Search results for: Resistance domain

Authors: Fatih Hattatoglu, Abdulrezzak Bakiş

Abstract:

In this study, fiberless reactive powder concrete (RPC) was produced with high pressure and flexural strength. C30/37 concrete was chosen as the control sample. In this study, 9 different cure types were applied to fiberless RPC. the most suitable combined cure type was selected according to the pressure and flexure strength. Pressure and flexural strength tests were applied to these samples after curing. As a result of the study, the combined cure type with the highest pressure resistance was obtained. The highest pressure resistance was achieved with consecutive standard water cure at 20 °C for 7 days – hot water cure at 90 °C for 2 days - drying oven cure at 180 °C for 2 days. As a result of the study, the highest pressure resistance of fiberless RPC was found as 123 MPa with water cure at 20 °C for 7 days - hot water cure at 90 °C for 2 days - drying oven cure at 180 °C for 2 days; and the highest flexural resistance was found as 8.37 MPa for the same combined cure type.

Keywords: Rigid pavement, reactive powder concrete, combined cure, pressure test, flexural test.

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Authors: Martin Cermak, Stanislav Sysala

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In this paper we present the efficient parallel implementation of elastoplastic problems based on the TFETI (Total Finite Element Tearing and Interconnecting) domain decomposition method. This approach allow us to use parallel solution and compute this nonlinear problem on the supercomputers and decrease the solution time and compute problems with millions of DOFs. In our approach we consider an associated elastoplastic model with the von Mises plastic criterion and the combination of linear isotropic-kinematic hardening law. This model is discretized by the implicit Euler method in time and by the finite element method in space. We consider the system of nonlinear equations with a strongly semismooth and strongly monotone operator. The semismooth Newton method is applied to solve this nonlinear system. Corresponding linearized problems arising in the Newton iterations are solved in parallel by the above mentioned TFETI. The implementation of this problem is realized in our in-house MatSol packages developed in MatLab.

Keywords: Isotropic-kinematic hardening, TFETI, domain decomposition, parallel solution.

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Authors: Meng-Hao Tsai, Tsuei-Chiang Huang

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Interior brick-infill partitions are usually considered as non-structural components and only their weight is accounted for in practical structural design. In this study, their effect on the progressive collapse resistance of an RC building subjected to sudden column loss is investigated. Three notional column loss conditions with four different brick-infill locations are considered. Column-loss response analyses of the RC building with and without brick infills are carried out. Analysis results indicate that the collapse resistance is only slightly influenced by the brick infills due to their brittle failure characteristic. Even so, they may help to reduce the inelastic displacement response under column loss. For practical engineering, it is reasonably conservative to only consider the weight of brick-infill partitions in the structural analysis.

Keywords: Progressive collapse, column loss, brick-infill partition, compression strut.

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Authors: Chun-Yao Lee, Siang-Ren Wang

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This paper aims to discuss the influence of resistance characteristic on the high conductive concrete considering the changes of voltage and environment. The high conductive concrete with appropriate proportion is produced to the press-electrode method. The curve of resistivity with the changes of voltage and environment is plotted and the changes of resistivity are explored.

Keywords: conductive concrete, resistivity.

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Authors: Amir-Massoud Bidgoli, Mehdi Naseri Parsa

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In this paper a combined feature selection method is proposed which takes advantages of sample domain filtering, resampling and feature subset evaluation methods to reduce dimensions of huge datasets and select reliable features. This method utilizes both feature space and sample domain to improve the process of feature selection and uses a combination of Chi squared with Consistency attribute evaluation methods to seek reliable features. This method consists of two phases. The first phase filters and resamples the sample domain and the second phase adopts a hybrid procedure to find the optimal feature space by applying Chi squared, Consistency subset evaluation methods and genetic search. Experiments on various sized datasets from UCI Repository of Machine Learning databases show that the performance of five classifiers (Naïve Bayes, Logistic, Multilayer Perceptron, Best First Decision Tree and JRIP) improves simultaneously and the classification error for these classifiers decreases considerably. The experiments also show that this method outperforms other feature selection methods.

Keywords: feature selection, resampling, reliable features, Consistency Subset Evaluation.

