Search results for: Optimal parameters

Authors: Sh. Derakhshan, A. Mostafavi

Abstract:

Nowadays, the challenge in hydraulic turbine design is the multi-objective design of turbine runner to reach higher efficiency. The hydraulic performance of a turbine is strictly depends on runner blades shape. The present paper focuses on the application of the multi-objective optimization algorithm to the design of a small Francis turbine runner. The optimization exercise focuses on the efficiency improvement at the best efficiency operating point (BEP) of the GAMM Francis turbine. A global optimization method based on artificial neural networks (ANN) and genetic algorithms (GA) coupled by 3D Navier-Stokes flow solver has been used to improve the performance of an initial geometry of a Francis runner. The results show the good ability of optimization algorithm and the final geometry has better efficiency with initial geometry. The goal was to optimize the geometry of the blades of GAMM turbine runner which leads to maximum total efficiency by changing the design parameters of camber line in at least 5 sections of a blade. The efficiency of the optimized geometry is improved from 90.7% to 92.5%. Finally, design parameters and the way of selection have been considered and discussed.

Keywords: Francis Turbine, Runner, Optimization, CFD

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Authors: Grigorios N. Beligiannis, Georgios A. Tsirogiannis, Panayotis E. Pintelas

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In this contribution, the use of a new genetic operator is proposed. The main advantage of using this operator is that it is able to assist the evolution procedure to converge faster towards the optimal solution of a problem. This new genetic operator is called ''intuition'' operator. Generally speaking, one can claim that this operator is a way to include any heuristic or any other local knowledge, concerning the problem, that cannot be embedded in the fitness function. Simulation results show that the use of this operator increases significantly the performance of the classic Genetic Algorithm by increasing the convergence speed of its population.

Keywords: Genetic algorithms, intuition operator, reasonable genomes, complex search space, nonlinear fitness functions

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Authors: Suleiman M. Elhamali, K. M. Etmimi, A. Usha

Abstract:

The paper presents the results of microhardness and microstructure of low carbon steel surface melted using carbon dioxide laser with a wavelength of 10.6μm and a maximum output power of 2000W. The processing parameters such as the laser power, and the scanning rate were investigated in this study. After surface melting two distinct regions formed corresponding to the melted zone MZ, and the heat affected zone HAZ. The laser melted region displayed a cellular fine structures while the HAZ displayed martensite or bainite structure. At different processing parameters, the original microstructure of this steel (Ferrite+Pearlite) has been transformed to new phases of martensitic and bainitic structures. The fine structure and the high microhardness are evidence of the high cooling rates which follow the laser melting. The melting pool and the transformed microstructure in the laser surface melted region of carbon steel showed clear dependence on laser power and scanning rate.

Keywords: Carbon steel, laser surface melting, microstructure, microhardness.

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Authors: C. A. Cortes-Quiroz, A. Azarbadegan, E. Moeendarbary

Abstract:

A new design of a planar passive T-micromixer with fin-shaped baffles in the mixing channel is presented. The mixing efficiency and the level of pressure loss in the channel have been investigated by numerical simulations in the range of Reynolds number (Re) 1 to 50. A Mixing index (Mi) has been defined to quantify the mixing efficiency, which results over 85% at both ends of the Re range, what demonstrates the micromixer can enhance mixing using the mechanisms of diffusion (lower Re) and convection (higher Re). Three geometric dimensions: radius of baffle, baffles pitch and height of the channel define the design parameters, and the mixing index and pressure loss are the performance parameters used to optimize the micromixer geometry with a multi-criteria optimization method. The Pareto front of designs with the optimum trade-offs, maximum mixing index with minimum pressure loss, is obtained. Experiments for qualitative and quantitative validation have been implemented.

Keywords: Computational fluids dynamics, fin-shaped baffle, mixing strategies, multi-objective optimization, passive micromixer.

