Search results for: Lie Classical method
8036 A Novel Method for the Characterization of Synchronization and Coupling in Multichannel EEG and ECoG
Authors: Manfred Hartmann, Andreas Graef, Hannes Perko, Christoph Baumgartner, Tilmann Kluge
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In this paper we introduce a novel method for the characterization of synchronziation and coupling effects in multivariate time series that can be used for the analysis of EEG or ECoG signals recorded during epileptic seizures. The method allows to visualize the spatio-temporal evolution of synchronization and coupling effects that are characteristic for epileptic seizures. Similar to other methods proposed for this purpose our method is based on a regression analysis. However, a more general definition of the regression together with an effective channel selection procedure allows to use the method even for time series that are highly correlated, which is commonly the case in EEG/ECoG recordings with large numbers of electrodes. The method was experimentally tested on ECoG recordings of epileptic seizures from patients with temporal lobe epilepsies. A comparision with the results from a independent visual inspection by clinical experts showed an excellent agreement with the patterns obtained with the proposed method.Keywords: EEG, epilepsy, regression analysis, seizurepropagation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14328035 Evolutionary Computing Approach for the Solution of Initial value Problems in Ordinary Differential Equations
Authors: A. Junaid, M. A. Z. Raja, I. M. Qureshi
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An evolutionary computing technique for solving initial value problems in Ordinary Differential Equations is proposed in this paper. Neural network is used as a universal approximator while the adaptive parameters of neural networks are optimized by genetic algorithm. The solution is achieved on the continuous grid of time instead of discrete as in other numerical techniques. The comparison is carried out with classical numerical techniques and the solution is found with a uniform accuracy of MSE ≈ 10-9 .
Keywords: Neural networks, Unsupervised learning, Evolutionary computing, Numerical methods, Fitness evaluation function.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17808034 Development of Variable Stepsize Variable Order Block Method in Divided Difference Form for the Numerical Solution of Delay Differential Equations
Authors: Fuziyah Ishak, Mohamed B. Suleiman, Zanariah A. Majid, Khairil I. Othman
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This paper considers the development of a two-point predictor-corrector block method for solving delay differential equations. The formulae are represented in divided difference form and the algorithm is implemented in variable stepsize variable order technique. The block method produces two new values at a single integration step. Numerical results are compared with existing methods and it is evident that the block method performs very well. Stability regions of the block method are also investigated.Keywords: block method, delay differential equations, predictor-corrector, stability region, variable stepsize variable order.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14758033 An Efficient Segmentation Method Based on Local Entropy Characteristics of Iris Biometrics
Authors: Ali Shojaee Bakhtiari, Ali Asghar Beheshti Shirazi, Amir Sepasi Zahmati
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An efficient iris segmentation method based on analyzing the local entropy characteristic of the iris image, is proposed in this paper and the strength and weaknesses of the method are analyzed for practical purposes. The method shows special strength in providing designers with an adequate degree of freedom in choosing the proper sections of the iris for their application purposes.Keywords: Iris segmentation, entropy, biocryptosystem, biometric identification.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14288032 A Novel Eccentric Lapping Method with Two Rotatable Lapping Plates for Finishing Cemented Carbide Balls
Authors: C. C. Lv, Y. L. Sun, D. W. Zuo
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Cemented carbide balls are usually implemented in industry under the environment of high speed, high temperature, corrosiveness and strong collisions. However, its application is limited due to high fabrication cost, processing efficiency and quality. A novel eccentric lapping method with two rotatable lapping plates was proposed in this paper. A mathematical model was constructed to analyze the influence of each design parameter on this lapping method. To validate this new lapping method, an orthogonal experiment was conducted with cemented carbide balls (YG6). The simulation model was verified and the optimal lapping parameters were derived. The results show that the surface roundness of the balls reaches to 0.65um from 2um in 1 hour using this lapping method. So, using this novel lapping method, it can effectively improve the machining precision and efficiency of cemented carbide balls.
