Search results for: variational inequality problems
2344 Genetic Algorithms with Oracle for the Traveling Salesman Problem
Authors: Robin Gremlich, Andreas Hamfelt, Héctor de Pereda, Vladislav Valkovsky
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By introducing the concept of Oracle we propose an approach for improving the performance of genetic algorithms for large-scale asymmetric Traveling Salesman Problems. The results have shown that the proposed approach allows overcoming some traditional problems for creating efficient genetic algorithms.
Keywords: Genetic algorithms, Traveling Salesman Problem, optimal decision distribution, oracle.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17222343 LED Lighting Interviews and Assessment in Forest Machines
Authors: Rauno Pääkkönen, Fabriziomaria Gobba, Leena Korpinen
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The objective of the study is to assess the implementation of LED lighting into forest machine work in the dark. In addition, the paper includes a wide variety of important and relevant safety and health parameters. In modern, computerized work in the cab of forest machines, artificial illumination is a demanding task when performing duties, such as the visual inspections of wood and computer calculations. We interviewed entrepreneurs and gathered the following as the most pertinent themes: (1) safety, (2) practical problems, and (3) work with LED lighting. The most important comments were in regards to the practical problems of LED lighting. We found indications of technical problems in implementing LED lighting, like snow and dirt on the surfaces of lamps that dim the emission of light. Moreover, service work in the dark forest is dangerous and increases the risks of on-site accidents. We also concluded that the amount of blue light to the eyes should be assessed, especially, when the drivers are working in a semi-dark cab.Keywords: Forest machines, health, LED, safety.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 21302342 Application of Soft Systems Methodology in Solving Disaster Emergency Logistics Problems
Authors: Alhasan Hakami, Arun Kumar, Sung J Shim, Yousef Abu Nahleh
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In recent years, many high intensity earthquakes have occurred around the world, such as the 2011 earthquake in Tohoku, Japan. These large-scale disasters caused huge casualties and losses. In addition, inefficient disaster response operations also caused the second wave of casualties and losses, and expanded the damage. Effective disaster management can be used to respond to the chaotic situation, and reduce the damage; however, some inefficient disaster response operations are still used. Therefore, this case study chose the 921 earthquake for analyzing disaster emergency logistics problems and proposed the Soft Systems Methodology (SSM) to solve disaster emergency logistics problems. Moreover, it analyses the effect of human factors on system operation, and suggests a solution to improve the system.
Keywords: Soft systems methodology, emergency logistics.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 30122341 Effective Class of Discreet Programing Problems
Authors: Kaziyev G. Z., Nabiyeva G. S., Kalizhanova A.U.
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We consider herein a concise view of discreet programming models and methods. There has been conducted the models and methods analysis. On the basis of discreet programming models there has been elaborated and offered a new class of problems, i.e. block-symmetry models and methods of applied tasks statements and solutions.Keywords: Discreet programming, block-symmetry, analysis methods, information systems development.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 13462340 Existence of Solution for Four-Point Boundary Value Problems of Second-Order Impulsive Differential Equations (I)
Authors: Li Ge
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In this paper, we study the existence of solution of the four-point boundary value problem for second-order differential equations with impulses by using leray-Schauder theory:Keywords: impulsive differential equations, impulsive integraldifferentialequation, boundary value problems
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 11952339 Existence of Solution for Four-Point Boundary Value Problems of Second-Order Impulsive Differential Equations (II)
Authors: Li Ge
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In this paper, we study the existence of solution of the four-point boundary value problem for second-order differential equations with impulses by using leray-Schauder theory:Keywords: impulsive differential equations, impulsive integraldifferentialequation, boundary value problems
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 11002338 High Performance Computing Using Out-of- Core Sparse Direct Solvers
Authors: Mandhapati P. Raju, Siddhartha Khaitan