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Authors: Sayani Sil, Sukanta Das

Abstract:

This paper reports a distributed mutual exclusion algorithm for mobile Ad-hoc networks. The network is clustered hierarchically. The proposed algorithm considers the clustered network as a logical tree and develops a token passing scheme to get the mutual exclusion. The performance analysis and simulation results show that its message requirement is optimal, and thus the algorithm is energy efficient.

Keywords: Critical section, Distributed mutual exclusion, MobileAd-hoc network, Token-based algorithms.

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Authors: H. Soleimanjahi, M. J. Nategh, S. Falahi

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Deciding the numerous parameters involved in designing a competent artificial neural network is a complicated task. The existence of several options for selecting an appropriate architecture for neural network adds to this complexity, especially when different applications of heterogeneous natures are concerned. Two completely different applications in engineering and medical science were selected in the present study including prediction of workpiece's surface roughness in ultrasonic-vibration assisted turning and papilloma viruses oncogenicity. Several neural network architectures with different parameters were developed for each application and the results were compared. It was illustrated in this paper that some applications such as the first one mentioned above are apt to be modeled by a single network with sufficient accuracy, whereas others such as the second application can be best modeled by different expert networks for different ranges of output. Development of knowledge about the essentials of neural networks for different applications is regarded as the cornerstone of multidisciplinary network design programs to be developed as a means of reducing inconsistencies and the burden of the user intervention.

Keywords: Artificial Neural Network, Malignancy Diagnosis, Papilloma Viruses Oncogenicity, Surface Roughness, UltrasonicVibration-Assisted Turning.

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Authors: B. S. Raghavendra, D. Narayana Dutt

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Many recent electrophysiological studies have revealed the importance of investigating meditation state in order to achieve an increased understanding of autonomous control of cardiovascular functions. In this paper, we characterize heart rate variability (HRV) time series acquired during meditation using nonlinear dynamical parameters. We have computed minimum embedding dimension (MED), correlation dimension (CD), largest Lyapunov exponent (LLE), and nonlinearity scores (NLS) from HRV time series of eight Chi and four Kundalini meditation practitioners. The pre-meditation state has been used as a baseline (control) state to compare the estimated parameters. The chaotic nature of HRV during both pre-meditation and meditation is confirmed by MED. The meditation state showed a significant decrease in the value of CD and increase in the value of LLE of HRV, in comparison with premeditation state, indicating a less complex and less predictable nature of HRV. In addition, it was shown that the HRV of meditation state is having highest NLS than pre-meditation state. The study indicated highly nonlinear dynamic nature of cardiac states as revealed by HRV during meditation state, rather considering it as a quiescent state.

Keywords: Correlation dimension, Embedding dimension, Heartrate variability, Largest Lyapunov exponent, Meditation, Nonlinearity score.

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Authors: M. A. Elghorab, A. Abou El-Azm Aly, A. S. Elwetedy, M. A. Kotb

Abstract:

Later marine propeller is the main component of ship propulsion system. For a non-series propeller, it is difficult to indicate the open water marine propeller performance without an experimental study to measure the marine propeller parameters. In the present study, the open water performance of a non-series marine propeller has been carried out experimentally. The geometrical aspects of a commercial non-series marine propeller have been measured for a propeller blade area ratio of 0.3985. The measured propeller performance parameters were the thrust and torque coefficients for different propeller rotational speed and different water channel flow velocity, then the open water performance for the propeller has been plotted. In addition, a direct comparison between the obtained experimental results and a theoretical study of a B-series marine propeller of the same blade area ratio has been carried out. A correction factor has been introduced to apply the operating conditions of the experimental results to that of the theoretical study for the studied marine propeller.

Keywords: Advance speed, marine propeller, open water performance, thrust coefficient, torque coefficient.