Keywords: Cemented carbide balls, eccentric lapping, high precision, lapping tracks, V-groove.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 25208031 Radiation Heat Transfer Effect in Solid Oxide Fuel Cell: Application of the Lattice Boltzmann Method
Authors: Imen Mejri, Ahmed Mahmoudi, Mohamed A. Abbassi, Ahmed Omri
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The radiation effect within the solid anode, electrolyte, and cathode SOFC layers problem has been investigated in this paper. Energy equation is solved by the Lattice Boltzmann method (LBM). The Rosseland method is used to model the radiative transfer in the electrodes. The Schuster-Schwarzschild method is used to model the radiative transfer in the electrolyte. Without radiative effect, the found results are in good agreement with those published. The obtained results show that the radiative effect can be neglected.
Keywords: SOFC, lattice Boltzmann method, conduction, radiation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 24518030 Dynamics and Feedback Control for a New Hyperchaotic System
Authors: Kejun Zhuang, Hailong Zhu
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In this paper, stability and Hopf bifurcation analysis of a novel hyperchaotic system are investigated. Four feedback control strategies, the linear feedback control method, enhancing feedback control method, speed feedback control method and delayed feedback control method, are used to control the hyperchaotic attractor to unstable equilibrium. Moreover numerical simulations are given to verify the theoretical results.Keywords: Feedback control, Hopf bifurcation, hyperchaotic system, stability.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17598029 The Method of Evaluation Artery Diameter from Ultrasound Video
Authors: U. Rubins, Z. Marcinkevics, K.Volceka
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The cardiovascular system has become the most important subject of clinical research, particularly measurement of arterial blood flow. Therefore correct determination of arterial diameter is crucial. We propose a novel, semi-automatic method for artery lumen detection. The method is based on Gaussian probability function. Usability of our proposed method was assessed by analyzing ultrasound B-mode CFA video sequences acquired from eleven healthy volunteers. The correlation coefficient between the manual and semi-automatic measurement of arterial diameter was 0.996. Our proposed method for detecting artery boundary is novel and accurate enough for the measurement of artery diameter.Keywords: Ultrasound, boundary detection, artery diameter, curve fitting.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15938028 Generalized Chebyshev Collocation Method
Authors: Junghan Kim, Wonkyu Chung, Sunyoung Bu, Philsu Kim
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In this paper, we introduce a generalized Chebyshev collocation method (GCCM) based on the generalized Chebyshev polynomials for solving stiff systems. For employing a technique of the embedded Runge-Kutta method used in explicit schemes, the property of the generalized Chebyshev polynomials is used, in which the nodes for the higher degree polynomial are overlapped with those for the lower degree polynomial. The constructed algorithm controls both the error and the time step size simultaneously and further the errors at each integration step are embedded in the algorithm itself, which provides the efficiency of the computational cost. For the assessment of the effectiveness, numerical results obtained by the proposed method and the Radau IIA are presented and compared.
Keywords: Generalized Chebyshev Collocation method, Generalized Chebyshev Polynomial, Initial value problem.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 26408027 An Improved Algorithm for Calculation of the Third-order Orthogonal Tensor Product Expansion by Using Singular Value Decomposition
Authors: Chiharu Okuma, Naoki Yamamoto, Jun Murakami
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As a method of expanding a higher-order tensor data to tensor products of vectors we have proposed the Third-order Orthogonal Tensor Product Expansion (3OTPE) that did similar expansion as Higher-Order Singular Value Decomposition (HOSVD). In this paper we provide a computation algorithm to improve our previous method, in which SVD is applied to the matrix that constituted by the contraction of original tensor data and one of the expansion vector obtained. The residual of the improved method is smaller than the previous method, truncating the expanding tensor products to the same number of terms. Moreover, the residual is smaller than HOSVD when applying to color image data. It is able to be confirmed that the computing time of improved method is the same as the previous method and considerably better than HOSVD.