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In-core memory requirement is a bottleneck in solving large three dimensional Navier-Stokes finite element problem formulations using sparse direct solvers. Out-of-core solution strategy is a viable alternative to reduce the in-core memory requirements while solving large scale problems. This study evaluates the performance of various out-of-core sequential solvers based on multifrontal or supernodal techniques in the context of finite element formulations for three dimensional problems on a Windows platform. Here three different solvers, HSL_MA78, MUMPS and PARDISO are compared. The performance of these solvers is evaluated on a 64-bit machine with 16GB RAM for finite element formulation of flow through a rectangular channel. It is observed that using out-of-core PARDISO solver, relatively large problems can be solved. The implementation of Newton and modified Newton's iteration is also discussed.Keywords: Out-of-core, PARDISO, MUMPS, Newton.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 21442337 The Differential Transform Method for Advection-Diffusion Problems
Authors: M. F. Patricio, P. M. Rosa
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In this paper a class of numerical methods to solve linear and nonlinear PDEs and also systems of PDEs is developed. The Differential Transform method associated with the Method of Lines (MoL) is used. The theory for linear problems is extended to the nonlinear case, and a recurrence relation is established. This method can achieve an arbitrary high-order accuracy in time. A variable stepsize algorithm and some numerical results are also presented.
Keywords: Method of Lines, Differential Transform Method.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17442336 An Integrated Planning Framework for Sustainable Tourism: Case Study of Tunisia
Authors: S. Halioui, I. Arikan, M. Schmidt
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Tourism sector in Tunisia faces several problems that range from economic challenges to environmental degradation and social instability. These problems have been intensified because of the increased competition in the tourism market, the political instability, financial crises, and recently terrorism problems have aggravated the situation. As a consequence, a new framework that promotes sustainable tourism in the country and increases its competitiveness is urgently needed. Planning for sustainable tourism sector requires the integration of complex interactions between economic, social and environmental aspects. Sustainable tourism principles can be implemented with the help of Strategic Environmental Assessment (SEA) process, which ensures the full integration of economic, social and environmental considerations while planning for the tourism sector in Tunisia. Results of the paper have broad implications for policy makers and tourism professionals.Keywords: Sustainable tourism, strategic environmental assessment, tourism planning, policy.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15042335 On a Class of Inverse Problems for Degenerate Differential Equations
Authors: Fadi Awawdeh, H.M. Jaradat
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In this paper, we establish existence and uniqueness of solutions for a class of inverse problems of degenerate differential equations. The main tool is the perturbation theory for linear operators.Keywords: Inverse Problem, Degenerate Differential Equations, Perturbation Theory for Linear Operators
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16362334 Approximate Solutions to Large Stein Matrix Equations
Authors: Khalide Jbilou
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In the present paper, we propose numerical methods for solving the Stein equation AXC - X - D = 0 where the matrix A is large and sparse. Such problems appear in discrete-time control problems, filtering and image restoration. We consider the case where the matrix D is of full rank and the case where D is factored as a product of two matrices. The proposed methods are Krylov subspace methods based on the block Arnoldi algorithm. We give theoretical results and we report some numerical experiments.
Keywords: IEEEtran, journal, LATEX, paper, template.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 19042333 Improved Asymptotic Stability Criteria for Uncertain Neutral Systems with Time-varying Discrete Delays
Authors: Changchun Shen, Shouming Zhong
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This paper investigates the robust stability of uncertain neutral system with time-varying delay. By using Lyapunov method and linear matrix inequality technology, new delay-dependent stability criteria are obtained and formulated in terms of linear matrix inequalities (LMIs), which can be easy to check the robust stability of the considered systems. Numerical examples are given to indicate significant improvements over some existing results.
Keywords: Neutral system, linear matrix inequalities, Lyapunov, stability.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 15142332 Women’s Rights in Conflict with People’s Cultural Autonomy: Problems of Cultural Accommodation
Authors: Nazia Khan
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The paper explores the cultural rights accommodation by the state which has left many unresolved problems. The cultural rights sometimes violate the basic individual rights of the members inside the community like women. The paper further explicates certain cultural norms and practices which violates the rights of women inside the community in the name of culture.