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Authors: Jungho Moon, Myunggon Yoon

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This paper presents an implementation of a configurable UART-to-Ethernet converter using an ARM-based 32-bit microcontroller as well as a dedicated configuration program running on a PC for configuring the operating parameters of the converter. The program was written in Python. Various parameters pertaining to the operation of the converter can be modified by the configuration program through the Ethernet interface of the converter. The converter supports 3 representative asynchronous serial communication protocols, RS-232, RS-422, and RS-485 and supports 3 network modes, TCP/IP server, TCP/IP client, and UDP client. The TCP/IP and UDP protocols were implemented on the microcontroller using an open source TCP/IP protocol stack called lwIP (A lightweight TCP/IP) and FreeRTOS, a free real-time operating system for embedded systems. Due to the use of a real-time operating system, the firmware of the converter was implemented as a multi-thread application and as a result becomes more modular and easier to develop. The converter can provide a seamless bridge between a serial port and an Ethernet port, thereby allowing existing legacy apparatuses with no Ethernet connectivity to communicate using the Ethernet protocol.

Keywords: Converter, embedded systems, Ethernet, lwIP, UART.

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Authors: Arthur David Snider, Laiq Azam

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The classic problem of recovering arbitrary values of a band-limited signal from its samples has an added complication in software radio applications; namely, the resampling calculations inevitably fold aliases of the analog signal back into the original bandwidth. The phenomenon is quantified by the spur-free dynamic range. We demonstrate how a novel application of the Remez (Parks- McClellan) algorithm permits optimal signal recovery and SFDR, far surpassing state-of-the-art resamplers.

Keywords: Sampling methods, Signal sampling, Digital radio, Digital-analog conversion.

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Authors: Anant Oonsivilai, Kenedy A. Greyson

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The demand of the energy management systems (EMS) set forth by modern power systems requires fast energy management systems. Contingency analysis is among the functions in EMS which is time consuming. In order to handle this limitation, this paper introduces agent based technology in the contingency analysis. The main function of agents is to speed up the performance. Negotiations process in decision making is explained and the issue set forth is the minimization of the operating costs. The IEEE 14 bus system and its line outage have been used in the research and simulation results are presented.

Keywords: Agents, model, negotiation, optimal dispatch, powersystems.

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Authors: Sidhartha Panda, N.P.Padhy, R.N.Patel

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This paper presents a procedure for modeling and tuning the parameters of Thyristor Controlled Series Compensation (TCSC) controller in a multi-machine power system to improve transient stability. First a simple transfer function model of TCSC controller for stability improvement is developed and the parameters of the proposed controller are optimally tuned. Genetic algorithm (GA) is employed for the optimization of the parameter-constrained nonlinear optimization problem implemented in a simulation environment. By minimizing an objective function in which the oscillatory rotor angle deviations of the generators are involved, transient stability performance of the system is improved. The proposed TCSC controller is tested on a multi-machine system and the simulation results are presented. The nonlinear simulation results validate the effectiveness of proposed approach for transient stability improvement in a multimachine power system installed with a TCSC. The simulation results also show that the proposed TCSC controller is also effective in damping low frequency oscillations.

Keywords: Genetic algorithm, TCSC, transient stability, multimachinepower system.

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Authors: Anjaneyulu M.V.L.R., Harikrishna M., Chenchuobulu S.

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Rapid urbanization, industrialization and population growth have led to an increase in number of automobiles that cause air pollution. It is estimated that road traffic contributes 60% of air pollution in urban areas. A case by case assessment is required to predict the air quality in urban situations, so as to evolve certain traffic management measures to maintain the air quality levels with in the tolerable limits. Calicut city in the state of Kerala, India has been chosen as the study area. Carbon Monoxide (CO) concentration was monitored at 15 links in Calicut city and air quality performance was evaluated over each link. The CO pollutant concentration values were compared with the National Ambient Air Quality Standards (NAAQS), and the CO values were predicted by using CALINE4 and IITLS and Linear regression models. The study has revealed that linear regression model performs better than the CALINE4 and IITLS models. The possible association between CO pollutant concentration and traffic parameters like traffic flow, type of vehicle, and traffic stream speed was also evaluated.

Keywords: CO pollution, Modelling, Traffic stream parameters.