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Authors: S. Behnia, S. Fathizadeh

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Conductivity properties of DNA molecule is investigated in a simple, but chemically specific approach that is intimately related to the Su-Schrieffer-Heeger (SSH) model. This model is a tight-binding linear nanoscale chain. We have tried to study the electrical current flowing in DNA and investigated the characteristic I-V diagram. As a result, It is shown that there are the (quasi-) ohmic areas in I-V diagram. On the other hand, the regions with a negative differential resistance (NDR) are detectable in diagram.

Keywords: Charge transfer in DNA, Chaos theory, Molecular electronics, Negative Differential resistance.

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Authors: Bachir Boucheham, Youcef Ferdi, Mohamed Chaouki Batouche

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We suggest a novel method to incorporate longterm redundancy (LTR) in signal time domain compression methods. The proposition is based on block-sorting and curve simplification. The proposition is illustrated on the ECG signal as a post-processor for the FAN method. Test applications on the new so-obtained FAN+ method using the MIT-BIH database show substantial improvement of the compression ratio-distortion behavior for a higher quality reconstructed signal.

Keywords: ECG compression, Long-term redundancy, Block-sorting, Curve Simplification.

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Authors: Somtop Keawchuer

Abstract:

This research aims to study (1) the relationship between competency-based learning and learning efficiency of new media communication students at Suan Sunandha University (2) the demographic factor effect on learning efficiency of students at Suan Sunandha University. This research method will use quantitative research; data was collected by questionnaires distributed to students from new media communication in management science faculty of Suan Sunandha Rajabhat University for 1340 sample by purposive sampling method. Data was analyzed by descriptive statistic including percentage, mean, standard deviation and inferential statistic including T-test, ANOVA and Pearson correlation for hypothesis testing. The results showed that the competency-based learning in term of ability to communicate, ability to think and solve the problem, life skills and ability to use technology has a significant relationship with learning efficiency in term of the cognitive domain, psychomotor domain and affective domain at the 0.05 level and which is in harmony with the research hypotheses.

Keywords: Competency-based learning, learning efficiency, new media communication students, Suan Sunandha Rajabhat University.

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Authors: B. Chouhan, A. Denesyuk, J. Heino, M. S. Johnson, K. Denessiouk

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Integrins are a large family of multidomain α/β cell signaling receptors. Some integrins contain an additional inserted I domain, whose earliest expression appears to be with the chordates, since they are observed in the urochordates Ciona intestinalis (vase tunicate) and Halocynthia roretzi (sea pineapple), but not in integrins of earlier diverging species. The domain-s presence is viewed as a hallmark of integrins of higher metazoans, however in vertebrates, there are clearly three structurally-different classes: integrins without I domains, and two groups of integrins with I domains but separable by the presence or absence of an additional αC helix. For example, the αI domains in collagen-binding integrins from Osteichthyes (bony fish) and all higher vertebrates contain the specific αC helix, whereas the αI domains in non-collagen binding integrins from vertebrates and the αI domains from earlier diverging urochordate integrins, i.e. tunicates, do not. Unfortunately, within the early chordates, there is an evolutionary gap due to extinctions between the tunicates and cartilaginous fish. This, coupled with a knowledge gap due to the lack of complete genomic data from surviving species, means that the origin of collagen-binding αC-containing αI domains remains unknown. Here, we analyzed two available genomes from Callorhinchus milii (ghost shark/elephant shark; Chondrichthyes – cartilaginous fish) and Petromyzon marinus (sea lamprey; Agnathostomata), and several available Expression Sequence Tags from two Chondrichthyes species: Raja erinacea (little skate) and Squalus acanthias (dogfish shark); and Eptatretus burgeri (inshore hagfish; Agnathostomata), which evolutionary reside between the urochordates and osteichthyes. In P. marinus, we observed several fragments coding for the αC-containing αI domain, allowing us to shed more light on the evolution of the collagen-binding integrins.