Keywords: Singular value decomposition (SVD), higher-orderSVD (HOSVD), outer product expansion, power method.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16908026 Lagrangian Method for Solving Unsteady Gas Equation
Authors: Amir Taghavi, kourosh Parand, Hosein Fani
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In this paper we propose, a Lagrangian method to solve unsteady gas equation which is a nonlinear ordinary differential equation on semi-infnite interval. This approach is based on Modified generalized Laguerre functions. This method reduces the solution of this problem to the solution of a system of algebraic equations. We also compare this work with some other numerical results. The findings show that the present solution is highly accurate.
Keywords: Unsteady gas equation, Generalized Laguerre functions, Lagrangian method, Nonlinear ODE.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15228025 Generation of Numerical Data for the Facilitation of the Personalized Hyperthermic Treatment of Cancer with An Interstital Antenna Array Using the Method of Symmetrical Components
Authors: Prodromos E. Atlamazoglou
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The method of moments combined with the method of symmetrical components is used for the analysis of interstitial hyperthermia applicators. The basis and testing functions are both piecewise sinusoids, qualifying our technique as a Galerkin one. The dielectric coatings are modeled by equivalent volume polarization currents, which are simply related to the conduction current distribution, avoiding in that way the introduction of additional unknowns or numerical integrations. The results of our method for a four dipole circular array, are in agreement with those already published in literature for a same hyperthermia configuration. Apart from being accurate, our approach is more general, more computationally efficient and takes into account the coupling between the antennas.Keywords: Hyperthermia, integral equations, insulated antennas, method of symmetrical components.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 6948024 Extend Three-wave Method for the (3+1)-Dimensional Soliton Equation
Authors: Somayeh Arbabi Mohammad-Abadi, Maliheh Najafi
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In this paper, we study (3+1)-dimensional Soliton equation. We employ the Hirota-s bilinear method to obtain the bilinear form of (3+1)-dimensional Soliton equation. Then by the idea of extended three-wave method, some exact soliton solutions including breather type solutions are presented.
Keywords: Three-wave method, (3+1)-dimensional Soliton equation, Hirota's bilinear form.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15598023 EZW Coding System with Artificial Neural Networks
Authors: Saudagar Abdul Khader Jilani, Syed Abdul Sattar
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Image compression plays a vital role in today-s communication. The limitation in allocated bandwidth leads to slower communication. To exchange the rate of transmission in the limited bandwidth the Image data must be compressed before transmission. Basically there are two types of compressions, 1) LOSSY compression and 2) LOSSLESS compression. Lossy compression though gives more compression compared to lossless compression; the accuracy in retrievation is less in case of lossy compression as compared to lossless compression. JPEG, JPEG2000 image compression system follows huffman coding for image compression. JPEG 2000 coding system use wavelet transform, which decompose the image into different levels, where the coefficient in each sub band are uncorrelated from coefficient of other sub bands. Embedded Zero tree wavelet (EZW) coding exploits the multi-resolution properties of the wavelet transform to give a computationally simple algorithm with better performance compared to existing wavelet transforms. For further improvement of compression applications other coding methods were recently been suggested. An ANN base approach is one such method. Artificial Neural Network has been applied to many problems in image processing and has demonstrated their superiority over classical methods when dealing with noisy or incomplete data for image compression applications. The performance analysis of different images is proposed with an analysis of EZW coding system with Error Backpropagation algorithm. The implementation and analysis shows approximately 30% more accuracy in retrieved image compare to the existing EZW coding system.Keywords: Accuracy, Compression, EZW, JPEG2000, Performance.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 19338022 A Geometrical Perspective on the Insulin Evolution
Authors: Yuhei Kunihiro, Sorin V. Sabau, Kazuhiro Shibuya
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We study the molecular evolution of insulin from metric geometry point of view. In mathematics, and in particular in geometry, distances and metrics between objects are of fundamental importance. Using a weaker notion than the classical distance, namely the weighted quasi-metrics, one can study the geometry of biological sequences (DNA, mRNA, or proteins) space. We analyze from geometrical point of view a family of 60 insulin homologous sequences ranging on a large variety of living organisms from human to the nematode C. elegans. We show that the distances between sequences provide important information about the evolution and function of insulin.