Keywords: Culture, Patriarchy, Rights, Women.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16632331 A New Heuristic Approach for the Large-Scale Generalized Assignment Problem
Authors: S. Raja Balachandar, K.Kannan
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This paper presents a heuristic approach to solve the Generalized Assignment Problem (GAP) which is NP-hard. It is worth mentioning that many researches used to develop algorithms for identifying the redundant constraints and variables in linear programming model. Some of the algorithms are presented using intercept matrix of the constraints to identify redundant constraints and variables prior to the start of the solution process. Here a new heuristic approach based on the dominance property of the intercept matrix to find optimal or near optimal solution of the GAP is proposed. In this heuristic, redundant variables of the GAP are identified by applying the dominance property of the intercept matrix repeatedly. This heuristic approach is tested for 90 benchmark problems of sizes upto 4000, taken from OR-library and the results are compared with optimum solutions. Computational complexity is proved to be O(mn2) of solving GAP using this approach. The performance of our heuristic is compared with the best state-ofthe- art heuristic algorithms with respect to both the quality of the solutions. The encouraging results especially for relatively large size test problems indicate that this heuristic approach can successfully be used for finding good solutions for highly constrained NP-hard problems.
Keywords: Combinatorial Optimization Problem, Generalized Assignment Problem, Intercept Matrix, Heuristic, Computational Complexity, NP-Hard Problems.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 23482330 A New Approach to Optimal Control Problem Constrained by Canonical Form
Authors: B. Farhadinia
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In this article, it is considered a class of optimal control problems constrained by differential and integral constraints are called canonical form. A modified measure theoretical approach is introduced to solve this class of optimal control problems.Keywords: control problem, Canonical form, Measure theory.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 12022329 Improved Exponential Stability Analysis for Delayed Recurrent Neural Networks
Authors: Miaomiao Yang, Shouming Zhong
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This paper studies the problem of exponential stability analysis for recurrent neural networks with time-varying delay.By establishing a suitable augmented LyapunovCKrasovskii function and a novel sufficient condition is obtained to guarantee the exponential stability of the considered system.In order to get a less conservative results of the condition,zero equalities and reciprocally convex approach are employed. The several exponential stability criterion proposed in this paper is simpler and effective. A numerical example is provided to demonstrate the feasibility and effectiveness of our results.
Keywords: Exponential stability , Neural networks, Linear matrix inequality, Lyapunov-Krasovskii, Time-varying.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 17662328 The Algorithm to Solve the Extend General Malfatti’s Problem in a Convex Circular Triangle
Authors: Ching-Shoei Chiang
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The Malfatti’s problem solves the problem of fitting three circles into a right triangle such that these three circles are tangent to each other, and each circle is also tangent to a pair of the triangle’s sides. This problem has been extended to any triangle (called general Malfatti’s problem). Furthermore, the problem has been extended to have 1 + 2 + … + n circles inside the triangle with special tangency properties among circles and triangle sides; it is called the extended general Malfatti’s problem. In the extended general Malfatti’s problem, call it Tri(Tn), where Tn is the triangle number, there are closed-form solutions for the Tri(T₁) (inscribed circle) problem and Tri(T₂) (3 Malfatti’s circles) problem. These problems become more complex when n is greater than 2. In solving the Tri(Tn) problem, n > 2, algorithms have been proposed to solve these problems numerically. With a similar idea, this paper proposed an algorithm to find the radii of circles with the same tangency properties. Instead of the boundary of the triangle being a straight line, we use a convex circular arc as the boundary and try to find Tn circles inside this convex circular triangle with the same tangency properties among circles and boundary as in Tri(Tn) problems. We call these problems the Carc(Tn) problems. The algorithm is a mO(Tn) algorithm, where m is the number of iterations in the loop. It takes less than 1000 iterations and less than 1 second for the Carc(T16) problem, which finds 136 circles inside a convex circular triangle with specified tangency properties. This algorithm gives a solution for circle packing problem inside convex circular triangle with arbitrarily-sized circles. Many applications concerning circle packing may come from the result of the algorithm, such as logo design, architecture design, etc.