Keywords: Integrin αI domain, integrin evolution, collagen binding, structure, αC helix

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Authors: S. Krishnan, J. Dumbre, S. Bhatt, Esther T. Akinlabi, R. Ramalingam

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The localized corrosion behavior of laser surface melted 304L austenitic stainless steel was studied by potentiodynamic polarization test. The extent of improvement in corrosion resistance was governed by the preferred orientation and the percentage of delta ferrite present on the surface of the laser melted sample. It was established by orientation imaging microscopy that the highest pitting potential value was obtained when grains were oriented in the most close- packed [101] direction compared to the random distribution of the base metal and other laser surface melted samples oriented in [001] direction. The sample with lower percentage of ferrite had good pitting resistance.

Keywords: Crystallographic orientation, Ferrite percentage, Laser melting, Pitting corrosion, 304L SS.

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Authors: I. Struhár, L. Dovrtělová, M. Kumstát

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Regular exercise promotes reduction in blood pressure, reduction in body weight and it also helps to increase in insulin sensitivity. Participation in physical activity should always be linked to medical screening which can reveal serious medical problems. One of them is high blood pressure. Hypertension is risk factor for one billion people worldwide and the highest prevalence is found in Africa. Another component of hypertension is that people who suffer from hypertension have no symptoms. It is estimated that reduction of 3mm Hg in Systolic Blood Pressure decreases cardiac morbidity at least 5%. The most of the guidelines suggest aerobic exercise in a prevention of cardiovascular diseases. On the other hand, it is important to emphasize the impact of resistance training. Even, it was found higher effect for reduction on the level of systolic blood pressure than aerobic exercise.

Keywords: Coronary artery disease, physical activity, prevention, resistance training.

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Authors: K.Sowmyan, A.Siddarth, D.Menaka

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Several methods have been proposed for color image compression but the reconstructed image had very low signal to noise ratio which made it inefficient. This paper describes a lossy compression technique for color images which overcomes the drawbacks. The technique works on spatial domain where the pixel values of RGB planes of the input color image is mapped onto two dimensional planes. The proposed technique produced better results than JPEG2000, 2DPCA and a comparative study is reported based on the image quality measures such as PSNR and MSE.Experiments on real time images are shown that compare this methodology with previous ones and demonstrate its advantages.

Keywords: Color Image compression, spatial domain, planereduction, root mean square, image restoration

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Authors: Nandy Putra, Atrialdipa Duanovsah, Kristofer Haliansyah

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The aim of this research is to design a LHP with low thermal resistance and low condenser temperature. A Self-designed cascade LHP was tested by using biomaterial, sintered copper powder, and aluminum screen mesh as the wick. Using pure water as the working fluid for the first level of the LHP and 96% alcohol as the working fluid for the second level of LHP, the experiments were run with 10W, 20W, and 30W heat input. Experimental result shows that the usage of biomaterial as wick could reduce more temperature at evaporator than by using sintered copper powder and screen mesh up to 22.63% and 37.41% respectively. The lowest thermal resistance occurred during the usage of biomaterial as wick of heat pipe, which is 2.06 ^oC/W. The usage of cascade system could be applied to LHP to reduce the temperature at condenser and reduced thermal resistance up to 17.6%.

Keywords: Biomaterial, cascade loop heat pipe, screen mesh, sintered Cu.

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Authors: Mohsin T. Mohammed, Zahid A. Khan, Arshad N. Siddiquee

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The field of biomedical materials plays an imperative requisite and a critical role in manufacturing a variety of biological artificial replacements in a modern world. Recently, titanium (Ti) materials are being used as biomaterials because of their superior corrosion resistance and tremendous specific strength, free- allergic problems and the greatest biocompatibility compared to other competing biomaterials such as stainless steel, Co-Cr alloys, ceramics, polymers, and composite materials. However, regardless of these excellent performance properties, Implantable Ti materials have poor shear strength and wear resistance which limited their applications as biomaterials. Even though the wear properties of Ti alloys has revealed some improvements, the crucial effectiveness of biomedical Ti alloys as wear components requires a comprehensive deep understanding of the wear reasons, mechanisms, and techniques that can be used to improve wear behavior. This review examines current information on the effect of thermal and thermomechanical processing of implantable Ti materials on the long-term prosthetic requirement which related with wear behavior. This paper focuses mainly on the evolution, evaluation and development of effective microstructural features that can improve wear properties of bio grade Ti materials using thermal and thermomechanical treatments.