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Authors: Javadi Alimohammad, Zanjanizadeh Homa, Javadi Maryam

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Regarding the multi-media property of internet and the facilities that can be provided for the users, the purpose of this paper is to investigate the users- behavioral patterns and the impact of internet on taboos of marriage. For this purpose a survey technique on the sample size amounted 403 students of governmental guidance schools of city of Mashhad in country of Iran were considered. The results showed, the process of using various internet environments depends on the degree of the users- familiarity with these sites. In order to clarify the effects of the Internet on the taboos of marriage, the non – internet parameters also considered to be controlled. The ttest held among the internet users and non-users, indicated that internet users possess lower taboos of marriage. Extraction of the effects of internet via considering the effects of non-internet parameters, indicate that addiction to the internet, creating a cordial atmosphere, emotional communication, and message attractive factors have significant effects on the family's traditional values.

Keywords: Internet, taboos of marriage, family, masscommunication, computer mediate communication.

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Authors: Lazim Abdullah, Nurhakimah Ab. Rahman

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Linear systems are widely used in many fields of science and engineering. In many applications, at least some of the parameters of the system are represented by fuzzy rather than crisp numbers. Therefore it is important to perform numerical algorithms or procedures that would treat general fuzzy linear systems and solve them using iterative methods. This paper aims are to solve fuzzy linear systems using four types of Jacobi based iterative methods. Four iterative methods based on Jacobi are used for solving a general n × n fuzzy system of linear equations of the form Ax = b , where A is a crisp matrix and b an arbitrary fuzzy vector. The Jacobi, Jacobi Over-Relaxation, Refinement of Jacobi and Refinement of Jacobi Over-Relaxation methods was tested to a five by five fuzzy linear system. It is found that all the tested methods were iterated differently. Due to the effect of extrapolation parameters and the refinement, the Refinement of Jacobi Over-Relaxation method was outperformed the other three methods.

Keywords: Fuzzy linear systems, Jacobi, Jacobi Over- Relaxation, Refinement of Jacobi, Refinement of Jacobi Over- Relaxation.

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Authors: Ekkaluk Eksook, Chutima Prommak

Abstract:

This paper address the network reliability optimization problem in the optical access network design for the 3G cellular systems. We presents a novel 0-1 integer programming model for designing optical access network topologies comprised of multi-rings with common-edge in order to guarantee always-on services. The results show that the proposed model yields access network topologies with the optimal reliablity and satisfies both network cost limitations and traffic demand requirements.

Keywords: Network Reliability, Topological Network Design, 3G Cellular Networks.

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Authors: József Valyon, Gábor Horváth

Abstract:

In comparison to the original SVM, which involves a quadratic programming task; LS–SVM simplifies the required computation, but unfortunately the sparseness of standard SVM is lost. Another problem is that LS-SVM is only optimal if the training samples are corrupted by Gaussian noise. In Least Squares SVM (LS–SVM), the nonlinear solution is obtained, by first mapping the input vector to a high dimensional kernel space in a nonlinear fashion, where the solution is calculated from a linear equation set. In this paper a geometric view of the kernel space is introduced, which enables us to develop a new formulation to achieve a sparse and robust estimate.

Keywords: Support Vector Machines, Least Squares SupportVector Machines, Regression, Sparse approximation.

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Authors: Z. Pavlík, J. Žumár, M. Pavlíková, J. Kočí, R. Černý

Abstract:

Water vapour transport properties of gypsum block are studied in dependence on relative humidity using inverse analysis based on genetic algorithm. The computational inverse analysis is performed for the relative humidity profiles measured along the longitudinal axis of a rod sample. Within the performed transient experiment, the studied sample is exposed to two environments with different relative humidity, whereas the temperature is kept constant. For the basic gypsum characterisation and for the assessment of input material parameters necessary for computational application of genetic algorithm, the basic material properties of gypsum are measured as well as its thermal and water vapour storage parameters. On the basis of application of genetic algorithm, the relative humidity dependent water vapour diffusion coefficient and water vapour diffusion resistance factor are calculated.

Keywords: Water vapour transport, gypsum block, transient experiment, genetic algorithm.