Keywords: Circle packing, computer-aided geometric design, geometric constraint solver, Malfatti’s problem.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1432327 Evaluation of the Effect of Nursing Services Provided in a Correctional Institution on the Physical Health Levels and Health Behaviors of Female Inmates
Authors: Şenay Pehli̇van, Gülümser Kublay
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Female inmates placed in a Correctional Institution (CI) have more physical health problems than other women and their male counterparts. Thus, they require more health care services in the CI and nursing services in particular. CI nurses also have the opportunity to teach behaviors which will protect and improve their health to these women who are difficult to reach in the community. The aim of this study was to evaluate effect of nursing services provided in a CI on the physical health levels and health behaviors of female inmates. The study has a quasi-experimental design. The study was done in Female Closed CI in Ankara, Turkey. The study was conducted on 30 female inmates. Before the implementation of nursing interventions in the initial phase of the study, female inmates were evaluated in terms of physical health problems and health behavior using forms, a physical examination, medical history, health files (file containing medical information related to prisons) and the Omaha System (OS). Findings obtained from evaluations were grouped and symptoms-findings were expressed with OS diagnosis codes. Knowledge, behavior and status scores of prisoners in relation to health problems were determined. After the implementation of the nursing interventions, female inmates were evaluated in terms of physical health problems and health behavior using OS. The research data were collected using the Female Evaluation Form developed by the researcher and the OS. It was found that knowledge, behavior and status scores of prisoners significantly increased after the implementation of nursing interventions (p < 0.05).
Keywords: Correctional institution, correctional nursing, prison nursing, female inmates, physical health problems, health behaviors.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14692326 Particle Swarm Optimization with Reduction for Global Optimization Problems
Authors: Michiharu Maeda, Shinya Tsuda
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This paper presents an algorithm of particle swarm optimization with reduction for global optimization problems. Particle swarm optimization is an algorithm which refers to the collective motion such as birds or fishes, and a multi-point search algorithm which finds a best solution using multiple particles. Particle swarm optimization is so flexible that it can adapt to a number of optimization problems. When an objective function has a lot of local minimums complicatedly, the particle may fall into a local minimum. For avoiding the local minimum, a number of particles are initially prepared and their positions are updated by particle swarm optimization. Particles sequentially reduce to reach a predetermined number of them grounded in evaluation value and particle swarm optimization continues until the termination condition is met. In order to show the effectiveness of the proposed algorithm, we examine the minimum by using test functions compared to existing algorithms. Furthermore the influence of best value on the initial number of particles for our algorithm is discussed.Keywords: Particle swarm optimization, Global optimization, Metaheuristics, Reduction.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16212325 Improved Robust Stability Criteria for Discrete-time Neural Networks
Authors: Zixin Liu, Shu Lü, Shouming Zhong, Mao Ye
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In this paper, the robust exponential stability problem of uncertain discrete-time recurrent neural networks with timevarying delay is investigated. By constructing a new augmented Lyapunov-Krasovskii function, some new improved stability criteria are obtained in forms of linear matrix inequality (LMI). Compared with some recent results in literature, the conservatism of the new criteria is reduced notably. Two numerical examples are provided to demonstrate the less conservatism and effectiveness of the proposed results.