Keywords: Wear Resistance, Heat Treatment, Thermomechanical Processing, Biomedical Titanium Materials.

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Authors: A. M. H. Elyasir, K. S. M. Anbananthen

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The internet is growing larger and becoming the most popular platform for the people to share their opinion in different interests. We choose the education domain specifically comparing some Malaysian universities against each other. This comparison produces benchmark based on different criteria shared by the online users in various online resources including Twitter, Facebook and web pages. The comparison is accomplished using opinion mining framework to extract, process the unstructured text and classify the result to positive, negative or neutral (polarity). Hence, we divide our framework to three main stages; opinion collection (extraction), unstructured text processing and polarity classification. The extraction stage includes web crawling, HTML parsing, Sentence segmentation for punctuation classification, Part of Speech (POS) tagging, the second stage processes the unstructured text with stemming and stop words removal and finally prepare the raw text for classification using Named Entity Recognition (NER). Last phase is to classify the polarity and present overall result for the comparison among the Malaysian universities. The final result is useful for those who are interested to study in Malaysia, in which our final output declares clear winners based on the public opinions all over the web.

Keywords: Entity Recognition, Education Domain, Opinion Mining, Unstructured Text.

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Authors: E. S. Gower, T. Tsalaile, E. Rakgati, M. O. J. Hawksford

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A frequency grouping approach for multi-channel instantaneous blind source separation (I-BSS) of convolutive mixtures is proposed for a lower net residual inter-symbol interference (ISI) and inter-channel interference (ICI) than the conventional short-time Fourier transform (STFT) approach. Starting in the time domain, STFTs are taken with overlapping windows to convert the convolutive mixing problem into frequency domain instantaneous mixing. Mixture samples at the same frequency but from different STFT windows are grouped together forming unique frequency groups. The individual frequency group vectors are input to the I-BSS algorithm of choice, from which the output samples are dispersed back to their respective STFT windows. After applying the inverse STFT, the resulting time domain signals are used to construct the complete source estimates via the weighted overlap-add method (WOLA). The proposed algorithm is tested for source deconvolution given two mixtures, and simulated along with the STFT approach to illustrate its superiority for fairly motionless sources.

Keywords: Blind source separation, short-time Fouriertransform, weighted overlap-add method

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Authors: Fayez M. Idris, Nehal I. AlZubaidi

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Breast cancer detection techniques have been reported to aid radiologists in analyzing mammograms. We note that most techniques are performed on uncompressed digital mammograms. Mammogram images are huge in size necessitating the use of compression to reduce storage/transmission requirements. In this paper, we present an algorithm for the detection of microcalcifications in the JPEG2000 domain. The algorithm is based on the statistical properties of the wavelet transform that the JPEG2000 coder employs. Simulation results were carried out at different compression ratios. The sensitivity of this algorithm ranges from 92% with a false positive rate of 4.7 down to 66% with a false positive rate of 2.1 using lossless compression and lossy compression at a compression ratio of 100:1, respectively.

Keywords: Breast cancer, JPEG2000, mammography, microcalcifications.

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Authors: Zaihisma C. Cob, Alicia Y.C. Tang, Sharifah J. Syed Aziz

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This paper proposes a new model to support user queries on postgraduate research information at Universiti Tenaga Nasional. The ontology to be developed will contribute towards shareable and reusable domain knowledge that makes knowledge assets intelligently accessible to both people and software. This work adapts a methodology for ontology development based on the framework proposed by Uschold and King. The concepts and relations in this domain are represented in a class diagram using the Protégé software. The ontology will be used to support a menudriven query system for assisting students in searching for information related to postgraduate research at the university.

Keywords: Ontology, Protégé, postgraduate program, query system.

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Authors: Emmy Pratiwi, Ketut B. Artana, A. A. B. Dinariyana

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Madura Strait is considered as one of the busiest shipping channels in Indonesia. High vessel traffic density in Madura Strait gives serious threat due to navigational safety in this area, i.e. ship collision. This study is necessary as an attempt to enhance the safety of marine traffic. Fuzzy inference system (FIS) is proposed to calculate risk collision of ships. Collision risk is evaluated based on ship domain, Distance to Closest Point of Approach (DCPA), and Time to Closest Point of Approach (TCPA). Data were collected by utilizing Automatic Identification System (AIS). This study considers several ships’ domain models to give the characteristic of marine traffic in the waterways. Each encounter in the ship domain is analyzed to obtain the level of collision risk. Risk level of ships, as the result in this study, can be used as guidance to avoid the accident, providing brief description about safety traffic in Madura Strait and improving the navigational safety in the area.