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Authors: Sergun Kurtoglu

Abstract:

The struggle between modern and postmodern understanding is also displayed in terms of the superiorities of quantitative and qualitative methods to each other which are evaluated within the scope of these understandings. By way of assuming that the quantitative researches (modern) are able to account for structure while the qualitative researches (postmodern) explain the process, these methods are turned into a means for worldviews specific to a period. In fact, process is not a functioning independent of structure. In addition to this issue, the ability of quantitative methods to provide scientific knowledge is also controversial so long as they exclude the dialectical method. For this reason, the critiques charged against modernism in terms of quantitative methods are, in a sense, legitimate. Nevertheless, the main issue is in which parameters postmodernist critique tries to legitimize its critiques and whether these parameters represent a point of view enabling democratic solutions. In this respect, the scientific knowledge covered in Turkish media as a means through which ordinary people have access to scientific knowledge will be evaluated by means of content analysis within a new objectivity conception.

Keywords: knowledge and objectivity, dialectic method, qualitative and quantitative methods, modernism/postmodernism.

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Authors: M. Zelinkova, M. Ondova

Abstract:

Fly ash (FA) thanks to the significant presence of SiO2 and Al2O3 as the main components is a potential raw material for geopolymers production. Mechanical activation is a method for improving FA reactivity and also the porosity of final mixture; those parameters can be analysed through sorption properties. They have direct impact on the durability of fly ash based geopolymer mortars. In the paper, effect of FA fineness on sorption properties of geopolymers based on sodium silicate, as well as relationship between fly ash fineness and apparent density, compressive and flexural strength of geopolymers are presented. The best results in the evaluated area reached the sample H1, which contents the highest portion of particle under 20μm (100% of GFA). The interdependence of individual tested properties was confirmed for geopolymer mixtures corresponding to those in the cement based mixtures: higher is portion of fine particles < 20μm, higher is strength, density and lower are sorption properties. The compressive strength as well as sorption parameters of the geopolymer can be reasonably controlled by grinding process and also ensured by the higher share of fine particle (to 20μm) in total mass of the material.

Keywords: Alkali activation, geopolymers, fly ash, particle fineness.

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Authors: Azhar Equbal, Anoop Kumar Sood, M. Asif Equbal, M. Israr Equbal

Abstract:

In the present work response surface methodology (RSM) based central composite design (CCD) is used for analyzing the electrical discharge machining (EDM) process. For experimentation, mild steel is selected as work piece and copper is used as electrode. Three machining parameters namely current (I), spark on time (T_on) and spark off time (T_off) are selected as the input variables. The output or response chosen is material removal rate (MRR) which is to be maximized. To reduce the number of runs face centered central composite design (FCCCD) was used. ANOVA was used to determine the significance of parameter and interactions. The suitability of model is tested using Anderson darling (AD) plot. The results conclude that different parameters considered i.e. current, pulse on and pulse off time; all have dominant effect on the MRR. At last, the optimized parameter setting for maximizing MRR is found through main effect plot analysis.

Keywords: Electrical discharge machining, electrode, MRR, RSM, ANOVA.

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Authors: Ł. Kiedrowski, H. Gierszal, W. Hołubowicz

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This paper presents the H-ARQ techniques comparison for OFDM systems with a new family of non-binary LDPC codes which has been developed within the EU FP7 DAVINCI project. The punctured NB-LDPC codes have been used in a simulated model of the transmission system. The link level performance has been evaluated in terms of spectral efficiency, codeword error rate and average number of retransmissions. The NB-LDPC codes can be easily and effective implemented with different methods of the retransmission needed if correct decoding of a codeword failed. Here the Optimal Symbol Selection method is proposed as a Chase Combining technique.

Keywords: H-ARQ, LDPC, Non-Binary, Punctured Codes.

