a porous medium. In particular we investigate the suppression of convection when a steady magnetic field is applied in the vertical direction. The left and right vertical walls of the cavity are kept at constant but different temperatures while both the top and bottom horizontal walls are insulated. The effects of the controlling parameters involved in the heat transfer and hydrodynamic characteristics are studied in detail. The heat and mass transfer mechanisms and the flow characteristics inside the enclosure depended strongly on the strength of the magnetic field and Darcy number. The average Nusselt number decreases with rising values of the Hartmann number while this increases with increasing values of the Darcy number.

Keywords: Lattice Boltzmann method , Natural convection , Magnetohydrodynamic , Porous medium

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Authors: Bastian Hartmann, Christoph Schauer, Norbert Link

Abstract:

This paper addresses the problem of recognizing and interpreting the behavior of human workers in industrial environments for the purpose of integrating humans in software controlled manufacturing environments. In this work we propose a generic concept in order to derive solutions for task-related manual production applications. Thus, we are able to use a versatile concept providing flexible components and being less restricted to a specific problem or application. We instantiate our concept in a spot welding scenario in which the behavior of a human worker is interpreted when performing a welding task with a hand welding gun. We acquire signals from inertial sensors, video cameras and triggers and recognize atomic actions by using pose data from a marker based video tracking system and movement data from inertial sensors. Recognized atomic actions are analyzed on a higher evaluation level by a finite state machine.

Keywords: activity recognition, task modeling, marker-based video-tracking, inertial sensors.

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Authors: Cuong D. Dao, Rob J.I. Basten, Andreas Hartmann

Abstract:

This paper studies the optimal maintenance planning of preventive maintenance and renewal activities for components in a single railway track when the available time for maintenance is limited. The rail-track system consists of several types of components, such as rail, ballast, and switches with different preventive maintenance and renewal intervals. To perform maintenance or renewal on the track, a train free period for maintenance, called a possession, is required. Since a major possession directly affects the regular train schedule, maintenance and renewal activities are clustered as much as possible. In a highly dense and utilized railway network, the possession time on the track is critical since the demand for train operations is very high and a long possession has a severe impact on the regular train schedule. We present an optimization model and investigate the maintenance schedules with and without the possession capacity constraint. In addition, we also integrate the social-economic cost related to the effects of the maintenance time to the variable possession cost into the optimization model. A numerical example is provided to illustrate the model.

Keywords: Rail-track components, maintenance, optimal clustering, possession capacity.

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