Keywords: Automatic identification system, collision risk, DCPA, fuzzy inference system, TCPA.

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Authors: Jun Yop An, Kyoung Ryoung Park, Jung-Gyu Lee, Hyung-Seop Youn, Jung-Yeon Kang, Gil Bu Kang, Soo Hyun Eom

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MinC plays an important role in bacterial cell division system by inhibiting FtsZ assembly. However, the molecular mechanism of the action is poorly understood. E. coli MinC Nterminus domain was purified and crystallized using 1.4 M sodium citrate pH 6.5 as a precipitant. X-ray diffraction data was collected and processed to 2.3 Å from a native crystal. The crystal belonged to space group P212121, with the unit cell parameters a = 52.7, b = 54.0, c = 64.7 Å. Assuming the presence of two molecules in the asymmetric unit, the Matthews coefficient value is 1.94 Å3 Da-1, which corresponds to a solvent content of 36.5%. The overall structure of MinCN is observed as a dimer form through anti-parallel ß-strand interaction.

Keywords: MinC, Cell division, Crystallization.

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Authors: Manal Mhada, BrahimEzzahiri, Ouafae Benlhabib

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Seventy-nine accessions, including two local wild species (Chenopodium album and C. murale) and several cultivated quinoa lines developed through recurrent selection in Morocco were screened for their resistance against Peronospora farinose, the causal agent of downy mildew disease. The method of artificial inoculation on detached healthy leaves taken from the middle stage of the plant was used. Screened accessions showed different levels of quantitative resistance to downy mildew as they were scored through the calculation of their area under disease progress curve and their two resistance components, the incubation period and the latent period. Significant differences were found between accessions regarding the three criteria (Incubation Period, Latent Period and Area Under Diseases Progress Curve). Accessions M2a and S938/1 were ranked resistant as they showed the longest Incubation Period (7 days) and Latent Period (12 days) and the lowest area under diseases progress curve (4). Therefore, M24 is the most susceptible accession as it has presented the highest area under diseases progress curve (34.5) and the shortest Incubation Period (1 day) and Latent Period (3 days). In parallel to this evaluation approach, the accession resistance was confirmed under the field conditions through natural infection by using the tree-leaf method. The high correlation found between detached leaf inoculation method and field screening under natural infection allows us to use this laboratory technique with sureness in further selection works.

Keywords: Detached leaf inoculation, Downy mildew, Field screening, Quinoa.

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Authors: Lhoussain Simour

Abstract:

This essay endeavors to read Ama Ata Aidoo-s Our Sister Killjoy with a postocolonially-inflected consciousness. It aims at demonstrating how her work could be read as a sophisticated postcolonial revision of the colonial travel narrative whereby the protagonist-s black-eyed squint operates as 'the all-seeing-eye' to subvert the historically unbroken legacy of the Orientalist ideology. It tries to demonstrate how Sissie assumes authority and voice in an act that destabilizes the traditionally established modes of western representation. It is also an investigation into how Aidoo-s text adopts processes which disengage the Eurocentric view produced by the discursive itineraries of western institutions through diverse acts of resistance and 'various strategies of subversion and appropriation'. Her counter discursive strategies of resistance are shaped up in various ways by a feminist consciousness that attempts to articulate a distinct African version of identity and preserve cultural distinctiveness.

Keywords: Orientalism, Africaness, discursive resistance, interracial lesbianism, politics of race, the migrant intellectual.

