Search results for: Yuhei Kunihiro
1 A Geometrical Perspective on the Insulin Evolution
Authors: Yuhei Kunihiro, Sorin V. Sabau, Kazuhiro Shibuya
Abstract:
We study the molecular evolution of insulin from metric geometry point of view. In mathematics, and in particular in geometry, distances and metrics between objects are of fundamental importance. Using a weaker notion than the classical distance, namely the weighted quasi-metrics, one can study the geometry of biological sequences (DNA, mRNA, or proteins) space. We analyze from geometrical point of view a family of 60 insulin homologous sequences ranging on a large variety of living organisms from human to the nematode C. elegans. We show that the distances between sequences provide important information about the evolution and function of insulin.
Keywords: Metric geometry, evolution, insulin.
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