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Authors: R.K. Behera, S.Behera

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In a wind power generator using doubly fed induction generator (DFIG), the three-phase pulse width modulation (PWM) voltage source converter (VSC) is used as grid side converter (GSC) and rotor side converter (RSC). The standard linear control laws proposed for GSC provides not only instablity against comparatively large-signal disturbances, but also the problem of stability due to uncertainty of load and variations in parameters. In this paper, a nonlinear controller is designed for grid side converter (GSC) of a DFIG for wind power application. The nonlinear controller is designed based on the input-output feedback linearization control method. The resulting closed-loop system ensures a sufficient stability region, make robust to variations in circuit parameters and also exhibits good transient response. Computer simulations and experimental results are presented to confirm the effectiveness of the proposed control strategy.

Keywords: Doubly fed Induction Generator, grid side converter, machine side converter, dc link, feedback linearization.

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Authors: V. Hepsiba Mabel, K. Alagarsamy, Justus S.

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Chord formation in western music notations is an intelligent art form which is learnt over the years by a musician to acquire it. Still it is a question of creativity that brings the perfect chord sequence that matches music score. This work focuses on the process of forming chords using a custom-designed knowledgebase (KB) of Music Expert System. An optimal Chord-Set for a given music score is arrived by using the chord-pool in the KB and the finding the chord match using Jusic Distance (JD). Conceptual Graph based knowledge representation model is followed for knowledge storage and retrieval in the knowledgebase.

Keywords: Knowledge, Music, Representation, Knowledgebase, Chord-Set.

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Authors: Mohamed Abdallah, Mostafa Warith, Roberto Narbaitz, Emil Petriu, Kevin Kennedy

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Heterogeneity of solid waste characteristics as well as the complex processes taking place within the landfill ecosystem motivated the implementation of soft computing methodologies such as artificial neural networks (ANN), fuzzy logic (FL), and their combination. The present work uses a hybrid ANN-FL model that employs knowledge-based FL to describe the process qualitatively and implements the learning algorithm of ANN to optimize model parameters. The model was developed to simulate and predict the landfill gas production at a given time based on operational parameters. The experimental data used were compiled from lab-scale experiment that involved various operating scenarios. The developed model was validated and statistically analyzed using F-test, linear regression between actual and predicted data, and mean squared error measures. Overall, the simulated landfill gas production rates demonstrated reasonable agreement with actual data. The discussion focused on the effect of the size of training datasets and number of training epochs.

Keywords: Adaptive neural fuzzy inference system (ANFIS), gas production, landfill

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Authors: Hala O. El-Mesallamy, Salwa M. Suwailem, Mae M. Seleem

Abstract:

Visfatin and apelin are two new adipokines that recently gained a special interest in diabetes research. This study was conducted to study the interplay between these two adipokines and their correlation with other inflammatory and biochemical parameters in type 2 diabetic (T2D) postmenopausal women with CAD. Visfatin and apelin were measured by enzyme-linked immunoassay (ELISA). Visfatin was found to be significantly higher in the following groups: T2D patients without CAD, non-obese and obese T2D patients with CAD when compared to control group. Apelin was found to be significantly lower in non-obese and obese T2D patients with CAD when compared to control group. Visfatin and apelin were found to be significantly associated with each other and with other biochemical parameters. The current study provides evidence for the interplay between visfatin and apelin through the inflammatory milieu characteristic of T2D and their possible role in the pathogenesis of CAD complication of T2D. 

Keywords: Apelin, Coronary artery disease, Inflammation, Type 2 diabetes, Visfatin.

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Authors: Amin Hajizadeh, Ehsan Hajizadeh

Abstract:

This paper presents a multi-objective formulation for optimal siting and sizing of distributed generation (DG) resources in distribution systems in order to minimize the cost of power losses and energy not supplied. The implemented technique is based on particle swarm optimization (PSO) and weight method that employed to obtain the best compromise between these costs. Simulation results on 33-bus distribution test system are presented to demonstrate the effectiveness of the proposed procedure.