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Authors: Lalit Garg, Sally McClean, Maria Barton

Abstract:

Healthcare issues continue to pose huge problems and incur massive costs. As a result there are many challenging problems still unresolved. In this paper, we will carry out an extensive scientific survey of different areas of management and planning in an attempt to identify where there has already been a substantial contribution from management science methods to healthcare problems and where there is a clear potential for more work to be done. The focus will be on the read-across to the healthcare domain from such approaches applied generally to management and planning and how the methods can be used to improvement patient care. We conclude that, since the healthcare domain significantly differs from traditional areas of management and planning, in some cases there is a need to modify the approaches so as to incorporate the complexities of healthcare, and fully exploit the potential for improvement.

Keywords: Management science, management and planning, transforming services, healthcare.

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Authors: A. Javed, K. Djidjeli, J. T. Xing, S. J. Cox

Abstract:

A method for simulating flow around the solid bodies has been presented using hybrid meshfree and mesh-based schemes. The presented scheme optimizes the computational efficiency by combining the advantages of both meshfree and mesh-based methods. In this approach, a cloud of meshfree nodes has been used in the domain around the solid body. These meshfree nodes have the ability to efficiently adapt to complex geometrical shapes. In the rest of the domain, conventional Cartesian grid has been used beyond the meshfree cloud. Complex geometrical shapes can therefore be dealt efficiently by using meshfree nodal cloud and computational efficiency is maintained through the use of conventional mesh-based scheme on Cartesian grid in the larger part of the domain. Spatial discretization of meshfree nodes has been achieved through local radial basis functions in finite difference mode (RBF-FD). Conventional finite difference scheme has been used in the Cartesian ‘meshed’ domain. Accuracy tests of the hybrid scheme have been conducted to establish the order of accuracy. Numerical tests have been performed by simulating two dimensional steady and unsteady incompressible flows around cylindrical object. Steady flow cases have been run at Reynolds numbers of 10, 20 and 40 and unsteady flow problems have been studied at Reynolds numbers of 100 and 200. Flow Parameters including lift, drag, vortex shedding, and vorticity contours are calculated. Numerical results have been found to be in good agreement with computational and experimental results available in the literature.

Keywords: CFD, Meshfree particle methods, Hybrid grid, Incompressible Navier Strokes equations, RBF-FD.

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Authors: Altab Hossain, Ataur Rahman, A. K. M. Mohiuddin, Yulfian Aminanda

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Fuzzy logic system (FLS) is used in this study to predict the tractive performance in terms of traction force, and motion resistance for an intelligent air cushion track vehicle while it operates in the swamp peat. The system is effective to control the intelligent air –cushion system with measuring the vehicle traction force (TF), motion resistance (MR), cushion clearance height (CH) and cushion pressure (CP). Ultrasonic displacement sensor, pull-in solenoid electromagnetic switch, pressure control sensor, micro controller, and battery pH sensor are incorporated with the Fuzzy logic system to investigate experimentally the TF, MR, CH, and CP. In this study, a comparison for tractive performance of an intelligent air cushion track vehicle has been performed with the results obtained from the predicted values of FLS and experimental actual values. The mean relative error of actual and predicted values from the FLS model on traction force, and total motion resistance are found as 5.58 %, and 6.78 % respectively. For all parameters, the relative error of predicted values are found to be less than the acceptable limits. The goodness of fit of the prediction values from the FLS model on TF, and MR are found as 0.90, and 0.98 respectively.

Keywords: Cushion pressure, Fuzzy logic, Motion resistance, Traction force.

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Authors: Ching-Huei Lin, Yao-Pang Hsu, M. Z. Dosaev, Yu. D. Selyutskii, L. A. Klimina

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Hysteresis phenomenon has been observed in the operations of both horizontal-axis and vertical-axis wind turbines (HAWTs and VAWTs). In this study, wind tunnel experiments were applied to investigate the characters of hysteresis phenomena between the angular speed and the external resistance of electrical loading during the operation of a Darrieus type VAWT. Data of output voltage, output current, angular speed of wind turbine under different wind speeds are measured and analyzed. Results show that the range of external resistance changes with the wind speed. The range decreases as the wind speed increases following an exponential decay form. Experiments also indicate that the maximum output power of wind turbines is always inside the range where hysteresis happened. These results provide an important reference to the design of output control system of wind turbines.