Keywords: Robust exponential stability, delay-dependent stability, discrete-time neutral networks, time-varying delays.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14772324 The Giant Component in a Random Subgraph of a Weak Expander
Authors: Yilun Shang
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In this paper, we investigate the appearance of the giant component in random subgraphs G(p) of a given large finite graph family Gn = (Vn, En) in which each edge is present independently with probability p. We show that if the graph Gn satisfies a weak isoperimetric inequality and has bounded degree, then the probability p under which G(p) has a giant component of linear order with some constant probability is bounded away from zero and one. In addition, we prove the probability of abnormally large order of the giant component decays exponentially. When a contact graph is modeled as Gn, our result is of special interest in the study of the spread of infectious diseases or the identification of community in various social networks.
Keywords: subgraph, expander, random graph, giant component, percolation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 16972323 Augmented Reality in Schools: Preliminary Evaluation Results from a Summer School
Authors: Alexandru Balog, Costin Pribeanu, Dragos Iordache
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Formative usability evaluation aims at finding usability problems during the development process. The earlier these problems are identified, the less expensive to fix they are. This paper presents some preliminary results from a formative usability testing of the 1st prototype developed for the ARiSE (Augmented Reality in School Environments) project.Keywords: AR-based educational systems, formative evaluation, usability evaluation, user testing.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 25512322 FEM Simulation of Triple Diffusive Magnetohydrodynamics Effect of Nanofluid Flow over a Nonlinear Stretching Sheet
Authors: Rangoli Goyal, Rama Bhargava
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The triple diffusive boundary layer flow of nanofluid under the action of constant magnetic field over a non-linear stretching sheet has been investigated numerically. The model includes the effect of Brownian motion, thermophoresis, and cross-diffusion; slip mechanisms which are primarily responsible for the enhancement of the convective features of nanofluid. The governing partial differential equations are transformed into a system of ordinary differential equations (by using group theory transformations) and solved numerically by using variational finite element method. The effects of various controlling parameters, such as the magnetic influence number, thermophoresis parameter, Brownian motion parameter, modified Dufour parameter, and Dufour solutal Lewis number, on the fluid flow as well as on heat and mass transfer coefficients (both of solute and nanofluid) are presented graphically and discussed quantitatively. The present study has industrial applications in aerodynamic extrusion of plastic sheets, coating and suspensions, melt spinning, hot rolling, wire drawing, glass-fibre production, and manufacture of polymer and rubber sheets, where the quality of the desired product depends on the stretching rate as well as external field including magnetic effects.Keywords: FEM, Thermophoresis, Diffusiophoresis, Brownian motion.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 14512321 A Finite Volume Procedure on Unstructured Meshes for Fluid-Structure Interaction Problems
Authors: P I Jagad, B P Puranik, A W Date
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Flow through micro and mini channels requires relatively high driving pressure due to the large fluid pressure drop through these channels. Consequently the forces acting on the walls of the channel due to the fluid pressure are also large. Due to these forces there are displacement fields set up in the solid substrate containing the channels. If the movement of the substrate is constrained at some points, then stress fields are established in the substrate. On the other hand, if the deformation of the channel shape is sufficiently large then its effect on the fluid flow is important to be calculated. Such coupled fluid-solid systems form a class of problems known as fluidstructure interactions. In the present work a co-located finite volume discretization procedure on unstructured meshes is described for solving fluid-structure interaction type of problems. A linear elastic solid is assumed for which the effect of the channel deformation on the flow is neglected. Thus the governing equations for the fluid and the solid are decoupled and are solved separately. The procedure is validated by solving two benchmark problems, one from fluid mechanics and another from solid mechanics. A fluid-structure interaction problem of flow through a U-shaped channel embedded in a plate is solved.Keywords: Finite volume method, flow induced stresses, fluidstructureinteraction, unstructured meshes.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18902320 Stability Criteria for Uncertainty Markovian Jumping Parameters of BAM Neural Networks with Leakage and Discrete Delays
Authors: Qingqing Wang, Baocheng Chen, Shouming Zhong
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In this paper, the problem of stability criteria for Markovian jumping BAM neural networks with leakage and discrete delays has been investigated. Some new sufficient condition are derived based on a novel Lyapunov-Krasovskii functional approach. These new criteria based on delay partitioning idea are proved to be less conservative because free-weighting matrices method and a convex optimization approach are considered. Finally, one numerical example is given to illustrate the the usefulness and feasibility of the proposed main results.