Keywords: Metric geometry, evolution, insulin.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15318021 Application of Four-electrode Method to Analysis Resistance Characteristics of Conductive Concrete
Authors: Chun-Yao Lee, Siang-Ren Wang
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The purpose of this paper is to discuss the influence of resistance characteristic on the high conductive concrete considering the various voltage and environment. The four-electrode method is applied to the tailor-made high conductive concrete with appropriate proportion. The curve of resistivity with the changes of voltage and environment is plotted and the changes of resistivity are explored. The result based on the methods reveals that resistivity is less affected by the temperature factor, and the four-electrode method would be an applicable measurement method on a site inspection.Keywords: Conductive concrete, Resistivity.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16048020 The Core and Shapley Function for Games on Augmenting Systems with a Coalition Structure
Authors: Fan-Yong Meng
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In this paper, we first introduce the model of games on augmenting systems with a coalition structure, which can be seen as an extension of games on augmenting systems. The core of games on augmenting systems with a coalition structure is defined, and an equivalent form is discussed. Meantime, the Shapley function for this type of games is given, and two axiomatic systems of the given Shapley function are researched. When the given games are quasi convex, the relationship between the core and the Shapley function is discussed, which does coincide as in classical case. Finally, a numerical example is given.
Keywords: Cooperative game, augmenting system, Shapley function, core.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 11958019 A Study of Cooperative Co-evolutionary Genetic Algorithm for Solving Flexible Job Shop Scheduling Problem
Authors: Lee Yih Rou, Hishammuddin Asmuni
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Flexible Job Shop Problem (FJSP) is an extension of classical Job Shop Problem (JSP). The FJSP extends the routing flexibility of the JSP, i.e assigning machine to an operation. Thus it makes it more difficult than the JSP. In this study, Cooperative Coevolutionary Genetic Algorithm (CCGA) is presented to solve the FJSP. Makespan (time needed to complete all jobs) is used as the performance evaluation for CCGA. In order to test performance and efficiency of our CCGA the benchmark problems are solved. Computational result shows that the proposed CCGA is comparable with other approaches.Keywords: Co-evolution, Genetic Algorithm (GA), Flexible JobShop Problem(FJSP)
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17888018 Contingent Presences in Architecture: Vitruvian Theory as a Beginning
Authors: Zelal Çinar
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This paper claims that architecture is a contingent discipline, despite the fact that its contingency has long been denied through a retreat to Vitruvian writing. It is evident that contingency is rejected not only by architecture but also by modernity as a whole. Vitruvius attempted to cover the entire field of architecture in a systematic form in order to bring the whole body of this great discipline to a complete order. The legacy of his theory hitherto lasted not only that it is the only major work on the architecture of Classical Antiquity to have survived, but also that its conformity with the project of modernity. In the scope of the paper, it will be argued that contingency should be taken into account rather than avoided as a potential threat.