Keywords: Hysteresis phenomenon, Angular speed, Range ofexternal resistance

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Authors: Ahmed S. Elamary

Abstract:

Ultimate shear resistance (USR) of slender plate girders can be predicted theoretically using Cardiff theory or Höglund theory. This paper will be concerned with predicting the USR using Höglund theory and EC3. Two main factors can affect the USR, the panel width “b” and the web depth “d”, consequently, the panel aspect ratio (b/d) has to be identified by limits. In most of the previous study, there is no limit for panel aspect ratio indicated. In this paper theoretical analysis has been conducted to study the effect of (b/d) on the USR. The analysis based on ninety six test results of steel plate girders subjected to shear executed and collected by others. New formula proposed to predict the percentage of the distance between the plastic hinges form in the flanges “c” to panel width “b”. Conservative limits of (c/b) have been suggested to get a consistent value of USR.

Keywords: Ultimate shear resistance, Plate Girder, Höglund’s theory, EC3.

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Authors: Rezvan Najafi, Korosh Heydari, Massoud Saidijam

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5-FU is a chemotherapeutic agent that has been used in colorectal cancer (CRC) treatment. However, it is usually associated with the acquired resistance, which decreases the therapeutic effects of 5-FU. miR-200c is involved in chemotherapeutic drug resistance, but its mechanism is not fully understood. In this study, the effect of inhibition of miR-200c in sensitivity of HCT-116 CRC cells to 5-FU was evaluated. HCT-116 cells were transfected with LNA-anti- miR-200c for 48 h. mRNA expression of miR-200c was evaluated using quantitative real- time PCR. The protein expression of phosphatase and tensin homolog (PTEN) and E-cadherin were analyzed by western blotting. Annexin V and propidium iodide staining assay were applied for apoptosis detection. The caspase-3 activation was evaluated by an enzymatic assay. The results showed LNA-anti-miR-200c inhibited the expression of PTEN and E-cadherin protein, apoptosis and activation of caspase 3 compared with control cells. In conclusion, these results suggest that miR-200c as a prognostic marker can overcome to 5-FU chemoresistance in CRC.

Keywords: Colorectal cancer, miR-200c, 5-FU resistance, E-cadherin, PTEN.

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Authors: Altab Hossain, Ataur Rahman, A. K. M. Mohiuddin, Yulfian Aminanda

Abstract:

Fuzzy logic approach is used in this study to predict the tractive performance in terms of traction force, and motion resistance for an intelligent air cushion track vehicle while it operates in the swamp peat. The system is effective to control the intelligent air –cushion system with measuring the vehicle traction force (TF), motion resistance (MR), cushion clearance height (CH) and cushion pressure (CP). Sinkage measuring sensor, magnetic switch, pressure sensor, micro controller, control valves and battery are incorporated with the Fuzzy logic system (FLS) to investigate experimentally the TF, MR, CH, and CP. In this study, a comparison for tractive performance of an intelligent air cushion track vehicle has been performed with the results obtained from the predicted values of FLS and experimental actual values. The mean relative error of actual and predicted values from the FLS model on traction force, and total motion resistance are found as 5.58 %, and 6.78 % respectively. For all parameters, the relative error of predicted values are found to be less than the acceptable limits. The goodness of fit of the prediction values from the FLS model on TF, and MR are found as 0.90, and 0.98 respectively.

Keywords: Cushion pressure, Fuzzy logic, Motion resistance, Traction force.

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Authors: Yuan J. Lui

Abstract:

Prospective readers can quickly determine whether a document is relevant to their information need if the significant phrases (or keyphrases) in this document are provided. Although keyphrases are useful, not many documents have keyphrases assigned to them, and manually assigning keyphrases to existing documents is costly. Therefore, there is a need for automatic keyphrase extraction. This paper introduces a new domain independent keyphrase extraction algorithm. The algorithm approaches the problem of keyphrase extraction as a classification task, and uses a combination of statistical and computational linguistics techniques, a new set of attributes, and a new machine learning method to distinguish keyphrases from non-keyphrases. The experiments indicate that this algorithm performs better than other keyphrase extraction tools and that it significantly outperforms Microsoft Word 2000-s AutoSummarize feature. The domain independence of this algorithm has also been confirmed in our experiments.

Keywords: classification, keyphrase extraction, machine learning, summarization

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