Keywords: Stability, Markovian jumping neural networks, Timevarying delays, Linear matrix inequality.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 51402319 Promoting Non-Formal Learning Mobility in the Field of Youth
Authors: Juha Kettunen
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The purpose of this study is to develop a framework for the assessment of research and development projects. The assessment map is developed in this study based on the strategy map of the balanced scorecard approach. The assessment map is applied in a project that aims to reduce the inequality and risk of exclusion of young people from disadvantaged social groups. The assessment map denotes that not only funding but also necessary skills and qualifications should be carefully assessed in the implementation of the project plans so as to achieve the objectives of projects and the desired impact. The results of this study are useful for those who want to develop the implementation of the Erasmus+ Programme and the project teams of research and development projects.
Keywords: Non-formal learning, youth work, social inclusion, innovation.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 8272318 The Homotopy Analysis Method for Solving Discontinued Problems Arising in Nanotechnology
Authors: Hassan Saberi-Nik, Mahin Golchaman
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This paper applies the homotopy analysis method method to a nonlinear differential-difference equation arising in nanotechnology. Continuum hypothesis on nanoscales is invalid, and a differential-difference model is considered as an alternative approach to describing discontinued problems. Comparison of the approximate solution with the exact one reveals that the method is very effective.
Keywords: Homotopy analysis method, differential-difference, nanotechnology.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 19782317 Delay-Dependent Stability Analysis for Neutral Type Neural Networks with Uncertain Parameters and Time-Varying Delay
Authors: Qingqing Wang, Shouming Zhong
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In this paper, delay-dependent stability analysis for neutral type neural networks with uncertain paramters and time-varying delay is studied. By constructing new Lyapunov-Krasovskii functional and dividing the delay interval into multiple segments, a novel sufficient condition is established to guarantee the globally asymptotically stability of the considered system. Finally, a numerical example is provided to illustrate the usefulness of the proposed main results.
Keywords: Neutral type neural networks, Time-varying delay, Stability, Linear matrix inequality(LMI).
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 18192316 Existence of Multiple Positive Periodic Solutions to n Species Nonautonomous Lotka-Volterra Cooperative Systems with Harvesting Terms
Authors: Kaihong Zhao
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In this paper, the existence of 2n positive periodic solutions for n species non-autonomous Lotka-Volterra cooperative systems with harvesting terms is established by using Mawhin-s continuation theorem of coincidence degree theory and matrix inequality. An example is given to illustrate the effectiveness of our results.
Keywords: Multiple positive periodic solutions, Nonautonomous Lotka-Volterra cooperative system, Coincidence degree, Harvesting term.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 13362315 A Probability based Pair Extension Method in Protein 2-DE Gel Image Analysis
Authors: Yanhua Jin, Won Suk Lee
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The two-dimensional gel electrophoresis method (2-DE) is widely used in Proteomics to separate thousands of proteins in a sample. By comparing the protein expression levels of proteins in a normal sample with those in a diseased one, it is possible to identify a meaningful set of marker proteins for the targeted disease. The major shortcomings of this approach involve inherent noises and irregular geometric distortions of spots observed in 2-DE images. Various experimental conditions can be the major causes of these problems. In the protein analysis of samples, these problems eventually lead to incorrect conclusions. In order to minimize the influence of these problems, this paper proposes a partition based pair extension method that performs spot-matching on a set of gel images multiple times and segregates more reliable mapping results which can improve the accuracy of gel image analysis. The improved accuracy of the proposed method is analyzed through various experiments on real 2-DE images of human liver tissues.Keywords: Proteomics, spot-matching, two-dimensionalelectrophoresis.
Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1487