Keywords: Architecture, contingency, modernity, Vitruvius.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 26028017 Improvement of MLLR Speaker Adaptation Using a Novel Method
Authors: Ing-Jr Ding
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This paper presents a technical speaker adaptation method called WMLLR, which is based on maximum likelihood linear regression (MLLR). In MLLR, a linear regression-based transform which adapted the HMM mean vectors was calculated to maximize the likelihood of adaptation data. In this paper, the prior knowledge of the initial model is adequately incorporated into the adaptation. A series of speaker adaptation experiments are carried out at a 30 famous city names database to investigate the efficiency of the proposed method. Experimental results show that the WMLLR method outperforms the conventional MLLR method, especially when only few utterances from a new speaker are available for adaptation.Keywords: hidden Markov model, maximum likelihood linearregression, speech recognition, speaker adaptation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18428016 Homogeneous and Heterogeneous Catalysis: Teachings of the Thermal Energy and Power Engineering Course
Authors: Junjie Chen
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It is usually difficult for students to understand some basic theories in learning thermal energy and power engineering course. A new teaching method was proposed that we should introduce the comparison research method of those theories to help them being understood. “Homogeneous and heterogeneous catalysis” teaching is analyzed as an example by comparison research method.
Keywords: Homogeneous catalysis, heterogeneous catalysis, thermal energy and power engineering, teaching method, comparison research method.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 55838015 A Fully Implicit Finite-Difference Solution to One Dimensional Coupled Nonlinear Burgers’ Equations
Authors: Vineet K. Srivastava, Mukesh K. Awasthi, Mohammad Tamsir
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A fully implicit finite-difference method has been proposed for the numerical solutions of one dimensional coupled nonlinear Burgers’ equations on the uniform mesh points. The method forms a system of nonlinear difference equations which is to be solved at each iteration. Newton’s iterative method has been implemented to solve this nonlinear assembled system of equations. The linear system has been solved by Gauss elimination method with partial pivoting algorithm at each iteration of Newton’s method. Three test examples have been carried out to illustrate the accuracy of the method. Computed solutions obtained by proposed scheme have been compared with analytical solutions and those already available in the literature by finding L2 and L∞ errors.
Keywords: Burgers’ equation, Implicit Finite-difference method, Newton’s method, Gauss elimination with partial pivoting.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 59458014 On a Pitch Duration Technique for Prosody Control
Authors: JongKuk Kim, HernSoo Hahn, Uei-Joong Yoo, MyungJin Bae
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In this paper, we propose a method of alter duration in frequency domain that control prosody in real time after pitch alteration. If there has a method to alteration duration freely among prosody information, that may used in several fields such as speech impediment person's pronunciation proof reading or language study. The pitch alteration method used control prosody altered by PSOLA synthesis method which is in time domain processing method. However, the duration of pitch alteration speech is changed by the frequency domain. In this paper, we altered the duration with the method of duration alteration by Fast Fourier Transformation in frequency domain. Consequently, the intelligibility of the pitch and duration are controlled has a slight decrease than the case when only pitch is changed, but the proposed algorithm obtained the higher MOS score about naturalness.Keywords: PSOLA, Pitch Alteration, Duration Control.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16858013 Rational Structure of Panel with Curved Plywood Ribs
Authors: Janis Šliseris, Karlis Rocens
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Optimization of rational geometrical and mechanical parameters of panel with curved plywood ribs is considered in this paper. The panel consists of cylindrical plywood ribs manufactured from Finish plywood, upper and bottom plywood flange, stiffness diaphragms. Panel is filled with foam. Minimal ratio of structure self weight and load that could be applied to structure is considered as rationality criteria. Optimization is done, by using classical beam theory without nonlinearities. Optimization of discreet design variables is done by Genetic algorithm.Keywords: Curved plywood ribs, genetic algorithm, rationalparameters of ribbed panel, structure optimization.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17398012 On the Solution of Fully Fuzzy Linear Systems
Authors: Hsuan-Ku Liu
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A linear system is called a fully fuzzy linear system (FFLS) if quantities in this system are all fuzzy numbers. For the FFLS, we investigate its solution and develop a new approximate method for solving the FFLS. Observing the numerical results, we find that our method is accurate than the iterative Jacobi and Gauss- Seidel methods on approximating the solution of FFLS.