Keywords: Distributed generation, distribution networks, particle swarm optimization, reliability, weight method

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Authors: Gokhan Dok, Hakan Ozturk, Aydin Demir

Abstract:

The behavior of reinforced concrete (RC) members is quite important in RC structures. When evaluating the performance of structures, the nonlinear properties are defined according to the cross sectional behavior of RC members. To be able to determine the behavior of RC members, its cross sectional behavior should be known well. The moment-curvature (MC) relationship is used to represent cross sectional behavior. The MC relationship of RC cross section can be best determined both experimentally and numerically. But, experimental study on RC members is very difficult. The aim of the study is to obtain the MC relationship of RC shear walls. Additionally, it is aimed to determine the parameters which affect MC relationship. While obtaining MC relationship of RC members, XTRACT which can represent robustly the MC relationship is used. Concrete quality, longitudinal and transverse reinforcing ratios, are selected as parameters which affect MC relationship. As a result of the study, curvature ductility and effective flexural stiffness are determined using this parameter. Effective flexural stiffness is compared with the values defined in design codes.

Keywords: Moment-curvature, reinforced concrete, shear wall, numerical.

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Authors: Pravin S. Bodke, Shradha S. Binani, Ravi V. Joat

Abstract:

Science and technology of ultrasonic is widely used in recent years for industrial and medicinal application. The acoustical properties of 2-mercapto substituted pyrimidines viz.,2- Mercapto-4- (2’,4’ –dichloro phenyl) – 6-(2’ – hydroxyl -4’ –methyl-5’ – chlorophenyl) pyrimidine and 2 –Mercapto – 4-(4’ –chloro phenyl) – 6-(2’ – hydroxyl -4’ –methyl-5’ –chlorophenyl) pyrimidine have been investigated from the ultrasonic velocity and density measurements at different concentration and different % in dioxane-water mixture at 305K. The adiabatic compressibility (βs), acoustic impedance (Z), intermolecular free length (Lf), apparent molar volume(ϕv) and relative association (RA) values have been calculated from the experimental data of velocity and density measurement at concentration range of 0.01- 0.000625 mol/lit and 70%,75% and 80% dioxane water mixture. These above parameters are used to discuss the structural and molecular interactions.

Keywords: Acoustical parameters, Density, Dioxane-water mixture, Ultrasonic velocity.

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Authors: Tommaso Adamo, Gianpaolo Ghiani, Antonio D. Grieco, Emanuela Guerriero

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Batch production plants provide a wide range of scheduling problems. In pharmaceutical industries a batch process is usually described by a recipe, consisting of an ordering of tasks to produce the desired product. In this research work we focused on pharmaceutical production processes requiring the culture of a microorganism population (i.e. bacteria, yeasts or antibiotics). Several sources of uncertainty may influence the yield of the culture processes, including (i) low performance and quality of the cultured microorganism population or (ii) microbial contamination. For these reasons, robustness is a valuable property for the considered application context. In particular, a robust schedule will not collapse immediately when a cell of microorganisms has to be thrown away due to a microbial contamination. Indeed, a robust schedule should change locally in small proportions and the overall performance measure (i.e. makespan, lateness) should change a little if at all. In this research work we formulated a constraint programming optimization (COP) model for the robust planning of antibiotics production. We developed a discrete-time model with a multi-criteria objective, ordering the different criteria and performing a lexicographic optimization. A feasible solution of the proposed COP model is a schedule of a given set of tasks onto available resources. The schedule has to satisfy tasks precedence constraints, resource capacity constraints and time constraints. In particular time constraints model tasks duedates and resource availability time windows constraints. To improve the schedule robustness, we modeled the concept of (a, b) super-solutions, where (a, b) are input parameters of the COP model. An (a, b) super-solution is one in which if a variables (i.e. the completion times of a culture tasks) lose their values (i.e. cultures are contaminated), the solution can be repaired by assigning these variables values with a new values (i.e. the completion times of a backup culture tasks) and at most b other variables (i.e. delaying the completion of at most b other tasks). The efficiency and applicability of the proposed model is demonstrated by solving instances taken from a real-life pharmaceutical company. Computational results showed that the determined super-solutions are near-optimal.

Keywords: Constraint programming, super-solutions, robust scheduling, batch process, pharmaceutical industries.

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