Keywords: Fully fuzzy linear equations, iterative method, homotopy perturbation method, approximate solutions.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17468011 Continuity of Defuzzification and Its Application to Fuzzy Control
Authors: Takashi Mitsuishi, Kiyoshi Sawada, Yasunari Shidama
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The mathematical framework for studying of a fuzzy approximate reasoning is presented in this paper. Two important defuzzification methods (Area defuzzification and Height defuzzification) besides the center of gravity method which is the best well known defuzzification method are described. The continuity of the defuzzification methods and its application to a fuzzy feedback control are discussed.
Keywords: Fuzzy approximate reasoning, defuzzification, area method, height method.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16768010 Production Structure Monitoring - A Neurologic Based Approach
Authors: G. Reinhart, J. Pohl
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Manufacturing companies are facing a broad variety of challenges caused by a dynamic production environment. To succeed in such an environment, it is crucial to minimize the loss of time required to trigger the adaptation process of a company-s production structures. This paper presents an approach for the continuous monitoring of production structures by neurologic principles. It enhances classical monitoring concepts, which are principally focused on reactive strategies, and enables companies to act proactively. Thereby, strategic aspects regarding the harmonization of certain life cycles are integrated into the decision making process for triggering the reconfiguration process of the production structure.Keywords: Continuous Factory Planning, Production Structure, Production Management.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14478009 The Conditioning Effect on Celebrity Multiple Endorsements
Authors: Chia-Ching Tsai
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This research adapts experimental design to investigate the effect of conditioning or not and pre-exposure or not on brand attitude, so it is a 2×2=4 factorial design. The results show that the brand attitude of conditioning group is significantly higher than that of unconditioning group. The brand attitude with pre-exposure is significantly higher than that without pre-exposure. Conditioning or not and pre-exposure or not have significant interaction. No matter the celebrity is pre-exposure or not, the brand attitude is higher under conditioning process.Keywords: Celebrity, Multiple endorsements, Pre-exposure, Classical condition, Second-order conditioning
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 29558008 Convergence and Comparison Theorems of the Modified Gauss-Seidel Method
Authors: Zhouji Chen
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In this paper, the modified Gauss-Seidel method with the new preconditioner for solving the linear system Ax = b, where A is a nonsingular M-matrix with unit diagonal, is considered. The convergence property and the comparison theorems of the proposed method are established. Two examples are given to show the efficiency and effectiveness of the modified Gauss-Seidel method with the presented new preconditioner.
Keywords: Preconditioned linear system, M-matrix, Convergence, Comparison theorem.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15048007 Method Development and Validation for the Determination of Cefixime in Pure and Commercial Dosage Forms by Specrophotometry
Authors: S. N. H. Azmi, B. Iqbal, J. K. Al Mamari, K. A. Al Hattali, W. N. Al Hadhrami
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A simple, accurate and precise direct spectrophotometric method has been developed for the determination of cefixime in tablets and capsules. The method is based on the reaction of cefixime with a mixture of potassium iodide and potassium iodate to form yellow coloured product in ethanol-distilled water medium at room temperature which absorbed maximally at 352 nm. The factors affecting the reaction product were carefully studied and optimized. The validation parameters based on International Conference on Harmonisation (ICH, USA) guidelines were followed. The effect of common excipients used as additives has been tested and the tolerance limit was calculated for the determination of cefixime. Beer’s law is obeyed in the concentration range of 4 – 24 ug mL-1 with apparent molar absorptivity of 1.52 × 104 L mol-1cm-1 and Sandell’s sensitivity of 0.033 ug/cm2/ 0.001 absorbance unit. The limits of detection and quantitation for the proposed method are 0.32 and 1.06 ug mL-1, respectively. The proposed method has been successfully applied for the determination of cefixime in pharmaceutical formulations. The results obtained by the proposed method were statistically compared with the reference method using t- and F- values and found no significant difference between the two methods. The proposed method can be used as an alternate method for routine quality control analysis of cefixime in pharmaceutical formulations.
Keywords: Spectrophotometry, cefixime, validation, pharmaceutical formulations.
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